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Chinese Journal of Structural Chemistry 2022年第5期41卷 70-76页

作者： Yu-feng sang Liang-Jin Xu Zhong-Ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

Mn^(2+)-doped lead halide perovskites either in 3D or 2D have been extensively explored due to their rich energy-transfer *** their application on LED is still lagging behind in comparison to non-doped 3D perovskite due to inferior film-formation and low luminescent *** we report an in-situ-formed Mn^(2+)doped 2D perovskite nanocrystal(NCs)film by introducing quaternary phosphonium salt during the crystallizing *** as-formed film shows improved luminescent efficiency with emission peaked at 600 nm and photo-luminescence quantum yield(PLQY)of as high as 73.37%,which is about 1.3 times higher than that of pristine *** characterizations confirm the enhanced confinement effect from smaller size particle is responsible for the improved luminescent *** perovskite LEDs based on pristine and phosphonium passivated thin films were fabricated,and a great improvement in the external quantum efficiency of these LEDs(from 0.0017%to 0.12%)is observed due to the improved morphology and enhanced luminescent efficiency.

关键词： 2D perovskite Mn^(2+)doped energy transfer perovskite LED

Potential Mechanisms and Effects of Chinese Medicines in Treatment of Diabetic Atherosclerosis by Modulating NLRP3 Inflammasome:A Narrative Review

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Chinese Journal of Integrative Medicine 2022年第8期28卷 753-761页

作者： YUAN Jia-yao FU Yu feng Zhi-hai sang feng SHAO Ming-yi LI Lei-lei School of First Clinical Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine of Henan Province The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Gastroenterology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3)is an intracellular sensor that detects endogenous danger signals and environmental irritants to assemble into the NLRP3 *** of the NLRP3 inflammasome leads to the secretion of the proinflammatory cytokines interleutkin(IL)-1β and IL-18 and induces *** studies have shown that the NLRP3 inflammasome participates in the initiation and progression of diabetic atherosclerosis through pathological mechanisms such as β-cell dysfunction,insulin resistance,endothelial cell dysfunction,monocyte adhesion and infiltration,and smooth muscle cell proliferation and *** diabetic atherosclerosis,Chinese medicine has been proven effective for the inflammatory response mediated by the NLRP3 *** review summarizes the latest progress on the NLRP3 inflammasome in the pathogenesis and potential Chinese medicine treatment of diabetic atherosclerosis.

关键词： Chinese medicine diabetic atherosclerosis NLRP3 inflammasome interleukin-1β TXNIP pyroptosis

Neonatal Cri du chat syndrome with atypical facial appearance:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11031-11036页

作者： Meng-Meng Bai Wen Li Lin Meng Yan-feng sang Yu-Jie Cui Hui-Ying feng Zhi-Tao Zong Hong-Bo Zhang Department of Pediatrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070Hubei ProvinceChina Department of Pediatrics Chengde Central HospitalChengde Medical UniversityChengde 067000Hebei ProvinceChina Department of Neurosurgery Jiujiang Hospital of Traditional Chinese MedicineJiujiang 332005Jiangxi ProvinceChina Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Cri du chat syndrome(CdCS),also known as 5p deletion syndrome(5p-)is a syndrome caused by partial deletion of the 5p chromosome in human *** incidence accounts for 1/50000 and the cause of CdCS is related to partial deletion of chromosome 5 short arm(p).CdCS is a sporadic *** one case of CdCS was detected by chromosome screening in 125 and 170 pregnant Iranian women[1].The most prominent clinical manifestations of CdCS are typical high-pitched cat calls,severe mental retardation or mental retardation and is most harmful to both language and growth retardation[2].CdCS is a chromosome mutation disease which occurs during embryonic development and the symptoms of some cases are extremely *** is difficult to make an early diagnosis and screening in *** can suspect the disease from its atypical manifestations in the weak crying of cats,and chromosome karyotype analysis can find some questionable gene deletion fragments to assist the clinical diagnosis and prognosis of *** SUMMARY A 2-d-old male child who was admitted to our hospital with a poor postnatal reaction and poor milk *** baby’s crying and sucking is weak,reaction and feeding time is poor and the baby has nausea and *** analysis showed that the chromosomes were 46,XY,deletion(5)*** genome microarray analysis(named ISCN2013)showed that the chromosomes of the child were male karyotypes and contained three chromosomal *** them,loss of 5p15.2pter(113576-13464559)was associated with cat call *** 3 mo of follow-up,the child still vomited repeatedly,had poor milk intake,did not return to normal growth,had developmental retardation and a poor directional *** Therefore,when cat crying and laryngeal sounds occur in the neonatal period,it should be considered that they are related to *** karyotype and genome analysis are helpful for the diagnosis of CdCS.

关键词： CdCS Gene Chromosome karyotype Neonatal Case report

Application of Parallel Mechanism in Varistructured Quadruped/Biped Human-carrying Walking Chair Robot

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International Journal of Automation and computing 2013年第5期10卷 447-454页

作者： Ling-feng sang Hong-Bo Wang Dian-Fan Zhang Zhen-Hua Tian Fu-Hai Deng De-Lei Fang Parallel Robot and Mechatronic System Laboratory of Hebei Province Yanshan University Key Laboratory of Advanced Forging & Stamping Technology and Science of Ministry of Education Yanshan University Science and Technology Research Institute Yanshan University

For the existing problems of walking chair robot such as simple function,lower bearing capacity and not walking in complex environment,a novel varistructured quadruped / biped human-carrying walking chair robot is *** proposed robot could be used as biped and quadruped walking chair *** the conversion of the walking chair robot from the quadruped to the biped or vice versa,6-UPS and 2-UPS＋UP（U,P and S are universal joint,the prismatic pair,and sphere joint,respectively） parallel mechanisms are selected as the leg mechanism of the biped walking robot and quadruped walking robot,*** the screw theory and theory of mechanism,the degrees of freedom of the leg mechanism and the body mechanism in diferent motion states are computed so as to meet the requirements of mechanism *** motion characteristics of the 2-UPS＋UP parallel mechanism which is the key part of the walking chair robot are ***,the workspace of the moving platform is drawn and the efect of the structural parameters on the workspace volume is ***,it is found that the volume of the workspace of the moving platform is bigger when the side length ratio and the vertex angle ratio of the fxed platform and the moving platform which are isosceles triangles are close to *** study provides a theoretical foundation for the prototype development.

关键词： Human-carrying walking chair robot parallel leg mechanism degree of freedom varistructure workspace kinematics

Intraportal mesenchymal stem cell transplantation prevents acute liver failure through promoting cell proliferation and inhibiting apoptosis

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 602-611页

作者： Jian-feng sang Xiao-Lei Shi Bin Han Tao Huang Xu Huang Hao-Zhen Ren Yi-Tao Ding Department of General Surgery the Affiliated Drum Tower Hospital of Nanjing University Medical School

BACKGROUND： Transplantation of mesenchymal stem cells （MSCs） has been regarded as a potential treatment for acute liver failure （ALF）, but the optimal route was unknown. The present study aimed to explore the most effective MSCs transplantation route in a swine ALF model. METHODS： The swine ALF model induced by intravenous injection of D-Gal was treated by the transplantation of swine MSCs through four routes including intraportal injection （InP group）, hepatic intra-arterial injection （AH group）, peripheral intravenous injection （PV group） and intrahepatic injection （IH group）. The living conditions and survival time were recorded. Blood samples before and after MSCs trans- plantation were collected for the analysis of hepatic function. The histology of liver injury was interpreted and scored in terminal samples. Hepatic apoptosis was detected by TUNEL assay. Apoptosis and proliferation related protein expressions including cleaved caspase-3, survivin, AKT, phospho-AKT （Ser473）, ERK and phospho-ERK （Tyr204） were analyzed by Western blotting. RESULTS： The average survival time of each group was 10.7± 1.6 days （InP）, 6.0±0.9 days （AH）, 4.7±1.4 days （PV）, 4.3± 0.8 days （IH）, respectively, when compared with the average survival time of 3.8±0.8 days in the D-Gal group. The survival rates between the InP group and D-Gal group revealed a statistically significant difference （P〈0.01）. Pathological and biochemical analysis showed that liver damage was the worst in the D-Gal group, while less injury in the InP group. Histopathological scores revealed a significant decrease in the InP group （3.17±1.04, P〈0.01） and AH group （8.17±0.76, P〈0.05） as compared with that in the D-Gal group （11.50±1.32）. The apoptosis rate in the InP group （25.0%±3.4%, P〈0.01） and AH group （40.5%±1.0% , P〈0.05） was lower than that in the D-Gal group （70.6%±8.5%）. The expression of active caspase-3 was inhibited, while the expression of survivin, AKT, phospho- AKT （Ser473）, ERK and phospho-ERK （Tyr20

关键词： mesenchymal stem cells stem cell transplantation acute liver failure apoptosis regeneration

Numerical study of influence of J×B force on melt layer under conditions relevant to ITER ELMs

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Chinese Physics B 2019年第4期28卷 254-260页

作者： Yan Huang Ji-Zhong Sun Juan Cai Zhen-Yue Sun Chao-feng sang De-Zhen Wang School of Information Science and Engineering Dalian Polytechnic University Key Laboratory of Materials Modification by Laser Ion and Electron Beams (Ministry of Education)School of Physics Dalian University of Technology School of Physics and Electronic Technology Liaoning Normal University

The influence of the J×B force on the topographical modification of W targets during a type-I-like ELM in ITER has been studied numerically. A two-dimensional(2D) fluid dynamics model is employed by solving liquid hydrodynamic Navier-Stokes equation with the 2D heat conduction equation in addition to driving forces for surface topography, such as surface tension and pressure gradient, the J×B force is particularly addressed. The governing equations are solved with the finite volume method by adequate prediction of the moving solid-liquid interface. Numerical simulations are carried out for a range of type-I ELM characteristic parameters. Our results indicate that both the surface tension and the J×B force contributes to the melt motion of tungsten plates when the energy flux is under 3000 MW·m^(-2), the surface tension is a major driving force while the pressure gradient is negligible. Our results also indicate that the J×B force makes the small hills grow at different rates at both the crater edges under a type-I-like ELM heat load with a Gaussian power density profile.

关键词： ELMs tungsten divertor plates J×B force melt motion

Protective effects of Lingguizhugan decoction on amyloid-beta peptide (25-35)-induced cell injury Anti-inflammatory effects

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Neural Regeneration Research 2012年第36期7卷 2867-2873页

作者： Feifei Xi feng sang Chunxiang Zhou Yun Ling Basic Medicine College Nanjing University of Chinese Medicine Henan Clinical Research Center of AIDS Controlled with Traditional Chinese Medicine the First Affiliated Hospital of Henan University of Traditional Chinese Medicine Nanjing BenQ Hospital

In the present study, a human neuroblastoma cell line （SH-SY5Y） and BV-2 microglia were treated with amyloid-β peptide （25-35）, as a model of Alzheimer＇s disease, to evaluate the protective effects of 10-3-10-8 g/mL Lingguizhugan decoction and to examine the underlying anti-inflammatory mechanism. Lingguizhugan decoction significantly enhanced the viability of SH-SY5Y cells with amyloid-β peptide-induced injury, and lowered levels of interleukin-1β, interleukin-6, tumor necrosis factor-a and nitric oxide in the culture supernatant of activated BV-2 microglia. The effects of 103 g/mL Lingguizhugan decoction were more significant. These results suggest that Lingguizhugan decoction can protect SH-SY5Y cells against amyloid-β peptide （25-35）-induced injury in a dose-dependent manner by inhibiting overexpression of inflammatory factors by activated microglia.

关键词： Aizheimer's disease Lingguizhugan decoction phlegm-warming and fluid-dispersing inflammatoryreaction SH-SY5Y BV-2

Removing the Destructive Quantum Interference in Cross Conjugation System by Structural Restraint

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Chemical Research in Chinese Universities 2023年第2期39卷 224-227页

作者： QU Kai PAN Zi-You WANG Jin-Yun ZHANG Bochao ZENG Hao sang Yu-feng ZHANG Qian-Chong CHEN Zhong-Ning College of Chemistry Fuzhou UniversityFuzhou350108P.R.China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002P.R.China Department of Pharmacy Xiamen Medical CollegeXiamen361005P.R.China School of Physical Science and Technology ShanghaiTech UniversityShanghai201210P.R.China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108P.R.China University of Chinese Academy of Sciences Beijing100049P.R.China

Understanding the quantum effect in the cross-conjugated system is of fundamental significance in molecular *** this study,four molecules Xa-O,Xa,BP and BP-O were synthesized to investigate the destructive quantum interference(DQI)of a carbonyl *** single-molecule conductance measured by the scanning tunneling microscope break junction(STM-BJ)technique demonstrates an increase in the conductance from molecule BP-O to molecule Xa-O as the cross-conjugated system is *** calculations show that the explicit DQI feature is presented in BP-O but absent in Xa-O,which indicates the removal of DQI in the restrained structures and results in the conductance enhancement in Xa-O.

关键词： Single-molecule conductance Cross conjugation Quantum interference Carbonyl Conductance enhancement

Combined mesenchymal stem cell transplantation and interleukin-1 receptor antagonism after partial hepatectomy

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World Journal of Gastroenterology 2016年第16期22卷 4120-4135页

作者： Jian-feng sang Xiao-Lei Shi Bing Han Xu Huang Tao Huang Hao-Zhen Ren Yi-Tao Ding Department of General Surgery the Affiliated Drum Tower Hospital of Nanjing University Medical School

AIM: To study the therapeutic effects of mesenchymal stem cells (MSCs) and an interleukin-1 receptor antagonist (IL-1Ra) in acute liver ***: Chinese experimental miniature swine (15 ± 3 kg, 5-8 mo) were obtained from the Laboratory Animal Centre of the Affiliated Drum Tower Hospital of Nanjing University Medical School. Acute liver failure was induced via 85% hepatectomy, and animals were treated by MSC transplantation combined with IL-1Ra injection. Blood samples were collected for hepatic function analysis, and the living conditions and survival time were recorded. Liver injury was histologically analyzed. Hepatic cell regeneration and apoptosis were studied by Ki67 immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling, respectively. The levels of protein kinase B and nuclear factor-κB expression were analyzed by Western ***: MSCs were infected with a lentivirus for expression of green fluorescent protein (GFP) for subsequent identification; 97.3% of the MSCs were positive for GFP as assessed by flow cytometry. Additional flow cytometric analysis of cell surface marker expression demonstrated that > 90% of GFP-expressing MSCs were also positive for CD29, CD44, and CD90, indicating that most of these cells expressed typical markers of MSCs, and the population of MSCs was almost pure. Transplantation of MSCs in combination with 2 mg/kg IL-1Ra therapy significantly improved survival time compared to the acute liver failure model group (35.3 ± 6.7 d vs 17.3 ± 5.5 d, P < 0.05). Combined therapy also promoted improvement in serum inflammatory cytokines and biochemical conditions. The observed hepatic histopathologic score was significantly lower in the group with combined therapy than in the model group (3.50 ± 0.87 vs 8.17 ± 1.26, P < 0.01). In addition, liver cell apoptosis in the combined therapy group was significantly inhibited (18.1 �

关键词： Mesenchymal stem cells Interleukin-1 receptor antagonist Stem cell transplantation Acute liver failure Hepatoectomy

Stereocontrol during the radical polymerization of methyl methacrylates with combined Lewis acids:Aluminium trichloride(AlCl_3) and iron dichloride tetrahydrate

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Science China Chemistry 2010年第5期53卷 1141-1147页

作者： sang Qian,feng Ying ,DONG XiuCai & ZHAO JiRuo Key Laboratory of Rubber-Plastics,Ministry of Education Qingdao University of Science and Technology,Qingdao 266042,China 1. Key Laboratory of Rubber-Plastics Ministry of Education Qingdao University of Science and Technology Qingdao 266042 China

The radical polymerization of methyl methacrylate(MMA) was carried out in the presence of combined Lewis acids of the AlCl3-FeCl2 *** with the polymerization produced in the presence of single Lewis acids,AlCl3 or FeCl2,the MMA polymerization in the presence of AlCl3-FeCl2 composite in CHCl3 or 1-butanol produced a polymer with a higher isotacticity and in toluene produced a polymer with a much higher isotacticity(mm=50%) .The molecular weight and polydispersity of PMMA in the presence of Lewis acids were similar with those in the absence of Lewis acids,although Lewis acids decelerate the polymerization of *** effects of the Lewis acids were greater in a solvent with a lower polarity.A possible stereocontrol mechanism of the polymerization was *** Lewis acid composite of AlCl3-FeCl2 readily formed a complex with growing *** complexes possessed apparent bulkiness that changes the direction of monomer addition to the growing radical center.

关键词： MMA radical polymerization tacticity Lewis acid stereocontrol polymerization