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斜入射平面声波由弹性圆盘引起的散射

声学技术 1976年第2期 8-20页

作者： Max R.Knittel Charles s.nichols Don Barach 孙璇笙

在前一篇的报告中,作者们建立了表述平面声波在弹性物体上散射的数学模型,给出了平面声波垂直入射在一个圆盘上引起的散射的结果。在本文中,给出了平面声波斜入射到相同的圆盘上引起的散射的结果,把总散射截面计算成频率和入射角的函数... 详细信息

在前一篇的报告中,作者们建立了表述平面声波在弹性物体上散射的数学模型,给出了平面声波垂直入射在一个圆盘上引起的散射的结果。在本文中,给出了平面声波斜入射到相同的圆盘上引起的散射的结果,把总散射截面计算成频率和入射角的函数。对入射角为60°的入射波,把圆盘上算得的位移分布分解成圆盘在所选频率上的自由振动的本征方式。在几个有意义的频率上,还给出了总声压和散射声压的散射指向性图以及近场声压分布的等声压线。

关键词：调谐子声压指向性圆盘斜入射平面内自由振动自由共振简谐振动

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解弹性柱体声散射问题的有限元素法

声学技术 1981年第1期 53-68页

作者： John T.Hunt Max R.Knittel Charles s.nichols Don Barach 蒋廷华海军水下中心

本文给出一种近似方法,解弹性体被浸在无限流体介质中的声散射运动方程,此处发表的数字模型是用有限元素法来计算弹性体的振动响应及靠近弹性体周围的有限体积介质的声压场。使用解析方法来获得这种数字模型的边界条件,对于平面声波垂... 详细信息

本文给出一种近似方法,解弹性体被浸在无限流体介质中的声散射运动方程,此处发表的数字模型是用有限元素法来计算弹性体的振动响应及靠近弹性体周围的有限体积介质的声压场。使用解析方法来获得这种数字模型的边界条件,对于平面声波垂直入射到铝园盘上的情况发表了总的声散射截面,轴向声压,散射指向性图等结果.

关键词：方程式项数方程圆盘结构函数有限元素法矩阵数学分析声散射结构模型结构范式粒子模型声压

Effect of external and internal cues on core muscle activation during the sahrmann five-level core stability test

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World Journal of Methodology 2025年第1期15卷 95-104页

作者： skyla stifter Jessie McCaffrey Tyler nichols Ayse Ozcan Edeer Justine Ward Physical Therapy Dominican University New YorkOrangeburgNY 10962United States

BACKGROUND Pain in the back or pelvis or fear of back pain may affect the timing or cocontraction of the core *** both static and dynamic movements,the sahrmann core stability test provides an assessment of core muscle activation and a person's ability to stabilize the lumbopelvic *** cues and images can be used to increase the activation of these *** attain optimal movement patterns,it will be necessary to determine what cueing will give the most effective results for core *** To investigate the effects of external and internal cues on core muscle activation during the sahrmann five-level core stability *** Total 68 participants(21.83±3.47 years)were randomly allocated to an external(n=35)or internal cue group(n=33).Participants performed the sahrmann fivelevel core stability test without a cue as baseline and the five-level stability exercises with an internal or external *** cue group received a pressure biofeedback unit(PBU),and the internal cue group received an audio cue.A Delsys Trigno^(TM)surface electromyography unit was used for muscle activation from the rectus abdominis,external oblique,and transverse abdominis/internal oblique *** Linear mixed effects model analysis showed that cueing had a significant effect on core muscle activation(P=0.001);however,there was no significant difference between cue types(internal or external)(P=0.130).CONCLUsION Both external and internal cueing have significant effects on core muscle activation during the sahrmann five-level core stability test and the PBU does not create higher muscle activation than internal cueing.

关键词： External cue Internal cue Muscle activation Core muscles Lumbopelvic stability Pressure biofeedback unit

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

Microglial dysfunction and genetic risk for neurodegenerative disease

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases