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Tribological performance of uncoated and TiCN-coated D2,m2 and m4 steels under lubricated condition

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Journal of Iron and Steel Research International 2017年第8期24卷 823-829页

作者： Luis Daniel Aguilera Camacho santos García miranda Karla Judith moreno Instituto Tecnologico de Celaya/TNm Apartado Postal 5738010-CelayaGuanajuatoMexico

Hard coatings are used to improve the wear resistance of metals which largely depends on adhesion between substrate and *** wear and friction behavior of uncoated and TiCN-coated D2,m2 and m4 steels were evaluated by apin-on-disk test under lubricated *** order to evaluate the influence of lubricant on wear performance,dry friction tests were also *** results showed that friction coefficients were very similar for both uncoated and TiCN-coated *** lubricated conditions,the uncoated D2 tool steel exhibited the lowest friction coefficient,but the TiCN-coated D2 steel presented the smallest wear *** was the main wear mechanism in all the ***,microhardness measurements were carried out,finding an influence of the steel substrate on the hardness of the ***,adhesion test was conducted,suggesting agood adhesion of class 1 between substrates and TiCN coatings.

关键词： D2 tool steel m2 high speed steel m4 high speed steel TiCN coating Friction Wear

Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

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World Journal of Gastroenterology 2023年第14期29卷 2202-2221页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro mariana santos Calmon marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza mendes dos santos Gabriel Lima Correa santos Hanna santos marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza márcio Vasconcelos Oliveira Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029094BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919899ParanáBrazil

BACKGROUND Gastric mucosa-associated lymphoid tissue(mALT)lymphoma(GmL)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(***)-induced chronic *** practice guidelines currently recommend *** eradication as the preferred initial treatment for early-stage *** determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GmL,an updated analysis and review of available evidence is *** To perform a meta-analysis to assess the rate of complete remission(CR)of ***-positive early-stage GmL following bacterial *** We performed independent,computer-assisted literature searches using the Pubmed/mEDLINE,Embase,and Cochrane Central databases through September *** and retrospective observational studies evaluating the CR of early-stage GmL following bacterial eradication in ***-positive *** risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal *** pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects *** and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P50%,*** and meta-regression analyses were conducted to explore potential sources of *** The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text ***,61 studies were included in the proportional meta-analysis(P-mA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational *** overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 ***-positive early-stage GmL patients,in whom *** was successfully eradicated,were incl

关键词： Lymphoma B-cell marginal zone Gastric mucosa-associated lymphoid tissue lymphoma Stomach lymphoma Helicobacter pylori Therapeutics Eradication therapy

半干旱条件下青贮饲料对羔羊肉品质和感官品质的影响

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饲料博览 2017年第2期27卷 54-54页

作者： Campos F S Carvalho G G P santos E m Araújo G G L Gois G C Rebou?as R A Le?o A G santos S A Oliveira J S Leite L C Araújo m L G m L Cirne L G A Silva R R Carvalho B m A

选取32头混合品种羔羊,分成4组,日粮中分别包含榆钱、蒺藜纤毛、南洋樱和木薯,试验结束后评估其肉品质和感官品质。饲喂榆钱组羔羊肉品质蒸煮损失显著减小(P0.05)。然而,青贮饲料的不同对羊肉的香味、肉色和风味有显著影响(P<0.05)。木... 详细信息

选取32头混合品种羔羊,分成4组,日粮中分别包含榆钱、蒺藜纤毛、南洋樱和木薯,试验结束后评估其肉品质和感官品质。饲喂榆钱组羔羊肉品质蒸煮损失显著减小(P0.05)。然而,青贮饲料的不同对羊肉的香味、肉色和风味有显著影响(P<0.05)。木薯组和南洋樱组羊肉风味更好。榆钱组羊肉的风味较佳,蒺藜纤毛组风味较差。日粮中添加蒺藜纤毛降低产肉量。基于胴体重和肉品质的差异,饲料中添加榆钱和木薯可提高肥育绵羊生产性能。

关键词：绵羊蛋白质风味多汁性水分含量

mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

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Cellular & molecular Immunology 2023年第8期20卷 955-968页

作者： manuel m.Vicente Inês Alves Ângela Fernandes Ana m.Dias Beatriz santos-Pereira Elena Pérez-Anton Sofia santos Tao Yang Alexandra Correia Anja münster-Kühnel Afonso R.m.Almeida Sarina Ravens Gabriel A.Rabinovich manuel Vilanova Ana E.Sousa SaloméS.Pinho i3S–Institute for Research and Innovation in Health University of PortoPortoPortugal Institute of Biomedical Sciences Abel Salazar(ICBAS) University of PortoPortoPortugal Graduate Program in Areas of Basic and Applied Biology(GABBA) ICBASUniversity of PortoPortoPortugal Faculty of medicine University of PortoPortoPortugal Nephrology Department Centro Hospitalar e Universitário do PortoPortoPortugal Institute of Immunology Hannover Medical SchoolHannoverGermany Institute of Clinical Biochemistry Hannover Medical SchoolHannoverGermany Instituto de medicina molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Laboratorio de Inmunopatología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Laboratorio de Inmuno-oncología Translacional Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Facultad de Ciencias Exactas y Naturales(FCEyN) Universidad de Buenos AiresCiudad de Buenos AiresArgentina

T-cell development ensures the formation of diverse repertoires of T-cell receptors(TCRs)that recognize a variety of *** is a major posttranslational modification present in virtually all cells,including T-lymphocytes,that regulates activity/*** these structures are known to be involved in TCR-selection in DP thymocytes,it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to ***,we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes,as well as dynamic *** restricting the N-glycosylation profile of thymocytes to high-mannose structures,using specific glycoengineered mice(Rag1Cremgat1fl/fl),we showed remarkable defects in key developmental checkpoints,includingß-selection,regulatory T-cell generation andγδT-cell development,associated with increased susceptibility to colon and kidney inflammation and *** further demonstrated that a single N-glycan antenna(modeled in Rag1Cremgat2fl/fl mice)is the sine-qua-non condition to ensure normal *** conclusion,we revealed that mannosylated thymocytes lead to a dysregulation in T-cell development that is associated with inflammation susceptibility.

关键词： N-glycosylation T-cell development Thymocytes Glycocalyx Inflammation

Dexamethasone intravitreal implant(Ozurdex) in diabetic macular edema: real-world data versus clinical trials outcomes

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1571-1580页

作者： Pedro Neves mário Ornelas Inês matias João Rodrigues margarida santos marco Dutramedeiros David martins Department of Ophthalmology Centro Hospitalar de SetúbalSetúbal 2910-549Portugal Department of Ophthalmology Hospital BeatrizÂngeloLoures 2674-514Portugal Department of Ophthalmology Hospital da Luz SetúbalSetúbal 2900-722Portugal Department of Ophthalmology Centro Hospitalar Lisboa CentralFaculdade de Ciências MédicasNOVA University of LisbonLisbon 1990-237Portugal

AIm: To investigate the safety and efficacy of intravitreal dexamethasone implants(Ozurdex?/DEX) in patients with diabetic macular edema(DmE) either na?ve or nonna?ve to anti-VEGF therapies who switched to DEX implant independent of response to anti-vascular endothelial growth factors(anti-VEGFs).mETHODS: This was an audit retrospective review of medical records of patients with DmE who switched to the DEX intravitreal implant. Patients were divided into 2 groups: patients na?ve to antiangiogenic therapy and patients who were previously treated with anti-VEGFs. Data regarding demographics, changes in mean best-corrected visual acuity(BCVA), central macular thickness(CmT), and intraocular pressure(IOP) was collected over 6 mo. The demographic data mean changes in BCVA, CmT, and IOP were compared. Six-month follow-up data of 47 patients(57 eyes), who either switched to DEX implant irrespective of response to previous treatments or were treatment na?ve before receiving DEX implant, was ***: Improvement in mean BCVA was observed from 1-4 mo after injection with a decreased effect at month 6 as expected, with better outcomes in na?ve compared to non-na?ve patients. A statistically relevant decrease in mean CmT was observed during the follow-up period. An increase in mean IOP was observed in the first 2 mo after DEX therapy. The mean number of injections of the overall population during the 6 mo was 1.3. A subgroup analysis showed no relevant difference between phakic versus pseudophakic patients relative to measured outcomes. There was no cataract progression during the follow-up period and no adverse events ***: This real-life setting study shows that intravitreal DEX implant is effective and safe. The timings of greater therapeutic impact are concordant with previous studies and suggest that earlier treatment with corticosteroids may have an additional benefit in na?ve patients.

关键词： anti-VEGF therapy diabetic macular edema dexamethasone intravitreal implant na?ve eyes steroids

Fire dynamics in mato Grosso State,Brazil:the relative roles of gross primary productivity

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Big Earth Data 2020年第1期4卷 23-44页

作者： Fernando Saragosa Rossi Gustavo Andrede Araujo santos State University of mato Grosso(UNEmAT) Mato GrossoSinopBrazil Department of Exact Sciences São Paulo State University(FCAV–UNESP)Via de Acesso Prof.Paulo Donato Castellane s/n14884-900 JaboticabalSão PauloBrazil

The fires and biomass burning are responsible for affect ecosystem processes in a wide range of biomes at regional and global *** Brazil,the state of mato Grosso is one of the most affected by the occurrence of forest ***,this study aims to quantify the longterm changes in the temporal and spatial patterns of fire occurrence and their effect on gross primary productivity(GPP)in the state of mato Grosso,Brazil,considering the biomes that compose *** images used in the study were acquired by satellite Terra and Aqua combined in the product mCD64A1.006,a monthly resolution of 500m by the moderate Resolution Imaging Spectroradiometer(mODIS)sensor,during the period from 01/10/2000 to 12/31/*** mOD17A2 product derived from the mODIS sensor provides the accumulated value of *** points without the presence of burning presented higher values of GPP for all studied *** some points with the presence of burning the GPP even decreased by 44.20%,30.04%and 55.78%for Amazonia,Cerrado,and Pantanal,*** to the results presented here,it is concluded that the burnings negatively impact gross primary production in the biomes of the state of mato Grosso,Brazil and the dynamics of the burns do not keep up with the intensity of drought *** use of cluster analysis techniques,such as principal component analysis(PCA),is an alternative to bigdata analysis when the objective is to evaluate the presence of forest burning in more than one biome.

关键词： Carbon cycle remote sensing Amazon Cerrado Pantanal

In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 methyltransferase Inhibitors by molecular Docking

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Journal of Biosciences and medicines 2024年第7期12卷 214-229页

作者： Luciene Soares Silva Tiago Soares Barbosa maria Leonisa Sanchez-Nuñez Aldenise mont Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos santos Corrêa Amorim Leonardo Alves miceli Percilene Fazolin Vegi Alice Bernardino Helena Carla Castro Izabel Christina Nunes de Palmer Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chemistry at the Institute of Chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μm) and the highest selectivity (SI = 342). mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 methyltransferase Antivirals

Comment on “Constraining the smoothness parameter and dark energy using observational H(z) data”

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Research in Astronomy and Astrophysics 2011年第6期11卷 637-640页

作者： V.C.Busti R.C.santos Instituto de Astronomia Geofísica e Ciências AtmosféricasUniversidade de So PauloSo Paulo05508-090 SPBrazil Departamento de Ciê ncias Exatas e da Terra Universidade Federal de So Paulo(UNIFESP)Diadema09972-270 SPBrazil

We discuss a recent analysis by Yu et al.[RAA 11,125（2011）] about constraints on the smoothness parameter α and dark energy models using observational H（z） *** is argued here that their procedure is conceptually inconsistent with the basic assumptions underlying the adopted Dyer-Roeder *** order to properly quantify the influence of the H（z） data on the smoothness parameter α,a χ2-test involving a sample of type Ia supernovae and H（z） data in the context of a flat ΛCDm model is *** result is confronted with an earlier approach discussed by santos et al.（2008） without H（z） *** the（Ωm,α） plane,it is found that such parameters are now restricted to be in the intervals 0.66 ≤ α ≤ 1.0 and 0.27 ≤ Ωm ≤ 0.37 within the 95.4 confidence level（2σ）,and,therefore,are fully compatible with the homogeneous *** basic conclusion is that a joint analysis involving H（z） data can indirectly improve our knowledge about the influence of the ***,this happens only because the H（z） data provide tighter constraints on the matter density parameter Ωm.

关键词： cosmology — dark energy — cosmological parameters

Cardiovascular rehabilitation in patients aged 70-year-old or older:benefits on functional capacity,physical activity and metabolic profile in younger *** patients

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Journal of Geriatric Cardiology 2020年第9期17卷 544-553页

作者： marta Fontes-Oliveira maria Trêpa Patrícia Rodrigues Preza Fernandes Sandra magalhães Sofia Cabral mário santos Severo Torres Cardiology Department University Hospital Centre of PortoPortoPortugal Cardiac Rehabilitation Unit Cardiology DepartmentUniversity Hospital Centre of PortoPortoPortugal Pulmonary Vascular Disease Unit University Hospital Centre of PortoPortoPortugal

Background The benefits of exercise-based cardiac rehabilitation(EBCR)programs in post-acute myocardial infarction(AmI)patients have been *** aim was to assess the impact of EBCR in³70-years-old *** post-AmI *** We retrospectively evaluated patients who underwent a supervised EBCR protocol,twice a week during 6-12 *** evaluated changes in several outcomes based on pre-and post-CRP *** Of a total of 1607 patients,333(21%)were³*** the EBCR,an overall improvement on functional capacity,daily physical activity,lipid profile,body mass index,glycated hemoglobin(HbA1c),N-terminal pro-brain natriuretic peptide(NT-pro-BNP)and C-reactive protein was observed in both younger and older patients(Pmaller benefit on the increment of daily physical activity and lipid profile improvement,but a larger reduction in *** the multivariate analysis,only improvements on daily physical activity and HbA1c were dependent on *** As their younger counterparts,older patients,significantly improved functional capacity,metabolic parameters and level of daily physical activity after EBCR.

关键词： Aging Cardiovascular prevention Exercise-based cardiac rehabilitation