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A Clean Technology for Future prospective: Emission Modeling of Gas Based power plant

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Open Journal of Air pollution 2016年第4期5卷 144-159页

作者： Markandeya s.p.shukla G.C.Kisku Department of Civil Engineering Institute of Engineering and Technology Lucknow India Environmental Monitoring Laboratory Environmental Toxicology Group CSIR-Indian Institute of Toxicology Research (CSIR-IITR) Lucknow India

The aim of present research is to study the dispersion of air pollutants using the air quality model, AERMOD and to predict the impact of pollutants (pM10, NO2 and CO) at the receptor level released from Gas Based pow... 详细信息

The aim of present research is to study the dispersion of air pollutants using the air quality model, AERMOD and to predict the impact of pollutants (pMsub>10sub>, NOsub>2sub> and CO) at the receptor level released from Gas Based power plant (GBpp). The net-concentrations including monitored data plus predicted values of pMsub>10sub>, NOsub>2sub> and CO would be increased from base value 75 to 77.61 μg/msup>3sup> with an increase of 3.48%, 22 to 26.66 μg/msup>3sup> with an increase of 21.18% and 428 to 538.37 μg/msup>3sup> with an increase of 25.79% respectively. The study of hill effect showed that it had profound impact upon the dispersion of pollutants and the ratio (with hill and without hill) of each pollutant was 3.89 for pMsub>10sub> (24 hr), 2.40 for NOsub>2sub> (24 hr) and 13.98 for CO (1 hr). The natural gas based plant not only decreases the pollution level but also reduces the hospital treatment cost and protects the public health. The modeling results suggest that the GBpp could be a clean technology as replacement of coal power plants located in the city which pollute the environment considerably in spite of control measures installed.

关键词： Gas Based power plant AERMOD Fine particulates and Gaseous pollutants Health Effects

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.V.p.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Liposome based drug delivery as a potential treatment option for Alzheimer’s disease

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Neural Regeneration Research 2022年第6期17卷 1190-1198页

作者： Carely Hernandez surabhi shukla Department of pharmaceutical sciences College of PharmacyLarkin UniversityMiamiFLUSA

Alzheimer’s disease is a neurodegenerative condition leading to atrophy of the brain and robbing nearly 5.8 million individuals in the United states age 65 and older of their cognitive ***’s disease is associated with dementia and a progressive decline in memory,thinking,and social skills,eventually leading to a point that the individual can no longer perform daily activities *** available drugs on the market temporarily alleviate the symptoms,however,they are not successful in slowing down the progression of Alzheimer’s *** and cures have been constricted due to the difficulty of drug delivery to the blood-brain *** studies have led to identification of vesicles to transport the necessary drugs through the blood-brain barrier that would typically not achieve the targeted area through systemic delivered ***,liposomes have emerged as a viable drug delivery agent to transport drugs that are not able to cross the blood-brain *** are being used as a component of nanoparticle drug delivery;due to their biocompatible nature;and possessing the capability to carry both lipophilic and hydrophilic therapeutic agents across the blood brain barrier into the brain *** indicate the importance of liposomal based drug delivery in treatment of neurodegenerative *** idea is to encapsulate the drugs inside the properly engineered liposome to generate a response of *** are engineered to target specific diseased moieties and also several surface modifications of liposomes are under research to create a clinical path to the management of Alzheimer’s *** review deals with Alzheimer’s disease and emphasize on challenges associated with drug delivery to the brain,and how liposomal drug delivery can play an important role as a drug delivery method for the treatment of Alzheimer’s *** review also sheds some light on variation of ***

关键词： Alzheimer’s disease beta-amyloid blood-brain barrier brain delivery drug delivery systems encapsulated drugs liposomes nanoparticles neurodegenerative diseases pEGylation targeted delivery tau

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine program and Department of pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of parkinson’s disease(pD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes pD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

A spatio-temporal assessment and prediction of Ahmedabad's urban growth between 1990–2030

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Journal of Geographical sciences 2022年第9期32卷 1791-1812页

作者： shobhit CHATURVEDI Kunjan shukla Elangovan RAJAsEKAR Naimish BHATT Department of Architecture and planning Indian Institute of TechnologyRoorkee247667India Department of Civil Engineering School of TechnologyPandit Deendayal Petroleum UniversityGandhinagar382007India

Analyzing long term urban growth trends can provide valuable insights into a city’s future *** study employs LANDsAT satellite images from 1990,2000,2010 and 2019 to perform a spatiotemporal assessment and predict Ahmedabad’s urban *** Use Land Change(LULC)maps developed using the Maximum Likelihood classifier produce four principal classes:Built-up,Vegetation,Water body,and“Others”.In between 1990-2019,the total built-up area expanded by 130%,132 km^(2) in 1990 to 305 km^(2) in *** population growth is the chief contributor towards urban growth as the city added 3.9 km^(2) of additional built-up area to accommodate every 100,000 new ***,a Multi-Layer perceptron-Markov Chain model(MLp-MC)predicts Ahmedabad’s urban expansion by *** to 2019,the MLp-MC model predicts a 25%and 19%increase in Ahmedabad’s total urban area and population by ***,these trends shall generate many socio-economic and environmental ***,future urban development policies must balance further development and environmental damage.

关键词： land use land cover urbanization maximum likelihood classification multi-layer perceptron–Markov chain model

Analysis on Krasnoselskii’s fixed point theorem of fuzzy variable fractional differential equation for a novel coronavirus(COVID-19)model with singular operator

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International Journal of Modeling, simulation, and scientific Computing 2021年第3期12卷 150-166页

作者： pratibha Verma Manoj Kumar Anand shukla Department of Mathematics Motilal Nehru National Institute of Technology Allahabad Prayagraj 211004 Uttar PradeshIndia Department of Mathematics Wollega UniversityEthiopia

The fuzzy variable fractional differential equations(FVFDEs)play a very important role in mathematical modeling of *** scientists are studying and developing several aspects of these COVID-19 *** existence and uniqueness of the solution,stability analysis are the most common and important study *** is no study in the literature to establish the existence,uniqueness,and UH stability for fuzzy variable fractional(FVF)order COVID-19 *** to high demand of this study,we investigate results for the existence,uniqueness,and UH stability for the considered COVID-19 model based on FVFDEs using a fixed point theory approach with the singular ***,discuss the maximal/minimal solution for the FVFDE of the COVID-19 model.

关键词： Novel coronavirus(COVID-19) variable Caputo fractional derivative fixed point theorem existence and uniqueness Ulam-Hyers stability

some Characterizations of a Normal subgroup of a Group and Isotopic Classes of Transversals

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Algebra Colloquium 2016年第3期23卷 409-422页

作者： Vipul Kakkar R.p. shukla Department of Mathematics University of Allahabad Allahabad 211 002 India

Let G be a group and H be a subgroup of G which is either finite or of finite index in G. In this paper, we give some characterizations for the normality of H in G. As a consequence we get a very short and elementary proof of the main theorem of a paper of Lal and shukla, which avoids the use of the classification of finite simple groups. Further, we study the isotopy between the transversals in some groups and determine the number of isotopy classes of transversals of a subgroup of order 2 in D2p, the dihedral group of order 2p, where p is an odd prime and the isotopism classes are formed with respect to induced right loop structures.

关键词： right loop normalized right transversal right inverse property isotopy