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连续5年采用数字乳腺断层融合成像筛查：基于筛查年份及轮次的结果

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国际医学放射学杂志 2020年第4期 482-482页

作者： E.F.Conant s.p.Zuckerman E.s.McDonald s.p.weinstein K.E.Korhonen J.A.Birnbaum 任继亮 Department of Radiology Perelman School of MedicineUniversity of Pennsylvania

目的比较多年份及多轮次的数字乳腺断层融合成像(DBT)筛查和数字乳腺摄影(DM)筛查结果。材料与方法该回顾性研究包含1年的DM及5年的DBT筛查(2011

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同时性数字化乳腺X线摄影与数字化乳腺断层成像对乳腺癌辨识度的比较

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国际医学放射学杂志 2019年第5期 607-607页

作者： K.E.Korhonen E.F.Conant E.A.Cohen M.synnestvedt E.s.McDonald s.p.weinstein 罗骁 Department of Radiology Division of Breast ImagingHospital of the University of Pennsylvania

摘要既往研究证明数字乳腺断层成像(DBT)较数字化乳腺X线摄影(DM)能有效改善筛查的结果,但少有研究探索DM和DBT在乳腺肿瘤辨识度上的优劣。目的比较DM

关键词：乳腺癌 MLO CC 乳腺肿瘤同时性断层成像

乳腺数字化体层融合成像全自动定量估测乳腺体积密度:数字化钼靶成像和MR成像比较的初步研究结果

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国际医学放射学杂志 2016年第3期 310-310页

作者： s.pertuz E.s.McDonald s.p.weinstein E.F.Conant D.Kontos 孔祥 Department of Radiology Perelman School of MedicineUniversity of Pennsylvania

摘要目的评估乳腺数字化体层融合技术(DBT)中乳腺体积密度(VBD)全自动化定量方法,并比较全数字化乳腺钼靶成像(FFDM)和MR成像的结果。方法本研究经伦理委员会批准并符合HIpAA要求,回顾性收集了2011年10月—2012年9月进行乳腺癌筛查的68... 详细信息

摘要目的评估乳腺数字化体层融合技术(DBT)中乳腺体积密度(VBD)全自动化定量方法,并比较全数字化乳腺钼靶成像(FFDM)和MR成像的结果。方法本研究经伦理委员会批准并符合HIpAA要求,回顾性收集了2011年10月—2012年9月进行乳腺癌筛查的68例女性的双侧乳腺DBT影像、FFDM影像以及矢状面乳腺MR影像。DBT成像中VBD作为一种全自动化的计算机算法被开发用于定量评

关键词：乳腺 DBT VBD 乳房 FFDM MR 体层体积密度

乳腺MR增强诊断的良性病变最终确诊为恶性的比例:来自美国影像网络放射学会6667例诊断结果

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国际医学放射学杂志 2010年第4期 381-381页

作者： s.p.weinstein L.G.Hanna C.Gatsonis M.D.schnall M.A.Rosen C.D.Lehman 郭丽君 Department of Radiology University of Pennsylvania Medical Center3400 Spruce St1 Silverstein BuildingPhiladelphiaPA 19104USA

目的美国影像网络放射学会(ACRIN)登记的6667例诊断结果中,已知乳腺癌病人对侧乳腺MR筛查,检出良性病变中最终确诊为恶性的比例。材料与方法由ACRIN指导多个机构,对近期确诊

关键词：良性病变 MR 乳腺乳房诊断结果放射学会美国美利坚合众国北美洲

A new direction for Alzheimer's research

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Neural Regeneration Research 2018年第2期13卷 190-193页

作者： James D.weinstein Marshall University school of Medicine Medical Center

Despite decades of research, at present there is no curative therapy for Alzheimer＇s disease. Changes in the way new drugs are tested appear to be necessary. Three changes are presented here and will be discussed. The first change is that Alzheimer＇s disease must be considered a disease of four major pathological processes, not one. The four processes are： 1） vascular hy- poperfusion of the brain with associated mitochondrial dysfunction, 2） destructive protein inclusions, 3） uncontrolled oxidative stress, and 4） proinflammatory immune processes second- ary to microglial and astrocytic dysfunction in the brain. The second change recommended is to alter the standard cognitive measurement tools used to quantify mental decline in test patients. specifically the Dementia severity Rating scale （DsRs） should supersede Mini-Mental state Examination （MMsE） and other popular tests, and a measurement scale developed in research should be used to produce a linear and non-irregular baseline. Finally, accepting the concept that four etiologies cause Alzheimer＇s disease leads to the last necessary change, that new thera- pies must be employed directed against all four causes, likely as a combination. There are drugs ready to be employed in such a combinations which are available and used clinically for other purposes so can be used ＂offlabel＂ and one such combination is suggested.

关键词： Alzheimer's disease etiologies combination therapy cognitive testing failed research off-label use Dementia severity Rating scale

production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer cell line

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Frontiers of Chemical science and Engineering 2013年第4期7卷 482-489页

作者： Jacqueline CONCHA Caroline weinstein Maria Elvira ZUNIGA Department of Biochemistry Pharmacy School Universidad de Valparaiso Gran Bretafia 1093 Playa Ancha Valparaiso Chile school of Biochemistry Engineering Pontificia Universidad Catolica de Valparaiso General Cruz 34 Valparaiso Chile Creas Conicyt-Regional Gore Region de Valparaiso R12C1001 Blanco 1623 of 1402 Valparaiso Chile

In the last years, sugar beet pectins have been the subject of several investigations involving extraction methodologies, chemical composition and functional properties. The structure of pectins, which depends on the extraction method, is decisive in their capacity to induce apoptosis on several cancer cell lines like colon, prostate and breast. In this work, sugar beet pectin extraction was performed in the following steps： lipid extraction with hexane, removal of soluble complex carbohydrates and proteins, and enzymatic treatment with amyloglucosidase, protease, and pectinase. The enzymatic treatment was carried out with Rohapect DA6L under the following conditions： 50℃, pH 4.0, 2% enzyme/substrate （E/s） ratio, 15 h, and a solid to liquid ratio of 1 ： 10. The pectic extract showed a degree of polymerization （Dp） profile of 55.8% with Dp≥7; 4.9% with Dp6; 5.8% between Dp2 and Dp6 ; 4.7% with Dp2; and 28.8% with Dp1. The pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line. At a concentration range of 12.5-25 mg/mL the pectic extract killed 80.6% of the cells, exhibiting a higher antiproliferative activity than 4-hydroxytamoxifen （4- OHT）, a classical anticancer drug, which killed 56.5% of the cells.

关键词： pectic extracts antiproliferative activity,breast cancer enzymatic treatment

A tunable ferroelectric based unreleased RF resonator

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Microsystems & Nanoengineering 2020年第1期6卷 1334-1340页

作者： Yanbo He Bichoy Bahr Mengwei si peide Ye Dana weinstein purdue University West LafayetteINUSA Kilby Labs Texas InstrumentsDallasTXUSA

This paper introduces the first tunable ferroelectric capacitor(FeCAp)-based unreleased RF MEMs resonator,integrated seamlessly in Texas Instruments’130 nm Ferroelectric RAM(FeRAM)*** designs presented here are monolithically integrated in solid-state CMOs technology,with no post-processing or release step typical of other MEMs *** array of FeCAps in this complementary metal-oxide-semiconductor(CMOs)technology’s back-end-of-line(BEOL)process were used to define the acoustic resonance cavity as well as the electromechanical *** achieve high quality factor(Q)of the resonator,acoustic waveguiding for vertical confinement within the CMOs stack is studied and *** design considerations are discussed to obtain lateral confinement and suppression of spurious *** FeCAp resonator is demonstrated with fundamental resonance at 703 MHz and Q of *** gives a frequency-quality factor product f·Q=7:11×10^(11) which is 1.6×higher than the most state-of-the-art pb(Zr,Ti)O_(3)(pZT)*** to the ferroelectric characteristics of the FeCAps,transduction of the resonator can be switched on and off by adjusting the electric *** this case,the resonance can be turned off completely at±0.3 V corresponding to the coercive voltage of the constituent FeCAp *** novel switchable resonators may have promising applications in on-chip timing,ad-hoc radio front ends,and chip-scale sensors.

关键词： resonator tunable switched

Gα_s Relays sphingosine-1-phosphate Receptor 1 signaling to stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity

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Journal of Genetics and Genomics 2015年第11期42卷 613-624页

作者： Ximing shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee s.weinstein Hongchang Li Huashun Li West China Developmental and stem Cell Institute West China Second HospitalSichuan University state Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for Biotherapy shenzhen Key Laboratory for Molecular Biology of Neural Development Laboratory of Developmental and Regenerative BiologyInstitute of Biomedicine and BiotechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of Sciences National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health sARITEX Center for stem Cell Engineering Translational Medicine Shanghai East HospitalTongji University School of Medicine Nerdbio Inc. SIP Biobay

sphingosine-1-phosphate receptor 1 （s1pR1）, a G protein-coupled recep （GpCR）. controls vasct stability by stabilizing vascular endothelial （VE）-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2（VEGFR2） signaling. However, the molecular mechanisms that link s1pR1 signaling to intracellular effectors remain *** this study,we demonstrate that the heterotrimeric G protein subfamily member Gαs, encoded by GNAs,acts as a relay mediator of s1pR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions. The endothelial cell -spectific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized *** immunostaining results revealed that Gαs deletion remarkably reduces the junctional localization of VE-cadherin, whereas the mull cell coverage of the vessels is not *** addition, we found-that Gαs depletion blocks the s1pR1-activation induced VE-cadherin stabilization at junctons,supporting that Gαs acts downstream of s1pR1 signaling Thus, our results demonstrate that Gαs is an essential mediator to relay s1pR1 signaling and maintain vascular integrity.

关键词： Gαs VE-eadherin s1pR1 signaling adherens junctions vascular integrity

Health effects of natural spring waters:A protocol for systematic reviews with a regional case example

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Journal of Integrative Medicine 2015年第6期13卷 416-420页

作者： Jessica stanhope philip weinstein Angus Cook school of population Health The University of Western Australia school of Biological sciences The University of Adelaide school of pharmacy and Medical sciences The University of South Australia

BACKGROUND： spring water therapies have been used since at least 1550 BC. Despite the growing body of evidence supporting these therapies for a range of conditions, including musculoskeletal, dermatological, respiratory and cardiovascular conditions, they do not currently form part of mainstream healthcare in many countries. The protocol established in this paper aims to support systematic reviews that examine the health outcomes associated with human exposure to regional spring waters, using the Australia and New Zealand context as a case study. METHODs/DEsIGN： The protocol searches for studies in eight health/medical databases, searches three local health/medical journals, and includes forwards and backwards searching. standard systematic review methods are used including： specifying pre-deterrnined inclusion criteria and data management plans, appraising the studies for bias, and allocation to a hierarchy of evidence. DIsCUssION： The protocol supports a review and comprehensive synthesis of the current evidence regarding the health effects of natural spring water, and can be adapted for reviews in other regions. From this evidence, recommendations regarding practice and future research can be made on the therapeutic role of spring water.

关键词： hot springs Australia New Zealand review study protocol