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胰胆管型和小肠型壶腹癌的MRI鉴别诊断特征

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国际医学放射学杂志 2011年第1期34卷 71-72页

作者： Y.E.Chung M.J.kim M.s.Park J.Y.Choi H.kim s.k.kim 朱跃强 Department of Radiology Institute of GastroenterologyResearch Institute of Radiological ScienceSeverance HospitalYonsei University College of Medicine

目的确定胰胆管型和小肠型壶腹癌的MRI鉴别诊断特征,并将其与病理表现对照。材料与方法医院伦理委员会批准了此次回顾性研究,并免除了知情同意的要求。

关键词：小肠型壶腹癌胰胆管鉴别诊断 MRI

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肺腺癌:与气道播散相关的CT征象

国际医学放射学杂志 2019年第1期 115-115页

作者： s.k.kim T.J.kim M.J.Chung T.s.kim k.s.Lee J.I. Zo 李佳佳 Department of Radiology Samsung Medical CenterSungkyunkwan University School of Medicine

摘要目的通过分析外科切除肺腺癌来判定CT征象预测发生肺气道播散(sTAs)的可能性。材料与方法本回顾性研究对2015年4月—2016年12月接受过肺腺癌手术切除

关键词：肺腺癌空气支气管征 CT

Carboplatin restores neuronal toxicity in FUs-linked amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第8期20卷 2319-2320页

作者： kiyoung kim Department of Medical science Soonchunhyang UniversityAsanKorea

Amyotrophic lateral sclerosis(ALs),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal *** leads to muscle weakness,paralysis,and ultimate... 详细信息

关键词： paralysis sclerosis respiratory

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal sharma sehwan kim Hyemi Eo sang Ryong kim school of Life science Kyungpook National UniversityDaeguKorea Bk21 FOUR kNU Creative BioResearch Group kyungpook National University DaeguKorea Brain science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki kim Bum Jun kim seungyon koh Hyo Jin Cho Xuelian Jin Byung Gon kim Jun Young Choi Department of Brain science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

软组织良恶性肿瘤鉴别:在3.0T标准MR成像序列中附加定性和定量的扩散成像序列

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国际医学放射学杂志 2016年第3期 324-324页

作者： s.Y.Lee W.H.Jee J.Y.Jung M.Y.Park s.k.kim C.k.Jung 蓝星 Department of Radiology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

摘要目的了解3.0 T MRI基础上增加DWI来鉴别软组织肿瘤良恶性的优势。方法回顾性分析63例因软组织肿瘤而手术的病人,均行3.0 T MRI及DWI。2位专家独立阅片,按照两步法分析肿瘤的恶性度:(1)标准MRI;(2)标准MRI联合定量及定性DWI。结果 6... 详细信息

摘要目的了解3.0 T MRI基础上增加DWI来鉴别软组织肿瘤良恶性的优势。方法回顾性分析63例因软组织肿瘤而手术的病人,均行3.0 T MRI及DWI。2位专家独立阅片,按照两步法分析肿瘤的恶性度:(1)标准MRI;(2)标准MRI联合定量及定性DWI。结果 63例肿瘤中有34例为恶性,29例为良性。在定性分析中,与良性肿瘤相比,DWI上恶性肿瘤信号高于骨骼肌更常见(P=0.003)。在定量分析中,恶性肿瘤

关键词：成像序列 DWI 软组织肿瘤良恶性 MR

Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee kim Rudolph ETanzi se Hoon Choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： kiran A.Nirmal Tukaram D.Dongale Atul C.khot Chenjie Yao Nahyun kim Tae Geun kim school of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for solid‑state Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram kim Myeong‑Chang sung Gwang‑Hee Lee Byoungjoon Hwang sojung seo Ji‑Hun seo Dong‑Wan kim Department of Materials science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea school of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(sPE)design that simultaneously mitigates solvent-related problems and improves ***-sPE exhibits high ion conductivity(2.8×10^(−3)s cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-sPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the sPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain