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Overview of the immunological mechanisms in hepatitis B virus reactivation:Implications for disease progression and management strategies

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World Journal of Gastroenterology 2024年第10期30卷 1295-1312页

作者： Hui ma Qing-Zhu Yan Jing-Ru ma Dong-Fu Li Jun-Ling Yang Department of Clinical Laboratory The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Ultrasound Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Digestive Diseases Center Department of Hepatopancreatobiliary MedicineThe Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease *** review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and *** delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive *** factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are ***,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease *** reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is *** strategies,including anti-viral and immunomodulatory approaches,are critically *** role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent *** conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HBV *** a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge *** more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient *** dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory *** role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.

关键词： Hepatitis B virus reactivation Immunological mechanisms Disease progression management strategies Immune response

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Opportunities and challenges of CD47-targeted therapy in cancer immunotherapy

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Oncology Research 2024年第1期32卷 49-60页

作者： QIUQIANG CHEN XUEJUN GUO WENXUE ma key Laboratory for Translational Medicine The First Affiliated HospitalHuzhou University School of MedicineHuzhou313000China Department of Hematology Puyang Youtian General HospitalPuyang457001China Department of Medicine Moores Cancer CenterSanford Stem Cell InstituteUniversity of California San DiegoLa JollaSan Diego92093USA

Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer,with the tumor microenvironment(TME)playing a pivotal role in modulating the immune ***47,a cell surface protein,has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer ***,the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely *** comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion,elucidating its impact on various types of immunotherapy outcomes,including checkpoint inhibitors and CAR T-cell ***,CD47-targeted therapies offer a promising avenue for improving cancer treatment outcomes,especially when combined with other immunotherapeutic *** review also discusses current and potential CD47-targeted therapies being explored for cancer treatment and delves into the associated challenges and opportunities inherent in targeting *** the demonstrated effectiveness of CD47-targeted therapies,there are potential problems,including unintended effects on healthy cells,hematological toxicities,and the development if ***,further research efforts are warranted to fully understand the underlying mechanisms of resistance and to optimize CD47-targeted therapies through innovative combination approaches,ultimately improving cancer treatment ***,this comprehensive review highlights the significance of CD47 as a promising target for cancer immunotherapy and provides valuable insight into the challenges and opportunities in developing effective CD47-targeted therapies for cancer treatment.

关键词： CD47 Cancer immunotherapy CD47-targeted therapies Tumor microenvironment macrophage Cancer cell Immune evasion Checkpoint inhibitors CAR T-cell therapy Cancer treatment outcomes

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Bifurcation and optimal control for an infectious disease model with the impact of information

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International Journal of Biomathematics 2024年第1期17卷 113-149页

作者： Zhihui ma shenghua Li shuyan Han school of mathematics and statistics Lanzhou University Lanzhou Gansu 730000P.R.China

A nonlinear infectious disease model with information-influenced vaccination behavior and contact patterns is proposed in this paper,and the impact of information related to disease prevalence on increasing vaccination coverage and reducing disease incidence during the outbreak is ***,we perform the analysis for the existence of equilibria and the stability properties of the proposed *** particular,the geometric approach is used to obtain the sufficient condition which guarantees the global asymptotic stability of the unique endemic equilibrium Ee when the basic reproduction number Ro>***,mathematical derivation combined with numerical simulation shows the existence of the double Hopf bifurcation around ***,based on the numerical results,it is shown that the information coverage and the average information delay may lead to more complex dynamical ***,the optimal control problem is established with information-infuenced vaccination and treatment as control *** corresponding optimal paths are obtained analytically by using Pontryagin's maximum principle,and the applicability and validity of virous intervention strategies for the proposed controls are presented by numerical experiments.

关键词： Infectious disease model information index stability double Hopf bifurcation optimal control Pontryagin's maximum principle

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magnesium-containing pellet regulating blast furnace ferrous burden interaction:softening-melting behavior and mechanism

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Journal of Iron and steel Research International 2024年第7期31卷 1623-1635页

作者： Li-ming ma Jian-liang Zhang Yao-zu Wang Xiao-yong ma Gui-lin Wang Zhuo Li Hui-qing Jiang Zheng-jian Liu school of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China school of Intelligence science and Technology University of Science and Technology BeijingBeijing 100083China Lingyuan Iron and steel Group Co. Lingyuan 122500LiaoningChina

MgO participates in all stages of sintering,pelletizing,and blast furnace ironmaking,and synergistically optimizing the distribution of MgO in ferrous burden can effectively enhance the interaction within the ferrous burdens and optimize the softening-melting properties of the mixed ***-containing pellets mixed with low-MgO sinter or mixed with high-MgO sinter in the blast furnace ferrous burden structure have opposite softening-melting performance *** the structure of the ferrous burden is magnesium-containing pellets mixed with low-MgO sinter,the magnesium-containing pellets can enhance the interaction of the ferrous burden in the process of softening-melting,which can optimize the composition of the slag phase and improve the slag *** the structure of the ferrous burden is magnesium-containing pellets mixed with high-MgO sinter,the magnesium-containing pellets weaken the interaction of the ferrous burden in the process of softening-melting,increase the content of the high melting point solid-phase particles in the slag,lead to an increase in the viscosity of the slag and difficult separation of the slag and iron,and decrease the permeability of the charge ***,to ensure good permeability of the mixed burden,the following measures are suggested:optimizing the MgO distribution of the ferrous burden,reducing the MgO content of the sinter to 1.96 wt.%,increasing the MgO content of the pellets to 1.03-1.30 wt.%,controlling the MgO/Al_(2)O_(3) ratio of the mixed burden within 1.15-1.32,narrowing the position of the cohesive zone,and maintaining an s value(permeability index)of approximately 150 kPa℃.

关键词： Ironmaking Ferrous burden softening-melting property Interaction Permeability slag

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Cost-sensitive Dual-stream Residual Networks for Imbalanced Classification

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Computers, materials & Continua 2024年第9期80卷 4243-4261页

作者： Congcong ma Jiaqi Mi Wanlin Gao sha Tao College of Information and Electrical Engineering China Agricultural UniversityBeijing100083China key Laboratory of Agricultural Informatization standardization Ministry of Agriculture and Rural AffairsChina Agricultural UniversityBeijing100083China

Imbalanced data classification is the task of classifying datasets where there is a significant disparity in the number of samples between different *** task is prevalent in practical scenarios such as industrial fault diagnosis,network intrusion detection,cancer detection,*** imbalanced classification tasks,the focus is typically on achieving high recognition accuracy for the minority ***,due to the challenges presented by imbalanced multi-class datasets,such as the scarcity of samples in minority classes and complex inter-class relationships with overlapping boundaries,existing methods often do not perform well in multi-class imbalanced data classification tasks,particularly in terms of recognizing minority classes with high ***,this paper proposes a multi-class imbalanced data classification method called CsDsResNet,which is based on a cost-sensitive dualstream residual ***,to address the issue of limited samples in the minority class within imbalanced datasets,a dual-stream residual network backbone structure is designed to enhance the model’s feature extraction ***,considering the complexities arising fromimbalanced inter-class sample quantities and imbalanced inter-class overlapping boundaries in multi-class imbalanced datasets,a unique cost-sensitive loss function is *** loss function places more emphasis on the minority class and the challenging classes with high interclass similarity,thereby improving the model’s classification ***,the effectiveness and generalization of the proposed method,CsDsResNet,are evaluated on two datasets:‘DryBeans’and‘Electric Motor Defects’.The experimental results demonstrate that CsDsResNet achieves the best performance on imbalanced datasets,with macro_F1-score values improving by 2.9%and 1.9%on the two datasets compared to current state-of-the-art classification methods,***,it achieves the highest precision in single-class r

关键词： Deep learning imbalanced data classification fault diagnosis cost-sensitivity

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Exploring the molecular mechanisms and potential therapeutic strategies of ferroptosis in ovarian cancer

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BIOCELL 2024年第3期48卷 379-386页

作者： LIsHA ma WANQI sHAO WEILI ZHU Department of Gynecology Jiaxing University Master Degree Cultivation BaseZhejiang Chinese Medical UniversityJiaxingChina Department of Gynecology Jiaxing University Affiliated Women and Children’s HospitalJiaxingChina

The morbidity rate of ovarian cancer,a malignant tumour in gynaecological tumours,is rising,and it is considered to be the most lethal *** majority of patients are typically diagnosed during the advanced stages of the illness due to the elusive characteristics of ovarian cancer and an absence of highly sensitive and speciﬁc diagnostic *** excision of the lesions,along with chemotherapy,is the conventional treatment for ovarian cancer;however,resistance to platinum-based chemotherapeutic drugs and molecular targeted therapies frequently *** the survival rate and prognosis of patients with end-stage or recurring ovarian cancer requires the identiﬁcation of new therapeutic targets due to the absence of efﬁcient medications,and this has emerged as a highly demanding *** have demonstrated that ferroptosis effectively hinders the proliferation of ovarian cancer and induces the demise of malignant *** is composed of the cystine/glutamate antiporter system(the system Xc-)and glutathione peroxidase 4(GPX4).solute carrier family 7 member 11(sLC7A11)and solute carrier family 3 member 2(sLC3A2)play crucial roles in the regulation of ferroptosis by facilitating the uptake of cystine into cells and the efﬂux of glutamate out of cells,*** cells,GPX4 is the exclusive enzyme employed for reducing liposomal peroxide through glutathione peroxidase *** occurrence of ferroptosis in ovarian cancer is strongly associated with three main pathways,namely,the GPX4-glutathione(GsH)protective pathway,the ferroptosis suppressor protein 1(FsP1)-coenzyme Q10(CoQ10)protective pathway,and the guanosine 5'-triphosphate cyclohydrolase I(GCH1)protective *** ovarian cancer cells,the postsynaptic density-95,discs-large,zona occludens 1(PDZ)-binding motif-angiopoietin-like 4-nicotinamide adenine dinucleotide phosphate oxidases 2(TAZ-ANGPTL4-NOX2)pathway can be regulated by Yes-associated protein(YAP)/TAZ,a downstream

关键词： Ovarian cancer Ferroptosis Therapy

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Tunable Phase structure of side-chain Liquid Crystalline Polymers Enabled by Molecular Engineering of Dual Mesogenic Cores

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Chinese Journal of Polymer science 2024年第10期42卷 1459-1469,I0009页

作者： Wen-Huan Yao Lan-sheng Liu Jie Zhao Yan-Xia Wang An-Zhi ma Zheng-Rui ma Lan-Ying Zhang Ruo-Chen Lan College of Chemistry and Chemical Engineering Hunan UniversityChangsha410082China key Laboratory of Eco-Functional Polymer materials of the Ministry of Education Key Laboratory of Eco-Environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou730070China Department of materials science and Engineering College of EngineeringPeking UniversityBeijing100871China Institute of Advanced materials&key Lab of Fluorine and silicon for Energy materials and Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang330022China

A series of novel side-chain liquid crystalline(sCLC)copolymers were synthesized by attaching two distinct mesogenic units,namely a chiral cholesteryl-based monomer(M1)and an achiral biphenyl-based monomer(M2),to a poly(3-mercaptopropylmethylsiloxane)(PMMs)backbone via thiol-ene click *** influence of side chain composition on the self-assembly behavior and phase structures of these sCLC copolymers was systematically investigated using different *** indicate that three distinct liquid crystalline phases and four unique molecular configurations were identified within the polymer series,with the emergence of the liquid crystalline phase being a synergistic outcome of the two distinct side *** study underscores the critical influence of side chain dimensions,rigidity,and spatial volume on the self-assembly structures and phase characteristics of liquid crystalline polymers,providing valuable insights for the rational design and development of advanced functional materials with tailored properties.

关键词： Liquid crystalline copolymers self-assembly Phase structure Chiral molar ratio

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Heterogeneous MXene-based films with graded electrical conductivity towards highly efficient EMI shielding and electrothermal heating

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Nano Research 2024年第8期17卷 7264-7274页

作者： Yu Zhang Guangcheng Zhang Zhonglei ma Jianbin Qin Xi shen Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina shaanxi key Laboratory of macromolecular science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Research Institute for sports science and Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

The increasing need for electromagnetic interference(EMI)shielding of electronics in cold environments such as those in aircraft,space exploration,and wearable heaters to avoid hazardous icing conditions or hypothermia requires the development of thin and lightweight EMI shielding materials preferably by absorbing rather than reflecting electromagnetic(EM)waves while also generating heat through energy-efficient electrothermal ***,it is challenging to achieve absorption-dominant EMI shielding and energy-efficient electrothermal heating simultaneously in a thin and lightweight ***,we develop a heterogeneous composite film comprising a porous multi-walled carbon nanotubes(MWCNTs)/bacterial cellulose(BC)film and an aligned MXene/Ag nanowires(NWs)backing via a sequential vacuum filtration *** porous film contains random conductive networks of MWCNTs with moderate conductivity while the aligned MXene sheets atop Ag NWs network affords high conductivity in the backing,giving rise to graded electrical conductivity for absorption-dominant EMI *** increasing Ag NW coverage leads to significantly increased electrical conductivity without increasing the EM wave reflection as well as the density and thickness of the film,yielding excellent specific EMI shielding effectiveness(>8500 dB/(g·cm^(2))),low driving voltage for energy-efficient electrothermal heating(163℃at 2.5 V),and fast response time(60 s)at a low areal density of 0.015 mg/cm^(2).Combining EMI shielding and electrothermal heating,the heterogeneous film developed here are promising contenders for the protection of electronic equipment in low-temperature environment.

关键词： heterogenous composite film MXene electromagnetic interference(EMI)shielding thermal management

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sDCC: software-defined collective communication for distributed training

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science China(Information sciences) 2024年第9期67卷 105-125页

作者： Xin JIN Zhen ZHANG Yunshan JIA Yun ma Xuanzhe LIU school of Computer science Peking University Department of Computer science and Technology Johns Hopkins University

Communication is crucial to the performance of distributed training. Today's solutions tightly couple the control and data planes and lack flexibility, generality, and performance. In this study, we present sDCC, a software-defined collective communication framework for distributed training. sDCC is based on the principle of modern systems design to effectively decouple the control plane from the data *** abstracts the operations for collective communication in distributed training with dataflow operations and unifies computing and communication with a single dataflow graph. The abstraction, together with the unification, is powerful: it enables users to easily express new and existing collective communication algorithms and optimizations, simplifies the integration with different computing engines(e.g., Py Torch and Tensor Flow) and network transports(e.g., Linux TCP and kernel bypass), and allows the system to improve performance by exploiting parallelism exposed by the dataflow graph. We further demonstrate the benefits of sDCC in four use cases.

关键词： machine learning systems distributed training deep learning collective communication software-defined networking

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Layerwise third-order shear deformation theory with transverse shear stress continuity for piezolaminated plates

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CHINEsE JOURNAL OF AERONAUTICs 2024年第9期37卷 490-505页

作者： Gao, Yingshan Zhang, shunqi Hu, Wei ma, songyun markert, Bernd shanghai Univ Sch Mech Engn & Automat Shanghai 200444 Peoples R China shanghai Univ Key Lab Silicate Cultural Rel Conservat Minist Educ Shanghai 200444 Peoples R China Rhein Westfal TH Aachen Inst Gen Mech D-52062 Aachen Germany

Regarding laminated structures, an electromechanically coupled Finite Element (FE) model based on Layerwise Third-Order shear Deformation (LW-TOsD) theory is proposed for static and dynamic analysis. LW-TOsD ensures the continuity of in-plane displacements and transverse shear stresses. The current LW-TOsD can be applied to arbitrary multi-layer laminated structures with only seven Degrees of Freedom (DOFs) for each element node and eliminates the use of the shear correction factors. Moreover, a shear penalty stiffness matrix is constructed to satisfy artificial constraints to optimize the structural shear strain. A dynamic finite element model is obtained based on LW-TOsD using the Hamilton's principle. First, the accuracy of the current model is validated by comparing with literature and ABAQUs results. Then, this study carries out numerical investigations of piezolaminated structures for different width-to-thickness ratios, length-to-width ratios, penalty stiffness matrix, boundary conditions, electric fields and dynamics. (c) 2024 Production and hosting by Elsevier Ltd. on behalf of Chinese society of Aeronautics and Astronautics.

关键词： Laminated structures Piezolaminated structures Third-order shear deforma- tion theory shear stress continuity Electromechanically coupled LAMINATED COMPOsITE FREE-VIBRATION sANDWICH PLATEs

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