检索结果-南通市图书馆

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Uniform assembly of gold nanoparticles on s-doped g-C3N4 nanocomposite for effective conversion of 4-nitrophenol by catalytic reduction

在线全文

学校读者我要写书评

暂无评论

Journal of Materials science & Technology 2020年第5期40卷 176-184页

作者： Vellaichamy Balakumar Hyungjoo Kim Ji Won Ryu ramalingam Manivannan Young-A son Department of Advanced Organic Materials Engineering Chungnam National University220 Gung-dongYuseong-guDaejeon305-764South Korea

In this work,a simple synthesis of sulfur doped graphitic carbon nitride(s-g-C3N4)act as a support cum stabilizers for gold nanoparticles(Au)and its was characterized by UV–vis and XRD to measure the absorbance and crystallinity,*** functional group and morphology of the samples were identified using FT-IR and ***,the Au@s-g-C3N4 nanocatalyst exhibits good catalytic performance and stability in the reduction of hazardous 4-nitrophenol(NP)compared to s-g-C3N4 using Na ***,the Au@s-g-C3N4 nanocomposite holds a good catalytic efficiency(near 100%)achieved by within 5 *** highest catalytic reduction of NP is due to the synergistic effect of Au nanoparticles decorated on *** fast electron transfer reduction mechanism was elucidated and *** reusability and stability of the developed nanocomposites were also observed in consecutive reduction *** filtering and catalyzing device was used for the direct conversion of NP polluted *** method can open a new avenue for the metal nanoparticles based carbon materials heterogeneous catalyst and its reduction of toxic contaminants.

关键词： Gold nanoparticles s-doped g-C3N4 Catalytic reduction 4-nitrophenol

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Comparative studies on numerical sensitivity of different scenarios of enhanced oil recovery by water-alternating-gas(CO_(2))injection

在线全文

学校读者我要写书评

暂无评论

Petroleum Research 2023年第4期8卷 505-513页

作者： saddam Mohammed Mohammed Nasser Achinta Bera Vivek ramalingam school of Energy Technology Pandit Deendayal Energy UniversityGandhinagarGujarat382007India

Enhanced oil recovery by CO_(2) injection technology(CO_(2)-EOR)plays a crucial role in enhancing oil production and the permanent sequestration of anthropogenic CO_(2) in depleted oil ***,the availability of CO_(2) in oil field locations and its mobility in contrast with reservoir fluids are prime challenges in CO_(2)-*** cost of CO_(2) and its availability at the oil fields has prompted investigations on efficient injection of CO_(2) at the fields to achieve the best sweep efficiency *** strategies such as water-alternating-gas(WAG),simultaneous vertical and horizontal WAG,simultaneous water injection into the aquifer and vertical WAG,water and gas injection simultaneously but separately(ss-WAG),and water and gas injection simultaneously but not separately(sNs-WAG)play a significant role,as well as the purity of CO_(2).In this work,the significance of the above criteria was investigated indi-vidually and in *** coupled sequence of injection rate,soaking time,WAG ratio,and purity of injected CO_(2) for enhancement of oil production were delineated.A realistic reservoir simulation model conceptualizing the CO_(2)-EOR system with five spot injection patterns was developed by the company *** history-matched model that was developed was used to investigate the sensitivity of the coupled effects to the criteria listed above on oil *** investigations quantitatively emphasized that purity and soaking time of CO_(2) have an inverse effect in the oil production rate and that sNs-WAG resulted in a better oil production rate than ss-WAG.

关键词： Water-alternating-gas Enhanced oil recovery sensitivityanalysis Modelingand simulation simultaneouslybut not separately water-alternating-gas(ss-WAG) simultaneously pressure maintenance and WAG

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Understanding activity of butyrate at a cellular level

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

Microglial dysfunction and genetic risk for neurodegenerative disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases

Effect of mercuric chloride on membrane-bound enzymes in rat testis

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2002年第4期4卷 309-311页

作者： V. ramalingam V.Vimaladevi Department of Zoology Bharathidasan Govt. College for Women Pondicherry-605 003 India5 Lancelot Court #4 Salem NH 03079 USA

Aim: To study the effect of mercuric chloride on the membrane-bound enzymes. Methods: The effect of mercuric chloride at two different doses, 1 mg/kg (low dose) and 2 mg/kg (high dose), orally for 30 days, was observed on the membrane-bound enzymes in the testis of adult albino rats. Results: Mercuric chloride significantly decreased the body weight and testis weight in the high dose group (Pse group. The activities of 5' nucleotidase and adenosine triphosphatases were markedly decreased (Pstis of both groups. Alkaline phosphatase and γ-glutamyl transferase activities were significantly increased (Ps. However, the effect was more pronounced in the high than in the low dose groups. Conclusion: The dose dependent effect of mercuric chloride on these enzymes may affect the membrane characteristics and thereby the fertility of the animal. (Asian J Androl 2002 Dec; 4:309-311)

关键词： mercuric chloride testis alkaline phosphatase 5'nucleotidase γ-glutamyl transferase adenosine triphosphatase

GPs： a constraint-based gene position procurement in chromosome for solving large-scale multiobjective multiple knapsack problems

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer science 2018年第1期12卷 101-121页

作者： Jayanthi MANICAssAMY Dinesh KARUNANIDHI sujatha POTHULA Vengattaraman THIRUMAL Dhavachelvan PONNURANGAM subramanian ramalingam Department of Computer science Pondicherry University Pondicherry 605 014 India

The multiple knapsack problem （MKP） forms a base for resolving many real-life problems. This has also been considered with multiple objectives in genetic algorithms （GAs） for proving its efficiency. GAs use self- adaptability to effectively solve complex problems with constraints, but in certain cases, self-adaptability fails by converging toward an infeasible region. This pitfall can be resolved by using different existing repairing techniques; however, this cannot assure convergence toward attaining the optimal solution. To overcome this issue, gene position-based suppression （GPs） has been modeled and embedded as a new phase in a classical GA. This phase works on the genes of a newly generated individual after the recombination phase to retain the solution vector within its feasible region and to im- prove the solution vector to attain the optimal solution. Genes holding the highest expressibility are reserved into a subset, as the best genes identified from the current individuals by re- placing the weaker genes from the subset. This subset is used by the next generated individual to improve the solution vec- tor and to retain the best genes of the individuals. Each gene＇s positional point and its genotype exposure for each region in an environment are used to fit the best unique genes. Further, suppression of expression in conflicting gene＇s relies on the requirement toward the level of exposure in the environment or in eliminating the duplicate genes from the *** MKP benchmark instances from the OR-library are taken for the experiment to test the new model. The outcome por- trays that GPs in a classical GA is superior in most of the cases compared to the other existing repairing techniques.

关键词： combinatorial problems evolutionary algo-rithm multiobjective problems multiple knapsack problem,gene position effect gene suppression