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Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity

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Signal Transduction and Targeted Therapy 2021年第2期6卷 542-554页

作者： Mingliang Chen Xunhu Dong Haoyue Deng Feng Ye Yuanpeng Zhao Jin Cheng Guorong Dan Jiqing Zhao yan sai Xiuwu Bian Zhongmin Zou Department of Chemical Defense Medicine School of Military Preventive MedicineThird Military Medical University(Army Medical University)30 Gaotanyan StreetShapingba DistricChongqing 400038China Institute of Pathology and Southwest Cancer Centre Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Toxicology School of Miliary Preventive MedicineThird Miltay Medical University(Army Medical University)30 Gaotanyan StreetShapingba DistritChongqing 400038China State Key Laboratory of Trauma Burns and Combined InjurySecond Department of Research Institute of SurgeryDaping HospitalThird Military Medical University(Army Medical UniversityChongqing 400042China

Nitrogen mustard(NM)causes severe vesicating skin injury,which lacks effective targeted *** major limitation is that the specific mechanism of NM-induced skin injury is not well ***,autophagy has been found to play important roles in physical and chemical exposure-caused cutaneous ***,whether autophagy contributes to NM-induced dermal toxicity is ***,we initially confrmed that NM dose-dependently caused cell death and induced autophagy in *** of autophagy by 3-methyladenine,chloroquine,and baflomycin A1 or ATG5 siRNA attenuated NM-induced keratinocyte cell ***,NM increased transient receptor potential vanilloid 1(TRPV1)expression,intracellular Ca2+content,and the activities of Car+/calmodulin-dependent kinase kinaseβ(CaMKKB),AMP-activated protein kinase(AMPK),unc-51-like kinase 1(ULK1),and mammalian target of rapamycin(mTOR).NM-induced autophagy in keratinocytes was abolished by treatment with inhibitors of TRPV1(capsazepine),CaMKKβ(STO-609),AMPK(compound C),and ULK1(SBI-0206965)as well as TRPV1,CaMKKB,and AMPK siRNA *** addition,an mTOR inhibitor(rapamycin)had no signifcant effect on NM-stimulated autophagy or cell death of ***,the results of the in vivo experiment in NM-treated skin tissues were consistent with the findings of the in vitro *** conclusion,NM-caused dermal toxicity by overactivating autophagy partially through the activation of TRPV1-Ca2+-CaMKKB-AMPK-ULK1 signaling *** results suggest that blocking TRPV1-dependent autophagy could be a potential treatment strategy for NM-caused cutaneous injury.

关键词： TRPV1 injuries autophagy

Transport of a topologically protected photonic waveguide on-chip

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Photonics Research 2023年第6期11卷 1021-1028页

作者： sai yan JINGNAN yanG SHUSHU SHI ZHANCHUN ZUO CAN WANG XIULAI XU Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation and School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Songshan Lake Materials Laboratory Dongguan 523808China

We propose a design on integrated optical devices on-chip with an extra width degree of freedom by using a photonic crystal waveguide with Dirac points between two photonic crystals with opposite valley Chern *** such an extra waveguide,we demonstrate numerically that the topologically protected photonic waveguide retains properties of valley-locking and immunity to *** to the design flexibility of the width-tunable topologically protected photonic waveguide,many unique on-chip integrated devices have been proposed,such as energy concentrators with a concentration efficiency improvement of more than one order of magnitude,and a topological photonic power splitter with an arbitrary power splitting *** topologically protected photonic waveguide with the width degree of freedom could be beneficial for scaling up photonic devices,and provides a flexible platform to implement integrated photonic networks on-chip.

关键词： waveguide protected valley

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整欠:16-19世纪中缅暹间的曼陀罗政权

中国历史地理论丛 2022年第4期37卷 108-118页

作者：严赛中央民族大学历史文化学院北京100081

整欠是古代东南亚历史上相对自治的曼陀罗政权。其地域范围东面为猛搻,西面接猛笼,北面接橄榄坝,南面为景拉,即中、缅、暹3国交界之处。16-19世纪整欠根据自身实力变化臣属缅、中、暹三个不同的核心政权。整欠的历史发展过程体现了东南... 详细信息

整欠是古代东南亚历史上相对自治的曼陀罗政权。其地域范围东面为猛搻,西面接猛笼,北面接橄榄坝,南面为景拉,即中、缅、暹3国交界之处。16-19世纪整欠根据自身实力变化臣属缅、中、暹三个不同的核心政权。整欠的历史发展过程体现了东南亚曼陀罗体系中外层朝贡政权的普遍特点,即拥有自治权和军事权、领主多重性、政权属性多重性,它们将曼陀罗体系与朝贡体系有效结合,成为曼陀罗核心政权之间外层的平衡地带。这一地带的平衡性最终因西方殖民势力的入侵而打破。西方国家殖民体系在东南亚的建立,意味着曼陀罗政权及其体系的瓦解。

关键词：整欠中国缅甸暹罗曼陀罗政权

“戛于腊”与傣族土司的跨境纷争及清廷的处置方略

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中央民族大学学报（哲学社会科学版） 2019年第2期46卷 92-103页

作者：严赛中央民族大学历史文化学院北京100081

"戛于腊"是清代汉文献中对分布于今泰国、缅甸、中国毗邻地区的傣(泰)族群支系傣允的称呼。清嘉庆至道光年间,戛于腊与缅甸发生持续的军事冲突和纠纷,波及中国滇西南的土司地区。清廷采取了一系列外交和军事措施,最终化解了边境危机。

关键词：清廷戛于腊土司跨境民族

Suppression of host plant defense by bacterial small RNAs packaged in outer membrane vesicles

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Plant Communications 2024年第4期5卷 252-254页

作者： yan Wu sai Wang Peihong Wang Wenhan Nie Iftikhar Ahmad Panagiotis F.Sarris Gongyou Chen Bo Zhu Shanghai yangtze River Delta Eco-Environmental Change and Management Observation and Research Station Shanghai Cooperative Innovation Center for Modern Seed Industry School of Agriculture and Biology Shanghai Jiao Tong University Shanghai China Department of Environmental Sciences COMSATS University Islamabad Vehari-Campus Vehari 61100 Pakistan Department of Biology University of Crete 714 09 Heraklion Crete Greece Shanghai Jiao Tong University Chongqing Research Institute Shanghai China

(Plant Communications 5,100817;April 82024)After a careful,in-depth examination,the authors found some additional errors in the published *** revision,the authors created a mutant DXosr001(in which the full-length Xosr001 was deleted)and a mutant DXosr001’(in which the predicted binding motif of Xosr001 was deleted)as shown in Figure S4 of the original *** RNA-FISH assays,Xosr001 transcript could not be detected in leaves inoculated with DXosr001-OMVs,while leaves inoculated with WT-and DXosr001’-OMVs could emit green fluorescence.

关键词： deleted Figure outer

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基于模糊数学的农化生产企业财务风险评价

安徽农业科学 2009年第20期37卷 9666-9667页

作者：颜赛燕湖南人文科技学院审计处湖南娄底417000

介绍了模糊数学综合评价法的思路与步骤,并以湖北宜化化工股份有限公司为例,运用模糊数学综合评价法对其财务风险进行了评价与分析。

关键词：模糊数学农化企业财务风险

基于冻融循环本构的预应力对拉式挡墙的冻胀效应研究

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中南大学学报（自然科学版） 2024年第1期55卷 242-254页

作者：庄妍王赛东南大学土木工程学院江苏南京210000

预应力对拉式挡墙的冻胀受力状态复杂,墙背的冻胀力分布尚不明确,进一步探究预应力对拉式挡墙的冻胀力分布具有重要意义。根据哈尔滨某地区的实际监测温度,采用ABAQUS数值模拟软件模拟温度场在模型空间的合理分布。基于冻融循环后混凝... 详细信息

预应力对拉式挡墙的冻胀受力状态复杂,墙背的冻胀力分布尚不明确,进一步探究预应力对拉式挡墙的冻胀力分布具有重要意义。根据哈尔滨某地区的实际监测温度,采用ABAQUS数值模拟软件模拟温度场在模型空间的合理分布。基于冻融循环后混凝土塑性损伤本构,在所建立的温度场上进行热力耦合分析,研究预应力筋、冻胀时间对预应力对拉式挡墙冻胀效应的影响。研究结果表明:挡土墙所受冻胀力呈现“上小下大”的上三角分布趋势,且随着冻胀时间增加,冻胀力会呈现先逐渐增大然后逐渐减小的趋势,并在冻胀后120 d冻胀力达到最大。相比之下,由于预应力钢筋的存在,预应力对拉式挡土墙会使冻胀力在该处产生应力集中而增大,最大可使冻胀力增加200 kPa左右。在预应力钢筋的作用下,挡土墙的水平位移会减小40%~116%。本文研究结果可以为季节性冻土区的预应力对拉式挡土墙施工和设计提供技术支撑。

关键词：数值模拟预应力对拉式挡土墙冻胀效应季节性冻土

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MicroRNAs:A novel signature in the metastasis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第11期30卷 1497-1523页

作者： Qi-Ying Wei Feng Jin Zhong-Yu Wang Bing-Jie Li Wen-Bo Cao Zhi-yan Sun sai-Jun Mo Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Perioperative Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Division of Special Service Department of Basic OncologySchool of Basic MedicineZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths *** increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality ***,there is currently no specific and effective marker to predict and treat metastasis in ***(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in *** are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of ***,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic *** review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.

关键词： MicroRNAs Esophageal squamous cell carcinoma Metastasis Signaling pathway Epigenetics mechanism

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拓扑激光器研究进展(特邀)

红外与激光工程 2021年第11期50卷 6-16页

作者：闫赛谢昕许秀来中国科学院物理研究所北京100190

随着拓扑光子学的发展,对缺陷、微扰等具有鲁棒性的拓扑边缘态、拓扑角态的发现革新了半导体激光器,并且推动了拓扑激光器的发展。首先,回顾了近几年拓扑激光器的发展历程,以及不同拓扑激光器的原理;其次,分析了各类拓扑激光器的最新实... 详细信息

随着拓扑光子学的发展,对缺陷、微扰等具有鲁棒性的拓扑边缘态、拓扑角态的发现革新了半导体激光器,并且推动了拓扑激光器的发展。首先,回顾了近几年拓扑激光器的发展历程,以及不同拓扑激光器的原理;其次,分析了各类拓扑激光器的最新实现,并且解释了拓扑边缘态、拓扑角态的基础物理。在这些实验中,拓扑激光器的模式是由介质结构决定,并通过光学增益来激发激光。分析表明拓扑角态相比于拓扑边缘态具有强局域性、小模式体积,因此基于拓扑角态的拓扑激光器更高效,阈值更低,这为未来的光子集成芯片提供了可能;最后,展望了拓扑激光器面临挑战和潜在的应用方向,有助于探索更实用的拓扑激光器。

关键词：拓扑光子学拓扑边缘态拓扑角态拓扑激光器