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On the Rate of Convergence of Some New Modified Iterative Schemes

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American Journal of Computational Mathematics 2013年第4期3卷 270-290页

作者： Renu Chugh sanjay kumar Department of Mathematics M.D.U Rohtak India

In this article, following Bizare and Amriteimoori [1] and B. Parsad and R. Sahni [2], we modify Ishikawa, Agarwal et al., Noor, SP iterative schemes and compare the rate of convergence of Ishikawa, Agarwal et al., Noor, SP and new modified Ishikawa, Agarwal et al., Noor, SP iterative schemes not only for particular fixed value of an,bn,rn but also for varying the value of an,bn,rn. With the help of two numerical examples, we compare the converging step.

关键词： Metric Space New Modified Ishikawa New Modified Agarwal et al. New Modified SP New Modified Noor

Strong Convergence of a New Three Step Iterative Scheme in Banach Spaces

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American Journal of Computational Mathematics 2012年第4期2卷 345-357页

作者： Renu Chugh Vivek kumar sanjay kumar Department of Mathematics Maharshi Dayanand University Rohtak India

In this paper, we suggest a new type of three step iterative scheme called the CR iterative scheme and study the strong convergence of this iterative scheme for a certain class of quasi-contractive operators in Banach spaces. We show that for the aforementioned class of operators, the CR iterative scheme is equivalent to and faster than Picard, Mann, Ishikawa, Agarwal et al., Noor and SP iterative schemes. Moreover, we also present various numerical examples using computer programming in C++ for the CR iterative scheme to compare it with the other above mentioned iterative schemes. Our results show that as far as the rate of convergence is concerned 1) for increasing functions the CR iterative scheme is best, while for decreasing functions the SP iterative scheme is best;2) CR iterative scheme is best for a certain class of quasi-contractive operators.

关键词： Fixed Point Various Iterative Schemes Rate of Convergence

Coupled Fixed Point for (<i>α</i>, <i>Ψ</i>)-Contractive in Partially Ordered Metric Spaces Using Compatible Mappings

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Applied Mathematics 2015年第8期6卷 1380-1388页

作者： Preeti sanjay kumar Department of Mathematics DCRUST Sonepat India

In this paper, first we introduce notions of (α, Ψ)-contractive and (α)-admissible for a pair of map and prove a coupled coincidence point theorem for compatible mappings using these notions. Our work extends and g... 详细信息

关键词： Coupled Coincidence Point α-ψ-Contractive Mapping Compatible Mappings

Angiotensin-converting enzyme 2 as a potential therapeutic target for COVID-19:A review

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Journal of Pharmaceutical Analysis 2022年第2期12卷 215-220页

作者： Bhagat Singh Dheer Singh Vinod Verma Ramakant Yadav Raj kumar Department of Medical Laboratory Technology Faculty of Paramedical SciencesUttar Pradesh University of Medical SciencesEtawah206130India Department of Anaesthesiology and Critical Care Uttar Pradesh University of Medical SciencesEtawah206130India Stem Cell Research Centre Department of HematologySanjay Gandhi Post Graduate Institute of Medical SciencesLucknow226014India Department of Neurology Uttar Pradesh University of Medical SciencesEtawah206130India Department of Neurosurgery Uttar Pradesh University of Medical SciencesEtawah206130India

As of August 16,2021,there have been 207,173,086 confirmed cases and 4,361,996 deaths due to the coronavirus disease(COVID-19),and the pandemic remains a global *** date,no effective and approved drugs are available for the treatment of ***-converting enzyme 2(ACE2)plays a crucial role in the invasion into host cells by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the etiological agent of ***,ACE2 density is influenced by medical conditions,such as hypertension,or by drugs,including angiotensin-converting enzyme inhibitors(ACEIs)and angiotensin receptor blockers(ARBs),which can change the fate of SARS-CoV-2 ***2 is a target for these drugs and can be manipulated to limit the viral entry and replication within the *** strategies aimed at blocking ACE2 with small molecules,peptides,and antibodies,or by neutralizing the virus through its competitive binding with human recombinant soluble ACE2(hrsACE2)are currently under *** this article,we review the current state of knowledge that emphasizes the need to find effective therapeutic agents against COVID-19 by exploiting ACE2 as a potential *** increased soluble ACE2 levels and the application of hrsACE2 in patients with COVID-19 can be implemented to control the *** has not yet been established whether hypertension and other comorbidities,independent of age,have a direct role in ***,the use of renin-angiotensin system inhibitors,ACEIs and ARBs,should not be discontinued during COVID-19 treatment.

关键词： COVID-19 ACE2 receptors hrsACE2 ACE inhibitors RAS AT1R blocker

Endoscopic management of postoperative bile leaks

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 273-277页

作者： Naresh Agarwal Barjesh Chander Sharma sanjay Garg Rakesh kumar Shiv K Sarin Department of Gastroenterology GB Pant Hospital New DelhiIndia

BACKGROUND: Significant bile leak as an uncommon complication after biliary tract surgery may constitute a serious and difficult management problem. Surgical management of biliary fistulae is associated with high morbidity and mortality. Biliary endoscopic procedures have become the treatment of choice for management of biliary Gstulae. METHODS: Ninety patients presented with bile leaks after cholecystectomy ( open cholecystectomy in 45 patients, cholecystectomy with common bile duct exploration in 20 and laparoscopic cholecystectomy in 25). The presence of bile leaks was confirmed by ERCP and the appearance of bile in percutaneous drainage of abdominal collections. Of the 90 patients with postoperative bile leaks, 18 patients had complete transaction of the common bile duct by ERCP and were subjected to bilioenteric anastomosis. In the remaining patients after cholangiography and localization of the site of bile leaks. therapeutic procedures like sphinctero-tomy, biliary stenting and nasobiliary drainage ( NBD ) were performed. If residual stones were seen in the common bile duct, sphincterotomy was followed by stone extraction using dormia basket. Nasobiliary drain or stents of 7F size were placed according to the standard techniques. The NBD was removed when bile leak stopped and closure of the fistula confirmed cholangiographically. The stents were removed after an interval of 6-8 weeks. RESULTS: Bile leaks in 72 patients occurred in the cystic duct (38 patients), the common bile duct (30 ), and the right hepatic duct (4). Of the 72 patients with post-operative bile leak, 24 had associated retained common bile duct stones and 1 had ascaris in common bile duct. All the 72 patients were subjected to therapeutic procedures including sphincterotomy with stone extraction followed by biliary stenting (24 patients), removal of ascaris and biliary stenting (1), sphincterotomy with biliary stenting (18), sphincterotomy with NBD (12), biliary stenting alone (12), and NBD

关键词： biliary fistulae endoscopic retrograde cholangiopancreatography sphincterotomy biliary stent nasobiliary drain common bile duct stones

Hepatoprotective activity of Hepax-A polyherbal formulation

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 142-146页

作者： VC Devaraj B Gopala Krishna GL Viswanatha Jagadish V Kamath sanjay kumar Department of Pharmacology Krupanidhi College of Pharmacy Department of Pharmacognosy RR College of Pharmacy Department of Pharmacology PES College of Pharmacy

Objective:To evaluate the hepatoprotective potential of Hepax,a polyherbal formulation,against three experimentally induced hepatotoxicity models in ***:Hepatoprotective activity of Hepax was studied against three experimentally induced hepatotoxicity models,namely, carbon tetrachloride(CCl_4),paracetamol and thiocetamide induced hepatotoxicity in rats. Results:Administration of hepatotoxins(CCl_4,paracetamol and thiocetamide) showed significant morphological,biochemical and histological deteriorations in the liver of experimental animals. Pretreatment with Hepax had significant protection against hepatic damage by maintaining the morphological parameters(liver weight and liver weight to organ weight ratio) within normal range and normalizing the elevated levels of biochemical parameters(SGPT,SCOT,ALP and total bilirubin),which were evidently showed in histopathological ***:The Hepax has highly significant hepatoprotective effect at 100 and 200 mg/kg,*** the liver of all the three experimental animal models.

关键词： Hepax Paracetamol CCl4 Thiocetamide Hepatotoxicity

Dietary phytochemicals and their role in cancer chemoprevention

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 709-712页

作者： Shashank kumar sanjay Gupta Molecular Signaling and Drug Discovery Laboratory Department of BiochemistrySchool of Basic and Applied SciencesCentral University of PunjabBathinda 151401India Department of Urology Case Western Reserve UniversityClevelandOH 44106USA Department of Urology The Urology InstituteUniversity Hospitals Cleveland Medical CenterClevelandOH 44106USA Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA Divison of General Medical Sciences Case Comprehensive Cancer CenterClevelandOH 44106USA Department of Urology Louis Stokes Cleveland Veterans Affairs Medical CenterClevelandOH 44106USA.

Epidemiological studies suggest a close association between diet and cancer initiation,which provides evidence that the dietary components may be effectively developed as chemopreventive agents[1].These pieces of evidence are further supported by several case-control and cohort studies,which overwhelmingly support a converse association between the intake of phytochemicals and cancer risk[2,3].A number of clinical studies have been conducted demonstrating that dietary phytochemicals have the ability to inhibit tumorigenesis[4].Components presenting in fruit and vegetables termed“bioactive”phytochemicals belong to several classes of micronutrients,including flavonoids,polyphenols,and dietary *** components have the ability to reduce the cancer risk alone or by interactions between them.

关键词： prevention cancer dietary

Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3779-3790页

作者： Gundala Venkata Naveen kumar Keito Hoshitsuki sanjay Rathod Manda J.Ramsey Lauren Kokai Erin E.Kershaw Wen Xie Christian A.Fernandez Department of Pharmaceutical Sciences and Center for Pharmacogenetics University of Pittsburgh School of PharmacyPittsburghPA 15261USA Division of General Internal Medicine University of Pittsburgh School of MedicinePittsburghPA 15261USA Department of Plastic Surgery University of Pittsburgh and the McGowan Institute for Regenerative MedicinePittsburghPA 15261USA University of Pittsburgh Division of EndocrinologyDepartment of MedicinePittsburghPA 15261USA

PEGylated-L-asparaginase(PEG-ASNase)is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia(ALL).Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis,with obesity and older age considered risk factors of the *** study aims to elucidate the mechanism of PEG-ASNase-induced liver *** received 1500 U/kg of PEG-ASNase and were sacrificed 1,3,5,and 7 days after drug *** triglycerides were quantified,and plasma bilirubin,ALT,AST,and non-esterified fatty acids(NEFA)were *** mRNA and protein levels of genes involved in hepatic fatty acid synthesis,β-oxidation,very low-density lipoprotein(VLDL)secretion,and white adipose tissue(WAT)lipolysis were *** developed hepatic steatosis after PEG-ASNase,which associated with increases in bilirubin,ALT,and *** hepatic genes Ppara,Lcad/Mcad,Hadhb,Apob100,and Mttp were upregulated,and Srebp-1 c and Fas were downregulated after *** plasma NEFA,WAT loss,and adipose tissue lipolysis were also observed after ***,we found that PEG-ASNase-induced liver injury was exacerbated in obese and aged mice,consistent with clinical studies of ASNase-induced liver *** data suggest that PEG-ASNase-induced liver injury is due to drug-induced lipolysis and lipid redistribution to the liver.

关键词： Liver injury Leukemia Asparaginase Lipolysis Adverse drug reaction Adipose tissue Hepatic steatosis Amino acid response

Fuzzy Fault Tree Analysis for Fault Diagnosis of Cannula Fault in Power Transformer

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Applied Mathematics 2011年第11期2卷 1346-1355页

作者： sanjay kumar Tyagi Diwakar Pandey Vinesh kumar 不详

Being one of the most expensive components of an electrical power plant, the failures of a power transformer can result in serious power system issues. So fault diagnosis for power transformer is highly important to ensure an uninterrupted power supply. Due to information transmission mistakes as well as arisen errors while processing data in surveying and monitoring state information of transformer, uncertain and incomplete information may be produced. Based on these points, this paper presents an intelligent fault diagnosis method of power transformer using fuzzy fault tree analysis (FTA) and beta distribution for failure possibility estimation. By using the technique we proposed herein, the continuous attribute values are transformed into the fuzzy numbers to give a realistic estimate of failure possibility of a basic event in FTA. Further, it explains a new approach based on Euclidean distance between fuzzy numbers, to rank the basic events in accordance with their Fuzzy Importance Index.

关键词： Fault Tree Power Transformer Fuzzy Sets Expert Systems Fuzzy Importance Index