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Does progress in microfracture techniques necessarily translate into clinical effectiveness?

World Journal of Orthopedics 2024年第3期15卷 266-284页

作者： sathish Muthu Vibhu Krishnan Viswanathan Manoharan sakthivel Mohammed Thabrez Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Biotechnology Karpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Manoharan sakthivel Department of OrthopaedicsGovernment Medical CollegeKarur 639004Tamil NaduIndia Department of Orthopaedics Devadoss Multispecialty HospitalMadurai 625007Tamil NaduIndia Department of Medical Oncology Aster Medcity HospitalKochi 682034India

BACKGROUND Multitudinous advancements have been made to the traditional microfracture(MFx)technique,which have involved delivery of various acellular 2nd generation MFx and cellular MFx-III components to the area of cartilage defect.The relative benefits and pitfalls of these diverse modifications of MFx technique are still not widely understood.AIM To comparatively analyze the functional,radiological,and histological outcomes,and complications of various generations of MFx available for the treatment of cartilage defects.METHODs A systematic review was performed using PubMed,EMBAsE,Web of science,Cochrane,and scopus.Patients of any age and sex with cartilage defects undergoing any form of MFx were considered for analysis.We included only randomized controlled trials(RCTs)reporting functional,radiological,histological outcomes or complications of various generations of MFx for the management of cartilage defects.Network meta-analysis(NMA)was conducted in stata and Cochrane’s Confidence in NMA approach was utilized for appraisal of evidence.REsULTs Forty-four RCTs were included in the analysis with patients of mean age of 39.40(±9.46)years.Upon comparing the results of the other generations with MFX-I as a constant comparator,we noted a trend towards better pain control and functional outcome(KOOs,IKDC,and Cincinnati scores)at the end of 1-,2-,and 5-year time points with MFx-III,although the differences were not statistically significant(P>0.05).We also noted statistically significant Magnetic resonance observation of cartilage repair tissue score in the higher generations of microfracture(weighted mean difference:17.44,95%confidence interval:0.72,34.16,P=0.025;without significant heterogeneity)at 1 year.However,the difference was not maintained at 2 years.There was a trend towards better defect filling on MRI with the second and third generation MFx,although the difference was not statistically significant(P>0.05).CONCLUsION The higher generations of traditional MFx technique utilizing acellular and cellular comp

关键词： Cartilage injury Microfracture Mesenchymal stem cells Platelet-rich plasma Bone marrow aspiration concentrates Clinical outcome Radiological outcome Meta-analysis Network meta-analysis

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等离子喷涂制备Al_2O_3,ZrO_2,Al_2O_3/ZrO_2和ZrO_2/Al_2O_3涂层的腐蚀性能（英文）

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中国有色金属学报：英文版 2016年第5期26卷 1336-1344页

作者： s.sathish M.GEETHA Department of Mechanical Engineering Aalim Muhammed Salegh College of Engineering school of Mechanical and Building sciences VIT University

采用大气等离子喷涂技术在低碳钢表面制备Al_2O_3、ZrO_2、ZrO_2/Al_2O_3和Al_2O_3/ZrO_2涂层。利用扫描电镜(sEM)和X射线衍射(XRD)技术对涂层的显微组织和相组成进行分析,采用极化、盐雾和浸泡等实验手段对涂层在3.5%NaCl溶液中的腐蚀... 详细信息

采用大气等离子喷涂技术在低碳钢表面制备Al_2O_3、ZrO_2、ZrO_2/Al_2O_3和Al_2O_3/ZrO_2涂层。利用扫描电镜(sEM)和X射线衍射(XRD)技术对涂层的显微组织和相组成进行分析,采用极化、盐雾和浸泡等实验手段对涂层在3.5%NaCl溶液中的腐蚀行为进行研究。结果表明,双层Al_2O_3/ZrO_2涂层比另外三种涂层具有更好的抗腐蚀性能,这主要归因于该涂层中非常少的内联孔洞和稳定的相组成。

关键词：双层涂层 Al2O3 ZrO2 大气等离子喷涂腐蚀

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Heavy metal pollution of river water and eco-friendly remediation using potent microalgal species

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Water science and Engineering 2024年第1期17卷 41-50页

作者： Amudham Radha Amal Raj Prabhakaran Mylsamy V.sivasankar B.sathish Kumar Kiyoshi Omine T.G.sunitha Phycological Research Laboratory Research Department of BotanyPachaiyappa's College(Affliated to University of Madras)Chennai 600030India Research Department of Chemistry Pachaiyappa's College(Affliated to University of Madras)Chennai 600030India Department of Botany Sri Vidya Mandir Arts&Science College(Autonomous)KatteriUthangarai 636902India Department of Civil Engineering School of Engineering.Nagasaki UniversityNagasaki-Daigaku1-14 Bunkyo-machiNagasaki 8528521Japan

Pollution of rivers is mainly caused by anthropogenic activities such as discharge of effluent from industrial facilities,maintenance of sewage/effluent treatment plants,and dumping of solid waste on river banks.This study dealt with the pollution issues of the Cooum River in the well-known city of Chennai in south India.Water samples from 27 locations were collected and analyzed for 12 elements,including Ba,B,and Al,as well as heavy metals such as Pb,Cr,Mn,Fe,Co,Ni,Cu,Zn,and Cd.The samples showed levels of these elements that exceeded World Health Organization recommendations.Pearson correlation analysis revealed the inter-dependency among elements,and the contribution of each element based on factor loadings showed its percentage contribution compared to others.Water samples from six significant locations were chosen for remediation with three algae:Chlorella vulgaris,scenedesmus dimorphus,and Phormedium sp.The uptake of pollutants led to the continuous growth of algae during the incubation period of 15 d,effectively removing heavy metals from the river water.The increasing levels of algal counts and the chlorophyll a content confirmed the algal growth during the incubation period,followed by a declining stage after the incubation period.The scanning electron microscopic images of algae before and after the remediation showed no remarkable modification of morphological patterns.This study showed that the uptake of heavy metals using algae is an effective water pollution remediation measure,making the process practicable in the field on a large scale in the near future.

关键词： Heavy metal Cooum river Phycoremediation Microalgae Factor analysis

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Opportunistic Routing with Multi-Channel Cooperative Neighbour Discovery

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Intelligent Automation & soft Computing 2023年第2期35卷 2367-2382页

作者： s.sathish Kumar G.Ravi AVs College of Technology Salem636106India sona College of Technology Salem636005India

Due to the scattered nature of the network,data transmission in a dis-tributed Mobile Ad-hoc Network(MANET)consumes more energy resources(ER)than in a centralized network,resulting in a shorter network lifespan(NL).As a result,we build an Enhanced Opportunistic Routing(EORP)protocol architecture in order to address the issues raised before.This proposed routing protocol goal is to manage the routing cost by employing power,load,and delay to manage the routing energy consumption based on theﬂooding of control pack-ets from the target node.According to the goal of the proposed protocol techni-que,it is possible to manage the routing cost by applying power,load,and delay.The proposed technique also manage the routing energy consumption based on theﬂooding of control packets from the destination node in order to reduce the routing cost.Control packet exchange between the target and all the nodes,on the other hand,is capable of having an inﬂuence on the overall efﬁciency of the system.The EORP protocol and the Multi-channel Cooperative Neighbour Discovery(MCCND)protocol have been designed to detect the cooperative adja-cent nodes for each node in the routing route as part of the routing path discovery process,which occurs during control packet transmission.While control packet transmission is taking place during the routing path discovery process,the EORP protocol and the Multi-channel Cooperative Neighbour Discovery(MCCND)protocol have been designed to detect the cooperative adjacent nodes for each node in the routing.Also included is a simulation of these protocols in order to evaluate their performance across a wide range of packet speeds using Constant Bit Rate(CBR).When the packet rate of the CBR is 20 packets per second,the results reveal that the EORP-MCCND is 0.6 s quicker than the state-of-the-art protocols,according to theﬁndings.Assuming that the CBR packet rate is 20 packets per second,the EORP-MCCND achieves 0.6 s of End 2 End Delay,0.05 s of Routing Overhead Delay,120 s of Network Lifetime,and 20 J of En

关键词： Macro-addressable network power-and load-aware routing deterministic and opportunistic routing gradient routing multi-channel cooperative neighbor discovery

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Evaluation and Bulked segregant Analysis of Major Yield QTL qtl12.1 Introgressed into Indigenous Elite Line for Low Water Availability under Water stress

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Rice science 2013年第1期20卷 25-30页

作者： N.Manikanda BOOPATHI Gat sWAPNAsHRI P.KAVITHA s.sathish R.NITHYA Wickneswari RATNAM Arvind KUMAR Department of Plant Molecular Biology and Bioinformatics CPMB&BTamil Nadu Agricultural UniversityCoimbatore-3India Universiti Kebangsaan Malaysia Bangi SelangorMalaysia Division of Plant Breeding Genetics and BiotechnologyInternational Rice Research InstituteMetro ManilaPhilippines

Near isogenic lines carrying large-effect QTL （qtl2.1）, which has a consistent influence on grain yield under upland drought stress conditions in a wide range of environments, were evaluated under water stress in the fields. The line which gave higher yield under drought was crossed with a local elite line, PMK3, and forwarded to F2：3 generation. significant variation was found among the F2：3 lines for agronomic traits under water stress in the fields. Low to high broad sense heritability （H） for investigated traits was also found. Water stress indicators such as leaf rolling and leaf drying were negatively correlated with plant height, biomass and grain yield under stress. Bulked segregant analysis （BsA） was performed with the markers in the vicinity of qUl2.1, and RM27933 was found to be segregated perfectly well in individual components of drought resistant and drought susceptible bulks which were bulked based on yield under water stress among F2：3 lines. Hence, this simple and breeder friendly marker, RM27933, may be useful as a potentially valuable candidate marker for the transfer of the QTL qtl12.1 in the regional breeding program. Bioinformatic analysis of the DNA sequence of the qtl12.1 region was also done to identify and analyze positional candidate genes associated with this QTL and to ascertain the putative molecular basis of qUl2.1.

关键词： rice bulked segregant analysis water stress quantitative trait locus marker-assisted selection

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synthesis and Forming Behavior of In-situ AA 7075-TiC Composites

Synthesis and Forming Behavior of In-Situ AA 7075-TiC Compos...

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2012 International Conference on Engineering Materials (ICEM 2012)

作者： V.Anandakrishnan s.Baskaran s.sathish Department of Production Engineering National Institute of Technology

The forming behavior of a particulate reinforced AA 7075-TiC composite produced by in-situ stir casting process was investigated with cold upsetting test using graphite as lubricant. The prepared composites containing 0%, 4% and 8% of TiC reinforcement was completely investigated under tri-axial stress state condition. The various stress parameters were evaluated for all the above said composites and its variation with respect to axial strain was plotted, studied and discussed. Microstructural characterization of the composites was also done to study the distribution of the reinforcement in the metal matrix composite.

关键词： Metal Matrix Composites In-situ casting method Forming behavior

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Detection and clearance in Alzheimer’s disease: leading with illusive chemical, structural and morphological features of the targets

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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3s−Instituto de Investigação e Inovação em saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs−Instituto de Ciências Biomédicas Abel salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex organisms.The same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance purposes.Unfortunately,interference in biological systems is not that simple.For a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

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Plant Nitrogen Metabolism: Balancing Resilience to Nutritional stress andAbiotic Challenges

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 581-609页

作者： Muhammad Farhan Manda sathish Rafia Kiran Aroosa Mushtaq Alaa Baazeem Ammarah Hasnain Fahad Hakim syed Atif Hasan Naqvi Mustansar Mubeen Yasir Iftikhar Aqleem Abbas Muhammad Zeeshan Hassan Mahmoud Moustafa Department of Plant Pathology Faculty of Agricultural Sciences&TechnologyBahauddin Zakariya UniversityMultan60800Pakistan Centro de Investigación de Estudios Avanzados del Maule(CIEAM) Vicerrectoría de Investigación y PostgradoUniversidad Católica del MauleTalca3460000Chile College of Food science and Nutritional Engineering China Agricultural UniversityBeijingChina Department of Biology College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Biotechnology Faculty of Biological SciencesLahore University of Biological and Applied SciencesLahorePakistan Department of Plant Pathology College of AgricultureUniversity of SargodhaSargodha40100Pakistan Department of Agriculture and Food Technology Karakorum International UniversityGilgitPakistan Department of Biology Faculty of ScienceKing Khalid UniversityAbhaSaudi Arabia

Plant growth and resilience to abiotic stresses,such as soil salinity and drought,depend intricately on nitrogen metabolism.This review explores nitrogen’s regulatory role in plant responses to these challenges,unveiling a dynamic interplay between nitrogen availability and abiotic stress.In the context of soil salinity,a nuanced rela-tionship emerges,featuring both antagonistic and synergistic interactions between salinity and nitrogen levels.salinity-induced chlorophyll depletion in plants can be alleviated by optimal nitrogen supplementation;however,excessive nitrogen can exacerbate salinity stress.We delve into the complexities of this interaction and its agri-cultural implications.Nitrogen,a vital element within essential plant structures like chloroplasts,elicits diverse responses based on its availability.This review comprehensively examines manifestations of nitrogen deﬁciency and toxicity across various crop types,including cereals,vegetables,legumes,and fruits.Furthermore,we explore the broader consequences of nitrogen products,such as N_(2)O,NO_(2),and ammonia,on human health.Understand-ing the intricate relationship between nitrogen and salinity,especially chloride accumulation in nitrate-fed plants and sodium buildup in ammonium-fed plants,is pivotal for optimizing crop nitrogen management.However,prudent nitrogen use is essential,as overapplication can exacerbate nitrogen-related issues.Nitrogen Use Efﬁ-ciency(NUE)is of paramount importance in addressing salinity challenges and enhancing sustainable crop productivity.Achieving this goal requires advancements in crop varieties with efﬁcient nitrogen utilization,pre-cise timing and placement of nitrogen fertilizer application,and thoughtful nitrogen source selection to mitigate losses,particularly urea-based fertilizer volatilization.This review article delves into the multifaceted world of plant nitrogen metabolism and its pivotal role in enabling plant resilience to nutritional stress and abiotic challenges.It offers insights into future directions

关键词： synthetic nitrogen nitrogen signaling sustainable agriculture eutrophication ammonium nitrate

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Astrophysical s-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezerashvili N.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate school and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh National University 050040 AlmatyKazakhstan

We study radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying resonances.The investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 transition.We calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·b.The important role of the asymptotic constant(AC)for the ^(15)N(p,γ0)16O process with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances is elucidated.A comparison of our calculation for the s-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is found.The reaction rate is calculated and compared with the existing rates.It has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances in reference to the CNO Gamow windows,especially at low temperatures.We estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from Phys.Rev.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=1.3.We present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model CNO-cycle

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sleep-based neuronal oscillations as a physiological biomarker for Alzheimer's disease:is night time the right time?

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Neural Regeneration Research 2024年第7期19卷 1417-1418页

作者： Jonathan Witton Erica s.Brady Michael T.Craig Department of Clinical and Biomedical sciences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Gladstone Institute for Neurological Disease San FranciscoCAUSA school of Psychology and Neuroscience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dementia is a devastating syndrome characterized by memory problems,confusion,and behavior changes that prevent people from performing everyday activities.It is the leading cause of dependency and disability amongst older people,resulting in a global economic cost of ~$1.3 trillion.Around 58 million people are currently afflicted by dementia worldwide,with Alzheimer s disease(AD) causing most(60-70%) of these cases.

关键词： Alzheimer everyday performing

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