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Gut|基于纵向数据的乙型肝炎临床治愈预测新模型

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临床肝胆病杂志 2024年第7期40卷 1320-1320页

作者：赵思如南方医科大学南方医院感染内科

乙型肝炎临床治愈(即HBsAg转阴,伴或不伴有抗-HBs出现)是慢性乙型肝炎(CHB)患者的理想治疗终点。对CHB患者实现临床治愈的可能性进行精准预测,对于推动相关临床策略的实施以及新药随机对照临床研究的受试者筛选具有重要作用,通过科学的... 详细信息

乙型肝炎临床治愈(即HBsAg转阴,伴或不伴有抗-HBs出现)是慢性乙型肝炎(CHB)患者的理想治疗终点。对CHB患者实现临床治愈的可能性进行精准预测,对于推动相关临床策略的实施以及新药随机对照临床研究的受试者筛选具有重要作用,通过科学的方法预测并平衡各组受试者的特征,可以有效提升临床研究的效率和准确性。既往已发现多种与实现临床治愈相关的标志物,例如HBV RNA、HBV核心相关抗原(HBcrAg)和HBsAg定量(qHBsAg)等。然而,以上绝大部分预测标志物或模型仅基于单个时间点临床数据,或两个特定时间点的差值变化,尚无法完全反映CHB患者长期病程中qHBsAg动态变化对实现HBsAg转阴的影响。2024年6月,南方医科大学南方医院侯金林教授及樊蓉教授等依托一项来自我国50家中心的长期随访的真实世界前瞻性队列(search-B研究),基于纵向判别分析(LoDA)建模算法,高效利用患者随访期间的多时间点HBsAg定量数据,构建并验证了一项新型、精准的乙型肝炎临床治愈预测模型(GOLDEN评分)。该评分可平均提前18.94个月预测乙型肝炎临床治愈的发生[受试者工作特征曲线下面积(AUC):0.979~0.981]。

关键词：临床治愈南方医科大学 HBsAg定量临床数据随机对照临床研究乙型肝炎南方医院长期随访

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sMILE soft X-ray Imager flight model CCD370 pre-flight device characterisation

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Earth and Planetary Physics 2024年第1期8卷 25-38页

作者： s.Parsons D.j.Hall O.Hetherington T.W.Buggey T.Arnold M.W.j.Hubbard A.Holland Centre for Electronic Imaging the Open UniversityMilton KeynesMK76AAUK

Throughout the sMILE mission the satellite will be bombarded by radiation which gradually damages the focal plane devices and degrades their *** order to understand the changes of the CCD370s within the soft X-ray Imager,an initial characterisation of the devices has been carried out to give a baseline performance *** CCDs have been characterised,the two flight devices and the flight spa *** has been carried out at the Open University in a bespo ke cleanroom measure ment *** results show that there is a cluster of bright pixels in the flight spa re which increases in size with tempe *** at the nominal ope rating tempe rature(-120℃) it is within the procure ment ***,the devices meet the specifications when ope rating at -120℃ in 6 × 6 binned frame transfer science *** se rial charge transfer inefficiency degrades with temperature in full frame *** any charge losses are recovered when binning/frame transfer is implemented.

关键词： CCD soft X-ray imager characterisation sMILE

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Optimizing spatial Pattern Analysis in serial Remote sensing Images through Empirical Mode Decomposition and Ant Colony Optimization

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journal of Harbin Institute of Technology(New series) 2024年第4期31卷 52-60页

作者： j srinivasan s Uma saleem Raja Abdul samad jayabrabu Ramakrishnan Department of Computer Applications Madanapalle Institute of Technology&Science(MITS)Madanapalle 517325Andhra PradeshIndia Department of Information Technology Panimalar Engineering CollegeChennai 600123India Information Technology Department College of Computing and Information SciencesUniversity of Technology and Applied Sciences-Shinas 324Sultanate of Oman Department of Information Technology and security College of Computer Science and Information TechnologyJazan UniversityJazan 45142Kingdom of Saudi Arabia

serial remote sensing images offer a valuable means of tracking the evolutionary changes and growth of a specific geographical area over *** the original images may provide limited insights,they harbor considerable potential for identifying clusters and *** aggregation of these serial remote sensing images(sRsI)becomes increasingly viable as distinct patterns emerge in diverse scenarios,such as suburbanization,the expansion of native flora,and agricultural *** a novel approach,we propose an innovative method for extracting sequential patterns by combining Ant Colony Optimization(ACD)and Empirical Mode Decomposition(EMD).This integration of the newly developed EMD and ACO techniques proves remarkably effective in identifying the most significant characteristic features within serial remote sensing images,guided by specific *** findings highlight a substantial improvement in the efficiency of sequential pattern mining through the application of this unique hybrid method,seamlessly integrating EMD and ACO for feature *** study exposes the potential of our innovative methodology,particularly in the realms of urbanization,native vegetation expansion,and agricultural activities.

关键词： spatial pattern analysis EMD ACO

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Complexed amino acid minerals vs. bis-glycinate chelated minerals:Impact on the performance of old laying hens

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Animal Nutrition 2024年第1期16卷 395-408页

作者： Marcos.j.B.santos Maria C.M.M.Ludke Leandro M.silva Carlos B.V.Rabello Mércia R.Barros Fabiano s.Costa Clariana s.santos.j.mille s.s.Wanderley Department of Animal science Rural Federal University of Pernambuco Department of Veterinary science Rural Federal University of Pernambuco

The present study was to evaluate the effect of trace minerals(Zn, Mn, and Cu) from complexed amino acid minerals(ZMCAA) and bis-glycinate chelated minerals(ZMCGly) in laying hen diets on performance,internal and external egg quality, yolk mineral deposition, intestinal morphometry, and bone characteristics. From 78 to 98 weeks of age, 400 White LsL-Lite strain laying hens were distributed in a randomized design with 4 treatments with 10 replicates per treatment. Treatments were distributed in a 2 ×2 factorial arrangement using either Zn, Mn, and Cu of ZMCAA or ZMCGly source at 2 levels: low(20, 20,and 3.5 mg/kg of Zn, Mn, and Cu, respectively) or high(40, 40, and 7 mg/kg of Zn, Mn, and Cu,respectively). The analysis of variance was performed, and in cases where differences were observed, the means were compared using Tukey?s test(P source and level of trace mineral supplementation had a significant impact on the performance of laying hens. Hens fed ZMCAA had higher egg production(P = 0.01), egg weight(P = 0.02), egg mass(P = 0.01), and lower feed conversion ratio(P =0.05) compared to those fed ZMCGly. The ZMCAA supplementation showed higher albumen height(P =0.01), albumen weight(P = 0.01), and eggshell thickness(P sition of Zn(P s greater for hens received ZMCAA. Tibia weight(P = 0.04)and bone densitometry(P supplementation. In the small intestine, ZMCAA resulted in longer villi(P = 0.02) and shorter crypt depth(P = 0.01) in the *** and ileum measurements were influenced by the level and source of trace minerals(P s fed ZMCAA exhibited superior performance, egg quality, deposition of trace minerals in the egg yolk, and bone density compared to hens fed ZMCGly. In this study, older laying hens supplemented with ZMCAA at lower levels demonstrated adequate levels of supplementation.

关键词： Bis-glycinates Metal-amino acids Radiodensity Trace minerals

Evidence for particle acceleration approaching PeV energies in the W51 complex

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science Bulletin 2024年第18期69卷 2833-2841页

作者： LHAAsO Collaboration Zhen Cao F.Aharonian Axikegu Y.X.Bai Y.W.Bao D.Bastieri X.j.Bi Y.j.Bi W.Bian A.V.Bukevich Q.Cao W.Y.Cao Zhe Cao j.Chang j.F.Chang A.M.Chen E.s.Chen H.X.Chen Liang Chen Lin Chen Long Chen M.j.Chen M.L.Chen Q.H.Chen s.Chen s.H.Chen s.Z.Chen T.L.Chen Y.Chen N.Cheng Y.D.Cheng M.Y.Cui s.W.Cui X.H.Cui Y.D.Cui B.Z.Dai H.L.Dai Z.G.Dai Danzengluobu X.Q.Dong K.K.Duan j.H.Fan Y.Z.Fan j.Fang j.H.Fang K.Fang C.F.Feng H.Feng L.Feng s.H.Feng X.T.Feng Y.Feng Y.L.Feng s.Gabici B.Gao C.D.Gao Q.Gao W.Gao W.K.Gao M.M.Ge L.s.Geng G.Giacinti G.H.Gong Q.B.Gou M.H.Gu F.L.Guo X.L.Guo Y.Q.Guo Y.Y.Guo Y.A.Han M.Hasan H.H.He H.N.He j.Y.He Y.He Y.K.Hor B.W.Hou C.Hou X.Hou H.B.Hu Q.Hu s.C.Hu D.H.Huang T.Q.Huang W.j.Huang X.T.Huang X.Y.Huang Y.Huang X.L.ji H.Y.jia K.jia K.jiang X.W.jiang Z.j.jiang M.jin M.M.Kang I.Karpikov D.Kuleshov K.Kurinov B.B.Li C.M.Li Cheng Li Cong Li D.Li F.Li H.B.Li H.C.Li jian Li jie Li K.Li s.D.Li W.L.Li W.L.Li X.R.Li Xin Li Y.Z.Li Zhe Li Zhuo Li E.W.Liang Y.F.Liang s.j.Lin B.Liu C.Liu D.Liu D.B.Liu H.Liu H.D.Liu j.Liu j.L.Liu M.Y.Liu R.Y.Liu s.M.Liu W.Liu Y.Liu Y.N.Liu Q.Luo Y.Luo H.K.Lv B.Q.Ma L.L.Ma X.H.Ma j.R.Mao Z.Min W.Mitthumsiri H.j.Mu Y.C.Nan A.Neronov L.j.Ou P.Pattarakijwanich Z.Y.Pei j.C.Qi M.Y.Qi B.Q.Qiao j.j.Qin A.Raza D.Ruffolo A.sáiz M.saeed D.semikoz L.shao O.shchegolev X.D.sheng F.W.shu H.C.song Yu.V.stenkin V.stepanov Y.su D.X.sun Q.N.sun X.N.sun Z.B.sun j.Takata P.H.T.Tam Q.W.Tang R.Tang Z.B.Tang W.W.Tian C.Wang C.B.Wang G.W.Wang H.G.Wang H.H.Wang j.C.Wang Kai Wang Kai Wang L.P.Wang L.Y.Wang P.H.Wang R.Wang W.Wang X.G.Wang X.Y.Wang Y.Wang Y.D.Wang Y.j.Wang Z.H.Wang Z.X.Wang Zhen Wang Zheng Wang D.M.Wei j.j.Wei Y.j.Wei T.Wen C.Y.Wu H.R.Wu Q.W.Wu s.Wu X.F.Wu Y.s.Wu s.Q.Xi j.Xia G.M.Xiang D.X.Xiao G.Xiao Y.L.Xin Y.Xing D.R.Xiong Z.Xiong D.L.Xu R.F.Xu R.X.Xu W.L.Xu L.Xue D.H.Yan j.Z.Yan T.Yan C.W.Yang C.Y.Yang F.Yang F.F.Yang L.L.Yang M.j.Yang R.Z.Yang W.X.Yang Y.H.Yao Z.G.Yao L.Q.Yin N.Yin X.H.You Z.Y.You Y.H.Yu Q.Yuan H.Yue H.D.Zeng T.X.Zeng W.Zeng M.Zha B.B.Zhang F.Zhang H.Zhang 不详 Key Laboratory of Particle Astrophysics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Dublin Institute for Advanced studies 31 Fitzwilliam Place2 DublinIreland Max-Planck-Institut for Nuclear Physics P.O.Box 103980Heidelberg 69029Germany school of Physical science and Technology&school of Information science and Technology Southwest Jiaotong UniversityChengdu 610031China school of Astronomy and space science Nanjing UniversityNanjing 210023China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Tsung-Dao Lee Institute&school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Institute for Nuclear Research of Russian Academy of sciences Moscow 117312Russia Hebei Normal University Shijiazhuang 050024China University of science and Technology of China Hefei 230026China state Key Laboratory of Particle Detection and Electronics China Key Laboratory of Dark Matter and space Astronomy&Key Laboratory of Radio Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311121China Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China school of Physics and Astronomy Yunnan UniversityKunming 650091China Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China school of Physics and Astronomy(Zhuhai)&school of Physics(Guangzhou)&sino-French Institute of Nuclear Engineering and Technology(Zhuhai) Sun Yat-sen UniversityZhuhai 519000&Guangzhou 510275GuangdongChina Institute of Frontier and Interdisciplinary science Shandong UniversityQingdao 266237China APC UniversitéParis Cité

Theγ-ray emission from the W51 complex is widely acknowledged to be attributed to the interaction between the cosmic rays(CRs)accelerated by the shock of supernova remnant(sNR)W51C and the dense molecular clouds in the adjacent star-forming region,***,the maximum acceleration capability of W51C for CRs remains *** on observations conducted with the Large High Altitude Air shower Observatory(LHAAsO),we report a significant detection ofγrays emanating from the W51 complex,with energies from 2 to 200 *** LHAAsO measurements,for the first time,extend theγ-ray emission from the W51 complex beyond 100 TeV and reveal a significant spectrum bending at tens of *** combining the"π^(0)-decay bump"featured data from Fermi-LAT,the broadbandγ-ray spectrum of the W51 region can be well-characterized by a simple pp-collision *** observed spectral bending feature suggests an exponential cutoff at~400 TeV or a power-law break at~200 TeV in the CR proton spectrum,most likely providing the first evidence of sNRs serving as CR accelerators approaching the PeV ***,two young star clusters within W51B could also be theoretically viable to produce the most energeticγrays observed by *** findings strongly support the presence of extreme CR accelerators within the W51 complex and provide new insights into the origin of Galactic CRs.

关键词： UHE c-ray Cosmic rays sNR W51C star clusters

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再同步-除颤治疗心力衰竭患者可有效改善长期生存

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中国临床药理学杂志 2024年第8期40卷 1193-1193页

作者： sAPP j L sIVAKUMARAN s REDPATH C j 孟海峰

本研究为一项双盲、随机、对照的多中心临床试验。旨在确定植入式心律转复除颤器(ICD)中添加心脏再同步治疗(CRT)+最佳药物治疗与单独使用ICD+最佳药物治疗比较是否可以降低死亡率和心力衰竭入院治疗。然而,CRT对心衰患者长期生存的影... 详细信息

本研究为一项双盲、随机、对照的多中心临床试验。旨在确定植入式心律转复除颤器(ICD)中添加心脏再同步治疗(CRT)+最佳药物治疗与单独使用ICD+最佳药物治疗比较是否可以降低死亡率和心力衰竭入院治疗。然而,CRT对心衰患者长期生存的影响尚不清楚。

关键词：多中心临床试验长期生存植入式心律转复除颤器心力衰竭患者再同步心衰患者最佳药物 ICD

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蒸汽压缩式海水淡化装置

机电设备 1984年第2期 27-30+26页

作者： s.j.萨纳托里曹鑫达

本文提出了一种高产水比海水淡化装置的设计方案。该装置在进行工作时,盐水的最高温度为华氏250度。压缩比为1.58。高产水比的蒸汽压缩式流程用途广泛,既可用于双用途装置,也可用于单用途装置。采用了本设计方案就可较为容易地得到高产... 详细信息

本文提出了一种高产水比海水淡化装置的设计方案。该装置在进行工作时,盐水的最高温度为华氏250度。压缩比为1.58。高产水比的蒸汽压缩式流程用途广泛,既可用于双用途装置,也可用于单用途装置。采用了本设计方案就可较为容易地得到高产水比。从经济性方面来看,随着燃料价格的不断上涨,高产水比的流程正日益引人注目。本设计方案和工艺流程讨论了日产水量为237*万加仑的装置。本方案采用了以柴油机为动力源,容量为65700英尺3/分的离心压缩机,用它来操作与之相并联的四效立管泡沐式蒸发器（VTFE）。本方案采用了废热回收系统以及十七效立管泡沫式蒸发器,以便增加产水量。与普通的多级闪发式蒸发器相比,这种高产水比的装置在经济上具有竞争性。

关键词：蒸汽压缩立管管类蒸汽压缩机海水淡化装置产水量水比径流透平压缩机透平式压缩机离心式压缩机浓缩器蒸发器

Perturbations in the earthworm metabolite profile during a two-week exposure to metformin

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Emerging Contaminants 2024年第3期10卷 221-229页

作者： j.D.Gillis G.W.Price s.O.Prasher Department of Bioresource Engineering McGill UniversityFaculty of Agricultural and Environmental SciencesMacdonald-Stewart Building MS1-02721111 Lakeshore RoadSainte-Anne-de-BellevueQuebecH9X 3V9Canada Department of Engineering Dalhousie UniversityFaculty of Agriculture39 Cox RoadPO Box 550TruroNova ScotiaB2N 5E3Canada

Metformin is among the most prescribed pharmaceuticals in many countries,and as a result has shown up in biosolids derived from municipal wastewater treatment that are destined for land *** humans taking metformin,the effects include reduced glucose uptake in the intestine,a reduction in gluconeogenesis,increased oxidation of fatty acids,and reduced fatty acid *** effects of metformin on soil-dwelling organisms are not well *** study tested the effects of metformin exposure(0,10,40,160,640μg g^(-1))on the earthworm(***)at four time points(6 h,2 d,7 d,and 14 d)using GC-Ms to reveal sub-lethal effects and elucidate potential modes of action for *** were no mortalities observed,and earthworms exposed to the highest concentrations(160 and 640μg g^(-1))gained weight relative to the control on days 7 and *** reductions on day 7 were observed for glucose and malic acid(consistent with a reduction in gluconeogenesis),and for palmitic and margaric acid(consistent with increased oxidation and reduced synthesis of fatty acids).Lactic acid ranked first and second among canonicals 1 and 2 respectively and led to significant differences in discriminant scores across concentration and *** levels increased to equal or greater than the control on day 14,likely caused by reduced exposure as metformin is reported to be readily transformed by microorganisms under aerobic *** observations were consistent with the known effects of metformin in humans,and suggests that a similar mode of action exists in earthworms.

关键词： Metabolites Toxicity Earthworms Metformin GC-Ms

Rescattering of stimulated Raman side scattering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： s.Tan Q.Wang Y.Chen W.B.Yao C.Z.Xiao j.F.Myatt school of Physics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Physics and Computational Mathematics Beijing 100094China school of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and Computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stimulated Raman side scattering(sRss)is observed for the first time via two-dimensional(2D)particle-in-cell(PIC)*** construct a theoretical model for the rescattering process,which can predict the region of occurrence of mth-order sRss and estimate its *** rescattering process is identified by the 2D PIC simulations under typical conditions of a direct-drive inertial confinement fusion *** electrons produced by second-order sRss propagate nearly perpendicular to the density gradient and gain nearly the same energy as in first-order sRss,but there is no cascade acceleration to produce superhot *** studies for a wide range of ignition conditions show that sRss and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering