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Friction 2024年第5期12卷 884-896页

作者： xingwei WANG Chaoyang ZHANG Chen ZHAO Yijing LIANG Ming ZHANG Wufang yang Bo YU Qiangliang YU Meirong CAI Feng zhou Weimin LIU state Key Laboratory of solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai264000China

Developing functional additive resistant to space atomic oxygen(AO)irradiation through simple molecular design and chemical synthesis to enhance the lubricating performance of multialkylated cyclopentanes(MACs)oil is a significant ***,sulfur-containing polyhedral oligomere silsesquioxane(POss)were synthesize via a click-chemistry reaction of octavinyl polyhedral oligomeric with alkyl *** reduce-friction(RF),anti-wear(AW)properties and anti-AO irradiation of POss-s-R as MACs base oil additives in atmospheric and simulated space environments were systematically investigated for the first *** demonstrate that POss-s-R not only possesses outstanding anti-AO irradiation capacity but also effectively improves the RF and AW of MACs in atmospheric or simulated space *** improvement is due to the excellent anti-AO irradiation properties of the POss structure itself and the high load-carrying ability of silicon-containing and sulfur-containing compounds generated by tribo-chemical reactions,which effectively separates the direct contact of the friction *** believe that this synthesized POss-s-R is a promising additive for space lubricants.

关键词： POss additive reduce-friction anti-wear multialkylated cyclopentanes(MACs) resistant atomic irradiation

The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

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Asian Journal of Andrology 2024年第1期26卷 107-111页

作者： Liu Liu Jing yang Wen-Jing Zhang Yi-Ling zhou Gui-Jun Zhao Ya Huang shu-Yan Tang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China state Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development Department of Computational BiologySchool of Life SciencesFudan UniversityShanghai 200436China shanghai Towako Hospital Shanghai 200131China shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to *** several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,the genetic cause of vacuolated spermatozoa remains inadequately ***,we analyzed whole-exome sequencing(WEs)data for an individual from a consanguineous family with severely vacuolated *** analysis revealed a novel homozygous c.520A>G(***174Ala)variant in the archaelysin family metallopeptidase 2(AMZ2),a gene that encodes a zinc metalloprotease previously shown to be highly expressed in the testes and *** algorithms predicted this variant to be a damaging *** with an autosomal recessive mode of inheritance,this variant was inherited from heterozygous parental *** investigate the potential pathogenicity of the identified variant,we compared the AMZ2 expression in sperm cells from the patient with the AMZ2 variant and from a healthy *** analysis revealed that the homozygous missense variant in AMZ2 abolished AMZ2 expression in the *** findings reveal a candidate causative gene for vacuolated spermatozoa.

关键词： AMZ2 male infertility sperm quality teratozoospermia

Management of locally advanced non-small cell lung cancer: state of the art and future directions

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Cancer Communications 2024年第1期44卷 23-46页

作者： Da Miao Jing Zhao Ying Han Jiaqi zhou xiuzhen Li Ting Zhang Wen Li yang xia Key Laboratory of Respiratory Disease of Zhejiang Province Department of Respiratory and Critical Care MedicineSecond Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangP.R.China Department of Oncology Shaoxing Second HospitalShaoxingZhejiangP.R.China Department of Medical Oncology Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangP.R.China Department of Chemoradiotherapy The Affiliated People’s Hospital of Ningbo UniversityNingboZhejiangP.R.China Key Discipline of Jiaxing Respiratory Medicine Construction Project Jiaxing Key Laboratory of Precision Treatment for Lung CancerAffiliated Hospital of Jiaxing UniversityJiaxingZhejiangP.R.China Department of Pathology Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangP.R.China Department of Radiation Oncology Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangP.R.China Cancer Center Zhejiang UniversityHangzhouZhejiangP.R.China

Lung cancer is the second most common and the deadliest type of cancer ***,non-small cell lung cancer(NsCLC)is the most com-mon pathological type of lung cancer;approximately one-third of affected patients have locally advanced NsCLC(LA-NsCLC,stage III NsCLC)at *** of its heterogeneity,LA-NsCLC often requires multidisciplinary ***,the prognosis of affected patients is much below satisfac-tion,and the efficacy of traditional therapeutic strategies has reached a *** the emergence of targeted therapies and immunotherapies,as well as the continuous development of novel radiotherapies,we have entered an era of novel treatment paradigm for ***,we reviewed the landscape of relevant therapeutic modalities,including adjuvant,neoadjuvant,and periop-erative targeted and immune strategies in patients with resectable LA-NsCLC with/without oncogenic alterations;as well as novel combinations of chemora-diation and immunotherapy/targeted therapy in unresectable *** addressed the unresolved challenges that remain in the field,and examined future directions to optimize clinical management and increase the cure rate of LA-NsCLC.

关键词： locally advanced non-small cell lung cancer neoadjuvant therapy adjuvant therapy immunotherapy targeted therapy

Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： Jiali yang Yu Liu En-yang Wang Jinbo Pang shirong Huang Thomas Gemming Jinshun Bi Alicja Bachmatiuk Hao Jia shu-xian Hu Chongyun Jiang Hong Liu Gianaurelio Cuniberti Weijia zhou Mark H Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany state Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China school of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin Binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland school of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for Energy and Environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic state Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel materials for complementing the si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,Pts_(2),Ptse_(2),Pds_(2),and Pdse_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** them,Pdse_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of Pdse_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of Pdse_(2) is yet to be *** this study,the doping level of Pdse_(2) was correlated with the concentration of Lewis acids,for example,snCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after snCl_(4) soaking ***_(2) transistors were soaked in snCl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of Pdse_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials.

关键词： two-dimensional(2D)materials Lewis acid treatment p-type doping field-effect transistors transfer characteristic

High power cladding-pumped low quantum defect Raman fiber amplifier

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Photonics Research 2024年第5期12卷 995-1003页

作者： yang ZHANG JIANGMING xu JUNRUI LIANG sICHENG LI JUN YE xIAOYA MA TIANFU YAO ZHIYONG PAN JINYONG LENG PU zhou College of Advanced Interdisciplinary studies National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Hunan Provincial Key Laboratory of High Energy Laser Technology National University of Defense TechnologyChangsha 410073China

Heat generated by the quantum defect(QD)in optically pumped lasers can result in detrimental effects such as mode instability,frequency noise,and even catastrophic ***,we demonstrated that boson-peakbased Raman fiber lasers have great potential in low QD laser *** their power scalability and heat load characteristics have yet to be ***,we demonstrate a boson-peak-based Raman fiber amplifier(RFA)with 815 W output power and a QD of 1.3%.The low heat generation characteristics of this low QD RFA are *** experimental and simulation results show that at this power level,the heat load of the low QD RFA is significantly lower than that of the conventional RFA with a QD of 4.8%.Thanks to its low heat generation characteristics,the proposed phosphosilicate-fiber-based low QD RFA provides an effective solution for the intractable thermal issue in optically pumped lasers,which is of significance in reducing the laser’s noise,improving the laser’s stability and safety,and solving the challenge of heat removing.

关键词： pumped fiber amplifier

Design of integral sliding mode guidance law based on disturbance observer

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Journal of systems Engineering and Electronics 2024年第1期35卷 186-194页

作者： zhou Jianping ZHANG Wenjie zhou Hang LI Qiang xIA Qunli school of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China school of Informatic Engineering Mianyang Techers’CollegeMianyang 62100China Beijing Institute of Electronic system Engineering Beijing 100854China Beijing Institute of space Long March Vehicle Beijing 100076China

With the increasing precision of guidance,the impact of autopilot dynamic characteristics and target maneuvering abilities on precision guidance is becoming more and more *** order to reduce or even eliminate the autopilot dynamic operation and the target maneuvering influence,this paper suggests a guidance system model involving a novel integral sliding mode guidance law(IsMGL).The method utilizes the dynamic characteristics and the impact angle,combined with a sliding mode surface scheme that includes the desired line-ofsight angle,line-of-sight angular rate,and second-order differential of the angular *** the same time,the evaluation scenario considere the target maneuvering in the system as the external disturbance,and the non-homogeneous disturbance observer estimate the target maneuvering as a compensation of the guidance *** proposed system’s stability is proven based on the Lyapunov stability *** simulations reveale that IsMGL effectively intercepted large maneuvering targets and present a smaller miss-distance compared with traditional linear sliding mode guidance laws and trajectory shaping guidance ***,IsMGL has a more accurate impact angle and fast convergence speed.

关键词： disturbance observer pilot dynamics integral sliding mode impact angle constraint maneuvering target

A study on Near-Infrared Non-Invasive Blood Glucose Concentration Regression Prediction Based on PsO-MKL-sVR

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Journal of Applied Mathematics and Physics 2024年第1期12卷 1-11页

作者： xinjia yang Linhua zhou school of Mathematics and statistics Changchun University of Science and Technology Changchun China

To improve the accuracy of predicting non-invasive blood glucose concentration in the near-infrared spectrum, we utilized the Particle swarm Optimization (PsO) algorithm to optimize hyperparameters for the Multi-Kernel Learning support Vector Machine (MKL-sVR). With these optimized hyperparameters, we established a non-invasive blood glucose regression model, referred to as the PsO-MKL-sVR model. subsequently, we conducted a comparative analysis between the PsO-MKL-sVR model and the PsO-sVR model. In a dataset comprising ten volunteers, the PsO-MKL-sVR model exhibited significant precision improvements, including a 16.03% reduction in Mean square Error and a 0.29% increase in the squared Correlation Coefficient. Moreover, there was a 0.14% higher probability of the Clark’s Error Grid Analysis falling within Zone A. Additionally, the PsO-MKL-sVR model demonstrated a faster operational speed compared to the PsO-sVR model.

关键词： sVM MKL PsO Non-Invasive Blood Glucose

Design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu yang-zhou su Hai-Bo yang Fen-Hua Lu Yan yang xi-Wen Liu Ping Wei shu-Cai Wan Hao-Qing xie xian-Qin Li Cong Dai Hui-Jun Hu Hong-Bang Liu shu-Wen Tang Cheng-xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China school of Nuclear science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the sAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMs noise level not exceeding 0.15 fC,and the integral nonlinearity wasst with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics sAMPA Data acquisition Performance test

Gut microbiome and serum metabolome analyses identify Bacteroides fragilis as regulators of serotonin content and PRL secretion in broody geese

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Journal of Integrative Agriculture 2024年第6期23卷 2033-2051页

作者： Yu Zhang Ning zhou Jia Wu Lina song Qiang Bao Kaiqi Weng yang Zhang Wanwipa Vongsangnak Guohong Chen Qi xu College of Animal science and Technology Yangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture&Agri-Product safety of Ministry of Education Yangzhou UniversityYangzhou 225009China Department of Zoology Faculty of ScienceKasetsart UniversityBangkok 10900Thailand

Broody behavior is regulated by hypothalamic prolactin secretion,which seriously affects egg production in poulty *** studies have provided evidence that animal behavior is governed by dynamic bidirectional communication between specific gut bacteria and their host via the brain-gut-microbiome ***,little research focused on how the gut microbiota influence broody behavior in *** this study,Zhedong white geese in laying and brooding phases were *** differentially abundant bacteria in cecum were detected between brooding and laying geese through metagenomic analyses and 16s rRNA sequencing(Ps fragilis was specifically identified as a key driver species in the brooding ***,the serum metabolites were quantified,and the 313 differentially abundant metabolites were found between the two groups of different physiological *** were primarily enriched in the tryptophan metabolism *** correlation analyses revealed there was a significant positive correlation between *** abundance and the context of 11 tryptophan metabolism-related metabolites(such as serotonin,etc.)in broody geese,which hinted that those tryptophan metabolites might be produced or driven by ***,the serum hormone levels were also *** found there was a positive correlation between *** abundance and content of ***,prolactin secreted by the pituitary gland was greater in brooding geese than that in laying geese,which was also highly correlated with *** *** result implied that *** could promote the secretion of prolactin by the pituitary ***,the current study findings provided the information on gut microbiota influencing broody behavior,*** produced or driven more serum serotonin,and stimulated the pituitary gland to secret more prolactin,which potentially offered a new enlightenment for the intervention of broody behavior in pou

关键词： geese broody behavior gut microbiota serotonin prolactin

Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp(Ctenopharyngodon idella):in vitro and in vivo studies

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Journal of Animal science and Biotechnology 2024年第4期15卷 1638-1656页

作者： Piao Zhao Lin Feng Weidan Jiang Pei Wu yang Liu Hongmei Ren xiaowan Jin Lu Zhang Haifeng Mi xiaoqiu zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Fish Nutrition and safety Production University Key Laboratory of sichuan Province Sichuan Agricultural UniversityChengdu 611130SichuanChina Key Laboratory of Animal Disease‑Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130SichuanChina Tongwei Co. Ltd.Healthy Aquaculture Key Laboratory of Sichuan ProvinceChengdu 610041SichuanChina

Background Ochratoxin A(OTA),a globally abundant and extremely hazardous pollutant,is a significant source of contamination in aquafeeds and is responsible for severe food *** developmental toxicity of OTA and the potential relieving strategy of natural products remain *** study screened the substance curcumin(Cur),which had the best effect in alleviating OTA inhibition of myoblast proliferation,from 96 natural products and investigated its effect and mechanism in reducing OTA myotoxicity in vivo and in *** A total of 720 healthy juvenile grass carp,with an initial average body weight of 11.06±0.05 g,were randomly assigned into 4 groups:the control group(without OTA and Cur),1.2 mg/kg OTA group,400 mg/kg Cur group,and 1.2 mg/kg OTA+400 mg/kg Cur *** treatment consisted of 3 replicates(180 fish)for 60 *** Firstly,we cultured,purified,and identified myoblasts using the tissue block culture *** preliminary screening and re-screening of 96 substances,we examined cell proliferation-related indicators such as cell viability and ultimately found that Cur had the best ***,Cur could alleviate OTA-inhibited myoblast differentiation and myofibrillar development-related proteins(Myo G and MYHC)in vivo and in vitro and improve the growth performance of grass ***,Cur could also promote the expression of OTA-inhibited protein synthesis-related proteins(s6K1 and TOR),which was related to the activation of the AKT/TOR signaling ***,Cur could downregulate the expression of OTA-enhanced protein degradation-related genes(murf1,foxo3a,and ub),which was related to the inhibition of the Fox O3a signaling *** In summary,our data demonstrated the effectiveness of Cur in alleviating OTA myotoxicity in vivo and in *** study confirms the rapidity,feasibility,and effectiveness of establishing a natural product screening method targeting myoblasts to alleviate fungal toxin toxicity.

关键词： Curcumin Grass carp Myotoxic Ochratoxin A Protein deposition