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工程热物理学报 2017年第6期38卷 1323-1326页

作者：邱琳 SCHEIDER Kimberly RADWAN Abu Suhaib LARKIN Sarah LeighAnn saltonstall blair christopher 冯妍卉张欣欣 NORRIS M Pamela 北京科技大学能源与环境工程学院北京100083 北京科技大学冶金工业节能减排北京市重点实验室北京100083 弗吉尼亚大学机械与航空航天工程系夏洛茨维尔va229044746

由于杰出的导热和柔韧性能,碳纳米管被认为是提升大功率微电子系统热耗散性能的理想热界面材料。多壁碳纳米管阵列能实现低成本的大规模生产,成为制备热界面材料的最佳选择。但是多壁碳纳米管阵列的生长过程的最优因素尚未廓清。本文从... 详细信息

由于杰出的导热和柔韧性能,碳纳米管被认为是提升大功率微电子系统热耗散性能的理想热界面材料。多壁碳纳米管阵列能实现低成本的大规模生产,成为制备热界面材料的最佳选择。但是多壁碳纳米管阵列的生长过程的最优因素尚未廓清。本文从实验上系统研究了催化剂的升华温度对浮动催化化学气相沉积法制备出的多壁碳纳米管阵列结构及热输运的影响规律,得到了最佳的催化剂升华温度,为实现最优导热性能的多壁碳纳米管阵列热界面材料提供实验指导。

关键词：热界面材料多壁碳纳米管阵列浮动催化化学气相沉积拉曼光谱

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Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells

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Cancer Biology & Medicine 2021年第1期18卷 206-214页

作者： Arsen Osipov Alex B.blair Juliane Liberto Jianxin Wang Keyu Li Brian Herbst Yao Xu Shiqi Li Nan Niu Rufiaat Rashid Ding Ding Yanan Liu Zaiqi Wang christopher L.Wolfgang Richard A.Burkhart Daniel Laheru Lei Zheng The Sydney Kimmel Comprehensive Cancer Center Johns Hopkins University School of MedicineBaltimore 21287MDUSA The Pancreatic Cancer Precision Medicine Center of Excellence Program Johns Hopkins University School of MedicineBaltimore 21287MDUSA Department of Oncology Johns Hopkins University School of MedicineBaltimore 21287MDUSA Department of Surgery Johns Hopkins University School of MedicineBaltimore 21287MDUSA Inx Med Shanghai Shanghai 201202China

Objective:Pancreatic ductal adenocarcinoma(PDAC)is a deadly malignancy,due in large part to its resistance to conventional therapies,including radiotherapy(RT).Despite RT exerting a modest antitumor response,it has also been shown to promote an immunosuppressive tumor *** studies demonstrated that focal adhesion kinase inhibitors(FAKi)in clinical development inhibit the infiltration of suppressive myeloid cells and T regulatory(T regs)cells,and subsequently enhance effector T cell *** inhibitors in clinical development have not been investigated in combination with RT in preclinical murine models or clinical ***,we investigated the impact of FAK inhibition on RT,its potential as an RT sensitizer and immunomodulator in a murine model of ***:We used a syngeneic orthotopic murine model to study the effect of FAKi on hypofractionated ***:In this study we showed that IN10018,a small molecular FAKi,enhanced antitumor response to *** activity of the combination of FAKi and RT is T cell *** in combination with RT enhanced CD8+T cell infiltration significantly in comparison to the radiation or FAKi treatment alone(P<0.05).FAKi in combination with radiation inhibited the infiltration of granulocytes but enhanced the infiltration of macrophages and T regs in comparison with the radiation or FAKi treatment alone(P<0.01).Conclusions:These results support the clinical development of FAKi as a radiosensitizer for PDAC and combining FAKi with RT to prime the tumor microenvironment of PDAC for immunotherapy.

关键词： Focal adhesion protein-tyrosine kinases radiotherapy pancreatic neoplasms immunomodulation

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Release of unwanted flat-bodied fish from a horizontal-bar grid system as revealed through comparative fishing trials and underwater video observations

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Aquaculture and Fisheries 2021年第4期6卷 348-358页

作者： christopher B.Rillahan Pingguo He School for Marine Science and Technology University of Massachusetts Dartmouth836 South Rodney French BoulevardNew BedfordMA02744USA

Grid systems separate fish species primarily through physical means:fish size and body *** Georges Bank off the northeast USA,many species of flounders are overfished,and their catch needs to be ***-bodied skates are also often *** tested a European style horizontal-bar grid system to reduce these flat-bodied low quota species in a trawl targeting the haddock(Melanogrammus aeglefinus),whose population is *** grid system consisted of 4 grid sections,two on each side,with horizontal bars 70 mm *** alternating tow method was used to compare the catch characteristics between a trawl with a grid section and the same trawl without a grid section.A video camera was used to observe fish escape in the grid *** results indicate that the grid system reduced the flounder catch rate(mainly winter flounder,Pseudopleuronectes americanus)by 51.3%,and skates(mainly winter skate,Leucoraja ocellata and little skate,Leucoraja erinacea)by 29.4%,while there were no differences in the catch of Atlantic cod(Gadus morhua).While haddock was reduced by 37%by weight,the reduction was primarily small undersized *** was no reduction in large haddock greater than 50 *** observations indicates that flounders and cod mainly escaped from the bottom half of the grid while haddock were from the top *** finding suggest that this system reduced low quota flounders,as well as discarded skates and small haddock,while retaining Atlantic cod and large size *** observations indicate that differential spacing(narrower on the top and wider on the bottom)may improve the system performance by releasing more flat-bodied fish,that were observed to escape from the bottom part of the grid,while retaining more haddock,which typically escape from the top part of the grid.

关键词： Trawl Bycatch Selectivity Flounder Skate Haddock Atlantic cod

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Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates

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Cellular & Molecular Immunology 2022年第2期19卷 222-233页

作者： Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue christopher Monjure Robert V.blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward Medicago Inc. QuébecQCCanada. Institute for Immunity Transplantation and InfectionStanford University School of MedicineStanford UniversityStanfordCAUSA. Tulane National Primate Research Center CovingtonLAUSA. New Iberia Research Center University of Louisiana at LafayetteNew IberiaLAUSA. Department of Pathology Stanford University School of MedicineStanford UniversityStanfordCAUSA. Department of Microbiology and Immunology Tulane University School of MedicineNew OrleansLAUSA. Department of Microbiology and Immunology Stanford University School of MedicineStanford UniversityStanfordCAUSA. Institute for Immunity Transplantation&InfectionStanford University School of MedicineStanford UniversityStanfordCAUSA Research Institute of the McGill University Health Centre MontrealQCCanada.

Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)***-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against ***,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)*** a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted *** micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T *** were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of *** viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with *** clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated *** CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials.

关键词： SARS-CoV-2 Virus-like particles Non-humane primates AS03 CpG1018

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人OPG与肿瘤坏死因子族蛋白的结合研究

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军医进修学院学报 2004年第4期25卷 311-313页

作者：步荣发 christopher W Borysenko 李亚男 Sara E Kalla Harry C blair 解放军总医院口腔科 Departments of Pathology and Cell Biology & Physiology University of PittsburghSchool of Medicine and Veteran's Affairs Medical Center Pittsburgh PA 15243USA

目的 :检测OPG与TNF家族蛋白的结合及探索它们相互作用机制。方法 :免疫沉淀分析加Western印迹 ,酶联免疫吸附测定方法 ,偶联剂交叉链接 ,表面胞质团共振。结果 :OPG与RANKL ,TRAIL和TNFα用不同方法检测均有结合。OPG与TNFα的结合由Bi... 详细信息

目的 :检测OPG与TNF家族蛋白的结合及探索它们相互作用机制。方法 :免疫沉淀分析加Western印迹 ,酶联免疫吸附测定方法 ,偶联剂交叉链接 ,表面胞质团共振。结果 :OPG与RANKL ,TRAIL和TNFα用不同方法检测均有结合。OPG与TNFα的结合由Biacore进一步证实 ,在 pH为 7.4 ,温度在 2 0℃时 ,其离解系数为7.0nmol/L ,同OPG TRAIL亲和力。偶联剂交叉链接显示OPG TNFα结合的比例为 1∶1。结论 :TNFα能与OPG结合 ,物理条件影响其结合。

关键词： OPG 肿瘤坏死因子族蛋白相互作用免疫电泳技术检测

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Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas

Integrative and Comparative Genomic Analysis of HPV-Positive...

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中国生物工程学会第六次全国会员代表大会暨第九届学术年会

作者： Tanguy Y.Seiwert Zhixiang Zuo Michaela K.Keck Arun Khattri Chandra S.Pedamallu Thomas Stricker christopher Brown Trevor J.Pugh Petar Stojanov Juok Cho Michael S.Lawrence Gad Getz Johannes Br?gelmann Rebecca DeBoer Ralph R.Weichselbaum Alexander Langerman Louis Portugal Elizabeth blair Kerstin Stenson Mark W.Lingen Ezra E.W.Cohen Everett E.Vokes Kevin P.White Peter S.Hammerman Section of Hematology/Oncology Department of MedicineThe University of Chicago The University of Chicago Comprehensive Cancer Center Institute for Genomics and Systems Biology University of Chicago Broad Institute of Harvard and MIT Department of Medical Oncology Dana Farber Cancer Institute Department of Pathology Microbiologyand ImmunologyVanderbilt University Department of Genetics University of Pennsylvania Department of Radiation Oncology The University of Chicago Department of Otolaryngology/Head and Neck Surgery The University of Chicago Department of Pathology University of Chicago

Purpose:The genetic differences between human papilloma virus(HPV)–positive and –negative head and neck squamous cell carcinomas(HNSCC) remain largely *** identify differential biology and novel therapeutic targets for both entities,we determined mutations and copy-number aberrations in a large cohort of locoregionally advanced *** Design:We performed massively parallel sequencing of 617 cancer-associated genes in 120 matched tumor/normal samples(42.5% HPV-positive).Mutations and copy-number aberrations were determined and results validated with a secondary ***:The overall mutational burden in HPV-negative and HPV-positive HNSCC was similar with an average of 15.2 versus14.4 somatic exonic mutations in the targeted cancer-associated ***-negative tumors showed a mutational spectrum concordant with published lung squamous cell carcinoma analyses with enrichment for mutations in TP53,CDKN2 A,MLL2,CUL3,NSD1,PIK3 CA,and NOTCH ***-positive tumors showed unique mutations in DDX3 X,FGFR2/3 and aberrations in PIK3 CA,KRAS,MLL2/3,and NOTCH1 were enriched in HPVpositive *** targetable genomic alterations were identified in FGFR1,DDR2,EGFR,FGFR2/3,EPHA2,and PIK3 ***,CCND1,and FGFR1 amplifications occurred in HPV-negative tumors,whereas 17.6% of HPV-positive tumors harbored mutations in fibroblast growth factor receptor genes(FGFR2/3),including six recurrent FGFR3 S249 C ***-positive tumors showed a 5.8% incidence of KRAS mutations,and DNArepair gene aberrations,including 7.8% BRCA1/2 mutations,were ***:The mutational makeup of HPV-positive and HPV-negative HNSCC differs significantly,including targetable *** harbors multiple therapeutically important genetic aberrations,including frequent aberrations in the FGFR and PI3K pathway genes.

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