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Role of GAP-43 in Differentiation of Cerebellar Granule Cells

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Role of GAP-43 in Differentiation of Cerebellar Granule Cell...

Gut health,stress,and immunity in neonatal dairy calves:the host side of host-pathogen interactions

亚太地区国际脑研究研讨会

作者： R Mishra k F Meiri s Mani National Brain Research Centre ManesarGurgaon-122050HaryanaIndia Tufts University School Of MedicineBostonUSA National Brain Research Centre ManesarGurgaon-122050HaryanaIndia Tufts University School Of MedicineBostonUSA National Brain Research Centre ManesarGurgaon-122050HaryanaIndia Tufts University School Of MedicineBostonUSA

＜正＞ GAP-43 is a nervous system specific protein that plays an important role in regulating growth cone responses to extracellular signals. GAP-43 is expressed as early as E9.5 in mouse, which implicates its possible role in neurogenesis. All GAP-43 （-/-） mice display abnormal foliation of specific lobules at the cerebellar vermis, a defect that is apparent from the day of birth. Further, GAP-43 knockout mice have smaller cerebella and reduced size of external granule cell layer. We investigated whether the reduction in EGL was due to reduced cell proliferation. Using whole cerebellar cultures from P4 wild type and knockout mice we show that there is a two-fold increase in BrdU labeled cells in the knock out cultures

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Journal of Animal science and Biotechnology 2021年第1期12卷 49-63页

作者： Johan.s.Osorio Dairy and Food science Department South Dakota State University113 H Alfred Dairy Science HallBrookingsSD 57007USA

The cumulative evidence that perinatal events have long-lasting ripple effects through the life of livestock animals should impact future nutritional and management recommendations at the farm level. The implications of fetal programming due to malnutrition, including neonatal survival and lower birth weights, have been characterized,particularly during early and mid-gestation, when placental and early fetal stages are being developed. The accelerated fetal growth during late pregnancy has been known for some time, while the impact of maternal stressors during this time on fetal development and by extent its postnatal repercussions on health and performance are still being *** stressors during late pregnancy cannot only influence colostrogenesis but also compromise adequate intestinal development in the fetus, thus, that further limits the newborn's ability to absorb nutrients, bioactive compounds, and immunity(i.e., immunoglobulins, cytokines, and immune cells) from colostrum. These negative effects set the newborn calf to a challenging start in life by compromising passive immunity and intestinal maturation needed to establish a mature postnatal mucosal immune system while needing to digest and absorb nutrients in milk or milk replacer. Besides the dense-nutrient content and immunity in colostrum, it contains bioactive compounds such as growth factors, hormones, and cholesterol as well as molecular signals or instructions [e.g., microRNAs(miRNAs) and long non-coding RNAs(lncRNAs)] transferred from mother to offspring with the aim to influence postnatal gut maturation. The recent change in paradigm regarding prenatal materno-fetal microbiota inoculation and likely the presence of microbiota in the developing fetus intestine needs to be addressed in future research in ruminants. There still much to know on what prenatal or postnatal factors may predispose neonates to become susceptible to enteropathogens(e.g., enterotoxigenic Escherichia coli), causing

关键词： Dairy calves Fecal RNA Neonatal diarrhea

Minerogenetic mechanism of Rushan gold deposit, shandong Province——Evidence of ore-forming fluid and H, O, sr isotopes

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Chinese science Bulletin 1997年第3期42卷 240-243页

作者： Zhai, JP Hu, k Lu, JJ Department of Earth sciences Nanjing University Nanjing 210093 China

THE Rushan gold deposit, being of quartz-vein type, is located in biotite monzonitic granite of kunyushan complex pluton in eastern shandong, China, and the orebody No. 2 is the largest mono-vein deposits found in China. The gold mineralization can be divided into three stages according to crisscross relations of the various microlodes in the deposit: Ⅰ. pre-ore stage of comb-structured milky-white quartz veins; Ⅱ. main mineralization stage of multi-metal sulphides and siderite-quartz veins; Ⅲ. post-ore stage of mottled cryptocrystalline quartz veins.

关键词： granite quartz-vein type gold deposit ore-forming fluid origin of deposit.

A　study　on　the　Reaction　Mechanism　of　Bromocresol　Green　with　Bovine　serum　Albumin

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Chinese Chemical Letters 1996年第11期7卷 1029-1032页

作者： Zhu, k Li, kA Tong, sY BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA

The protein assay with bromocresol green (BCG) method is commonly ed because of itsconvenience, but it is not well understood on a molecular level. In this paper, the study on thereaction between BCG and bovine serum albumin (BsA) is reported The binding numbers and thebinding constants are given at different pH by using three methods with relevant comparison. It wasProved that there were three sorts of binding sites of BsA to react with BCG and BCG transformedinto its boo form in the presence of BsA.

关键词： Reaction Mechanism the Bovine Green Bromocresol

The Petrov–Galerkin finite element method for the numerical solution of time-fractional sharma–Tasso–Olver equation

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International Journal of Modeling, simulation, and scientific Computing 2019年第1期10卷 95-105页

作者： A.k.Gupta s.saha Ray kIIT University School of Applied Sciences Bhubaneswar 751024India National Institute of Technology Department of Mathematics Rourkela 769008 India

In this paper,time-fractional sharma-Tasso-Olver(sTO)equation has been solved numerically through the Petrov-Galerkin approach utilizing a quintic B-spline function as the test function and a linear hat function as the trial *** Petrov-Galerkin technique is effectively implemented to the fractional sTO equation for acquiring the approximate solution *** numerical outcomes are observed in adequate compatibility with those obtained from variational iteration method(VIM)and exact *** fractional order,the numerical outcomes of fractional sharma-Tasso-Olver equations are also compared with those obtained by variational iteration method(VIM)in song et al.[song L.,Wang Q.,Zhang H.,Rational approximation solution of the fractional sharma-Tasso-Olver equation,***.224:210-218,2009].Numerical experiments exhibit the accuracy and efficiency of the approach in order to solve nonlinear fractional sTO equation.

关键词： Fractional sharma-Tasso-Olver equation Petrov-Galerkin method B-spline Grunwald-Letnikov fractional derivative

soil Aggregates, Organic Matter, and Labile C and N Fractions after 37 Years of N, P and k Applications to an Irrigated subtropical soil under Maize-Wheat Rotation

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Journal of Agricultural science and Technology(A) 2011年第2X期1卷 170-181页

作者： s. kumar M. s. Aulakh A. k. Garg Department of soil science Punjab Agricultural University Ludhiana 141004 Punjab India

Abstract： Physical, chemical and biological soil properties in surface （0-5 cm） and subsurface soil （5-15 cm） were determined in a field experiment conducted with seven treatments consisted of different combinations of fertilizer N （0, 100 and 200 kg N ha^-1）, P （0, 22 and 44 kg P2O5 ha^-1） and k （0, 41 and 82 kg k2O ha^-1） applied both to summer-grown maize （Zea mays L.） and winter-grown wheat （Triticum aestivum L.） crops continuously for 37 years under irrigated subtropical conditions. Application of N, P and k significantly increased water stable aggregates and had profound effects in increasing the mean weight diameter as well as the formation of macro-aggregates, which were highest in both surface （81%） and subsurface （74%） soil layers with application of 100 kg N ＋ 22 kg P2O5 ＋ 41 kg k2O ha^-1 （N100P22k41）. The N100P22k41 treatment also enhanced total organic C （TOC） from 4.4 g kg^-1 in no-NPk control to 4.8 g kg^-1in surface layer and from 3.3 to 4.1 g kg1 in subsurface layer leading to the 20% higher TOC stocks in 0-15 cm soil. The labile C and N fractions such as water soluble C, particulate and light fraction organic matter, potentially mineralizable N and microbial biomass were also highest under the optimized balanced application of N100P22k41. Relatively higher increase in all labile fractions of C and N as proportion of TOC and total N, respectively suggested that these are potential indicators to reflect changes in management practices long before changes in TOC and TN are detectable. These results demonstrated that optimized balanced application of N, P and k is crucial for improving soil health ensuring long-term sustainability of farming systems in semiarid subtropical soils.

关键词： Total organic C water stable aggregate water soluble C particulate and light fraction organic matter potentiallymineralizable N microbial biomass C and N soil health.

Physiological Basis of stagnant Flooding Tolerance in Rice

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Rice science 2017年第2期24卷 73-84页

作者： sandhya R.kUANAR Anuprita RAY santosh k.sETHI krishnendu CHATTOPADHYAY Ramani k.sARkAR Crop Physiology&Biochemistry Division National Rice Research InstituteCuttack 753006India

stagnant flooding(sF) is an important constraint which prolonges partial submergence damages of rice plants and reduces grain yield. Due to the heterogeneity in flood-prone ecosystem, many different types of traditional rice varieties are being grown by the farmers. The local landraces adapted to extreme in water availability could be the sources of new gene(s) which would be utilized to improve the adaptability of rice to sF with high yield. The main goal of this study is to identify new genetic resources tolerant to sF based on morpho-physiological traits. A total of 16 rice varieties were selected after initial screening from more than 400 rice varieties which were collected from eastern states of India. The increase rate of plant height was higher under sF compared to control, whereas no such trend was observed in the increment rate of aboveground total dry weight and culm dry weight. Area of aerenchyma gas spaces per tiller increased whereas root oxidase activity decreased under sF. The reduction of root oxidase activity, leaf area, and leaf dry weight was higher in susceptible varieties under sF compared to control. stability index for different grain yield and yield attributes revealed that the impact of sF differed among different varieties. Correlation coefficient studies among different parameters taking stability index showed significant association with the grain yield. Based on the findings, it was concluded that maintenance of equivalent panicle weight and panicle number, plant height and harvest index at the maturity stage, leaf area, leaf and culm dry weights, root oxidase activity and tiller numbers at the flowering stage under sF compared to control help the plant to counteract the adverse effects of sF.

关键词： morpho-physiological trait rice stagnant flooding yield

Establishing the role of detoxifying enzymes in field-evolved resistance to various insecticides in the brown planthopper （Nilaparvata lugens） in south India

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Insect science 2017年第1期24卷 35-46页

作者： Vijayakumar Maheshwari Malathi sushil k. Jalali Dandinashivara k. sidde Gowda Muthugounder Mohan Thiruvengadam Venkatesan Division of Molecular Entomology ICAR-National Bureau of Agricultural Insect Resources Bengaluru 560 024 Karnataka India Department of Entomology College of Agriculture University of Agricultural Sciences-Bengaluru V.C. Farm Mandya 571 478 Karnataka India

The brown planthopper （BPH）, Nilaparvata lugens （stal）, is one of the major pests of rice throughout Asia. Extensive use of insecticides for suppressing N. lugens has resulted in the development of insecticide resistance leading to frequent control failures in the field. The aim of the present study was to evaluate resistance in the field populations of N. lugens from major rice growing states of south India to various insecticides. We also determined the activity of detoxifying enzymes （esterases [EsTs], glutathione s- transferases [GsTs], and mixed-fimction oxidases [MFOs]）. Moderate levels of resistance were detected in the field populations to acephate, thiamethoxam and buprofezin （resistance factors 1.05-20.92 fold, 4.52-14.99 fold, and 1.00-18.09 fold, respectively） as compared with susceptible strain while there were low levels of resistance to imidacloprid （resistance factor 1.23-6.70 fold） and complete sensitivity to etofenoprox （resistance factor 1.05- 1.66 fold）. EsT activities in the field populations were 1.06 to 3.09 times higher than the susceptible strain while for GsT and MFO the ratios varied from 1.29 to 3.41 and 1.03 to 1.76, respectively. The EsT activity was found to be correlated to acephate resistance （r = 0.999, P ≥ 0.001）. The high selection pressure of organophosphate, neonicotinoid, and insect growth regulator （IGR） in the field is likely to be contributing for resistance in BPH to multiple insecticides, leading to control failures. The results obtained will be beneficial to IPM recommendations for the use of effective insecticides against BPH.

关键词： esterases glutathione s-transferases insecticide resistance mixed function oxidases Nilaparvata lugens toxicological bioassay

scaling behavior of the thermopower of the archetypal heavy-fermion metal YbRh2si2

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Frontiers of physics 2016年第2期11卷 89-95页

作者： V. R. shaginyan A. Z. Msezane G. s. Japaridze k. G. Popov J. W. Clark V. A. khodel Petersburg Nuclear Physics Institute NRC Kurchatov Institute Gatchina 188300 Russia Clark Atlanta University Atlanta GA 30314 USA komi science Center Ural Division RAS Syktyvkar 167982 Russia Department of Physics St. Petersburg State University Russia McDonnell Center for the space sciences 8J Department of Physics Washington University St. Louis MO 63130 USA Centro de Ciencias Matemdticas Universidade de Madeira 9000-390 Funchal Madeira Portugal Russian Research Center kurchatov Institute Moscow 123182 Russia

We reveal and explain the scaling behavior of the thermopower s/T exhibited by the archetypal heavy-fermion （HF） metal YbRh2si2 under the application of magnetic field B at temperature T. We show that the same scaling is demonstrated by different HF compounds such as/3-YbA1B4 and the strongly correlated layered cobalt oxide [BiBa0.66k0.3602]CoO2. Using YbRh2si2 as an example, we demonstrate that the scaling behavior of sIT is violated at the antiferromagnetic phase transition, while both the residual resistivity Po and the density of states, N, experience jumps at the phase transition, causing the thermopower to make two jumps and change its sign. Our elucidation is based on flattening of the single-particle spectrum that profoundly affects Po and N. To depict the main features of the sIT behavior, we construct a T-B schematic phase diagram of YbRh2si2. Our calculated sIT for the HF compounds are in good agreement with experimental facts and support our observations.

关键词： thermoelectric and thermomagnetic effects quantum phase transition flat bands,non-Fermi-liquid states strongly correlated electron systems heavy fermions