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Antioxidant Potential of Extracts from Processing Residues from Brazilian Food Industries

Food and Nutrition Sciences 2013年第8期4卷 211-218页

作者： Natália mezzomo Daniela A. Oliveira sandra R. S. ferreira EQA-CTC/UFSC Chemical and Food Engineering Department Federal University of Santa Catarina Florianópolis Brazil

The objective of this work was to estimate the antioxidant potential of the extracts from pink shrimp residue and red grape pomaces (merlot and Syrah varietals), evaluated according to its antioxidant activity with different analytical methods, associating these properties with the chemical composition of the extract and, as a consequence, with the extraction procedure. The shrimp residue was pre-treated combining cooking, drying, and milling, whereas the grape pomaces were dried and ground. The shrimp residue extracts were obtained by Soxhlet (SOX) and by maceration using hexane (Hx), hexane: isopropanol (50:50) (Hx:IPA), isopropanol, ethanol (EtOH) and acetone as solvents;by ultrasonic maceration (UmE) with EtOH;by cold and hot oil extraction with soy and sunflower oils;and by Supercritical Fluid Extraction (SFE) with pure CO2 (100 -?300 bar;313.15 -?333.15 K) and with co-solvent (Hx: IPA and sunflower oil at 2%). The grape pomaces extracts were obtained by SOX using EtOH, ethyl acetate (EtOAc) and Hx;UmE with water (H2O), EtOH, EtOAc and Hx;and by SFE performed with pure CO2 (150 -?300 bar;323.15 -?333.15 K) and with cosolvent (EtOH at 15%). The antioxidant activity was determined by the DPPH free radical scavenging procedure and by the β-carotene bleaching method. Higher antioxidant activities in shrimp residue extracts were observed by the β-carotene bleaching method in alcoholic and cetonic extracts, among the low pressure extraction methods, while for the SFE, the higher activities were achieved by the extracts obtained at elevated pressures. For the grape pomaces extracts, the best results were obtained by the DPPH method from the low pressure extractions proceeded with EtOH. The SFE with merlot pomace at 323.15 K/150 bar (the lowest temperature and pressures tested) presented the best antioxidant activity by the β-carotene bleaching.

关键词： Supercritical Fluid Extraction Shrimp Residue Grape Pomace

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The growth and production modeling of individual trees of Eucalyptus urophylla plantations

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Journal of Forestry Research 2020年第5期31卷 1663-1672页

作者： Joao Victor Nobre Carrijo Ana Beatriz de Freitas ferreira marcela Costa ferreira mario Cesar de Aguiar Eder Pereira miguel Eraldo Aparecido Trondoli matricardi Alba Valeria Rezende Department of Forestry Faculty of TechnologyUniversity of Brası´liaBrası´lia 70910-900Brazil

Individual tree models(ITms)are classified as growth and production models for projecting current and future forest *** are more complex than other growth and production models,show a higher level of detail and,consequently,produce a better modeling ***,the accuracy and efficiency of ITms have not been properly assessed to *** this study,we estimated the growth in height,diameter,and individual tree volume of a Eucalyptus urophylla plantation by applying an *** used a continuing forest inventory dataset in which 1554 individual trees within 29 permanent plots were measured in the field over a 6-year period(24 to 72 months).Each individual tree volume was estimated for future tree *** achieve this,we adjusted the model to predict the height and diameter growth,and the probability of mortality as a function of the competition *** ITm accuracy was assessed based on the analysis of variance results and,subsequently,the multiple mean comparison test at the 5%significance *** tree volumes predicted by the ITm for the forest stand aged 72 months,beginning at ages 24,36,48,and 60 months,were compared to the field measured tree volume acquired from the 72-month forest inventory that was used as the reference *** and observed tree volumes were similar when the estimation was based on the 48-month forest *** results might help to reduce financial costs of forest inventory because the ITm produces accurate future predictions of forest stand *** estimated ITm for Eucalyptus plantations using measurement intervals up to 2 years is recommended because it significantly reduced the projected volume discrepancy compared to the field measurements.

关键词： Competition index Forest production Forest site Simulation models Tree mortality

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Curcumin-loaded polymeric nanoparticles for neuro-protection in neonatal rats with hypoxic-ischemic encephalopathy

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Nano Research 2018年第10期11卷 5670-5688页

作者： Andrea Joseph Thomas Wood Chih-Chung Chen Kylie Corry Jessica m. Snyder sandra E. Juul Pratik Parikh Elizabeth Nance Department of Chemical Engineering University of Washington Seattle WA 98195 USA Division of Neonatology Department of Pediatrics University of Washington Seattle WA 98195 USA Department of Comparative medicine University of Washington Seattle WA 98195 USA Department of Radiology University of Washington Seattle WA 98195 USA

Hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term newborns and currently has no cure. Inflammatory processes play a key role in the progression of this disease and may be amenable to a targeted pharmaceutical intervention. Curcumin is a dietary compound with potent anti-inflammatory, antioxidant, and antiapoptotic properties but is limited in therapeutic applications due to its low aqueous solubility, low bioavailability, and rapid first-pass hepatic metabolism. To address these limitations, loading curcumin into poly（lactic-co-glycolic acid）-poly（ethylene glycol）（PLGA-PEG） nanoparticles may increase relevant pharmacokinetic parameters and allow for effective drug delivery to the brain. Using the Vannucci model of unilateral hypoxic-ischemic brain injury in neonatal rats, we studied the in vivo effect of curcumin-loaded PLGA-PEG nanoparticles on brain uptake and diffusion of curcumin and on neuroprotection. The curcumin-loaded nanoparticles were able to overcome the impaired blood-brain barrier, diffuse effectively through the brain parenchyma, localize in regions of injury, and deliver a protective effect in the injured neonatal brain. The application of curcumin and PLGA-PEG nanoparticle-mediated delivery to a clinically relevant model of neonatal brain injury provides greater opportunities for clinical translation of targeted therapies for hypoxic-ischemic encephalopathy.

关键词： drug delivery neuroprotection brain penetrating neonatal hypoxia-ischemia curcumin nanotherapeutics

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mucosal T-cell responses to chronic viral infections:Implications for vaccine design

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Cellular & molecular Immunology 2024年第9期21卷 982-998页

作者： mohammed Al-Talib sandra Dimonte Ian R.Humphreys Systems Immunity University Research Institute/Division of Infection and Immunity School of MedicineCardiff UniversityCardiffCF144XNUK Bristol medical School University of Bristol5 Tyndall AvenueBristolBS81UDUK

mucosal surfaces that line the respiratory,gastrointestinal and genitourinary tracts are the major interfaces between the immune system and the *** unique immunological landscape is characterized by the necessity of balancing tolerance to commensal microorganisms and other innocuous exposures against protection from pathogenic threats such as *** pathogenic viruses,including herpesviruses and retroviruses,exploit this environment to establish chronic *** and regulatory T-cell populations,including effector and resident memory T cells,play instrumental roles in mediating the transition from acute to chronic infection,where a degree of viral replication is tolerated to minimize *** antigen exposure during chronic viral infection leads to the evolution and divergence of these *** this review,we discuss advances in the understanding of mucosal T-cell immunity during chronic viral infections and how features of T-cell responses develop in different chronic viral infections of the *** consider how insights into T-cell immunity at mucosal surfaces could inform vaccine strategies:not only to protect hosts from chronic viral infections but also to exploit viruses that can persist within mucosal surfaces as vaccine vectors.

关键词： Virus T cells mucosa Chronic infection Cytomegalovirus HIV

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Exploring overweight and obesity beyond body mass index:A body composition analysis in people with and without patellofemoral pain

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Journal of Sport and Health Science 2023年第5期12卷 630-638,F0003页

作者： Amanda Schenatto ferreira Benjamin F mentiplay Bianca Taborda marcella Ferraz Pazzinatto Fabio mıcolis de Azevedo Danilo De Oliveira Silva Department of Physiotherapy School of Science and TechnologySao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil La Trobe Sport and Exercise medicine Research Centre School of Allied HealthHuman Services and SportLa Trobe UniversityMelbourneVIC 3086Australia

Background:We compared body mass index(BmI),body fat,and skeletal muscle mass between(1) a mixed-sex nonathletic cohort of people with patellofemoral pain(PFP) and pain-free people,and(2) a nonathletic cohort of people with PFP and pain-free people subgrouped by sex(i.e.,men and women with PFP ***-free men and women).methods:This cross-sectional study included 114 people with PFP(71 women,43 men) and 54 pain-free controls(32 women,22 men).All participants attended a single testing session to assess body composition measures,which included BmI,percentage of body fat(%BFBioimpedance),and skeletal muscle mass(both assessed by bioelectrical impedance analysis),and percentage of body fat(%BFskinfoid)(assessed by skinfold caliper analysis).A one-way univariate analysis of covariance(age and physical activity levels as covariates) was used to compare body composition measures between groups(i.e.,PFP ***-free group;women with PFP ***-free women;men with PFP ***-free men).Results:Women with PFP presented significantly higher BmI,%BFBiompedance,and %BFSkinfold,and lower skeletal muscle mass compared to pain-free women(p≤0.04;effect size:-0.47 to 0.85).men with PFP and men and women combined had no differences in BmI,%BFBioimpedance,%BFSkinfold,and skeletal muscle mass compared to their respective pain-free groups(p> 0.05).Conclusion:Our findings indicate that BmI and body composition measures should be considered as part of the evaluation and management of people with PFP,especially in women,who have demonstrated higher BmI and body fat and lower skeletal muscle mass compared to pain-free *** studies should not assess body composition measures in a mixed-sex population without distinguishing men participants from women participants.

关键词： Body composition Body mass index Patellofemoral pain syndrome Skinfold thicknessTagedEnd

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Overweight and obesity in young adults with patellofemoral pain:Impact on functional capacity and strength

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Journal of Sport and Health Science 2023年第2期12卷 202-211页

作者： Amanda Schenatto ferreira Benjamin Fmentiplay Bianca Taborda marcella Ferraz Pazzinatto Fábio mícolis de Azevedo Danilo de Oliveira Silva Department of Physiotherapy School of Science and TechnologySao Paulo State University(UNESP)Presidente Prudente19060-900Brazil La Trobe Sport and Exercise medicine Research Centre School of Allied HealthHuman Services and SportLa Trobe UniversityMelbourneVIC 3086Australia

Purpose:This study aimed to(a)investigate the proportion of overweight/obesity in a cohort of young adults with patellofemoral pain(PFP)and(b)explore the association of body mass index(BmI),body fat,and lean mass with functional capacity and hip and knee strength in people with ***:We included a mixed-sex sample of young adults(18-35 years old)with PFP(n=100).measurements for BmI,percentage of body fat,and lean mass(assessed by bioelectrical impedance)were *** capacity was assessed by the Anterior Knee Pain Scale,plank test,and single-leg hop *** of the knee extensors,knee flexors,and hip abductors was evaluated isometrically using an isokinetic *** proportion of overweight/obesity was calculated based on *** association between BmI,body fat,and lean mass and functional capacity and strength was investigated using partial correlations,followed by hierarchical regression analysis,adjusted for covariates(sex,bilateral pain,and current pain level).Results:A total of 38%of our cohort had their BmI categorized as overweight/*** BmI was associated with poor functional capacity(ΔR^(2)=0.06-0.12,pmass was associated with poor functional capacity(ΔR^(2)=0.04-0.13,p≤0.032)and reduced strength(ΔR^(2)=0.29-0.31,pmI,body fat,and lean mass should be considered in the assessment and management of young people with PFP because it may be detrimental to function and strength.

关键词： Body fat distribution Body mass index Patellofemoral pain syndrome Torque

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Cardiovascular rehabilitation in patients aged 70-year-old or older:benefits on functional capacity,physical activity and metabolic profile in younger *** patients

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Journal of Geriatric Cardiology 2020年第9期17卷 544-553页

作者： marta Fontes-Oliveira maria Trêpa Patrícia Rodrigues Preza Fernandes sandra magalhães Sofia Cabral mário Santos Severo Torres Cardiology Department University Hospital Centre of PortoPortoPortugal Cardiac Rehabilitation Unit Cardiology DepartmentUniversity Hospital Centre of PortoPortoPortugal Pulmonary Vascular Disease Unit University Hospital Centre of PortoPortoPortugal

Background The benefits of exercise-based cardiac rehabilitation(EBCR)programs in post-acute myocardial infarction(AmI)patients have been *** aim was to assess the impact of EBCR in³70-years-old *** post-AmI *** We retrospectively evaluated patients who underwent a supervised EBCR protocol,twice a week during 6-12 *** evaluated changes in several outcomes based on pre-and post-CRP *** Of a total of 1607 patients,333(21%)were³*** the EBCR,an overall improvement on functional capacity,daily physical activity,lipid profile,body mass index,glycated hemoglobin(HbA1c),N-terminal pro-brain natriuretic peptide(NT-pro-BNP)and C-reactive protein was observed in both younger and older patients(Pmaller benefit on the increment of daily physical activity and lipid profile improvement,but a larger reduction in *** the multivariate analysis,only improvements on daily physical activity and HbA1c were dependent on *** As their younger counterparts,older patients,significantly improved functional capacity,metabolic parameters and level of daily physical activity after EBCR.

关键词： Aging Cardiovascular prevention Exercise-based cardiac rehabilitation

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Importance of overstorey attributes for understorey litter production and nutrient cycling in European forests

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Forest Ecosystems 2020年第4期7卷 591-601页

作者： Dries Landuyt Evy Ampoorter Cristina CBastias Raquel Benavides sandra müller michael Scherer-Lorenzen Fernando Valladares Safaa Wasof Kris Verheyen Forest&Nature Lab Department of EnvironmentGhent UniversityGhentBelgium LINCGlobal Department of Biogeography and Global ChangeNational Museum of Natural Science-CSICMadridSpain Faculty of Biology GeobotanyUniversity of FreiburgFreiburg im BreisgauGermany.

Background:In contrast with the negligible contribution of the forest understorey to the total aboveground phytobiomass of a forest,its share in annual litter production and nutrient cycling may be more *** and how this functional role of the understorey differs across forest types and depends upon overstorey characteristics remains to be ***:We sampled 209 plots of the FunDivEUROPE Exploratory Platform,a network of study plots covering local gradients of tree diversity spread over six contrasting forest types in *** estimate the relative contribution of the understorey to carbon and nutrient cycling,we sampled non-lignified aboveground understorey biomass and overstorey leaf litterfall in all *** samples were analysed for C,N and P concentrations,overstorey leaf litterfall for C and N *** additionally quantified a set of overstorey attributes,including species richness,proportion of evergreen species,light availability(representing crown density)and litter quality,and investigated whether they drive the understorey’s contribution to carbon and nutrient *** and conclusions:Overstorey litter production and nutrient stocks in litterfall clearly exceeded the contribution of the understorey for all forest types,and the share of the understorey was higher in forests at the extremes of the climatic *** most of the investigated forest types,it was mainly light availability that determined the contribution of the understorey to yearly carbon and nutrient *** species richness did not affect the contribution of the understorey to carbon and nutrient cycling in any of the investigated forest types.

关键词： FunDivEUROPE Nutrient cycling Litter production Understorey Overstorey Tree species richness Light availability Litter quality Proportion evergreen tree species

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Influence of parameters on the microstructure of a duplex stainless steel joint welded by a GmAW welding process

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Progress in Natural Science:materials International 2022年第4期32卷 415-423页

作者： sandra Chacón-Fernández Antonio Portolés García Gerardo Romaní Labanda Universidad Politécnica de madrid Escuela Técnica Superior de Ingenieros Industriales UPM

Duplex stainless steels（DSSs） are widely used in industry for their desirable properties. Any fusion welding technique modifies the microstructure and, consequently, the properties of the material. This paper presents a parametric study of the variables that determine the energy contribution（current, voltage and welding speed） and the structural modifications produced during gas metal arc welding. The analysis comprises metallographic study,phase balance, dimensioning of the weld beads and tensile and hardness tests. The influence of the variables studied on the thermal cycles obtained（temperatures reached and cooling rate） was determined by using a finite element model. The results showed that, in addition to the indicated parameters, the parameter power transfer per volume（W/m3） and the geometry in the bead must be controlled due to their influence on the heat flow distribution and phase balance.

关键词： Welding Heat input GmAW Duplex stainless steels (DSS) Finite element model (FEm)

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Lipid-lowering effect of microencapsulated peptides from brewer’s spent grain in high-sucrose diet-fed rats

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Food Bioscience 2022年第5期49卷 981-989页

作者： m.R.ferreira A.G.Garz´on m.E.Oliva R.E.Cian S.R.Drago m.E.D’Alessandro Laboratorio de Estudio de Enfermedades metab´olicas Relacionadas con la Nutrici´on Facultad de Bioquímica y Ciencias Biol´ogicasUniversidad Nacional del LitoralCiudad UniversitariaSanta FeArgentina Instituto de Tecnología de Alimentos Facultad de Ingeniería QuímicaUniversidad Nacional del Litoral1ro de Mayo3250Santa FeArgentina Consejo Nacional de Investigaciones Científicas y T´ecnicas(CONICET) Argentina

Brewer’s spent grain(BSG)-a byproduct generated from the processing of beer-brewing industry-is currently recognized as an important source of bioactive peptides with potential health *** previous studies we demonstrated that peptides obtained from BSG(BSG-P)can exert in vitro biofunctional activities including hypolipidemic ***,there are no studies about the effects of gastrointestinal digestion on BSG lipid-lowering peptides and it is unknown whether the bioactive properties observed in vitro remain in *** aims of this work were to evaluate the microencapsulation as strategy to preserve hypolipidemic BSG-P under a simulated gastrointestinal digestion,and the bioavailability of microencapsulated BSG-P using a rodent model of hyperlipidemia and other metabolic-related disorders induced by the consumption of a high-sucrose *** vitro studies showed that microencapsulation improved the BSG-P reduced hypolipidemic activity observed under a simulated gastrointestinal digestion by increasing the inhibition of the fat digestion enzymes,pancreatic lipase and cholesterol ***,in vivo studies demonstrated that microencapsulated BSG-P were also able to reduce the increased serum lipid levels(triglycerides-TG-cholesterol and free fatty acids),energy intake,visceral adipocytes size and TG content observed in sucrose-rich diet-fed *** was accompanied by reduced liver lipids levels and the activities of key enzymes involved in dietary fat ***,our findings show that microencapsulation is a useful strategy to preserve the hypolipidemic activity of BSG-P and support the concept that microencapsulated BSG-P would be an interesting and cheaper natural source to prevent hyperlipidemias and its related-disorders.

关键词： Bioactive peptides Brewer’s spent grain Hyperlipidemia Sucrose-rich diet metabolic tissue Digestive enzymes

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