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Adaptive Nonlinear sliding Mode Control for DC Power Distribution in Commercial Buildings

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Intelligent Automation & soft Computing 2023年第4期36卷 997-1012页

作者： R.Muthamil Arasi s.padma Thiagarajar Polytechnic College SalemTamilnaduIndia sona College of Technology SalemTamilnaduIndia

The developing populace and industrialization power demand prompted the requirement for power generation from elective *** desire for this pursuit is solid due to the ever-present common assets of petroleum deri-vatives and their predominant ecological *** is generally acknowledged that sustainable power sources are one of the best answers for the energy *** these,Photovoltaic(PV)sources have many beneﬁts to bestow a very promising *** integrated into the existing power distribution infrastructure,the solar source will be more successful,requiring efﬁcient Direct Current(DC)-Alternating Current(AC)*** paper mainly aims to improve control-lers’performance between AC/DC Energy sources and the DC loads using the Adaptive Nonlinear sliding Mode(ANsM)control *** proposed ANsM method efﬁciently controls power quality issues,such as transient response,powerﬂow reliability and Total Harmonics Distortion(THD).The proposed con-troller is applied for both AC/DC and DC/DC converters and the performance of the proposed controller is validated through simulation checking the above *** simulation results conﬁrm ANsM conﬁguration is more reliable and efﬁcient than the existing fuzzy and sliding mode control methods.

关键词： Photovoltaic AC-DC converter DC-DC converter adaptive nonlinear sliding mode transient response total harmonics distortion

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Intelligent approach of score-based artificial fish swarm algorithm(sAFsA)for Parkinson’s disease diagnosis

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International Journal of Intelligent Computing and Cybernetics 2022年第4期15卷 540-561页

作者： syed Haroon Abdul Gafoor padma Theagarajan Bharathiar University CoimbatoreIndia Department of Computer Applications Sona College of TechnologySalemIndia

Purpose-Conventional diagnostic techniques,on the other hand,may be prone to subjectivity since they depend on assessment of motions that are often subtle to individual eyes and hence hard to classify,potentially resulting in ***,early nonmotor signs of Parkinson’s disease(PD)can be mild and may be due to variety of other *** a result,these signs are usually ignored,making early PD diagnosis *** learning approaches for PD classification and healthy controls or individuals with similar medical symptoms have been introduced to solve these problems and to enhance the diagnostic and assessment processes of PD(like,movement disorders or other Parkinsonian syndromes).Design/methodology/approach-Medical observations and evaluation of medical symptoms,including characterization of a wide range of motor indications,are commonly used to diagnose *** quantity of the data being processed has grown in the last five years;feature selection has become a prerequisite before any *** study introduces a feature selection method based on the score-based artificial fish swarm algorithm(sAFsA)to overcome this ***-This study adds to the accuracy of PD identification by reducing the amount of chosen vocal features while to use the most recent and largest publicly accessible *** subset selection in PD detection techniques starts by eliminating features that are not relevant or *** to a few objective functions,features subset chosen should provide the best *** limitations/implications-In many situations,this is an Nondeterministic Polynomial Time(NPHard)*** method enhances the PD detection rate by selecting the most essential features from the *** begin,the data set’s dimensionality is reduced using singular Value Decomposition dimensionality ***,Biogeography-Based Optimization(BBO)for feature selection;the weight value is a vital parameter for find

关键词： Parkinson disease dysphonia features Feature subset selection score-based artificial fish swarm algorithm(sAFsA) singular value decomposition(sVD) Classification

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

sYNTHEsIs AND CHARACTERIZATION OF POLYBENZOTHIAZOLAMIDEs

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Chinese Journal of Polymer science 1989年第3期7卷 266-269页

作者： s. padma V. MAHADEVAN M. sRINIVAsAN Department of Chemistry Indian Institute of TechnologyMadras-600 036INDIADepartment of ChemistryIndian Institute of TechnologyMadras-600 036INDIADepartment of ChemistryIndian Institute of TechnologyMadras-600 036INDIA

Aromatic polybenzothiazolamides were prepared by low temperature solution method by condensing the 2, 2'-diarnino-6, 6'-bibenzothiazole with four different acid chlorides in quantitative yield. These polymers were characterized by IR and NMR. Viscosities of these polyamides range from 0.42 to 1 dl/gm. All these polymers were stable upto 300℃ in air.

关键词： sYNTHEsIs AND CHARACTERIZATION OF POLYBENZOTHIAZOLAMIDEs PA

H-infinity robust control technique for controlling the speed of switched reluctance motor

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Frontiers of Electrical and Electronic Engineering in China 2012年第3期7卷 337-346页

作者： A. RAJENDRAN s. padma Department of Electrical and Electronics Engineering Sona College ofTechnology Salem Tamilnadu India

The switched reluctance motor （sRM） is applied in various industrial applications due to its profitable advantages. However, the robustness speed of sRM is one of the major drawbacks, which greatly affects the performance of motor. Thus, the aim of this paper is to control the speed of sRM using H-infinity control strategy. This H-infinity control technique is stronger against robustness. In the proposed speed controller, the rotor position of the sRM is applied to the controller. The speed variation of the rotor is determined from the reference speed and applied to the controller as input. Then, the speed variation and the corresponding sensitivity function are determined. The sensitivity function determination is based on the input weight of the controller. The weight adjustment process is repeated until a stable speed condition is achieved. Then, the output of the proposed control technique is compared with the existing control technique and the robustness is analyzed. Here, the existing control techniques considered are proportional- integral （PI） controller and fuzzy logic controller （FLC）- based PI gain tuning. The proposed control strategy is simulated in MATLAB working platform and the control performance is analyzed.

关键词： switched reluctance motor (sRM) speedcontrol technique H-infinity control robust

Adaptive immunity at the crossroads of autophagy and metabolism

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Cellular & Molecular Immunology 2021年第5期18卷 1096-1105页

作者： shree padma Metur Daniel J.Klionsky University of Michigan Life Sciences Institute and Department of MolecularCellular and Developmental BiologyAnn ArborMIUSA

The function of lymphocytes is dependent on their plasticity,particularly their adaptation to energy availability and environmental stress,and their protein synthesis *** are constantly under metabolic stress,and macroautophagy/autophagy is the primary metabolic pathway that helps cells overcome *** intrinsic role of autophagy in regulating the metabolism of adaptive immune cells has recently gained increasing *** this review,we summarize and discuss the versatile roles of autophagy in regulating cellular metabolism and the implications of autophagy for immune cell function and fate,especially for T and B lymphocytes.

关键词： Immunology Lysosome Macroautophagy stress

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant