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伴有明显的肝动脉-门静脉分流不能手术切除的肝细胞癌在门静脉梗阻期间经导管动脉化疗栓塞的初步研究

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国际医学放射学杂志 2009年第5期32卷 518-518页

作者： s.murata H.Tajima K.Nakazawa s.Onozawa s.Kumita K.Nomura 秦乃姗 Department of Radiology Center for Advanced Medical TechnologyNippon Medical School1-1-5 SendagiBunkyou-kuTokyo113-8602Japan

本研究的目的是评价肝细胞癌（HCC）和明显动脉-门静脉（AP）分流的病人在相应门静脉梗阻（TACE-PVO）期间经导管动脉化疗栓塞（TACE）的临床效果，为HCC伴有明显AP分流病人的TACE-PVO的前瞻性非随机研究。研究对象为21例不能手术切除的... 详细信息

本研究的目的是评价肝细胞癌（HCC）和明显动脉-门静脉（AP）分流的病人在相应门静脉梗阻（TACE-PVO）期间经导管动脉化疗栓塞（TACE）的临床效果，为HCC伴有明显AP分流病人的TACE-PVO的前瞻性非随机研究。研究对象为21例不能手术切除的HCC病人且伴有明显AP分流．接受线圈和（或）明胶海绵颗粒的分流栓塞（A组：n=7）或TACE-PVO（B组：n=14）。

关键词：化疗栓塞肝细胞癌动脉门静脉分流门静脉梗阻

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经皮胰腺灌注化疗中顺铂的最小化系统性泄露的初步研究

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国际医学放射学杂志 2015年第5期 470-470页

作者： s.murata s.Onozawa T.Mine T.Ueda F.sugihara D.Yasui 李伟 Departments of Radiology and Center for Advanced Medical Technology and Analytic Human Pathology Nippon Medical School

摘要目的评估猪模型中经皮胰腺灌注(PIPP)法的可行性。材料与方法实验均获得公共动物实验伦理委员会批准。15头猪被分为5组,分别实行PIPP。进行血管成像和注入对比染色剂以确保PIPP系统的开放性(第一组)。体外循环中含有顺铂的血液以3... 详细信息

摘要目的评估猪模型中经皮胰腺灌注(PIPP)法的可行性。材料与方法实验均获得公共动物实验伦理委员会批准。15头猪被分为5组,分别实行PIPP。进行血管成像和注入对比染色剂以确保PIPP系统的开放性(第一组)。体外循环中含有顺铂的血液以3种不同的注射流率进入胰腺循环中(40、60及80 m L/min),用来得到合适的注射流率以确保安全性及药理有效性(第2、3、4组中)。第5组使用最佳注射流率进行实验,分别评估按时间顺序得到的实验数据以及组

关键词：胰腺开放性顺铂注射流率

对比研究有无闭合的肾脏回路对经导管肾动脉栓塞的影响:对猪进行的药物动力学和组织学的评估

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国际医学放射学杂志 2009年第3期 277-277页

作者： s.Onozawa s.murata A.shimizu H.Tajima F.Hidaka s.I.Kumita 陈翔宇 Department of Radiology Nippon Medical School1-1-5 SendajiBunkyo-kuTokyo 1188603Japan

目的评估无水乙醇和碘化油单独经导管肾动脉栓塞(TAE)和存在闭合的肾脏回路的TAE(TAE/CRC)猪肾坏死的程度和无水乙醇的泄露情况。方法所有的动物实验都符合有关动物关爱和试验原则。先将14只猪分成2组:一组是标准的TAE,一组是TAE/CRC。... 详细信息

目的评估无水乙醇和碘化油单独经导管肾动脉栓塞(TAE)和存在闭合的肾脏回路的TAE(TAE/CRC)猪肾坏死的程度和无水乙醇的泄露情况。方法所有的动物实验都符合有关动物关爱和试验原则。先将14只猪分成2组:一组是标准的TAE,一组是TAE/CRC。在TAE/CRC组中,肾动脉和静脉都用球囊导管阻塞。在TAE组中,只有肾动脉被阻塞。2组都要将无水乙醇(0.5mL/kg体质量)和碘油(乳化率为4∶1)乳化液注入肾动脉。

关键词：肾动脉栓塞 CRC 经导管 TAE 肾脏回路

应用顺铂逆血流方向行经皮肝脏隔离灌注:药代动力学和可行性的试验研究

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国际医学放射学杂志 2015年第4期 401-401页

作者： s.murata s.Onozawa T.Mine T.Ueda F.sugihara D.Yasui 孟祥鹿 Department of Radiology/Center for Advanced Medical Technology Nippon Medical School

摘要目的本研究旨在评估经皮肝脏隔离灌注(PIHP)逆血流方向技术的可行性和其根本药代动力学。方法对12只经门静脉重新定向肝血流方向的雄性猪(体质量37~

关键词：药代动力学隔离灌注药物动力学顺铂肝脏血流方向

La3+ substitution-adjusted magnetic and optical properties with enhanced photocatalytic activity and stability of copper zinc nickel ferrites for wastewater treatment applications

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Journal of Rare Earths 2025年第2期43卷 319-328页

作者： N.s.Al-Bassami General studies Department Jubail Industrial College

Copper-zinc-nickel（Cu-Zn-Ni） ferrite nanoparticles are used for wastewater treatment ***,low degradation efficiency and stability are two main issues that make them unsuitable for actual production *** this paper,the citrate-nitrate auto-combustion method was applied for the formation of Cu0.5Zn0.25Ni0.25LaxFe2-xO4;（0≤x≤0.1;step 0.02）(CZNL) *** the substitution process entails the replacement of a small ion with a larger one,the lattice constant and crystallite size does not exhibit a consistent incremental *** behavior is justified and *** size of all the CZNL ferrite nanoparticles is in the range of 8-12 nm,and the lattice constant is in the range of 8.6230 to 8.4865 *** morphological analysis conducted using field emission-scanning electron microscopy（FE-sEM） reveals that the CZNL exhibits agglomerated spherical *** energy dispersive X-ray spectrameter（EDAX） analysis was employed to confirm the elemental composition of CZNL *** the process entails the substitution of Fe3+magnetic ions with nonmagnetic ions La3+,the magnetic parameters of CZNL nanoferrites show a general decreasing trend as *** 20 K,saturation magnetization Ms shows an overall drop in its values from 59.302 emu/g at x=0.0-41.295 emu/g at x=0.1,the smallest value of 37.87 emu/g is recorded at x=*** highest coercivity（Hc=125.9 Oe） and remanence（Mr=13.32 emu/g） are recorded for x=0.08 and x=0.04 nanoferrite,*** band gap of all the CZNL nanoferrites was determined using the Kubelka-Munk function and Tauc plot for direct permitted *** doping modifies the band gap（within 1.86-1.75 eV）,increases light absorption,induces efficient e/h separation and charge migration to *** nanoferrite Cu0.5Zn0.25Ni0.25La0.06Fe1.94O4achieves a degradation efficiency of 97.3% for methylene blue（MB） dye removal after just 60 *** five recycling processes,the nanoc

关键词： Copper-zinc-nickel Ferrite Photocatalytic properties Rare earths Wastewater treatment

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAURABH R.KIRAN D.sINGH R.VAIsH V.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： bio-inspired composite plate finite element method (FEM) Green-Lagrange helicoidal inverse hyperbolic shear deformation theory (IHsDT) nonlinear O322

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Multi-component decompositions, linear superpositions, and new nonlinear integrable coupled KdV-type systems

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Communications in Theoretical Physics 2025年第2期77卷 3-14页

作者： Xiazhi Hao s Y Lou school of Mathematical science Zhejiang University of Technology school of Physical science and Technology Ningbo University

In the realm of nonlinear integrable systems, the presence of decompositions facilitates the establishment of linear superposition solutions and the derivation of novel coupled systems exhibiting nonlinear integrability. By focusing on single-component decompositions within the potential BKP hierarchy, it has been observed that specific linear superpositions of decomposition solutions remain consistent with the underlying equations. Moreover, through the implementation of multi-component decompositions within the potential BKP hierarchy,successful endeavors have been undertaken to formulate linear superposition solutions and novel coupled Kd V-type systems that resist decoupling via alterations in dependent variables.

关键词： integrable system single-component decomposition multi-component decomposition linear superposition integrable coupled KdV-type system