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3D printed fiber-optic nanomechanical bioprobe

International Journal of Extreme Manufacturing 2023年第1期5卷 222-234页

作者： Mengqiang Zou Changrui Liao Yanping Chen Lei Xu Shuo tang Gaixia Xu Ke Ma Jiangtao Zhou Zhihao Cai Bozhe Li Cong Zhao Zhourui Xu Yuanyuan Shen Shen Liu Ying Wang Zongsong Gan Hao Wang Xuming Zhang sandor Kasas Yiping Wang Guangdong and Hong Kong Joint Research Centre for Optical Fibre Sensors College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China School of Electronic and Communication Engineering Shenzhen PolytechnicShenzhen 518000People’s Republic of China Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhen 518055People’s Republic of China Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Laboratory of Food and Soft Materials Department of Health Sciences and TechnologyETH Zurich8092 ZurichSwitzerland Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and Technology(HUST)Wuhan 430074People’s Republic of China Department of Applied Physics The HongKong Polytechnic UniversityHong KongPeople’s Republic of China Laboratory of Biological Electron Microscopy Ecole Polytechnique Fédérale de Lausanne1015 LausanneSwitzerland UnitéFacultaire d’Anatomie et de Morphologie(UFAM) CUMRLUniversity of Lausanne1005 LausanneSwitzerland

Ultrasensitive nanomechanical instruments,*** force microscopy(AFM),can be used to perform delicate biomechanical measurements and reveal the complex mechanical environment of biological ***,these instruments are limited because of their size and complex feedback *** this study,we demonstrate a miniature fiber optical nanomechanical probe(FONP)that can be used to detect the mechanical properties of single cells and in vivo tissue measurements.A FONP that can operate in air and in liquids was developed by programming a microcantilever probe on the end face of a single-mode fiber using femtosecond laser two-photon polymerization *** realize stiffness matching of the FONP and sample,a strategy of customizing the microcantilever’s spring constant according to the sample was proposed based on structure-correlated *** a proof-of concept,three FONPs with spring constants varying from 0.421 N m^(−1)to 52.6 N m^(−1)by more than two orders of magnitude were *** highest microforce sensitivity was 54.5 nmμN^(−1)and the detection limit was 2.1 *** Young’s modulus of heterogeneous soft materials,such as polydimethylsiloxane,muscle tissue of living mice,onion cells,and MCF-7 cells,were successfully measured,which validating the broad applicability of this *** strategy provides a universal protocol for directly programming fiber-optic ***,this method has no special requirements for the size and shape of living biological samples,which is infeasible when using commercial *** has made substantial progress in realizing basic biological discoveries,which may create new biomedical applications that cannot be realized by current AFMs.

关键词： two-photon polymerization nanolithography optical fiber sensor nanomechanical probe stiffness tunable microcantilever biosensor

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Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort

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World Journal of Gastroenterology 2013年第14期19卷 2217-2226页

作者： Barbara Dorottya Lovasz Laszlo Lakatos Agnes Horvath Istvan Szita tunde Pandur Michael Mandel Zsuzsanna Vegh Petra Anna Golovics Gabor Mester Mihaly Balogh Csaba Molnar Erzsebet Komaromi Lajos sandor Kiss Peter Laszlo Lakatos First Department of Medicine Semmelweis University Department of Medicine Csolnoky F Province Hospital Department of Pediatrics Csolnoky F Province Hospital Department of Medicine Grof Eszterhazy Hospital Department of Infectious Diseases Magyar Imre Hospital Department of Gastroenterology Municipal Hospital

AIM:to investigate the evolution of disease phenotypein adult and pediatric onset Crohn's disease(CD) populations,diagnosed between 1977 and ***:Data of 506 incident CD patients were analyzed(age at diagnosis:28.5 years,interquartile range:22-38 years).Both in-and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which included incident patients diagnosed between January 1,1977 and December 31,2008 in adult and pediatric onset CD *** phenotype according to the Montreal classification and long-term disease course was analysed according to the age at onset in time-dependent univariate and multivariate ***:Among this population-based cohort,seventy-four(12.8%) pediatric-onset CD patients were identified(diagnosed ≤ 17 years of age).there was no significant difference in the distribution of disease behavior between pediatric(B1:62%,B2:15%,B3:23%) and adult-onset CD patients(B1:56%,B2:21%,B3:23%) at diagnosis,or during ***,the probability of developing complicated disease behaviour was 49.7% and 61.3% in the pediatric and 55.1% and 62.4% in the adult onset patients after 5-and 10-years of ***,time to change in disease behaviour from non stricturing,non penetrating(B1) to complicated,stricturing or penetrating(B2/B3) disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier *** year of diagnosis(P = 0.04),ileal location(P teroids(P ted with presence of,or progression to,complicated disease behavior at diagnosis and during follow-up.A change in disease location was observed in 8.9% of patients and it was associated with smoking status(P = 0.01),but not with age at ***:Long-term evolution of disease behavior was not different in pediatric-a

关键词： Crohn’s disease Age at diagnosis Disease behavior Disease course

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Mechanisms of vascularization in murine models of primary and metastatic tumor growth

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Chinese Journal of Cancer 2016年第2期35卷 80-87页

作者： Edina Bugyik Ferenc Renyi-Vamos Vanessza Szabo Katalin Dezso Nora Ecker Andras Rokusz Peter Nagy Balazs Dome sandor Paku 1 st Department of Pathology and Experimental Cancer Research Semmelweis University Department of thoracic Surgery Semmelweis University-National Institute of Oncology Hungarian Academy of Sciences Postdoctoral Research Programme Department of thoracic Surgery Medical University of Vienna Department of Biomedical Imaging and Image-guided therapy Medical University of Vienna tumor Progression Research Group Joint Research Organization of the Hungarian Academy of Sciences and Semmelweis University

Directed capillary ingrowth has long been considered synonymous with tumor ***,the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting;instead,malignant tumors can acquire blood vessels via alternative vascularization mechanisms,such as intussusceptive microvascular growth,vessel co-option,and glomeruloid ***,in response to anti-angiogenic therapies,malignant tumors can switch from one vascularization mechanism to *** this article,we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.

关键词： Vascularization, Primary tumor, Metastasis, Angiogenesis

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Integrative genomics reveals paths to sex dimorphism in Salix purpurea L

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Horticulture Research 2021年第1期8卷 2305-2318页

作者： Brennan Hyden Craig H.Carlson Fred E.Gouker Jeremy Schmutz Kerrie Barry Anna Lipzen Aditi Sharma Laura sandor Gerald A.tuskan Guanqiao Feng Matthew S.Olson Stephen P.DiFazio Lawrence B.Smart Horticulture Section School of Integrative Plant ScienceCornell UniversityCornell AgriTechGenevaNYUSA Floral and Nursery Plants Research Unit US National ArboretumUnited States Department of AgricultureAgricultural Research ServiceBeltsvilleMDUSA United States Department of Energy Joint Genome InstituteBerkeleyCAUSA HudsonAlpha Institute for Biotechnology HuntsvilleALUSA the Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTNUSA Department of Biology Texas Tech UniversityLubbockTXUSA Department of Biology West Virginia UniversityMorgantownWVUSA

Sex dimorphism and gene expression were studied in developing catkins in 159 F 2 individuals from the bioenergy crop Salix purpurea,and potential mechanisms and pathways for regulating sex development were *** expression,eQtL,bisulfite sequencing,and network analysis were used to characterize sex dimorphism,detect candidate master regulator genes,and identify pathways through which the sex determination region(SDR)may mediate sex *** genes are presented as candidates for master regulators of sex,supported by gene expression and network *** include genes putatively involved in hormone signaling,epigenetic modification,and regulation of *** analysis revealed a suite of transcription factors and genes involved in secondary metabolism and floral development that were predicted to be under direct control of the sex determination ***,data from bisulfite sequencing and small RNA sequencing revealed strong differences in expression between males and females that would implicate both of these processes in sex dimorphism *** data indicate that the mechanism of sex determination in Salix purpurea is likely different from that observed in the related genus *** further demonstrates the dynamic nature of SDRs in plants,which involves a multitude of mechanisms of sex determination and a high rate of turnover.

关键词： purpurea metabolism likely

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Organic Carbon Changes Over 40-years in a Haplic Luvisol type Farmland in Hungary

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Journal of Agricultural Science and technology(A) 2011年第6期1卷 913-920页

作者： L. Marton F. sandor Y. V. Kostyuchenko P. Konvalina Department of Agrochemistry Research Institute for Soil Science and Agricultural Chemistry Hungarian Academy of Sciences Budapest 1022 Hungary Department of Commercial Horticulture and Agriculture Marketing Roots of Peace Darul Aman Road Ayoub Khan Mina Kabul 100004 Afghanistan Heat and Mass Exchange in Geo-systems Department Scientific Centre for Aerospace Research of the Earth of the National Academy of Sciences of Ukraine Kiev 01601 Ukraine Department of Plant Production and Agroecology University of South Bohemia Studentska 133 7005 Czech Republic

It is well known the effect of fertilizer applications in Haplic Luvisols after crop production, but long term changes in precipitation and soil organic carbon are not well documented. Study aimed to determine the effect of precipitation and fertilization （NPKCaMg） on the changes in soil organic carbon （SOC） in a long-term field experiment set up in Nyirlugos （Nyirs6g region, Hungary： N： 47°41′60″ and E： 22°2′80″ since 1962） on a Haplic Luvisol. Over the 40 year period, from 1962 to 2002, SOC pool values ranged between 2.32 and 3.36 mg kg-1. On the untreated control plots the values remained nearly constant （3.31 mg kg-1, ± 0.29 mg kg1 and 0.52 mg kg-1）. NPKCaMg fertilization resulted in a significant （P 〈 0.001） decline （16.6%） in SOC in comparison to the control plots in the Ist 20-year interval, while in the 2nd 20-year period a significant （P 〈 0.001） increased （up to 31.9%） was noticed. During the 40 experimental years the seasonal correlations （R2 among SOC （mg kgl）, WHY and SHY precipitation （mm） ranged from 0.3343 to 0.9078 （on the P 〈 0.001 significance level）. the correlations （R2） on the influence of NPKCaMg fertilization on SOC （mg kg-1） and precipitation （mm） were significant （P 〈 0.001）： the means for WHY, SHY and over the 40 years were 0.4691, 0.6171 and 0.6582, respectively. Organic carbon reserves （mg kg-1） in soils decreased linearly as precipitation increased （from 3.22 to 7.27 mm yr-1）. In case this trend-increasing precipitation caused by climate change reduces SOC in arable soils-will continue, and is aggravated by warming temperatures and a more altering climate （as predicted by climate change forecasts）, the livelihoods of many Hungarian and European farmers may be substantially altered.

关键词： Organic carbon precipitation fertilization crop.

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线粒体DNA序列多位点分析揭示全球松茸复合种种内有限基因变异和种间稳定区别

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食用菌学报 2020年第1期27卷 1-19页

作者： sandor Sarah R 王汉臣 VAARIO Lumin tRUDELL Steven A 徐建平加拿大麦克马斯特大学生物系加拿大哈密尔顿安大略省L8S4K1 重庆师范大学生命科学学院重庆401331 赫尔辛基大学林业科学学院芬兰赫尔辛基00014 东京大学农业和生命科学学院日本东京113-8657 华盛顿大学伯克博物馆标本馆美国华盛顿98195-5325

松茸是外生菌根真菌,分布在北半球,在温带生态系统的物质循环和改善植物健康中发挥着重要作用。这类食用菌也具有很高的经济价值,尤其在日本。根据形态特征和基于细胞核核糖体RNA基因簇转录间隔区(ItS)序列的DNA条形码,已经把松茸按不... 详细信息

松茸是外生菌根真菌,分布在北半球,在温带生态系统的物质循环和改善植物健康中发挥着重要作用。这类食用菌也具有很高的经济价值,尤其在日本。根据形态特征和基于细胞核核糖体RNA基因簇转录间隔区(ItS)序列的DNA条形码,已经把松茸按不同地理区域来源归为几个物种:tricholoma matsutake(欧亚大陆),***(地中海区域),***(北美东部),***(北美西部)和***(墨西哥)。这些物种共同构成全球松茸复合种。本研究通过多位点序列分析进一步调查松茸系统地理学,更深入的理解这种生物的全球分布和进化历史。来自北美、北欧和东亚的42个松茸样品的ItS序列和4个线粒体位点被检测。总体上线粒体DNA多位点系统分析呈现出和ItS系统发育分析一致的模式和拓扑结构,即各个地理区域的样品分别聚在一起。然而,在我们的4个被检测物种的样品间,几乎没有或没有发现所选线粒体位点的基因变异。我们的研究结果表明松茸物种复合体中的线粒体基因组的进化速度较慢,或各个物种的广泛分布源于近期的扩散。深入理解松茸复合种的遗传多样性和演化关系,对制定保护政策有重要意义。

关键词：松茸复合种线粒体序列多样性系统地理学

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Dual Effects of Photo-Darkening and Photo-Bleaching in Ge-Se Films

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材料科学与工程（中英文A版） 2015年第1期5卷 78-86页

作者： Istvan Csarnovics Muhamma Rizwa Latif tyler Nichol Wan Kuang Maria Mitkova Miklos Veres sandor Kokenyesi Department of Experimental Physics University of Debrecen Debrecen 4026 Hungary Department of Electrical and Computer Engineering Boise State University Boise ID 83725-2075 USA Institute of Solid State Physics and Optics Wigner RCP HAS Budapest 1121 Hungary Department of Electrical Engineering University ofDebrecen Debrecen 4026 Hungary.

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API Development Increases Access to Shared Computing Resources at Boston University

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Journal of Software Engineering and Applications 2022年第6期15卷 197-207页

作者： George Jones Amanda E. Wakefield Jeff triplett Kojo Idrissa James Goebel Dima Kozakov sandor Vajda Department of Applied Mathematics and Statistics Stony Brook University Stony Brook USA Department of Chemistry Boston University Boston USA Department of Biomedical Engineering Boston University Boston USA Revolution Systems LLC. Lawrance USA College of Engineering Boston University Boston USA

Within the last few decades, increases in computational resources have contributed enormously to the progress of science and engineering (S & E). to continue making rapid advancements, the S & E community must be able to access computing resources. One way to provide such resources is through High-Performance Computing (HPC) centers. Many academic research institutions offer their own HPC Centers but struggle to make the computing resources easily accessible and user-friendly. Here we present SHABU, a REStful Web API framework that enables S & E communities to access resources from Boston University’s Shared Computing Center (SCC). the SHABU requirements are derived from the use cases described in this work.

关键词： API Framework Open Source High-Performance Computing Software Architecture Science and Engineering

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內燃机用硅油动力扭振减振器

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国外铁道机车与动车 1966年第6期 39-41页

作者： sandor BEtLEJ ,柳欣生

内燃发动机的曲轴在工作时承受周期性交叉方向的扭矩,该扭矩是在发动机机体内每个气缸按各自的方向作用的,对一般的六缸汽车用发动机,是造成曲轴材料疲劳以至毁坏的原因。为防止上述现象的出现,必须采取相应的措施使扭振力矩降至实际允... 详细信息

内燃发动机的曲轴在工作时承受周期性交叉方向的扭矩,该扭矩是在发动机机体内每个气缸按各自的方向作用的,对一般的六缸汽车用发动机,是造成曲轴材料疲劳以至毁坏的原因。为防止上述现象的出现,必须采取相应的措施使扭振力矩降至实际允许的限界。基于各种理论所设计的不同形式的扭振减振器,已为大家所熟知,并用以防止曲轴过大的扭矩。其目的是,按照需要消散由于振动系统扭振所生产的能量。最熟知的扭振减振器有以下几种: 1.摩擦式扭振减振器,其强制力矩能量主要消散于阻尼力矩,该力矩是在相互间用一定压力压紧的摩擦片间产生的,由于扭振的结果,摩擦片间产生相互滑动。

关键词：减振器曲轴传动轴扭振振动环合成液体绝缘材料硅油

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混凝土控制强度的快速确定

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武汉理工大学学报 1982年第3期 273-282页

作者： sandor Popovics 皮永林美国Drexel大学土木工程系教授

施工现场需要在早于28天、甚至早于7天前对混凝土的质量是否合格作出判断。如果不能较早地查出低强度的混凝土,而要纠正这种失误则往往花费很大,同时也很困难。一种较早的确定混凝土强度潜力的方法,是提高混凝土强度试件的早期温度。本... 详细信息

施工现场需要在早于28天、甚至早于7天前对混凝土的质量是否合格作出判断。如果不能较早地查出低强度的混凝土,而要纠正这种失误则往往花费很大,同时也很困难。一种较早的确定混凝土强度潜力的方法,是提高混凝土强度试件的早期温度。本文讨论了几种这类加速养护的方法。在美国一些标准化的方法中,沸水法(boilng water method)显得最可靠。此法提供了在24～25小时龄期时的加速强度。最简单的方法是自然养护法(autogenous curing method),此法在48小时龄期可得到强度。虽然利用加速养护1天或2天的强度不完全象28天的强度那样容易得到,但是工程师还是依靠这样一些试验,以迅速防止由于28天的强度不合标准而产生的复杂后果。

关键词：加速养护控制强度快速确定混凝土无机非金属材料混凝土强度试件

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