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Clinical implications of the molecular characterization of intraductal papillary mucinous neoplasms of the pancreas

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 430-447页

作者： Nicholas v.Peters John W.Kunstman Department of surgery Yale University School of MedicineNew Haven 06510CTUSA.

Intraductal papillary mucinous neoplasm(IPMN)is a pre-malignant,mucin-producing epithelial lesion arising from pancreatic *** reports define IPMN behavior as ranging from indolent,asymptomatic lesions to dysplasia that sometimes degenerate into pancreatic *** goal of IPMN management is risk-reducing surgery for high-risk cysts and observation of the *** high-from low-risk IPMN disease still relies on imaging and clinical cyst ***,we review the accepted classification of IPMN including the most common histological subtypes,their clinical features,and currently-accepted high-risk *** then deeply examine the known molecular landscape of IPMN,which has largely been derived from post-resection *** includes those gene variants unique to IPMN,chiefly GNAs and RNF43,but also examines the overlap between IPMN and conventional pancreatic *** molecular markers in the clinical setting relies on endoscopically-obtained cyst fluid and presumes that it accurately represents the molecular characteristics of the cystic *** synthesize existing data on mutational analysis from IPMN cyst fluid and consider the benefits and proper role of current commercially-available cyst fluid molecular analysis *** conclude that carefully interpreted molecular analysis of resected IPMN tissue reveals insights into its biology and natural history while cyst fluid analysis offers prognostication and data to guide treatment ***,knowledge gaps remain,especially in characterizing IPMN molecular heterogeneity,time to progression,and correlating cyst fluid genotype data with surveillance *** such,substantial additional research is required before the promise of true molecular guidance of IPMN management can be realized.

关键词： Intraductal papillary mucinous neoplasm pancreatic cancer molecular analysis GNAs KRAs RNF43

Power Prediction of vLsI Circuits Using Machine Learning

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Computers, Materials & Continua 2023年第1期74卷 2161-2177页

作者： E.Poovannan s.Karthik Department of ECE College of Engineering and TechnologySRM Institute of Science and TechnologyVadapalani CampusChennai600026TNIndia

The difference between circuit design stage and time requirements has broadened with the increasing complexity of the circuit.A big database is needed to undertake important analytical work like statistical method,heat research,and IR-drop research that results in extended running *** unit focuses on the assessment of test *** of the enormous number of successful designs for currentmodels and the unnecessary time required for every test,maximum energy ratings with all tests cannot be ***,test safety is important for producing trustworthy findings to avoid loss of output and harm to the ***,effective power assessment is only possible in a limited sample of pre-selected ***,a key objective is to find the experiments that might give the worst situations again for testing *** offers a machine-based circuit power estimation(MLCPE)system for the selection of *** distinct techniques of predicting are ***,to find testings with power dissipation,it forecasts the behavior of ***,the changemovement and energy data are linked to the semiconductor design,identifying small problem *** types of algorithms are *** particular,the methods *** findings show great accuracy and efficiency in *** enables such methods suitable for selecting the worst scenario.

关键词： Power estimation Machine learning circuit simulation vLsI implementation

Blasius flow and heat transfer of fourth-grade fluid with slip

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Applied Mathematics and Mechanics(English Edition) 2013年第12期34卷 1465-1480页

作者： B.sAHOO s.PONCET Department of Mathematics National Institute of Technology Laboratoire de Mecanique Modelisation and Procedes PropresAix-Marseille Universite

This investigation deals with the effects of slip, magnetic field, and non- Newtonian flow parameters on the flow and heat transfer of an incompressible, electrically conducting fourth-grade fluid past an infinite porous plate. The heat transfer analysis is carried out for two heating processes. The system of highly non-linear differential equations is solved by the shooting method with the fourth-order Runge-Kutta method for moderate values of the parameters. The effective Broyden technique is adopted in order to improve the initial guesses and to satisfy the boundary conditions at infinity. An exceptional cross-over is obtained in the velocity profile in the presence of slip. The fourth-grade fluid parameter is found to increase the momentum boundary layer thickness, whereas the slip parameter substantially decreases it. similarly, the non-Newtonian fluid parameters and the slip have opposite effects on the thermal boundary layer thickness.

关键词： Blasius flow partial slip fourth-grade fluid shooting method Broyden'smethod

An update on corneal and lens-based refractive surgery options

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Annals of Eye science 2019年第1期 68-69页

作者： Roy s.Chuck viral v.Juthani Joann J.Kang Department of Ophthalmology and visual sciences Montefiore Medical CenterAlbert Einstein College of MedicineBronxNYUSA

The demand for spectacle independence at all ages continues to grow,as our population ages and life expectancy continues to *** and older individuals alike expect greater freedom to pursue their active ***,as demands for higher levels of visual function increase,ophthalmologists have more technological options for refractive corrections than ever before,making it more important for surgeons to employ the most up to date methods and technology to fulfill patients’ever rising expectations of precise visual outcomes.

关键词： options continue independence

Wear characteristics of copper-based surface-level microcomposites and nanocomposites prepared by friction stir processing

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Friction 2016年第1期4卷 39-49页

作者： s.CARTIGUEYEN K.MAHADEvAN Department of Mechanical Engineering Pondicherry Engineering College Pondicherry 605014 India

In this study, microsized and nanosized silicon carbide particles (siCps) were successfully incorporated into commercial pure copper to form a surface metal matrix composite by friction stir processing (FsP) at low-heat-input conditions. A cluster of blind holes on a copper plate was used as particle deposition technique during the fabrication of the composite. Pin-on-disc testing was performed under dry sliding conditions to determine the wear characteristics of prepared composite surfaces. The homogeneity of particle distribution both inside the copper matrix and in the wear scar was determined via microstructural observations. It was observed that both microsized and nanosized siCps were well distributed and homogenous in a stir zone; particles observed were without defects, and good bonding was observed between siCps and the copper matrix. Comparisons between Cu/siCp composite layers and friction stir processed (FsPed) Cu and as-received Cu showed that Cu/siCp nanocomposite layers exhibited superior microhardness and dry sliding wear characteristics.

关键词： friction stir processing surface engineering surface metal matrix composites microstructure hardness wear characteristics

An Advanced Dynamic scheduling for Achieving Optimal Resource Allocation

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Computer systems science & Engineering 2023年第1期44卷 281-295页

作者： R.Prabhu s.Rajesh Department of Computer science and Engineering AAA College of Engineering and TechnologySivakasiTamilnaduIndia Department of Information Technology Mepco Schlenk Engineering College SivakasiTamilnadu India

Cloud computing distributes task-parallel among the various *** with self-service supported and on-demand service have rapid *** these applications,cloud computing allocates the resources dynami-cally via the internet according to user *** resource allocation is vital for fulfilling user *** contrast,improper resource allocations result to load imbalance,which leads to severe service *** cloud resources implement internet-connected devices using the protocols for storing,communi-cating,and *** extensive needs and lack of optimal resource allo-cating scheme make cloud computing more *** paper proposes an NMDs(Network Manager based Dynamic scheduling)for achieving a prominent resource allocation scheme for the *** proposed system mainly focuses on dimensionality problems,where the conventional methods fail to address *** proposed system introduced three–threshold mode of task based on its size sTT,MTT,LTT(small,medium,large task thresholding).Along with it,task mer-ging enables minimum energy consumption and response *** proposed NMDs is compared with the existing Energy-efficient Dynamic scheduling scheme(EDs)and Decentralized virtual Machine Migration(DvM).With a Network Manager-based Dynamic scheduling,the proposed model achieves excellence in resource allocation compared to the other existing *** obtained results shows the proposed system effectively allocate the resources and achieves about 94%of energy efficient than the other *** evaluation metrics taken for comparison are energy consumption,mean response time,percentage of resource utilization,and migration.

关键词： Cloud computing resource allocation load balance dynamic scheduling dimensionality reduction

Design, development and field assessment of a controlled seed metering unit to be used in grain drills for direct seeding of wheat

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Information Processing in Agriculture 2015年第3期2卷 169-176页

作者： s.Kamgar F.Noei-Khodabadi s.M.shafaei Department of Biosystems Engineering College of AgricultureShiraz UniversityShiraz 71441-65186Iran

A newcontrolled seed metering unit was designed and mounted on a common grain drill for direct seeding of wheat(DsW).It comprised the following main parts:(a)a variable-rate controlled direct current motor(DCM)as seed metering shaft driver,(b)two digital encoders for sensing the rotational speed of supplemental ground wheel(sGW)and seed metering shaft and(c)a control box to handle and process the data of the *** to the considered closed-loop control system,the designed control box regularly checked the revolution per minute(RPM)of seed metering shaft,as operation feedback,using its digital encoder *** seeding ratewas determined based on the calculated error signal and output signal of the digital encoder of the sGW.A field with four different levels of wheat stubble coverage(10%,30%,40%and 50%)was selected for evaluation of the fabricated seed metering unit(FsMU).The dynamic tests were conducted to compare the performance of installed FsMU on the grain drill and equipped grain drill with common seed metering unit(CsMU)at three forward speeds of 4,6 and 8(Km/h)for *** of the FsMU assessment demonstrated that an increase in forwardspeed of grain drill(FsGD)and stubble coverage did not significantly affect the seeding rate in the grain drill *** theFsMU reduced the coefficient of variation(Cv)by approximately 50%.Consequently,applying the FsMU on the common grain drill led to a desirable seeding rate at different forward speeds of the grain drill and stubble existence.

关键词： Control box seed metering mechanism Forward speed seed drilling Field operation

Novel eco-efficient reactive distillation process for dimethyl carbonate production by indirect alcoholysis of urea

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Frontiers of Chemical science and Engineering 2022年第2期16卷 316-331页

作者： Iulian Patrașcu Costin s.Bîldea Anton A.Kiss Department of Chemical and Biochemical Engineering University“Politehnica”of Bucharest011061 BucharestRomania Department of Chemical Engineering and Analytical science The University of ManchesterManchester M139PLUK

Dimethyl carbonate is an eco-friendly essential chemical that can be sustainably produced from CO_(2),which is available from carbon capture activities or can even be captured from the *** rapid increase in dimethyl carbonate demand is driven by the fast growth of polycarbonates,solvent,pharmaceutical,and lithium-ion battery *** carbonate can be produced from CO_(2)through various chemical pathways,but the most convenient route reported is the indirect alcoholysis of *** research used techniques such as heat integration and reactive distillation to reduce the energy use and costs,but the use of an excess of methanol in the trans-esterification step led to an energy intensive extractive distillation required to break the dimethyl carbonate-methanol *** work shows that the production of dimethyl carbonate by indirect alcoholysis of urea can be improved by using an excess of propylene carbonate(instead of an excess of methanol),a neat feat that we showed it requires only 2.64 kW·h·kg^(-1) dimethyl carbonate in a reaction-separation-recycle process,and a reactive distillation column that effectively replaces two conventional distillation columns and the reactor for dimethyl carbonate ***,less equipment is required,the methanol-dimethyl carbonate azeotrope does not need to be recycled,and the overall savings are ***,we propose the use of a reactive distillation column in a heat integrated process to obtain high purity dimethyl carbonate(>99.8 wt-%).The energy requirement is reduced by heat integration to just 1.25 kW·h·kg^(-1) dimethyl carbonate,which is about 52%lower than the reaction-separation-recycle *** benefit from the energy savings,the dynamics and control of the process are provided for10%changes in the nominal rate of 32 ktpy dimethyl carbonate,and for uncertainties in reaction kinetics.

关键词： dimethyl carbonate reactive distillation process design plantwide control

structure and Activity of strigolactones： New Plant Hormones with a Rich Future

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Molecular Plant 2013年第1期6卷 38-62页

作者： Binne Zwanenburg Tomás Pospísil Radboud University Nijmegen Institute for Molecules and Materials Cluster of Organic Chemistry Heyendaalseweg 135 6525AJ Nijmegen TheNetherlands Palacky University Faculty of Science Centre of the Region Haná for Biotechnological and Agricultural Research Department of Growth Regulators~lechtiteICJ 11 CZ-783 71 Olomouc Czech Republic

strigolactones （sLs） constitute a new class of plant hormones which are active as germination stimulants for seeds of parasitic weeds of striga, Orobanche, and Pelipanchi spp, in hyphal branching of arbuscular mycorrhizal （AM） fungi and as inhibitors of shoot branching. In this review, the focus is on molecular features of these sLs. The occurrence of sLs in root exudates of host plants is described. The naming protocol for sL according to the International Union of Pure and Applied Chemistry （IUPAC） rules and the ＇at a glance＇ method is explained. The total synthesis of some natural sLs is described with details for all eight stereoisomers of strigol. The problems encountered with assign- ing the correct structure of natural sLs are analyzed for orobanchol, alectrol, and solanacol. The structure-activity relationship of sLs as germination stimulants leads to the identification of the bioactiphore of sLs. Together with a tentative mechanism for the mode of action, a model has been derived that can be used to design and prepare active sL analogs. This working model has been used for the preparation of a series of new sL analogs such as Nijmegen-1, and analogs derived from simple ketones, keto enols, and saccharine. The serendipitous finding of sL mimics which are derived from the D-ring in sLs （appropriately substituted butenolides） is reported. For sL mimics, a mode of action is proposed as well. Recent new results support this proposal. The stability of sLs and sL analogs towards hydrolysis is described and some details of the mechanism of hydrolysis are discussed as well. The attempted isolation of the protein receptor for germination and the current status concerning the biosynthesis of natural sLs are briefly discussed. some non-sLs as germinating agents are mentioned. The structure-activity relationship for sLs in hyphal branching of AM fungi and in repression of shoot branching is also analyzed. For each of the principle functions, a working model for the desi

关键词： germination stimulant hyphal branching AM fungi inhibition shoot branching plant hormones strigolac-tones structure-activity relationship.