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原子核物理评论 2009年第S1期26卷 153-157页

作者： s.kubono T.Teranishi M.Notani H.Baba s.Nishimura J.Y.Moon M.Nishimura s.Michimasa H.Iwasaki Y.Yanagisawa N.Hokoiwa M.Kibe J.H.Lee s.Kato Y.Gono C.s.Lee Center for Nuclear study University of Tokyo(CNS) Department of Physics Kyushu University RIKEN(The Institute of Physical and Chemical Research) Department of Physics Chung-Ang University Department of Physics Yamagata University

Proton resonant states in 22Mg have been investigated by the resonant elastic scattering of 21Na+p. The 21Na beam with a mean energy of 4.00 MeV/u was separated by the CNs radioactive ion beam separator(CRIB) and bombarded a thick(CH2)n target. The energy spectra of recoiled protons were measured at scattering angles of θcm ≈172° and 146°,respectively. A new state at 7.06 MeV has been observed clearly and another new one at 7.28 MeV is tentatively identified due to its low statistics. The proton resonant parameters were deduced from an R-matrix analysis of the differential cross section data. The astrophysical resonant reaction rate for the 18Ne(α,p)21Na reaction has been estimated,and it is about five times larger than that assumed before.

关键词： nuclear astrophysics reaction rate nuclear structure and property

关键天体反应18Ne(α，p)21Na的实验研究

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原子核物理评论 2013年第4期30卷 385-390页

作者：张立勇许世伟何建军 H.Yamaguchi s.kubono Y.Wakabayashi: 陈思泽胡钧马朋 Y.Togano T.Hashimoto D.Kahl T.Teranishil 陈若富王宏伟田文栋郭冰 s.Hayakawa N.Iwasa T.Yamada T.Komatsubara 中国科学院近代物理研究所甘肃兰州730000 兰州大学核科学与技术学院甘肃兰州730000 中国科学院大学北京100049 Center for Nuclear study(CNs) University of TokyoHirosawa 3510198 Japan Advanced science Research Center JAEA Tokai Ibaraki 3191195 Japan RIKEN Hirosawa Wako Saitama 3510198 Japan Department of Physics University of KyushuFukuoka 8128581 Japan 中国科学院上海应用物理研究所上海201800 中国原子能科学研究院北京102413 Department of Physics University of TohokuSendal 9808577 Japan Department of Physics University of TsukubaTsukuba 3050006 Japan

在X射线暴高温高密度的环境中,18Ne(α,p)21Na很可能是由热CNO循环突破到rp过程的一个重要反应。到目前为止,人们测得的反应率还存在很大的不确定性。实验中用CRIB(CNs Radioactive Ion Beam separator)提供的21Na放射性束轰击8.8 mg/cm... 详细信息

在X射线暴高温高密度的环境中,18Ne(α,p)21Na很可能是由热CNO循环突破到rp过程的一个重要反应。到目前为止,人们测得的反应率还存在很大的不确定性。实验中用CRIB(CNs Radioactive Ion Beam separator)提供的21Na放射性束轰击8.8 mg/cm2的聚乙烯厚靶,利用放置在θlab=-14°,0°,14°处的3套硅条探测器望远镜阵列对反冲轻粒子进行鉴别和测量,测得在一段能区(Ex=5.5～9.2MeV)内21Na(p,p)21Na的激发函数。通过对21Na(p,p)共振弹性散射截面进行R矩阵拟合,得到了22Mg共振能级的自旋宇称以及质子宽度等信息,从而为计算18Ne(α,p)21Na反应率提供了实验参数。

关键词：核天体物理 X射线暴放射性束厚靶方法共振散射

Neutron and Alpha structure in Neutron Deficient Nuclei in Astrophysics

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原子核物理评论 2016年第2期33卷 212-216页

作者： s.kubono 何建军 H.Yamaguchi D.M.Kahl s.Hayakawa T.Teranishi s.Cheribini M.Gulino Y.K.Kwon T.Hashimoto Y.Wakabayashi N.Iwasa s.Kato T.Komatsubara D.N.Binh L.H.Khiem N.N.Duy T.Kawabata C.spitaleri G.G.Rapisarda M.La Cognata L.Lamia R.G.Pizzone s.Romano A.Coc N.de sereville F.Hammache G.Kiss s.Bishop Institute of Modern Physics Chinese Academy of Sciences RIKEN Nishina Center Center for Nuclear study University of Tokyo Department of Physics Kyushu University Laboratori Nazionali del sud Istituto Nazionale di Fisica Nucleare Institute for Basic science 70Yuseong-daero 1689-gil RIKEN Nishina Center 2-1 Hirosawa Department of Physics Tohoku University Department of Physics Yamagata University Institute of Physics Vietnam Academy for Science and Technology Department of Physics Kyoto University IN2P3 Institute for Nuclear Research (MTA-ATOMKI) TUM

The paper includes discussions on the important role of neutron and alpha configurations in proton-rich nuclei in nuclear astrophysics in terms of nucleosynthesis under extremely high-temperature hydrogenburning conditions. The νp-process, which is supposed to take place at the very early epoch of type II supernovae, has considerable neutrons and alphas together with protons. The alpha-induced reactions on proton-rich unstable nuclei in the light mass regions is expected to play a crucial role, but very few of them were investigated well yet because of the experimental difficulties. specifically, I report our recent experimental effort for the breakout process from the pp-chain region,~7Be(α, γ)^(11)C(α,p)^(14)N under the νp-process. The neutron-induced reactions on proton-rich nuclei, which is even more a challenging subject, were investigated previously for very few nuclei. One possible experimental method is the Trojan Horse Method(THM). We successfully have applied THM to the ^(18)F(n,α)^(14)N reaction study with an unstable beam of ^(18)F.

关键词： alpha-and neutron-induced stellar reactions in proton-rich nuclear region νp-process pp-chain breakout nuclear cluster structures in astrophysics low-energy RI beam

~1H(^(17)F,α)^(14)O反应截面测量

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原子核物理评论 2019年第1期36卷 37-42页

作者：贾宝路胡钧何建军许世伟 H.Yamaguchi D.Kahl 马朋苏俊王宏伟 T.Nakao Y.Wakabayashi T.Teranishi K.I.Hahn J.Y.Moon H.s.Jung T.Hashimoto A.A.Chen D.Irvine C.s.Lee s.kubono 中国科学院近代物理研究所兰州730000 中国科学院大学核科学与技术学院北京100049 中国科学院国家天文台北京100101 Center for Nuclear study (CNs) University of Tokyo 中国原子能科学研究院北京102413 中国科学院上海应用物理研究所上海201800 RIKEN Nishina Center Department of Physics Kyushu University Department of science Education Ewha Womans University Department of Physics Chung-Ang University RCNP Osaka University Department of Physics & Astronomy McMaster University

^(14)O(α, p)^(17)F是天体X射线暴中重要的突破反应。本工作通过厚靶方法测量其逆反应~1H(^(17)F,α)^(14)O的反应截面来研究这一关键反应。本实验工作是在日本东京大学原子核科学研究中心(CNs)的低能次级束流线(CRIB)上完成的,后续的... 详细信息

^(14)O(α, p)^(17)F是天体X射线暴中重要的突破反应。本工作通过厚靶方法测量其逆反应~1H(^(17)F,α)^(14)O的反应截面来研究这一关键反应。本实验工作是在日本东京大学原子核科学研究中心(CNs)的低能次级束流线(CRIB)上完成的,后续的扣除本底实验是在兰州放射性束流线(RIBLL1)上完成的。CRIB实验是通过~2H(^(16)O,n)^(17)F转移反应产生^(17)F次级束,经过CRIB分离提纯之后,利用该次级束轰击氢气靶。在氢气靶后布置了三套望远镜探测器系统,用以探测不同实验角度的反冲α粒子,在数据处理的过程中经过动力学重构后得到了~1H(^(17)F,α)^(14)O反应在质心系能区E_(c.m.)=2.7～3.4 MeV的反应截面。实验结果在3 MeV以上的高能区与前人的薄靶实验数据是一致的,在低能区本工作获得了新的实验数据,倾向于支持干涉相消的理论预言结果。

关键词： X射线暴厚靶方法放射性核束反应截面激发函数

Measurement of^(25)Al+p Resonant scattering

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IMP & HIRFL Annual Report 2019年第1期 54-55页

作者： Hu Jun H.Yamaguchi Xu shiwei Zhang Ningtao Ma shaobo Ru Longhui Liu Enqiang Liu Tong s.Hayakawa Yang Lei H.shimizu D.Kahl C.B.Hamill A.Murphy su Jun Fang Xiao K.Chae M.Kwag s.Cha N.N.Duy N.K.Uyen D.Kim R.G.Pizzone M.La Cognata s.Cherubini s.Romano A.Tumino J.Liang A.Psaltis M.sferrazza D.Kim s.kubono 不详

Type I X-ray bursts are the most frequently observed thermonuclear explosions in nature[1].They take place on the surface of accreting neutron star in low-mass X-ray binary systems.

关键词： scattering systems.

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17F+p共振散射的研究（英文）

IMP & HIRFL Annual Report 2012年第0期 55-56页

作者：胡钧 He Jianjun Xu shiwei H.Yamaguchi Ma Peng K.David su Jun Wang Hongwei T.Nakao Y.Wakabayashi J.Y.Moon T.Teranishi H.s.Jung T.Hashimoto A.Chen D.Irvine s.kubono Center for Nuclear study the University of Tokyo China Institute of Atomic Energy(CIAE) shanghai Institute of Applied Physics(sINAP) CAS Nishina Center RIKEN Department of Physics Chung-Ang University Department of Physics Kyushu University RCNP Osaka University Department of Physics and Astronomy McMaster University

X-ray bursts[1]are probably an important source for the production of proton-rich nuclei via the high temperature rp-process[2],and the 14 O(α,p)17F reaction is thought to be one of the crucial stellar reactions during the ignition *** far,its reaction rate is still ***,the studies of this waiting-point reaction are of great nuclear astrophysical importance to understand the energy generation and nucleosynthesis in the explosive stellar environments.

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Quasi-elastic scattering of 17F on 12C target at 60 MeV

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Quasi-elastic scattering of 17F on 12C target at 60 MeV

Revisiting cerebral endothelial cells in Alzheimer’s disease

第十四届全国核结构大会暨第十次全国核结构专题讨论会

作者： s.kubono H.Yamaguchi s.Hayakawa D.N.Binh Y.K.Kwon N.Iwasa M.Mazzocco M.La Commara Y.K.Kwon N.Iwasa a di Padova and Istituto Nazionale di Fisica Nucleare-sezione di Padova,via F.Marzolo 8,I-35131 Padova,Italy a diapoli,via Cinthia,I-80126 Napoli,Italy M.Romoli a di Padova and Istituto Nazionale di Fisica Nucleare-sezione di Padova,via F.Marzolo 8,I-35131 Padova,Italy Center of Nuclear study University of TokyoJapan Department of Physics Chung-Ang UniversitySeoul 156-756South Korea Istituto Nazionale di Fisica Nucleare-sezione di Napoli via CinthiaI-80126 NapoliItaly

Quasi-elastic scattering angular distribution of the exotic nucleus F on a C target at 60 MeV was *** experimental data have been analyzed by means of the optical model and continuum discretized coupled-channels(CDCC)...

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch