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Polyester-tethered near-infrared fluorophores confined in colloidal nanoparticles:Tunable and thermoresponsive aggregation and biomedical applications

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聚集体(英文)

聚集体(英文) 2023年第2期4卷 193-205页

作者： Cangjie Yang Wei Zhang Xin Pang Fan Xiao sandeep kumar kalva Yipeng Zhang Manojit Pramanik Leilei Tian Gang Liu Mingfeng Wang School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingaporeSingapore School of Science and Engineering The Chinese University of Hong KongShenzhenChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamenChina School of Materials Science and Engineering South University of Science and TechnologyShenzhenChina Institute of Pharmacology and Toxicology and Institute of Biomedical Engineering Faculty of MedicineUniversity of ZurichZurich CH-8057Switzerland

Intricate assembly of multiple molecular chromophores assisted by protein scaffolds is essential in tuning the optical absorption and energy transfer in the light-harvesting complexes of the photosynthetic systems in ***,it remains a challenge to achieve such structural complexity and functionality in synthetic polymer-chromophore ***,we report a series of polyester-tethered pyrrolopyrrole cyanine derivatives and their colloidal nanoparticles dispersed in water,which show tunable J-or H-aggregation excitonic coupling and near-infrared fluorescence by precise control of the polymer chain lengths,composition,and ***,the optimal fluorescence or photothermal effect of the Jaggregate nanoparticles enables broad applications in fluorescence or photoacoustic bioimaging and phototherapy.

关键词： bioimaging colloids fluorescence polymers self-assembly

Automated Time Based Multi-Criteria Bug Triage Approach:Developer Working Efficiency and Social Network Based Developer Recommendation

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Journal of Shanghai Jiaotong university(Science) 2024年第3期29卷 566-578页

作者： YADAV Asmita SINGH kumar sandeep Krishna Engineering College Ghaziabad 201007India JIIT Noida 201309India

In software development projects,bugs are common *** report bugs in open source *** is a need to develop high quality developer prediction model that considers developer work satisfaction,keep within limited development cost,and improve bug resolution *** address and resolve bug report as soon as possible is the main focus of triager when a new bug is ***,developer work efficiency is an important factor in *** address these issues,a proposed approach recommends a set of developers that could potentially share their knowledge with each other to fix new bug *** proposed approach is called developer working efficiency and social network based developer recommendation(DweSn).It is a composite model that builds developers'profile by using developer average bug fixing time,work efficiency to fix variety of bugs,as well as the developer's social interactions with other developers.A similarity measure is applied between new bug and bugs in corpus to extract the list of capable developers from the *** proposed approach only selects those developers who are active and less loaded with *** developer with the highest profile score is assigned the *** evaluated our approach on the subset of five large open-source projects including Mozilla,Netbeans,Eclipse,Firefox and OpenOffice,and compared it with the *** results demonstrate that combination of developers'efficiency with their average bug fixing time and interactions in their social network gives good accuracy and efficiently reduces bug tossing *** approach shows an improvement in prediction accuracy,precision,recall,F-score and reduced bug tossing length up to 93.89%,93.12%,93.46%,93.27%and 93.25%,*** proposed approach achieved a 93%hit ratio and 93.34%mean reciprocal rank,indicating that our proposed triager is able to efficiently assign bugs to correct developers.

关键词： open-source repository bug report bug assignment tossing length bug triager developer social network developer recommendation

Nitrosamines crisis in pharmaceuticals Insights on toxicological implications, root causes and risk assessment: A systematic review

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Journal of Pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth P.R.Vikram Tegginamath Pramod kumar Gunjan kumar Narasimha M.Beeraka Rajashree Deka Sheik Mohammed Suhail sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.Chandan Pramod kumar Bannimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(APIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

Robust Facial Biometric Authentication System Using Pupillary Light Reflex for Liveness Detection of Facial Images

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 725-739页

作者： Puja S.Prasad Adepu Sree Lakshmi sandeep Kautish Simar Preet Singh Rajesh kumar Shrivastava Abdulaziz S.Almazyad Hossam M.Zawbaa Ali Wagdy Mohamed CSE Department Geethanjali College of EngineeringHyderabadTelangana501301India Department of Computer Science LBEF CampusKathmandu44600Nepal School of Computer Science Engineering and Technology(SCSET) Bennett UniversityGreater Noida201310India Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia CeADAR Ireland’s Centre for AI Technological University DublinDublinD07 EWV4Ireland Operations Research Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied Science Research Center Applied Science Private UniversityAmman11937Jordan

Pupil dynamics are the important characteristics of face spoofing *** face recognition system is one of the most used biometrics for authenticating individual *** main threats to the facial recognition system are different types of presentation attacks like print attacks,3D mask attacks,replay attacks,*** proposed model uses pupil characteristics for liveness detection during the authentication *** pupillary light reflex is an involuntary reaction controlling the pupil’s diameter at different light *** proposed framework consists of two-phase *** the first phase,the pupil’s diameter is calculated by applying stimulus(light)in one eye of the subject and calculating the constriction of the pupil size on both eyes in different video *** above measurement is converted into feature space using Kohn and Clynes model-defined *** Support Vector Machine is used to classify legitimate subjects when the diameter change is normal(or when the eye is alive)or illegitimate subjects when there is no change or abnormal oscillations of pupil behavior due to the presence of printed photograph,video,or 3D mask of the subject in front of the *** the second phase,we perform the facial recognition ***-invariant feature transform(SIFT)is used to find the features from the facial images,with each feature having a size of a 128-dimensional *** features are scale,rotation,and orientation invariant and are used for recognizing facial *** brute force matching algorithm is used for matching features of two different *** threshold value we considered is 0.08 for good *** analyze the performance of the framework,we tested our model in two Face antispoofing datasets named Replay attack datasets and CASIA-SURF datasets,which were used because they contain the videos of the subjects in each sample having three modalities(RGB,IR,Depth).The CASIA-SURF datasets showed an 89.9%Equal Err

关键词： SIFT pupil CASIA-SURF pupillary light reflex replay attack dataset brute force

Corrigendum to“Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review”[***.14(2024)100919]

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Journal of Pharmaceutical Analysis 2024年第6期14卷 934-936页

Original statement in the Section 2:*** search Our primary screening of 180 articles yielded the relevant data for this *** selection A total of 180 articles spanning from 1960 to the present day,including original research,reviews,case reports and studies reporting nitrosamine impurities above the no-observed-adverse-effect levels(NOAEL)established by regulatory agencies,were initially *** the primary screening,we considered factors such as relevance,publication date,access to the full article text,and content.

关键词： statement initially spanning

A case study illustrating the use of an integrated approach to treat secondary Anal Fistula Post I&D of Perianal Abscess

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Clinical Research Communications 2024年第1期7卷 11-17页

作者： sandeep kumar Upadhyay Sheetal Asutkar Shreya Soni Department of Shalya Tantra Mahatma Gandhi Ayurved College Hospital and Research CentreWardha 442001India HOD Shalya Tantra Mahatma Gandhi Ayurved College Hospital and Research CentreWardha 442001India

Background:Anal fistula is a long-term disease characterized by a tubular structure with one end opening in the anorectal canal and the other end opening on the surface of the perineum or perianal skin with chronic pus *** is linked to Bhagandar in Ayurveda,and in Sushruta Samhita,Acharya has mentioned 5 forms of *** boil in the present case was Shukla,sthira *** and firm,with Picchila strava and Kandu resembling the features of Parisraavi *** and objective:The current case was diagnosed as Parisravi bhagandar,which resembles trans-sphincteric or intersphincteric fistula in modern *** Ayurveda,the management of Parisraavi Bhagandar,Shastra,kshara,and Agnikarma is advised and the use of Ksharasutra,which contributes to complete cutting and healing of the track without reoccurrence,similarly Modern surgeon depends on surgery i.e radical excision of the track,ligation with Seton,and use of chemical irritants like urethane,silver nitrates,etc.A cutting seton(tight)gently slices the confined muscle to close the fistula with the least interruption to *** operation is especially advised when a one-stage fistulotomy poses a considerable risk of *** and methods:The method performed here was Core Partial Fistulectomy followed by Ksharasutra application till complete healing of the *** and conclusion:This case study provides the successful management of Parisraavi Bhagandara(high anal,trans-sphincteric fistula in ano)in 61-year-old male patient with an integrated surgical&Ayurvedic management approach.

关键词： Anal fistula Colonoscopy ligation of trans-sphincteric fistula Methylene blue dye perianal abscess Radical excision Sushrut Samhita

Multiway Relay Based Framework for Network Coding in Multi-Hop WSNs

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Computers, Materials & Continua 2023年第1期74卷 1199-1216页

作者： Vinod kumar Menaria Anand Nayyar sandeep kumar Ketan Kotecha Department of IT&C(DoIT&C) Govt of RajasthanJaipurIndia Graduate School Faculty of Information TechnologyDuy Tan UniversityDa NangVietnam Department of Computer Science and Engineering CHRIST(Deemed to be University)Bangalore560074India Symbiosis Centre for Applied Artificial Intelligence Symbiosis International UniversityPuneIndia

In today’s information technology(IT)world,the multi-hop wireless sensor networks(MHWSNs)are considered the building block for the Internet of Things(IoT)enabled communication systems for controlling everyday tasks of organizations and industry to provide quality of service(QoS)in a stipulated time slot to end-user over the *** city(SC)is an example of one such application which can automate a group of civil services like automatic control of traffic lights,weather prediction,surveillance,etc.,in our daily *** IoT-based networks with multi-hop communication and multiple sink nodes provide efficient communication in terms of performance parameters such as throughput,energy efficiency,and end-to-end delay,wherein low latency is considered a challenging issue in next-generation networks(NGN).This paper introduces a single and parallels stable server queuing model with amulti-class of packets and native and coded packet flowto illustrate the simple chain topology and complexmultiway relay(MWR)node with specific neighbor ***,for improving data transmission capacity inMHWSNs,an analytical framework for packet transmission using network coding at the MWR node in the network layer with opportunistic listening is performed by considering bi-directional network flow at the MWR ***,the accuracy of the proposed multi-server multi-class queuing model is evaluated with and without network coding at the network layer by transmitting data *** results of the proposed analytical framework are validated and proved effective by comparing these analytical results to simulation results.

关键词： Multi-hop wireless sensor networks network coding multiway relay node throughput multi-server multi-class queuing models

PAPR Reduction of NOMA Using Vandermonde Matrix-Particle Transmission Sequence

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Computer Systems Science & Engineering 2022年第10期43卷 193-201页

作者： Arun kumar sandeep Gupta Himanshu Sharma Mehedi Masud Department of Electronics and Communication Engineering JECRC UniversityJaipur303905India Department of Electrical Engineering JECRC UniversityJaipur303905India Department of Computer Science and Engineering JECRC UniversityJaipur303905India Department of Computer Science College of Computers and Information TechnologyTaif University11099Saudi Arabia

Non-Orthogonal Multiple Access(NOMA)is an ideal choice for 5G waveforms due to their characteristics such as high data rate,massive device connectivity,high spectral access,and effective frequency selective ***,it permits gigantic *** spectrum overlaps with NOMA,which consents several operators to segment the spectrum at the same *** features make NOMA more suitable for use beyond *** to Average Power(PAPR)is a major problem in Multi-Carrier Techniques(MCT)like NOMA and it also degrades the performance of the *** Partial Transmission Sequence(PTS)is a superior algorithm for moderating the ***,it also increases the complexity of the *** PAPR is reduced in NOMA by multiplying the NOMA signal with optimised phase vectors(P).The phase vectors are generated by using the Vandermonde Matrix(VM).In this work,we proposed a VM-PTS algorithm for the NOMA system,and the number of computations to search the optimal phase vectors for NOMA high PAPR signal is less as compared with existing *** outcomes demonstrate that the performance of the recommended PTS in terms of PAPR,Bit Error Rate(BER),and complexity is better than the conventional PTS(C-PTS).

关键词： VM-PTS NOMA PAPR 5G

Hybrid generative regressionbased deep intelligence to predict the risk of chronic disease

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International Journal of Intelligent Computing and Cybernetics 2022年第1期15卷 144-164页

作者： sandeep kumar Hegde Monica R.Mundada Department of Computer Science and Engineering M.S.Ramaiah Institute of TechnologyBangaloreIndia Department of Computer Science and Engineering NMAM Institute of TechnologyNitteIndia Visvesvaraya Technological University BelagaviIndia

Purpose-Chronic diseases are considered as one of the serious concerns and threats to public health across the *** such as chronic diabetes mellitus(CDM),cardio vasculardisease(CVD)and chronic kidney disease(CKD)are major chronic diseases responsible for millions of *** of these diseases is considered as a risk factor for the other two ***,noteworthy attention is being paid to reduce the risk of these *** amount of medical data is generated in digital form from smart healthcare appliances in the current *** numerous machine learning(ML)algorithms are proposed for the early prediction of chronic diseases,these algorithmic models are neither generalized nor adaptive when the model is imposed on new disease ***,these algorithms have to process a huge amount of disease data iteratively until the model *** limitation may make it difficult forMLmodels to fit and produce imprecise results.A single algorithm may not yield accurate ***,an ensemble of classifiers built from multiple models,that works based on a voting principle has been successfully applied to solve many classification *** purpose of this paper is to make early prediction of chronic diseases using hybrid generative regression based deep intelligence network(HGRDIN)***/methodology/approach-In the proposed paper generative regression(GR)model is used in combination with deep neural network(DNN)for the early prediction of chronic *** GR model will obtain prior knowledge about the labelled data by analyzing the correlation between features and class ***,the weight assignment process of DNN is influenced by the relationship between attributes rather than random *** knowledge obtained through these processes is passed as input to the DNN network for further *** the inference about the input data instances is drawn at the DNN through the GR model,the model is named as

关键词： Deep neural network Generative regression Chronic disease Regularization Maximum likelihood estimation