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A two-pronged strategy utilizing exosomes extracted from antigenpresenting cells to combat hepatitis B

Nano Research 2024年第10期17卷 9084-9094页

作者： Fumin Hu Dangyang Wang Ting Lu Guanghui ma Hua Yue state key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of sciences Beijing 100049China key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190China

Chronic hepatitis B(CHB)is consistently challenging to conquer with numerous complications and *** the effectiveness of antiviral therapies in suppressing hepatitis B virus(HBV)replication,there is an urgent need for novel and more effective treatment *** strategies predominantly emphasize immune activation but still face challenges in sufficiently eliciting T cell *** into account the targeted delivery of nanoparticles to the liver and spleen via intravenous injection,we have proposed a dual-pronged therapeutic strategy based on antigen-presenting cells(APCs)-derived ***,exosomes targeted to the spleen can activate specific immune responses,while those targeted to the liver can modulate or reverse the liver’s immunosuppressive *** immunization,exosome formulations exhibit the remarkable ability to effectively activate APCs,thereby triggering the proliferation of CD8^(+)T ***,they also play an immunoregulatory role by converting M2 macrophages into M1 *** two-pronged therapeutic strategy precisely addresses the issues of T cell dysfunction and immune suppression,both characteristic features of CHB *** combined with Aluminum(Alum)-adjuvanted vaccine,these exosome formulations not only demonstrate a high level of cellular immune response but also secrete specific antibodies comparable to those induced by Alum *** combined approach effectively enhances both cellular and humoral immunity,offering a promising avenue for the development of therapeutic hepatitis B vaccines based on exosome formulations.

关键词： chronic hepatitis B antigen-presenting cells(APCs)-derived exosomes immunoregulatory role two-pronged therapeutic strategy

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Multi-gene-based investigation on the molecular phylogeny of the hypotrichous family strongylidiidae(Protista,Ciliophora),with notes on the ontogeny of a new genus and new species

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marine Life science & Technology 2024年第3期6卷 442-461页

作者： Wenya song shijing Zhang Yuqing Li Honggang ma Qiyu Li Xiaotian Luo khaled A.s.Al-Rasheid Hunter N.Hines Xiaoteng Lu Institute of Evolution&marine Biodiversity Ocean University of ChinaQingdao 266003China key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of sciences Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China Weishan special Aquaculture Base Jining 277600China Zoology Department King Saud University11451 RiyadhSaudi Arabia Harbor Branch Oceanographic Institute Florida Atlantic UniversityFort PierceFlorida 34946USA Department of Biology Shenzhen MSU-BIT UniversityShenzhen 518172China

Ciliates in the subclass Hypotrichia have long been difficult to classify as they are one of the most polymorphic and highly differentiated groups,leading to their systematics remaining *** relationships within the hypotrich family strongylidiidae have been ambiguous due to discordance between the morphological and genetic *** this study,a new strongylidiid genus Heterouroleptus is established,mainly based on the novel mode of origin of the ventral cirral rows:left ventral cirral row(LVR)originates from frontal-ventral-transverse cirral anlagen(FVTA)Ⅲ(anterior portion),IV(middle portion),and V(rear portion);right ventral cirral row comes from the entire FVTA VI.A new species,Hetero-uroleptus weishanensis ***.,***.,is investigated along with the morphometric and molecular data from a population of strongylidium *** new sequences and nuclear gene markers(single-gene and multi-gene)are provided to analyze the phylogenetic relationships of strongylidiids,with the COI gene utilized to uncover further genetic information at species level and *** results reveal that:(1)strongylidiidae is monophyletic and has a close relationship with Dorsomarginalia;(2)Heterouroleptus *** a clade that is sister to all the other strongylidiids;(3)Hemiamphisiella Foissner,1988 and Pseudouroleptus Hemberger,1985 should not be synonyms,and both genera should be subdivided due to their variable morphological characteristics;(4)LVR originating from three anlagen is a plesiomorphy of *** discovery of the origin of the LVR not only contributes to the establishment of the genus Heterouroleptus,but also helps to improve the diagnosis of the family strongylidiidae.

关键词： Ciliates Cytochrome c oxidase subunit I gene Morphogenesis Phylogeny·Ribosomal RNA gene Taxonomy

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Transcranial magneto-Acoustic stimulation Attenuates synaptic Plasticity Impairment through the Activation of Piezo1 in Alzheimer’s Disease Mouse Model

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Research 2024年第1期2023卷 81-95页

作者： Fangxuan Chu Ruxin Tan Xin Wang Xiaoqing Zhou Ren ma Xiaoxu ma Ying Li Ruixu Liu Chunlan Zhang Xu Liu Tao Yin Zhipeng Liu Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Tianjin Institutes of Health science Tianjin301600China Neuroscience Center Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing100730China

The neuropathological features of Alzheimer’s disease include amyloid *** emerging evidence suggests that Piezo1,a mechanosensitive cation channel,plays a critical role in transforming ultrasound-related mechanical stimuli through its trimeric propeller-like structure,but the importance of Piezo1-mediated mechanotransduction in brain functions is less ***,apart from mechanical stimulation,Piezo1 channels are strongly modulated by *** assume that Piezo1 may play a role in converting mechanical and electrical signals,which could induce the phagocytosis and degradation of Aβ,and the combined effect of mechanical and electrical stimulation is superior to single mechanical ***,we design a transcranial magneto-acoustic stimulation(Tmas)system,based on transcranial ultrasound stimulation(TUs)within a magnetic field that combines a magnetoacoustic coupling effect electric field and the mechanical force of ultrasound,and applied it to test the above hypothesis in 5xFAD *** tests,in vivo electrophysiological recordings,Golgi–Cox staining,enzyme-linked immunosorbent assay,immunofluorescence,immunohistochemistry,real-time quantitative PCR,Western blotting,RNA sequencing,and cerebral blood flow monitoring were used to assess whether Tmas can alleviate the symptoms of AD mouse model by activating Piezo1.

关键词： stimulation Alzheimer Piezo1

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Comparison of indicators for agricultural green development and the sustainable Development Goals,and mapping the way forward

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Frontiers of Agricultural science and Engineering 2024年第1期11卷 69-82页

作者： Jianjie ZHANG Xiangwen FAN Ling LIU Lin ma Zhaohai BAI Wenqi ma College of Resources and Environmental sciences Hebei Agricultural UniversityBaoding 071001China College of Resources and Environment Shanxi Agricultural UniversityTaiyuan 030031China Center for Agricultural Resources Research Institute of Genetics and Development BiologyChinese Academy of SciencesShijiazhuang 050022China

While agricultural green development(AGD)is highly recognized and has become a national strategy in China,it is imperative to bridge the knowledge gaps between AGD and the UN sustainable Development Goals(sDGs),and to evaluate the contribution of AGD to meeting the *** first aim of this study was to compare the AGD goals and indicators with those of the sDGs so as to identify their *** next aim was to examine the historical evolution of AGD indicators and analyze the gaps between the current status of various indicators and their *** factors were identified in China's transition toward *** findings reveal that the indicators of AGD align with those of the sDGs,but have greater specificity to the context in China and are more *** has been a significant increase per capita calorie and protein intakes in China,as well as a notable rise in agricultural output per unit of arable land and rural incomes from 1980 to the ***,these achievements have been accompanied by a high resource use and environmental pollution,highlighting the need for a more sustainable,environmentally responsible agriculture in China.

关键词： Agricultural green development sustainable development goals environmental sustainability indicator system optimization pathway

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Fake News Detection Based on Text-Modal Dominance and Fusing Multiple Multi-Model Clues

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Computers, materials & Continua 2024年第3期78卷 4399-4416页

作者： Li fang Fu Huanxin Peng Changjin ma Yuhan Liu College of Arts and sciences Northeast Agricultural UniversityHarbin150030China College of Engineering Northeast Agricultural UniversityHarbin150030China

In recent years,how to efficiently and accurately identify multi-model fake news has become more ***,multi-model data provides more evidence but not all are equally ***,social structure information has proven to be effective in fake news detection and how to combine it while reducing the noise information is ***,existing approaches fail to handle these *** paper proposes a multi-model fake news detection framework based on Tex-modal Dominance and fusing Multiple Multi-model Cues(TD-MMC),which utilizes three valuable multi-model clues:text-model importance,text-image complementary,and text-image ***-MMC is dominated by textural content and assisted by image information while using social network information to enhance text *** reduce the irrelevant social structure’s information interference,we use a unidirectional cross-modal attention mechanism to selectively learn the social structure’s features.A cross-modal attention mechanism is adopted to obtain text-image cross-modal features while retaining textual features to reduce the loss of important *** addition,TD-MMC employs a new multi-model loss to improve the model’s generalization *** experiments have been conducted on two public real-world English and Chinese datasets,and the results show that our proposed model outperforms the state-of-the-art methods on classification evaluation metrics.

关键词： Fake news detection cross-modal attention mechanism multi-modal fusion social network transfer learning

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Hepatitis B virus infection, infertility, and assisted reproduction

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2024年第8期25卷 672-685页

作者： Lingjian ZHANG Fangfang ZHANG Zhiyuan ma Jie JIN Department of Infectious Diseases Affiliated Hangzhou First People’s HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Women’s Hospital School of MedicineZhejiang UniversityHangzhou 310003China key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310003China

Background:Hepatitis B virus(HBV)is one of the most widespread viruses worldwide and a major cause of hepatitis,cirrhosis,and hepatocellular *** studies have revealed the impacts of HBV infection on *** increasing number of infertile couples with chronic hepatitis B(CHB)virus infection choose assisted reproductive technology(ART)to meet their fertility *** the high prevalence of HBV,the effects of HBV infection on assisted reproduction treatment remain limited and ***:The aim of this study was to provide a comprehensive overview of the effect of HBV infection on fertility and discuss its effects on pregnancy outcomes,vertical transmission,pregnancy complications,and viral activity during ART ***:We conducted a literature search in PubMed for studies on HBV infection and ART published from 1996 to ***:HBV infection negatively affected fertility in both males and *** research shows that HBV infection may increase the risk of pregnancy complications in couples undergoing assisted reproduction *** impact of HBV infection on the pregnancy outcomes of ART is still *** evidence does not support that ART increases the risk of vertical transmission of HBV,while relevant studies are *** the development of ART,the risk of HBV reactivation(HBVr)is increasing,especially due to the wide application of immunosuppressive ***:Regular HBV infection screening and HBVr risk stratification and management are essential to prevent HBVr during *** determination of optimal strategy and timing of prophylactic anti-HBV therapy during ART still needs further investigation.

关键词： Assisted reproductive technology(ART) Hepatitis B virus(HBV) Immunosuppressive agent Pregnancy

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Variational Neural Inference Enhanced Text semantic Communication system

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China Communications 2024年第7期21卷 50-64页

作者： Zhang Xi Zhang Yiqian Li Congduan ma Xiao school of Electronics and Communication Engineering Sun Yat-Sen UniversityShenzhen 518107China Guizhou University state key Laboratory of Public Big Data Guiyang 550025China shenzhen key Laboratory of Navigation and Communication Integration Shenzhen 518107China school of Computer science and Engineering Sun Yat-Sen UniversityGuangzhou 510006China

Recently,deep learning-based semantic communication has garnered widespread attention,with numerous systems designed for transmitting diverse data sources,including text,image,and speech,*** efforts have been directed toward improving system performance,many studies have concentrated on enhancing the structure of the encoder and ***,this often overlooks the resulting increase in model complexity,imposing additional storage and computational burdens on smart ***,existing work tends to prioritize explicit semantics,neglecting the potential of implicit *** paper aims to easily and effectively enhance the receiver's decoding capability without modifying the encoder and decoder *** propose a novel semantic communication system with variational neural inference for text ***,we introduce a simple but effective variational neural inferer at the receiver to infer the latent semantic information within the received *** information is then utilized to assist in the decoding *** simulation results show a significant enhancement in system performance and improved robustness.

关键词： deep learning semantic communication variational neural inference

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Hollow Metal-Organic Framework/MXene/Nanocellulose Composite Films for Giga/Terahertz Electromagnetic shielding and Photothermal Conversion

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Nano-Micro Letters 2024年第9期16卷 161-179页

作者： Tian mai Lei Chen Pei‑Lin Wang Qi Liu Ming‑Guo ma Research Center of Biomass Clean Utilization MOE Engineering Research Center of Forestry Biomass Materials and BioenergyBeijing Key Laboratory of Lignocellulosic ChemistryCollege of Materials Science and TechnologyBeijing Forestry UniversityBeijing 100083People’s Republic of China state silica-Based materials Laboratory of Anhui Province Bengbu 233000People’s Republic of China

With the continuous advancement of communication technology,the escalating demand for electromagnetic shielding interference(EMI)materials with multifunctional and wideband EMI performance has become *** the electrical and magnetic components and designing the EMI material structure have attracted extensive interest,but remain a huge ***,we reported the alternating electromagnetic structure composite films composed of hollow metal-organic frameworks/layered MXene/nanocellulose(HMN)by alternating vacuum-assisted filtration *** HMN composite films exhibit excellent EMI shielding effectiveness performance in the GHz frequency(66.8 dB at kaband)and THz frequency(114.6 dB at 0.1-4.0 THz).Besides,the HMN composite films also exhibit a high reflection loss of 39.7 dB at 0.7 THz with an effective absorption bandwidth up to 2.1 ***,HMN composite films show remarkable photothermal conversion performance,which can reach 104.6℃under 2.0 sun and 235.4℃under 0.8 W cm^(−2),*** unique micro-and macrostructural design structures will absorb more incident electromagnetic waves via interfacial polarization/multiple scattering and produce more heat energy via the local surface plasmon resonance *** features make the HMN composite film a promising candidate for advanced EMI devices for future 6G communication and the protection of electronic equipment in cold environments.

关键词： Metal-organic frameworks MXene Nanocellulose Electromagnetic shielding Photothermal conversion

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Effect of Ta_(2)O_(5)nanoparticles on bioactivity,composition,structure,in vitro and in vivo behavior of PEO coatings on Mg-alloy

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Journal of magnesium and Alloys 2024年第6期12卷 2360-2379页

作者： D.V.mashtalyar I.M.Imshinetskiy V.V.kashepa k.V.Nadaraia M.A.Piatkova A.I.Pleshkova k.A.Fomenko A.Yu.Ustinov s.L.sinebryukhov s.V.Gnedenkov Institute of Chemistry Far Eastern BranchRussian Academy of SciencesVladivostok690022Russia Far Eastern Federal University Vladivostok690950Russia Regional Clinical Dermatovenerological Dispensary Vladivostok690033Russia

The present study investigates the physical and chemical characteristics,behavior in vitro and in vivo,and biocompatibility of coatings containing Ta_(2)O_(5),which are obtained by plasma electrolytic oxidation(PEO)on ma8 magnesium *** obtained coatings demonstrate in vivo biocompatibility and in vitro *** to the base PEO coating,the layers containing Ta_(2)O_(5)facilitate the development of apatite in simulated body fluid,suggesting that the inclusion of nanoparticles improves bioactivity of the *** was found that incorporation of Ta_(2)O_(5)nanoparticles increases roughness and porosity of the formed layers by increasing particle concentration in electrolytes for the PEO process contributing to sufficient soft tissue ingrowth in *** on in vivo studies,these coatings also provide favorable tissue response and minimal inflammatory reaction in comparison with the bare magnesium alloy due to protection of living tissues from deleterious corrosion events of magnesium implant such as local alkalization and intense hydrogen *** results obtained in the present study concluded biocompatibility,tissue integration of the PEO coatings containing Ta_(2)O_(5)nanoparticles making them a promising protective layer for biodegradable magnesium implants.

关键词： Plasma electrolytic oxidation Bioactive coatings Tantalum pentoxide simulated body fluid(sBF) Apatite formation Histology

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Intraseasonal variability of the kuroshio observed via mooring at 18°N

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Journal of Oceanology and Limnology 2024年第2期42卷 468-483页

作者： Xin YUAN Qingye WANG Jie ma shijian HU Dunxin HU key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of sciences Beijing 100049China Laoshan Laboratory Qingdao 266237China Center for Ocean Mega-science Chinese Academy of SciencesQingdao 266071China

Insufficient observations near the origin of the kuroshio have led to incomplete understanding of the intraseasonal variability(IsV)of the *** measurements of the kuroshio velocity were performed with an array of three profiler moorings(122.7°E,123°E,and 123.3°E)along 18°N from January 2018 to February *** IsV of the kuroshio at 18°N was investigated based on a combination of mooring observations and global high-resolution HYbrid Coordinate Ocean Model reanalysis *** estimated time-averaged transport in the upper 350 m across the observation transect was 6.5±2.6 sv(1.0 sv=10^(6)m^(3)/s).Two significant IsV peaks at 50-60 and~100 d were recognized in the power spectra of the meridional velocity and *** analysis indicated that the IsV at 50-60 d was caused by westward-propagating eddies at average propagation speed of~13 cm/s and wavelength of~635 *** IsV peak at~100 d was mainly caused by northward-propagating eddies generated in the North Equatorial Current *** investigation indicated that the IsV of the kuroshio at 18°N is dominated by meridional transport,rather than by the zonal migration of the kuroshio main *** findings provide a better understanding of the IsV of the kuroshio east of Luzon Island.

关键词： intraseasonal variability(IsV) kuroshio mooring observation eddy

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