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Pathological changes in the cellular structures of retina and choroidea in the early stages of alloxan-induced diabetes

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World Journal of Diabetes 2018年第12期9卷 239-251页

作者： Irina Danilova Svetlana Medvedeva Svetlana Shmakova Margarita Chereshneva Alexey sarapultsev petr sarapultsev Department of Biology and Fundamental Medicine Institute of Natural Sciences and Mathematics Ural Federal University Named After the First Pres.of Russia B.N.Yeltsin Laboratory of Morphology and Biochemistry Institute of Immunology and Physiology Ural Division of Russian Academy of Sciences Laboratory of Immunophysiology and Immunopharmacology Institute of Immunology and Physiology Ural Division of Russian Academy of Sciences Institute of Chemical Engineering Ural Federal University Named After the First Pres. of Russia B.N. Yeltsin Laboratory of Immu-nophatophysiology Institute of Immunology and Physiology Ural Division of Russian Academy of Sciences

AIM To investigate the temporal sequence of pathological changes in the cellular structures of retina and choroidea in the early stages of diabetes in laboratory *** Experimental type 1 diabetes was modeled by three intraperitoneal injections of an alloxan solution into 30 male nonlinear rats at 16 wk of age. The 30 th and 60 th days from the final alloxan injection were chosen as the endpoints. Light and electron microscopy and morphometric and immunohistochemical studies were performed on histological slices of eyeballs from experimental *** Diabetic disturbances progressed to 60 d of the experiment. Thus, in the retina, a partial destruction of photoreceptors accompanied by interstitial edema was observed. The morphometric analysis revealed a reduction in the thickness of the retina. A reduction in the number of blood vessels of the choroid with disturbances of the endothelial cells and the vascular walls and a persistent reduction in the number of melanocytes were observed. The number of proliferating Ki-67 positive cells decreased, and the number of macrophages increased with diabetes *** The starting point in the development of destructive changes involves early reduction in the number of melanocytes of the choroidea and alterations in the retinal pigment epithelium.

关键词： Alloxan Diabetes Diabetic retinopathy Early stage Morphology Histological changes

The correctional modification of inflammatory response at the experimental acute pancreatitis

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Advances in Bioscience and Biotechnology 2012年第4期3卷 442-448页

作者： Alex P. sarapultsev Oleg N. Chupakhin Maxim А. Rantsev petr А. sarapultsev Irina G. Danilova Svetlana U. Medvedeva Larisa P. Sidorova Federal State Autonomous Educational Institution of Higher Professional Education Ural Federal University named after the first President of Russia B. N. Yeltsin Ekaterinburg Russia Institute of Immunology and Physiology of the Ural Branch of the RAS Ekaterinburg Russia The IJ Postovsky Institute of Organic Synthesis the Ural Branch of the RAS Ekaterinburg Russia

This study investigated the effects of the L-17 compound of the group of substituted 5R1, 6H2-1,3,4- thiadiazine-2-amines on the possibility of inflammatory reaction evolvement correction in experimental acute pancreatitis. The study was based upon recent clinical and experimental work which demonstrated the role of local and systemic inflammatory reactions in pancreatonecrosis. Pancreatonecrosis modeling in rats was performed in accordance with the author’s modification of ligation model of acute pancreatitis. The biochemical and hematological analysis were performed in all groups at day 1. For microscopic analysis, five histological slices of each animal were analyzed. The main group, consisting of 15 animals with the average body weight 223 g each, got intraperitoneal injection of L-17 compound, dozed 40 mg/kg in an hour after surgery of pancreatitis formation. Later on, a 40 mg/kg doze of L-17 compound was repeatedly injected as often as once every 24 hours. Already during the 1st day of the experiment, no leucopenia was observed and the signs of proliferative inflammation were detected. Later, at the background of L-17 compound introduction (5th day of the experiment) the necrosis area got surrounded by demarcation bank, and further on (by the 7th day) had been entirely replaced by granulation tissue. Thus, the application of L-17 compound in experimental acute pan-creatitis results in replacement of destructive purulent inflammation by exudative-proliferative one, prevents lympho- and monocytopenia development, minimizes amylase and pancreatic ferments level during the first day of development of the disease and cuts down the lethality rate as result of pancreatonecrosis complications twofold.

关键词： L-17 Compound Experimental Model Inflammation Acute Pancreatitis

Hybrid LES/RANS Simulations of Compressible Flow in a Linear Cascade of Flat Blade Profiles

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Journal of Thermal Science 2024年第5期33卷 1839-1850页

作者： Jaromír PRIHODA petr STRAKA David SIMURDA petr SIDLOF Jan LEPICOVSKY Institute of Thermomechanics of the Czech Academy of Sciences Dolejskova 1402/518200 Prague 5Czech Republic Aerospace Research and Test Centre Beranovych 13019905 PragueCzech Republic Technical University of Liberec Faculty of MechatronicsStudentska 246117 Liberec 1Czech Republic

The paper reports on 3D numerical simulations of unsteady compressible airflow in a blade cascade consisting of flat profiles using a hybrid LES/RANS approach including a transition *** a first step towards simulation of blade flutter in turbomachinery,various incidence angle offsets of the middle blade were *** simulations were run for the flow regime characterized by outlet isentropic Mach number M_(is)=0.5and zero *** results of the LES/RANS simulations(pressure and Mach number distributions)were compared to a baseline RANS model,and to experimental data measured in a high-speed wind *** numerical results show that both methods overpredict flow separation taking place at the leading *** this regard,the hybrid LES/RANS method does not provide superior results compared to the traditional RANS ***,the LES/RANS results also capture vortex shedding from the blunt trailing *** frequency of the trailing edge vortex shedding in CFD simulations matches perfectly the spectral peak recorded during wind tunnel measurements.

关键词： numerical simulation blade cascade hybrid LES/RANS

Energy management of buildings with energy storage and solar photovoltaic:A diversity in experience approach for deep reinforcement learning agents

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Energy and AI 2024年第1期15卷 1-14页

作者： Akhtar Hussain petr Musilek Department of Electrical and Computer Engineering University of AlbertaEdmontonT6G 2G2ABCanada Department of Applied Cybernetics University of Hradec Králové50003Hradec KrálovéCzech Republic

Deep reinforcement learning(DRL)is a suitable approach to handle uncertainty in managing the energy consumption of buildings with energy storage ***,DRL agents are trained by randomly selecting samples from a data set,which can result in overexposure to some data categories and under/no exposure to other data ***,the trained model may be biased towards some data groups and underperform(provide suboptimal results)for data groups to which it was less *** address this issue,diversity in experience-based DRL agent training framework is proposed in this *** approach ensures the exposure of agents to all types of *** proposed framework is implemented in two *** the first step,raw data are grouped into different clusters using the K-means clustering *** clustered data is then arranged by stacking the data of one cluster on top of *** the second step,a selection algorithm is proposed to select data from each cluster to train the DRL *** frequency of selection from each cluster is in proportion to the number of data points in that cluster and therefore named the proportional selection *** analyze the performance of the proposed approach and compare the results with the conventional random selection method,two indices are proposed in this study:the flatness index and the divergence *** model is trained using different data sets(1-year,3-year,and 5-year)and also with the inclusion of solar *** simulation results confirmed the superior performance of the proposed approach to flatten the building’s load curve by optimally operating the energy storage system.

关键词： Battery energy storage Building demand management Deep reinforcement learning Diversity in experience Energy management

Liquid superlubricity of lubricants containing hydroxyl groups and their aqueous solution under rolling/sliding conditions

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Friction 2024年第1期12卷 164-173页

作者： Tomáš POLÁČEK petr ŠPERKA Ivan KŘUPKA Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic

Macroscale rolling/sliding conditions are in the superlubricity,a little-studied topic so *** purpose of this paper is to examine the formation of elastohydrodynamic lubrication(EHL)films by water-based lubricants(glycerol and polyethylene glycol(PEG)),providing superlubricous *** were carried out on an optical ball-on-disc tribometer under rolling/sliding *** film thickness was measured by the thin film colorimetric interferometry,and the viscosity of liquids was measured by rotational and high-pressure falling body *** results show that tribochemical reactions are not the mandatory reason for friction to reach the superlubricity level when using the water-based *** studied liquids themselves are almost *** the addition of water,the signs of shear thinning behavior disappear even *** conditions for this type of lubricant can be predicted using the known Hamrock–Dowson *** anomaly in the thickness of the lubricants was observed as an abrupt change at certain *** more PEG there is in the lubricant,the higher the thickness at the beginning of the jump.

关键词： macroscale superlubricity super low traction water-based lubricants elastohydrodynamic lubrication(EHL) film thickness

Efficient cold atom source from a single-layer atom chip

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Chinese Optics Letters 2024年第6期22卷 103-108页

作者： petr Skakunenko Darya Bykova Anton Afanasiev Alexey Kalmykov Roman Kirtaev Victor Balykin Institute of Spectroscopy Russian Academy of Sciences Moscow 108840Russia Moscow Institute of Physics and Technology Moscow 141700Russia Skolkovo Institute of Science and Technology Moscow 121205Russia National Research University Higher School of Economics Moscow 101000Russia Present affiliation:Emerging Technologies Research Center XPANCEODubaiUnited Arab Emirates

We developed a new single-layer atom chip with an additional U-shaped current-carrying *** new U-shaped microwire creates optimized magnetic field distribution,which increases the trapping volume of a magneto-optical trap(MOT) near the *** approach allows one to localize more atoms,while a setup remains relatively simple (single-layer approach) and consumes low current (up to 10 A). The total number of trapped^(87)Rb atoms in our setup is 5×10^(7).

关键词： atom chip cold atoms laser cooling magneto-optical trap U-MOT

Effect of sodium nitroprusside on the microrheological properties of red blood cells in di®erent media

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 23-31页

作者： petr Ermolinskiy Matvey Maksimov Andrei Lugovtsov Alexey Muravyov Irina Tikhomirova Alexander Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University Moscow 119991Russia Faculty of Physical Education K.D.Ushinsky Yaroslavl State Pedagogical University Yaroslavl 150000 Russia Faculty of Natural Sciences K.D.Ushinsky Yaroslavl State Pedagogical University Yaroslavl 150000 Russia

Red blood cell(RBC)aggregation as well as their deformation signi¯cantly affects blood *** processes depend on various factors,one of which is concentration of the nitric oxide,one of the main signaling molecule in the *** purpose of this study was to investigate the effect of nitric oxide on the microrheological properties of red blood cells(RBCs)in RBC samples of various media after the addition of nitric oxide donor sodium nitroprusside in *** properties were measured using laser aggregometer and ektacytometer based on diffuse light scattering and diffraction of laser light on a suspension of RBCs,*** study found that heparin-stabilized blood showed increased RBC aggregation and deformation with sodium nitroprusside concentrations of 100,and 200M,while EDTA-stabilized blood showed slightly decreased aggregation and unchanged *** washed RBCs in dextran solution,the addition of sodium nitroprusside(in the concentrations of 100,and 200M)resulted in decreased aggregation and increased ***-ndings aid in our understanding of nitric oxide's effect on RBC microrheological properties.

关键词： Sodium nitroprusside nitric oxide red blood cells RBC aggregation diffuse light scattering laser diffractometer

Clinical and socioeconomic determinants of survival in biliary tract adenocarcinomas

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1374-1383页

作者： Laura Sahyoun Kay Chen Cynthia Tsay George Chen petr Protiva Department of Gastroenterology and Hepatology Weill Cornell MedicineNew YorkNY 10065United States Gastroenterology Section Jennifer Moreno VA San Diego Healthcare SystemSan DiegoCA 92161United States Division of Gastroenterology Department of MedicineUniversity of California San DiegoLa JollaCA 92093United States Department of Gastroenterology and Hepatology John Hopkins HospitalBaltimoreMD 21287United States Department of Digestive Diseases Yale New Haven HospitalNew HavenCT 06520United States Department of Gastroenterology VA Connecticut Health Care SystemWest HavenCT 06516United States

BACKGROUND Despite advances in detection and treatments,biliary tract cancers continue to have poor survival ***,there is limited data investigating the significance of socioeconomic status,race/ethnicity,and environmental factors in biliary tract cancer *** from the Surveillance,Epidemiology,and End Results database for biliary and gallbladder adenocarcinomas were extracted from 1975 to ***-conomic data included smoking,poverty level,education,adjusted household income,and percentage of foreign-born persons and urban *** was calculated with Cox proportional hazards models for death in the 5-year period following *** Our study included 15883 gallbladder,11466 intrahepatic biliary,12869 extrahepatic biliary and 7268 ampulla of Vater adenocarcinoma *** analyzing county-specific demographics,patients from counties with higher incomes were associated with higher survival rates[hazard ratio(HR)=0.97,P<0.05].Similarly,counties with a higher percentage of patients with a college level education and counties with a higher urban population had higher 5-year survival rates(HR=0.96,P=0.002 and HR=0.97,P=0.004,respectively).CONCLUSION Worse survival outcomes were observed in lower income counties while higher income and education level were associated with higher 5-year overall survival among gallbladder and biliary malignancies.

关键词： Biliary tract cancers Survival Outcomes research Socioeconomic factors Healthcare disparities

Garg incontinence scores: New scoring system on the horizon to evaluate fecal incontinence. Will it make a difference?

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World Journal of Gastroenterology 2024年第3期30卷 204-210页

作者： petr Tsarkov Inna Tulina Parvez Sheikh Darya D Shlyk Pankaj Garg Department of Colorectal Surgery Sechenov First Moscow State Medical UniversityMoscow 119991Russia Department of Oncologic Colorectal Surgery Sechenov First Moscow State Medical UniversityMoscow 119991Russia Department of Colorectal Surgery Saifee HospitalMumbai 400004MaharashtraIndia Department of Colorectal Surgery Garg Fistula Research InstitutePanchkula 134113HaryanaIndia

The main aim of this opinion review is to comment on the recent article published by Garg et al in the World Journal of Gastroenterology 2023;29:4593–*** authors in the published article developed a new scoring system,Garg incon-tinence scores(GIS),for fecal incontinence(FI).FI is a chronic debilitating disease that has a severe negative impact on the quality of life of the *** IV criteria define FI as multiple episodes of solid or liquid stool passed into the clothes at least twice a *** associated social stigmatization often leads to significant under-reporting of the condition,which further impairs *** important point is that the complexity and vagueness of the disease make it difficult for the patients to properly define and report the magnitude of the problem to their *** to this,the management becomes even more *** issue is resolved up to a considerable extent by a scoring *** were several scoring systems in use for the last three *** prominent of them were the Cleveland Clinic scoring system or the Wexner scoring system,*** Hospital or Vaizey’s scores,and the FI severity ***,there were several shortcomings in these scoring *** the opinion review,we tried to analyze the strength of GIS and compare it to the existing scoring *** main pitfalls in the existing scoring systems were that most of them gave equal weightage to different types of FI(solid,liquid,flatus,etc.),were not comprehensive,and took only the surgeon’s perception of FI into *** GIS,almost all shortcomings of previous scoring systems had been addressed:different weights were assigned to different types of FI by a robust statistical methodology;the scoring system was made comprehensive by including all types of FI that were previously omitted(urge,stress and mucus FI)and gave priority to patients’rather than the physicians’perceptions while developing the scoring *** to this,GIS in

关键词： Fecal incontinence Scoring system Urge Stress Flatus