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Levels of evidence and grades of recommendation supporting European society for medical oncology clinical practice guidelines

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Oncology Research 2024年第5期32卷 807-815页

作者： MARKO SKELIN BRUNA PERKOV-STIPIČIN sanja vušković MARINAŠANDRK PLEHAČEK ANE BAŠIĆ DAVIDŠARČEVIĆ MAJA ILIĆ IVAN KREČAK Pharmacy Department General Hospital ofŠibenik-Knin CountyŠibenikCroatia Faculty of Medicine University of RijekaRijekaCroatia Undergraduate Study in Nursing University of Applied SciencesŠibenikCroatia Department of Oncology University Hospital Center ZagrebZagrebCroatia Pharmacies Joukhadar Sveta NedeljaCroatia Pharmacies Prima Pharme ZagrebCroatia Pharmacy Department General Hospital ZadarZadarCroatia Pharmacy Department General Hospital PulaPulaCroatia Department of Internal Medicine General Hospital ofŠibenik-Knin CountyŠibenikCroatia

Background:The European Society for Medical Oncology(ESMO)guidelines are among the most comprehensive and widely used clinical practice guidelines(CPGs)***,the level of scientific evidence supporting ESMO CPG recommendations has not been systematically *** study assessed ESMO CPG levels of evidence(LOE)and grades of recommendations(GOR),as well as their trends over time across various cancer ***:We manually extracted every recommendation with the Infectious Diseases Society of America(IDSA)classification from each *** examined the distribution of LOE and GOR in all available ESMO CPG guidelines across different topics and cancer ***:Among the 1,823 recommendations in the current CPG,30%were classified as LOEⅠ,and 43%were classified as GOR ***,there was a slight decrease in LOEⅠ(−2%)and an increase in the proportion of GOR A(+1%)in the current CPG compared to previous *** proportion of GOR A recommendations based on higher levels of evidence such as randomized trials(LOEⅠ–Ⅱ)shows a decrease(71%vs.63%,p=0.009)while recommendations based on lower levels of evidence(LOEⅢ–Ⅴ)show an increase(29%vs.37%,p=0.01)between previous and current *** the current versions,the highest proportion of LOEⅠ(42%)was found in recommendations related to pharmacotherapy,while the highest proportion of GOR A recommendations was found in the areas of pathology(50%)and diagnostic(50%)*** variability in LOEⅠand GOR A recommendations and their changes over time was observed across different cancer ***:One-third of the current ESMO CPG recommendations are supported by the highest level of *** well-designed randomized clinical trials are needed to increase the proportion of LOEⅠand GOR A recommendations,ultimately leading to improved outcomes for cancer patients.

关键词： ESMO guidelines Clinical practice guidelines Level of evidence Grade of recommendation

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Analysis of particle dispersion and cavity formation during bulk particle water entry using fully coupled CFD-DEM-VOF approach

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Particuology 2024年第7期90卷 558-580页

作者： Utkan Çalışkan sanja Mišković Norman B.Keevil Institute of Mining Engineering University of British Columbia2329 West MallVancouverBC V6T 1Z4Canada

This paper presents the development and validation of a fully coupled computational fluid dynamics—discrete element method—volume of fluid(CFD-DEM-VOF)model to simulate the complex behavior of particle-laden flows with free *** coupling between the fluid and particle phases is established through the implemented continuity,momentum,and alpha transport *** coupled particle forces such as drag,pressure gradient,dense virtual mass,viscous,and interface forces are also integrated,with drag and dense virtual mass forces being dependent on local *** integrated conservative alpha transport equation ensures phase volume conservation during interactions between particles and ***,we have implemented a trilinear interpolation method designed to operate on unstructured hexahedral *** method has been tested for its ability to properly resolve the coupling effects in the numerical simulations,particularly in cases with a relatively low cell-size *** model is validated through three distinct test cases:single particle water entry,dam break with particles,and water entry of a group of particles *** experimental setup is built to study the dynamics of the water entry of a group of particles,where three key flow features are analyzed:the evolution of average particle velocity,cavity shape,and particle dispersion cloud profiles in *** tests involve four different scenarios,including two different water levels(16.1 and 20.1 cm)and two different particle densities(2650 and 4000 kg/m3).High-speed videometry and particle tracking velocimetry(using ImageJ/TrackMate)methods are employed for experimental data *** is demonstrated that numerical results are in excellent agreement with theoretical predictions and experimental *** study highlights the significance of vortices in cavity shaping and particle *** validated CFD-DEM-VOF model constitutes a robust tool for simulating particle-laden flows,cont

关键词： CFD-DEM-VOF Trilinear interpolation Particle-laden flow Free-surface Particle water entry Volume conservation

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Role of fullerenols derivative 3HFWC in the treatment of Alzheimer's disease

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Neural Regeneration Research 2024年第8期19卷 1641-1642页

作者： sanja Ivkovic Djuro Koruga Department of Molecular Biology and Endocrinology “VINCA”Institute of Nuclear Sciences-National Institute of Republic of SerbiaUniversity of BelgradeBeogradSrbija TFT Nano Center BelgradeSerbia

Fullerenes:The extensive development of nanoscience that has marked this century continues to evolve,producing new materials,structures,and devices for the treatments of diverse *** are a family of nanoparticles with great applicative promise due to their small size(approximately 1 nm in diameter),structure,and capacity to cross biological barriers.

关键词： treatment evolve size

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Blue Cap Is Effective and Safe for the Treatment of Atopic Dermatitis in Children

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Open Journal of Pediatrics 2024年第3期14卷 609-622页

作者： Mirjana Gajić-Veljić Biljana Marenović Margita Mijušković Vesna Reljić Danica Tiodorović Danijela Popović sanja Zorić-Blagojević Milica vučinić David Marquez-Soriano Jovan Lalošević University of Belgrade Faculty of Medicine Department of Dermatology and Venereology University Clinical Center of Serbia Beograd Serbia University of Niš Faculty of Medicine Department of Dermatology and Venereology University Clinical Center of Ni&#353 Ni&#353 Serbia City Institute for Skin and Venereal Diseases Beograd Serbia Scientific Department Catalysis S.L. Madrid Spain

Background: Atopic dermatitis (AD) is the most common inflammatory skin disease in children. Treatment of AD is based on skin barrier repair and reduction of inflammation. We analyzed the efficacy and safety of activated piroctone olamine (APO)—Blue Cap—in children with AD. Materials and Methods: An open-label interventional clinical study was carried out at three clinical centers in Serbia. A total of 58 patients with AD, aged between 3 and 18 years were included and treated with Blue Cap Foam (100 ml;CATALYSIS S.L. Madrid)—Activated Piroctone Olamine—applied twice a day in the affected areas with eczema for 30 days and final assessment at 45 days from baseline. Photographic documentation, clinical evaluation, therapy effectiveness and safety questionnaires were assessed at baseline, 15, 30 and 45 days. Results: Our results demonstrated a significant reduction in signs (erythema, scaling, infiltration, excoriations, xerosis) and symptoms (pruritus) at weeks 2 and 4 of the study. At the end of the study, most patients had moderate (28.6%) to great (62.5%) disappearance of manifestations and moderate (25%) to great (71.4%) skin quality improvement. The effect and tolerability of the therapy were evaluated as very good in 66.1 % and 67.9% and good in about 14.3% and 17.9%, assessed by the investigator and patient, respectively. Three patients experienced a burning sensation at the beginning of the study, the side-effects were resolved as the patients continued applying the foam. After two weeks of cessation of the investigated foam, a significant percentage of patients experienced worsening in the final assessment done by the investigator as well as the participant. In the final assessment, a significantly high percentage (57.1%) of patients had a total reduction of manifestation, and a significant number of participants considered the applied product as treatment success, assessed by the investigator (62.5%) as well as the participants (66.4%). Conclusions: Blue Cap

关键词： Pediatric Dermatology Atopic Dermatitis Piroctone Olamine Skin Care

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Breeding phase and outcome determine space use in European rollers Coracias garrulus prior to migration

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Current Zoology 2024年第2期70卷 137-149页

作者： Flavio Monti sanja Barisic Sebastian Cannarella Davor Cikovic Vesna Tutis JelenaKralj Carlo Catoni aUniversity of Siena Department of Physical SciencesEarth and EnvironmentVia Mattioli 453100 SienaItaly Institute of Ornithology Croatian Academy of Sciences and ArtsGunduliceva 24HR-1000 ZagrebCroatia Ornis italica Piazza Crati 1500199 RomeItaly

The breeding period is a demanding and time-constrained phase for migratory bird *** outcome and duration can interact with the extent and duration of post-breeding movements,resulting in individual differences in space use ultimately influencing later stages of the annual *** present space-use and home range estimates during the breeding season for 21 European rollers Coracias garrulus tracked between 2018 and 2022,in Italy and *** high-resolution spatial GPS data coupled with regular nest-box monitoring,we analyzed dif-ferences in space use during the incubation/nestling period versus post-breeding period prior to migration,accounting for the breeding outcome(successful ***).We found that adult movements were strongly reduced during the first phase,whereas increased in the post-breeding phase,especially for failed *** breeders remained in the surroundings of the nest site,whereas unsuccessful ones tended to abandon the nest and visit distant areas(up to 500 km)for long periods(60.5±6.2 days).Breeding outcome did not influence the departure date of autumn migration,suggesting that failed breeders used this period for exploratory movements but not for advancing the onset of *** exploratory movements may be functional to prospect and inform settlement decisions in failed breeders in search of new breeding opportunities and may be particularly important in migratory species,which generally have a limited period to gather information prior to autumn *** study demonstrates the need to investigate seasonal movements in different populations and the potential importance of pros-pectingpost-breeding movements for long-distance migratory species.

关键词： animal movement biologging conservation Coracidae Mediterranean nest-box population monitoring prospecting movements reproduction.

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Global warming scenarios for the Eastern Adriatic Sea indicate a higher risk of invasiveness of non-native marine organisms relative to current climate conditions

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Marine Life Science & Technology 2024年第1期6卷 143-154页

作者： Branko Glamuzina Lorenzo Vilizzi Marina Piria Ante Zuljevic Ana Bratos Cetinic Ana Pesic Branko Dragicevic Lovrenc Lipej Marijana Pecarevic Vlasta Bartulovic sanja Grđan Ivan Cvitkovic Tatjana Dobroslavic Ana Fortic Luka Glamuzina Borut Mavric Jovana Tomanic Marija Despalatovic Domen Trkov Marina Brailo Scepanovic Zoran Vidovic Predrag Simonovic sanja Matic-Skoko Pero Tutman Department of Applied Ecology University of DubrovnikDubrovnikCroatia Department of Ecology and Vertebrate Zoology Faculty of Biology and Environmental ProtectionUniversity of LodzLodzPoland Faculty of Agriculture Department of FisheriesApicultureWildlife Management and Special ZoologyUniversity of ZagrebZagrebCroatia Institute of Oceanography and Fisheries SplitCroatia Institute of Marine Biology University of MontenegroKotorMontenegro National Institute of Biology Marine Biology Station PiranPiranSlovenia Teacher Education Faculty University of BelgradeBelgradeSerbia Faculty of Biology University of BelgradeBelgradeSerbia

Globally,marine bioinvasions threaten marine ecosystem structure and function,with the Mediterranean Sea being one of the most affected *** invasions are expected to increase due to climate *** conducted a risk screening of marine organisms(37 fishes,38 invertebrates,and 9 plants),both extant and‘horizon’(i.e.,not present in the area but likely to enter it).Based on expert knowledge for the Eastern Adriatic Sea coasts of Slovenia,Croatia,and Montenegro,screenings were conducted under both current and predicted climate conditions indicating with an increase in sea surface temperature and salinity of the Adriatic Sea together with changes in precipitation *** aims were to:(1)identify non-native extant and horizon marine species that may pose threats to native biodiversity and(2)evaluate the risk of invasiveness of the selected species under current and predicted climate *** the 84 species screened,there was an increase in those ranked as‘high risk’from 33(39.3%)under current climate conditions and to 47(56.0%)under global warming *** those ranked as‘very high’risk,the increase was from 6(7.1%)to 21(25.0%).Amongst the screened species,the already established high-risk species Pacific oyster Magallana gigas and Atlantic blue crab Callinectes sapidus represent a threat to ecosystem *** the under-representation of marine species in the current European Union List,the species we have ranked as high to very high risk should be included.

关键词： AS-ISK Early detection Introduction vectors/pathways Invasive species Rapid response

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Hormone replacement therapy for menopausal mood swings and sleep quality:The current evidence

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World Journal of Psychiatry 2024年第10期14卷 1605-1610页

作者： sanja Borozan Abul Bashar M Kamrul-Hasan Joseph M Pappachan Department of Endocrinology Clinical Centre of MontenegroPodgorica 81000Montenegro Faculty of Medicine University of MontenegroPodgorica 81000Montenegro Department of Endocrinology Mymensingh Medical College HospitalMymensingh 2200DhakaBangladesh Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Department of Endocrinology Kathmandu Medical CollegeManipal UniversityManipal 576104India

Marked alterations in the normal female hormonal milieu in the perimenopausal period significantly affect women’s health,leading to decreased well-being,psychological distress,and impaired quality of *** menopausal symp-toms include hot flashes,sleep and mood changes,fatigue,weight gain,and urogenital *** often neglect mood swings and disrupted sleep,although those can significantly limit the productivity of women and impair their cognitive function and mental ***-based management should include a personalized,holistic approach to alleviate symptoms and careful consideration of the risks vs benefits of hormone replacement therapy(HRT),with due consideration of personal preferences.A research paper in the recent issue of the World Journal of Psychiatry by Liu et al investigated the role of HRT in altering mood changes and impaired sleep quality in menopausal women,which helps us to understand the benefits of this treatment approach.

关键词： Menopausal symptoms Mood changes Sleep quality Hormone replacement therapy Quality of life

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Blue Cap Is Effective and Safe for the Treatment of Atopic Dermatitis in Children

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Open Journal of Pediatrics（儿科学期刊） 2024年第3期 609页

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CFD simulation of single-phase flow in flotation cells:Effect of impeller blade shape,clearance,and Reynolds number

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International Journal of Mining Science and Technology 2019年第5期29卷 657-669页

作者： Manjunath Basavarajappa sanja Miskovic Department of Metallurgical Engineering University of UtahSalt Lake City 84112United States INEOS Pigments 6752 Baymeadow DriveGlen Burnie 21061United States Norman B.Keevil Institute of Mining Engineering The University of British ColumbiaBritish Columbia V6T 1Z4Canada

A series of numerical simulations of turbulent single-phase flows are performed to understand the flow and mixing characteristics in a laboratory scale flotation *** impeller blade shapes covering a wide range of surface areas and lip lengths are considered to highlight and contrast the flow behavior predicted in the impeller *** mean flow close to the impeller is fully characterized by considering velocity components along the axial direction at different radial *** results suggest the development of a comparatively stronger axial velocity component for a blade design with the smallest lip length,called big-tip impeller *** turbulent kinetic energy profiles close to the impeller reveal the existence of an asymmetric trailing vortex *** highest turbulence kinetic energy dissipation rates are observed close to the impeller blades and stator walls where the radial jet strikes the stator walls ***,liquid phase mixing in the flotation cell is studied using transient scalar tracing simulations providing mixing time ***,pumping capacity and efficiency of different impeller designs are calculated based on which the impeller blade design with a rectangular blade design is found to perform most efficiently.

关键词： Flotation Impeller blade design Turbulent flow Mixing Pumping efficiency

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Emergency Management in Critical Infrastructures: A Complex-Event-Processing Paradigm

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Journal of Systems Science and Systems Engineering 2019年第1期28卷 37-62页

作者： vuk Mijovic Nikola Tomasevic Valentina Janev Mladen Stanojevic sanja Vranes The Mihajlo Pupin Institute University of Belgrade Volgina 1511060 Belgrade Serbia

Critical infrastructures (CI) are difficult to handle due to their complexity, size and the number of stakeholders involved. During emergency situations (e.g. fire or terrorist attack), a CI operator in the control room is faced with a flood of information coming from different sensors and legacy monitoring systems. Since in these situations, time is critical and the operators are under a great deal of pressure, a holistic management of all the technical systems and actors involved is needed, reinforced by the Recommendation and Decision Support System (RDSS) that helps emergency managers to take correct and timely decisions. One way to provide an adequate RDSS support to the operator is proposed in this paper which is based on an intelligent, event driven layer that sits on top of the legacy CI monitoring system. Powered by the complex event processing capabilities and facility data model implemented in the form of CI ontology, this layer processes events originating from different sources, conducts the situation and risk assessment, and reacts accordingly, either automatically or via recommendations proposed to emergency personnel. To validate the proposed approach, an event-driven RDSS was deployed on an airport use case (Nikola Tesla airport in Belgrade), as one of the most complex CIs.

关键词： Emergency management event-driven decision support complex event processing emergency personnel training

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