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Journal of Rare Earths 2018年第12期36卷 1319-1325页

作者： s.shanmugasamy K.Balakrishnan A.subasri s.ramalingam A.subramania Centre for Nanoscience and Technology Pondicherry University Department of Chemistry Kalasalingam University

A simple electrodeposition technique was used to prepare Ni-CeOnanorods composite coating(Ni-CeONRs) using Watt’s nickel plating bath containing CeOnanorods(NRs) as the reinforcement phase under optimized process conditions. The X-ray diffraction analysis(XRD) was used for the structural analysis of Ni-CeONRs composite coatings and their average crystalline size is ～22 nm for pure Ni and ～18 nm,respectively. The crystalline structure is fcc for the Ni-CeOnanocomposite coatings. The surface morphology of the electrodeposited Ni-CeONRs composite coatings was analyzed by scanning electron microscopy(sEM). Microhardness of pure Ni and Ni-CeONRs composite coatings are found to be 253 HV and 824 HV, respectively. The inclusion of CeONRs increases the microhardness of Ni-CeONRs composite coatings. The corrosion resistance behavior of Ni-CeONRs composite coating was evaluated by Tafel polarization and AC impedance methods. It is revealed that CeONRs reinforced Ni matrix shows higher microhardness and corrosion resistance than existing reported electrodeposited pure Ni and CeOnanoparticles reinforced Ni coatings.

关键词： CeO_2 nanorods Rare earths Electrodeposition Nanocomposite coating Microhardness

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie Z.Li Nagendran ramalingam shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Performance studies on recycled aggregate concrete with treated recycled aggregates

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Waste Disposal and sustainable Energy 2023年第4期5卷 451-459页

作者： Malathy ramalingam Jagan sivamani Karuppasamy Narayanan Faculty Department of Civil EngineeringSona College of TechnologySalemTamil NaduIndia

Excessive construction activities generate huge quantities of waste that are disposed of in nearby sites,leading to environmental *** the concrete fractions of construction wastes for their utilization as aggregates has been predominant among industrialists and researchers in recent ***,the smearance of cement mortar on the recycled aggregates affects the concrete *** treatments were developed to remove the weak cement mortar or seal the micro-pores on the adhered cement mortar of recycled *** paper investigates the comparative efficiency of acid and carbonation treatment on recycled coarse aggregate(RCA)properties and its behaviour on recycled aggregate concrete(RAC).The RCA was treated with HCl acid at 0.1 mol/L,0.5 mol/L,and 0.8 mol/L and CO_(2) at 0.1 bar,0.2 bar,and 0.4 bar and tested for their physical properties,and the concrete mixtures with treated recycled aggregates were tested for fresh and hardened *** could be observed that the properties of RAC were affected owing to the smearance of weak mortar,whereas for the concrete with carbonated(RACc)and chemically treated aggregates(RACa),the concrete properties tended to *** strength of RAC was 28.59%less than that of normal aggregate concrete(NAC),whereas the strength of RACc and RACa was enhanced by 16.44%and 9.7%compared to that of RAC at 28 *** water absorption of RAC was 47.51%more than that of NAC,whereas the water absorption of RACa and RACc was 28.67%and 33.75%lesser than ***-soaking the RCA with acids removes the adhered mortar due to its acidic *** contrast,in carbonation,the CO_(2) reacts with the Ca(OH)_(2) on the cement mortar to form CaCO_(3),filling the micro-cracks in the cement mortar on the RCA.

关键词： Recycled aggregates Chemical Carbonation Adhered mortar Recycled aggregate concrete strength Water absorption

Emerging mosquito-borne arboviral infection Zika-An epidemiological review

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Asian Pacific Journal of Tropical Biomedicine 2020年第5期10卷 193-200页

作者： Ashwini Malla Balamurugan shanmugaraj sathishkumar ramalingam Plant Genetic Engineering Laboratory Department of BiotechnologyBharathiar UniversityCoimbatoreTamil NaduIndia

The unprecedented resurgence and geographical expansion of arboviral infections such as dengue, chikungunya, yellow fever, and Zika have a significant impact on human health and pose a serious threat to public health globally in recent years. Zika virus is a Flavivirus and is transmitted to humans through an infected mosquito bite. The Zika virus has been identified in many countries in Africa, Asia, and Pacific islands and sporadic human cases have been reported since 1947. The non-specific clinical symptoms of Zika fever are often misdiagnosed with other arboviral infections, especially dengue and chikungunya. Till now, there is no vaccine or specific antiviral treatment for Zika infection. The recent emergence of Zika is alarming and highlights the need for arboviral research to develop an effective treatment. Here in this review, we discussed the epidemiology of Zika, which has re-emerged in the recent decade and caused international concern.

关键词： Arboviruses Epidemiology Mosquito Zika

Dye-tolerant marine Acinetobacter baumannii-mediated biodegradation of reactive red

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Water science and Engineering 2018年第4期11卷 265-275页

作者： sneha Unnikrishnan Mohd Hashim Khan Karthikeyan ramalingam school of Life sciences B.S.Abdur Rahman Crescent Institute of Science and Technology

The objective of this study was to isolate a potent dye-degrading microbe that can be used to reduce the pollution caused by industrial *** red 198 is an extensively used textile dye and is a major environmental pollutant in water bodies. In this study, a bacterial strain was isolated from sea sediments and identified as Acinetobacter baumannii with 16s rRNA sequencing. The isolated bacteria were immobilized in calcium alginate and decolorization studies were carried out to determine the optimum pH, temperature, dye concentration, inoculum volume,and static/agitated condition using the one factor at a time(OFAT) approach. The Box-Behnken design, a type of response surface methodology,was adopted to improve the degradation efficiency. At 37℃ using an inoculum volume of six beads, 96.20% decolorization was observed in 500 mg/L of reactive red 198 after 72 h. Dye degradation was confirmed with UV-visible spectroscopy and Fourier-transform infrared(FTIR)spectroscopy studies of the dye and degraded metabolites. Microbial toxicity studies using Escherichia coli, staphylococcus aureus, and Pseudomonas aeruginosa and phytotoxicity studies using Vigna radiata proved that the toxicity of the dye was significantly reduced after degradation. We can conclude that the isolated A. baumannii strain is an efficient dye-degrading microbe that can be used to reduce the pollution caused by industrial dyes.

关键词： Immobilization Box-Behnken design Response surface methodology Microbial toxicity Dye degradation

Chikungunya infection:A potential re-emerging global threat

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 910-915页

作者： shanmugaraj Bala Murugan ramalingam sathishkumar Plant Genetic Engineering Laboratory Department of BiotechnologyBharathiar University

Infectious diseases are indeed a lifelong threat to everyone irrespective of age, sex, lifestyle and socio-economic status. The infectious diseases have persisted among the prominent causes of death globally. Recently, re-emergence of Chikungunya viral infection harmed many in Asian and African countries. Chikungunya was considered as a major threat in developing and underdeveloped countries; the recent epidemiological outbreak of Chikungunya in La Reunion urges the global researchers to develop effective vaccine against this viral disease. In this review, Chikungunya, pathogenesis and epidemiology were briefly described.

关键词： Aedes mosquitoes Alphavirus Arthropod-borne disease Chikungunya Non-structural Proteins structural Proteins

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Epidemiology, clinical features and transmission of re-emerging arboviral infection chikungunya

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Asian Pacific Journal of Tropical Biomedicine 2019年第4期9卷 135-139页

作者： Balamurugan shanmugaraj Ashwini Malla sathishkumar ramalingam Plant Genetic Engineering Laboratory Department of Biotechnology Bharathiar University Bharat Biotech International Limited Genome Valley

A number of re-emerging and emerging infectious diseases including chikungunya, West Nile, yellow fever, Zika, dengue, Japanese encephalitis, and others have increased in recent years, which threaten the public health across the globe. Chikungunya is a neglected re-emerging arboviral infection caused by chikungunya virus. Arboviral infections such as chikungunya, Zika and dengue have similar epidemiology, transmission cycles and clinical symptoms, which makes it difficult to diagnose these three infections. Moreover, there is no commercial vaccine or licensed therapy available for chikungunya infection, thus causing severe burden worldwide. Vector control may reduce the disease risk; however, this remains a challenge due to many factors including, but not limited to, evolution of insecticide resistance in mosquitoes, gaps in vector control tools, urbanization, environmental and demographic changes. Effective integrated vector control strategies and surveillance measures along with affordable vaccine development or anti-viral therapy are essential to control the infection. In this review, we discuss the epidemiology of mosquito-borne infection chikungunya which has re-emerged as an international concern in recent decades.

关键词： Arboviruses Chikungunya Epidemiology Mosquito

Application of GIs in urban utility mapping using image processing techniques

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Geo-spatial Information science 2012年第4期15卷 271-275页

作者： R.MANONMANI s.PRABAHARAN R.VIDHYA M.ramalingam Institute of Remote sensing Anna UniversityChennai 600025India Department of Geology Anna UniversityChennai 600025India

Growing cities are creating an alarming situation in all countries of the *** has led to serious land use problems such as loss of agricultural land,unauthorized urban sprawl,high land values,speculation in land,and other related *** this emerging scenario,it is essential to have updated information on urban growth patterns and their impact on the living *** and development of these cities are likely to continue and therefore there will be a need for proper planning and managing or improving the existing infrastructure *** study demonstrates image fusion of LIss-IV MX and Cartosat-1 satellite data to create detailed town planning and utility mapping for amenity patterns and facilities available in Karaikal city,*** patterns within the city are analyzed and a road network map is generated.A proximity analysis was carried out to understand the availability of institutions,hospitals,and industries for effective disaster *** has grown rapidly in all directions especially in north,northwest and west parts.A big question for planners is the provision of proper *** geographic information system and remote sensing,city administrators can now evolve an expert decision support system aimed at various decisionmaking processes.

关键词： high-resolution satellite data proximity analysis utility mapping