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Journal of Ocean Engineering and science 2022年第1期7卷 92-98页

作者： Ram Prakash sharma s.R.Mishra Department of Mechanical Engineering National Institute of TechnologyArunachal PradeshYupia 791112Papum Pare DistrictArunachal Pradesh Department of Mathematics Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswar 751030OdishaIndia

The current paper explores the behavior of the thermal radiation on the time-independent flow of mi-cropolar fluid past a vertical stretching surface with the interaction of a transverse magnetic *** ef-fect of thermo-diffusion(soret)along with the heat source is incorporated to enhance the thermal ***,the convective solutal condition is considered that affects the mass transfer *** transformed equations are modeled using suitable similarity ***,the complex cou-pled equations are handled mathematically employing the Runge-Kutta-Felhberg *** behavior of characterizing parameters on the flow phenomena as well as the engineering coefficients are displayed via graphs and the validation of the current outcome is reported with the previously published results in particular cases.

关键词： Magnetohydrodynamic Thermal radiation Heat source Thermo-diffusion Chemical reaction Runge-Kutta-Felhberg method

Non-occlusive mesenteric ischemia: Diagnostic challenges and perspectives in the era of artificial intelligence

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World Journal of Gastroenterology 2021年第26期27卷 4088-4103页

作者： simon Bourcier Julian Klug Lee s Nguyen Department of Intensive Care Medicine University Hospital of GenevaGeneva 1201Switzerland Department of Internal Medicine Groupement Hospitalier de l’Ouest LémaniqueNyon 1260Switzerland Department of Intensive Care Medicine CMC Ambroise ParéNeuilly-sur-Seine 92200France

Acute mesenteric ischemia(AMI)is a severe condition associated with poor prognosis,ultimately leading to death due to multiorgan *** mechanisms may lead to AMI,and non-occlusive mesenteric ischemia(NOMI)represents a particular form of *** is prevalent in intensive care units in critically ill *** NOMI management,promptness and accuracy of diagnosis are paramount to achieve decisive treatment,but the last decades have been marked by failure to improve NOMI prognosis,due to lack of tools to detect this *** real-life diagnostic management relies on a combination of physical examination,several biomarkers,imaging,and endoscopy to detect the possibility of several grades of NOMI,research studies only focus on a few elements at a *** the era of artificial intelligence(AI),which can aggregate thousands of variables in complex longitudinal models,the prospect of achieving accurate diagnosis through machine-learning-based algorithms may be *** the following work,we bring you a state-of-the-art literature review regarding NOMI,its presentation,its mechanics,and the pitfalls of routine work-up diagnostic exams including biomarkers,imaging,and endoscopy,we raise the perspectives of new biomarker exams,and finally we discuss what AI may add to the field,after summarizing what this technique encompasses.

关键词： Mesenteric ischemia Biomarkers Critically ill Machine learning Artificial intelligence

Trends in lactose-derived bioactives:synthesis and purification

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systems Microbiology and Biomanufacturing 2022年第3期2卷 393-412页

作者： Carlos Vera Cecilia Guerrero Andrés Illanes Department of Biology Faculty of Chemistry and BiologyUniversidad de Santiago de Chile(USACH)SantiagoChile school of Biochemical Engineering Pontificia Universidad Católica de Valparaíso(PUCV)ValparaisoChile

Lactose obtained from cheese whey is a low value commodity despite its great potential as raw material for the production of bioactive *** them,prebiotics stand out as valuable ingredients to be added to food matrices to build up functional foods,which currently represent the most active sector within the food *** foods market has been growing steadily in the recent decades along with the increasing awareness of the World population about healthy nutrition,and this is having a strong impact on lactose-derived *** of them are produced by enzyme biocatalysis because of molecular precision and environmental sustainability *** current status and outlook of the production of lactose-derived bioactive compounds is presented with special emphasis on downstream operations which are critical because of the rather modest lactose conversion and product yields that are *** though some of these products have already an established market,there are still several challenges referring to the need of developing better catalysts and more cost-effective downstream operations for delivering high quality products at affordable *** technological push is expected to broaden the spectrum of lactose-derived bioactive compounds to be produced at industrial scale in the near future.

关键词： Prebiotic Lactose β-Galactosidase Oligosaccharide purification

silicothermic reduction of MgO using diode laser:Experimental and kinetic study

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Journal of Magnesium and Alloys 2017年第4期5卷 430-438页

作者： M.s.Mahmoud T.Yabe Chemical Engineering Department Faculty of EngineeringMinia UniversityMinia61516Egypt Engineering Department Collage of Applied ScienceSuhar311Oman Mechanical Engineering Department Tokyo Institute of Technology2-12-1 O-okayamaMeguroTokyo 152-8552Japan Energy Genesis Cycle 405 East Wing3-2-1 SakadoTakatsukuKawasaki CityKanagawa 213-0012Japan

As a step toward realizing magnesium civilization,which needs a sustainable Mg production process,the reduction of MgO to Mg has been *** diode laser(DDL)produces high power and continuous beam in tiny *** laser with energy density up to 83*10^(5) W/cm^(2) is focused on MgO/si target inside the vacuum chamber,creating the high temperature zone,which stimulates the Mg production *** vapor is collected on the copper plate;and then,analyzed chemically in terms of Mg production *** largest reduction and energy efficiencies in Ar atmosphere were 41%and 15.3 mg kJ^(−1),while in the vacuum,13.5%and 15.8 mg kJ^(−1) were *** reactions of MgO and si have been *** revealed that the MgO reduction with si proceeds as heterogeneous *** rate of reaction of si with MgO is faster than the rate of MgO evaporation and Mg vapor deposition.

关键词： Diode laser Magnesium oxide Magnesium Reduction silicon

An estimation of the velocity profile for the laminar-turbulent transition in the plane jet on the basis of the theory of stochastic equations and equivalence of measures

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Advances in Aerodynamics 2022年第1期4卷 876-887页

作者： Artur V.Dmitrenko A.s.selivanov Department of Thermal Engineering Russian University of Transport(MIIT)Obraztsova Street 9Moscow127994Russian Federation

The theory of stochastic equations and the theory of equivalence of measures previously applied to flows in the boundary layer and in the pipe are considered to calculate the velocity profile of the flat *** theory previously made it possible to determine the critical Reynolds number and the critical point for the flow of the plane *** based on these results the analytical dependence for the index of the velocity profile is *** profiles are calculated for a laminar-turbulent transition in the *** formula reliably reflects an increase of the energy transferred from a deterministic state to a random one with an increase of the index of the velocity *** show satisfactory agreement with the known experimental data for the velocity profile of the flat *** obtained results it is possible to determine the location of technical devices for laminarization of the flow in the *** is important both for reducing friction in the flow around aerodynamic vehicles and for maintaining the jet profile if it is necessary to ensure the stability of the flow *** the obtained relations can be useful for researching of the processes in combustion chambers,in the case of welding and in other technical devices.

关键词： stochastic equations Equivalence of measures Turbulence Critical point Reynolds number The velocity profile The flat jet

Development of a sensitive and rapid method for quantitation of (s)-(-)- and (R)-(+)-metoprolol in human plasma by chiral LC–EsI–Ms/Ms

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Journal of Pharmaceutical Analysis 2014年第1期4卷 63-79页

作者： Primal sharma Pritesh Contractor swati Guttikar Daxesh P.Patel Pranav s.shrivastav Department of Chemistry School of Sciences Gujarat University Bioanalytical Research Department Veeda Clinical Research

A selective, sensitive and high throughput liquid chromatography-tandem mass spectro-metry （LC-EsI-Ms/Ms） method has been developed for separation and quantification of metoprolol enantiomers on a chiral Lux Amylose-2 （250 mm＆#215;4.6 mm, 5 mm） column. solid phase extraction of （s）-（-）- and （R）-（t）-metoprolol and rac-metoprolol-d6 as an internal standard （Is） was achieved on Lichrosep DVB HL cartridges employing 200 mL human plasma. Both the analytes were chromatographically separated with a resolution factor of 2.24 using 15 mM ammonium acetate in water, pH 5.0 and 0.1% （v/v） diethyl amine in acetonitrile （50：50, v/v） as the mobile phase within 7.0 min. The precursor-product ion transitions for the enantiomers and Is were monitored in the multiple reaction monitoring and positive ionization mode. The method was validated over the concentration range of 0.500-500 ng/mL for both the enantiomers. Matrix effect was assessed by post-column analyte infusion experiment and the mean extraction recovery was greater than 94.0% for both the enantiomers at all quality control levels. The stability of analytes was evaluated in plasma and whole blood under different storage conditions. The method was successfully applied to a clinical study in 14 healthy volunteers after oral administration of 200 mg metoprolol tablet under fasting conditions. The assay reproducibility is shown by reanalysis of 68 incurred samples. The suitability of the developed method was assessed in comparison with＆amp;nbsp;different chromatographic methods developed for stereoselective analysis of metoprolol in biological matrices.

关键词： s-(-)-metoprolol R-(+)-metoprolol Chiral column Chromatographicseparation LC-EsI-Ms/Ms Human plasma

Estimate of parameters changing of the Lymantria dispar artificial population in different environmental conditions using the quasispecies model

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International Journal of Modeling, simulation, and scientific Computing 2020年第5期11卷 226-236页

作者： A.V.sedelnikov E.s.Khnyryova samara National Research University 34Moskowskoe ShosseSamara 443086Russia

This paper gives an interpretation of the quasispecies concept for an experiment of growing the Lymantria dispar artificial *** changes estimate in the population parameters for a significant change in environmental conditions at the stage of hatching caterpillars from the eggs was *** numerical and two random parameters were used for quantitative *** characterize the development of individuals of the population at this *** parameter changes significance was verified with using statistical *** results obtained do not contradict the quasispecies *** use of fuzzy sets describes the transition from one quasispecies to another at a significant change in environmental conditions.

关键词： Quasispecies evolution Lymantria dispar artificial population population development parameters fuzzy sets

strongα-cut and associated membership-based modeling for fuzzy time series forecasting

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International Journal of Modeling, simulation, and scientific Computing 2021年第1期12卷 53-72页

作者： Gunjan Goyal Dinesh C.s.Bisht Department of Mathematics Jaypee Institute of Information Technology NoidaIndia

In this paper,a method is proposed to deal with factors affecting the fuzzy time series forecasting.A new fuzzification process is used by considering all the fuzzy sets with nonzero membership values corresponding to the data points.A strong alpha-cut based method is presented to select appropriate fuzzy logical relationships that carry importance in analyzing the trend of time ***,a unique defuzzification approach based on weights is proposed to get crisp *** obtained variation is finally converted to the forecasted *** presented method is tested on the benchmark enrolment dataset of Alabama University and seven datasets of the Taiwan Capitalization Weighted stock *** comparing the results,it is observed that the presented method performs better than the existing ***,the statistical measures indicate the good forecasting results of the presented method.

关键词： Associated membership grade forecasting fuzzy logical relationship fuzzy time series strongα-cut

Colorectal cancer vaccines: Tumor-associated antigens vs neoantigens

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World Journal of Gastroenterology 2018年第48期24卷 5418-5432页

作者： sandra Wagner Christina s Mullins Michael Linnebacher section of Molecular Oncology and Immunotherapy General SurgeryUniversity Medical Center

Therapeutic options for the treatment of colorectal cancer(CRC) are diverse but still not always satisfying. Recent success of immune checkpoint inhibition treatment for the subgroup of CRC patients suffering from hypermutated tumors suggests a permanent role of immune therapy in the clinical management of CRC. substantial improvement in treatment outcome could be achieved by development of efficient patient-individual CRC vaccination strategies. This mini-review summarizes the current knowledge on the two general classes of targets: tumor-associated antigens(TAAs) and tumorspecific antigens. TAAs like carcinoembryonic antigen and melanoma associated antigen are present in and shared by a subgroup of patients and a variety of clinical studies examined the efficacy of different TAA-derived peptide vaccines. Combinations of several TAAs as the next step and the development of personalized TAA-based peptide vaccines are discussed. Improvements of peptidebased vaccines achievable by adjuvants and immunestimulatory chemotherapeutics are highlighted. Finally, we sum up clinical studies using tumor-specific antigens-in CRC almost exclusively neoantigens-which revealed promising results; particularly no severe adverse events were reported so far. Critical progress for clinical outcomes can be expected by individualizing neoantigen-based peptide vaccines and combining them with immunestimulatory chemotherapeutics and immune checkpoint inhibitors. In light of these data and latest developments, truly personalized neoantigen-based peptide vaccines can be expected to fulfill modern precision medicine's requirements and will manifest as treatment pillar for routine clinical management of CRC.

关键词： Cancer vaccines Colorectal neoplasm Immunotherapy Neoplasm antigen tumor-associated antigens tumor-specific antigens Neoantigen(s)

Classifying Machine Learning Features Extracted from Vibration signal with Logistic Model Tree to Monitor Automobile Tyre Pressure

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structural Durability & Health Monitoring 2017年第2期11卷 191-208页

作者： P.s.Anoop V.sugumaran school of Mechanical and Building sciences(sMBs) Vellore Institute of Technology Chennai campusChennaiIndia

Tyre pressure monitoring system(TPMs)is compulsory in most countries like the United states and European *** existing systems depend on pressure sensors strapped on the tyre or on wheel speed sensor data.A difference in wheel speed would trigger an alarm based on the algorithm *** this paper,machine learning approach is proposed as a new method to monitor tyre pressure by extracting the vertical vibrations from a wheel hub of a moving vehicle using an *** obtained signals will be used to compute through statistical features and histogram features for the feature extraction *** LMT(Logistic Model Tree)was used as the classifier and attained a classification accuracy of 92.5%with 10-fold cross validation for statistical features and 90.5% with 10-fold cross validation for histogram *** proposed model can be used for monitoring the automobile tyre pressure successfully.

关键词： Machine learning Vibration accelerometer statistical Features Histogram Features Logistic model tree(LMT) Tyre pressure monitoring system