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国际医学放射学杂志 2021年第6期 732-733页

作者： s.R.Teixeira J.Elias Jr C.M.Coutinho M.C.Z.Zotin A.Y.Yamamoto s.f.b.de moura negrini 朱冬勇

就纳入标准和实验室检查结果而言,将神经影像学结果作为先天性寨卡病毒感染的主要结果的研究存在差异。目的研究产前接触寨卡病毒婴儿的颅内超声征象,并描

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Current guidelines for the management of celiac disease:A systematic review with comparative analysis

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World Journal of Gastroenterology 2022年第1期28卷 154-175页

作者： Alberto Raiteri Alessandro Granito Alice Giamperoli Teresa Catenaro Giulia negrini francesco Tovoli Division of Internal Medicine Hepatobiliary and Immunoallergic DiseasesIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy

bACKGROUND Wheat and other gluten-containing grains are widely consumed,providing approximately 50%of the caloric intake in both industrialised and developing *** widespread diffusion of gluten-containing diets has rapidly led to a sharp increase in celiac disease *** condition was thought to be very rare outside Europe and relatively ignored by health professionals and the global ***,in recent years,the discovery of important diagnostic and pathogenic milestones has led to the emergence of celiac disease(CD)from obscurity to global *** modifications have prompted experts worldwide to identify effective strategies for the diagnosis and follow-up of *** scientific societies,mainly from Europe and America,have proposed guidelines based on CD's most recent *** To identify the most recent scientific guidelines on CD,aiming to find and critically analyse the main *** We performed a database search on PubMed selecting papers published between January 2010 and January 2021 in the English *** was lastly accessed on 1 March *** We distinguished guidelines from 7 different scientific societies whose reputation is worldwide recognized and representative of the clinical practice in different geographical *** were noted in the possibility of a no-biopsy diagnosis,HLA testing,follow-up protocols,and *** We found a relatively high concordance between the guidelines for *** modifications have occurred in the last years,especially about the possibility of a no-biopsy diagnosis in *** modifications are expected in the next future and will probably involve the extension of the non-invasive diagnosis to the adult population and the follow-up modalities.

关键词： Celiac disease Gluten Gluten-free diet Gluten sensitivity Clinical guidelines Non-invasive diagnosis Histopathological findings serological markers Genetics

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAs detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad b. Abbott K. Abeling N.J. Abicht s.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti b.s. Acharya C. Adam bourdarios L. Adamczyk s.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad f. Ahmadov W.s. Ahmed s. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat b. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy s. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos f. Alfonsi M. Algren M. Alhroob b. Ali H.M.J. Ali s. Ali s.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire b.M.M. Allbrooke J.f. Allen C.A. Allendes flores P.P. Allport A. Aloisio f. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei s.P. Amor Dos santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders s.Y. Andrean A. Andreazza s. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli f. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio bella C. Appelt A. Apyan N. Aranzabal s.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-f. Arguin s. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai s. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos s. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten s. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. babal H. bachacou K. bachas A. bachiu f. backman A. badea P. bagnaia M. bahmani A.J. bailey V.R. bailey J.T. baines L. baines O.K. baker E. bakos D. bakshi Gupta V. balakrishnan R. balasubramanian E.M. baldin P. balek E. ballabene f. balli L.M. baltes W.K. balunas J. balz E. banas M. bandieramonte A. bandyopadhyay s. bansal L. barak M. barakat E.L. barberio D. barberis M. barbero M.Z. barel K.N. barends T. barillari M-s. barisits T. barklow P. baron D.A. baron Mo The ATLAs Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAs Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAs *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAs JET QUARK GLUON TAGGING

Transcriptome‑wide mapping of milk somatic cells upon subclinical mastitis infection in dairy cattle

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Journal of Animal science and biotechnology 2023年第6期14卷 2630-2648页

作者： Vittoria bisutti Nuria Mach Diana Giannuzzi Alice Vanzin Emanuele Capra Riccardo negrini Maria Elena Gelain Alessio Cecchinato Paolo Ajmone‑Marsan sara Pegolo DAfNAE University of PadovaViale Dell’Universita 16LegnaroPD 35020Italy. IHAP Universite de ToulouseINRAEENVT23 Chemin Des CapellesToulouse 31300France. IbbA National Research CouncilVia EinsteinLodi 26900Italy. DIANA Universita Cattolica del Sacro CuoreVia E.Parmense 84Piacenza 29122Italy. bCA University of PadovaViale Dell’Universita 16LegnaroPD 35020Italy.

background subclinical intramammary infection(IMI)represents a significant problem in maintaining dairy cows’*** severity and extent depend on the interaction between the causative agent,environment,and *** investigate the molecular mechanisms behind the host immune response,we used RNA-seq for the milk somatic cells(sC)transcriptome profiling in healthy cows(n=9),and cows naturally affected by subclinical IMI from Proto-theca spp.(n=11)and streptococcus agalactiae(***;n=11).Data Integration Analysis for biomarker discov-ery using Latent Components(DIAbLO)was used to integrate transcriptomic data and host phenotypic traits related to milk composition,sC composition,and udder health to identify hub variables for subclinical IMI *** A total of 1,682 and 2,427 differentially expressed genes(deGs)were identified when comparing Prototheca *** *** to healthy animals,***-specific pathway analyses evidenced that Proto-theca’s infection upregulated antigen processing and lymphocyte proliferation pathways while *** induced a reduction of energy-related pathways like the tricarboxylic acid cycle,and carbohydrate and lipid *** integrative analysis of commonly shared deGs between the two pathogens(n=681)referred to the core-mastitis response genes,and phenotypic data evidenced a strong covariation between those genes and the flow cytometry immune cells(r2=0.72),followed by the udder health(r2=0.64)and milk quality parameters(r2=0.64).Variables with r≥0.90 were used to build a network in which the top 20 hub variables were identified with the Cytoscape cyto-hubba *** genes in common between DIAbLO and cytohubba(n=10)were submitted to a ROC analysis which showed they had excellent predictive performances in terms of discriminating healthy and mastitis-affected animals(sensitivity>0.89,specificity>0.81,accuracy>0.87,and precision>0.69).Among these genes,CIITA could play a key role in re

关键词： Data integration Immune response Milk somatic cells RNA-sequencing subclinical mastitis

<i>Endopolygalacturonase</i>Gene Polymorphisms: Asset of the Locus in Different Peach Accessions

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American Journal of Plant sciences 2017年第4期8卷 941-957页

作者： silvia Morgutti Noemi negrini Alessandra Ghiani federica baldin Daniele bassi Maurizio Cocucci department of Agricultural and Environmental sciences-Production Landscape Agroenergy (DISAA) University of Milan Milan Italy

Endopolygalacturonase (endoPG) plays a pivotal role in determining peach [Prunus persica L. (batsch)] fruit characteristics. Different Pp-endoPG genes or allelic variants have been described, characterized by different polymorphisms: insertions-deletions (Indels) and single nucleotide polymorphisms (sNPs). Eighty-five peach accessions (comprising commercial cultivars, f1 progenies of selected crosses, and three haploid seedlings) with different flesh softening patterns (Non Melting: NM;Melting: M;slow softening: ss;stony Hard: sH) were screened by exploiting specific polymorphisms, with the aim to characterize their asset at the endoPG locus and evaluate a potential relationship with fruit flesh texture phenotype. The results of Indel analysis allowed to distinguish, by a simple genotyping procedure, NM flesh phenotypes from the others. further information arose from this analysis, showing that two Pp-endoPG genes, i.e., Pp-endoPGm (Ppa006839m), involved in the determination of the Melting/Non Melting trait, and Pp-endoPG_M (Ppa006857m), involved in the determination of the Clingstone/freestone trait, always co-segregate, and that ss big Top possesses a “null” Pp-endoPG allele. Cleaved Amplified Polymorphic sequence (CAPs) analysis allowed to preliminarily discriminate the Pp-endoPG variants of the ss and sH accessions considered. The integrated use of the considered polymorphisms in a high number of peach accessions proved useful, by individuating the different gene variants and their combinations, to describe the structure of the endoPG locus in different genotypes.

关键词： CAPs Analysis Indel/sNP Polymorphisms Pp-endoPG Prunus persica

The Primary Motor Cortex stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in <i>Rattus norvegicus</i>

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World Journal of Neuroscience 2019年第3期9卷 138-152页

作者： Priscila Medeiros sylmara Esther negrini-ferrari Ana Carolina Medeiros Lais Leite ferreira Josie Resende Torres da silva José Aparecido da silva Norberto Cysne Coimbra Renato Leonardo de freitas Neurosciences aboratory of Pain & Emotions and Multi-User Centre of Neuroelectrophysiology Department of Surgery and Anatomy Ribeir&atilde o Preto Medical school of the University of s&atilde o Paulo Ribeir&atilde o Preto S&atilde o Paulo Brazil Laboratory of Neuroanatomy and Neuropsychobiology Department of Pharmacology Ribeir&atilde o Preto Medical school of the University of s&atilde o Paulo (fMRP-UsP) Ribeir&atilde o Preto (sP) Brazil biomedical sciences Institute Federal University of Alfenas (UNIFAL-MG) Alfenas Minas Gerais (MG) Brazil Motricity sciences Institute UNIFAL-MG Alfenas MG Brazil Post-Graduate Program of biosciences Applied to Health (PPGb) UNIFAL Biomedical Sciences Institute Alfenas MG Brazil department of Psychology Ribeir&atilde o Preto school of Philosophy Sciences and Literature of the University of S&atilde o Paulo ffCLRP-UsP Ribeir&atilde o Preto Brazil department of Psychology Federal University of Juiz de Fora (UFJF-MG) Juiz de Fora (MG) Brazil behavioural Neurosciences Institute (INeC) Ribeir&atilde o Preto (sP) Brazil

background: The primary motor cortex (M1) stimulation (MCs) is a useful tool for attenuation of the peripheral neuropathic pain in patients with pharmacologically refractory pain. furthermore, that neurological procedure may also cause antinociception in rodents with neuropathic pain. Cold allodynia is a frequent clinical finding in patients with neuropathic pain, then, we evaluated if an adapted model of neuropathy induced by chronic constriction injury (CCI) of the ischiadicus nervus (sciatic nerve) produces cold allodynia in an animal model of chronic pain. In addition, we also investigated the effect of the electrical stimulation of the M1 on chronic neuropathic pain condition in laboratory animals. Methods: Male Wistar rats were used. An adapted model of peripheral mononeuropathy induced by CCI was carried out by placing a single loose ligature around the right sciatic nerve. The acetone test was used to evaluate the cold allodynia in CCI or sham (without ligature) rats. The MCs (M1) was performed at low-frequency (20 μA, 100 Hz) during 15 s by deep brain stimulation (Dbs-Thomas Recording device) 21 days after CCI or sham procedures. The cold allodynia was measured before and immediately after the neurostimulation of M1 in the following time-window: 0, 15 and 30 min after MCs. Results: Cold allodynia threshold increased in animals with chronic neuropathic pain submitted to the acetone test 21 days after the CCI surgery. The M1-stimulation by Dbs procedure decreased the cold allodynia immediately and until 30 min after M1-stimulation in rats with chronic neuropathic pain. Conclusion: The current proposal for a CCI model by a single loose ligature of the sciatic nerve can be employed as an experimental model of chronic neuropathic pain in rats submitted to peripheral nervous system injury. The M1-stimulation produced antinociception in rats with chronic neuropathic pain. Thus, we reinforced that the MCs decreases cold allodynia in laboratory animals submitted to

关键词： Peripheral Neuropathic Pain Chronic Pain sciatic Nerve Chronic Constriction Injury Cold Allodynia Primary Motor Cortex stimulation Antinociception

Clinical and diagnostic aspects of gluten related disorders

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World Journal of Clinical Cases 2015年第3期3卷 275-284页

作者： francesco Tovoli Chiara Masi Elena Guidetti Giulia negrini Paola Paterini Luigi bolondi department of Medical and surgical sciences University of Bologna

Gluten is one of the most abundant and widely distributed components of food in many areas. It can be included in wheat, barley, rye, and grains such as oats, barley, spelt, kamut, and triticale. Gluten-containinggrains are widely consumed; in particular, wheat is one of the world's primary sources of food, providing up to 50% of the caloric intake in both industrialized and developing countries. Until two decades ago, celiac disease(CD) and other gluten-related disorders were believed to be exceedingly rare outside of Europe and were relatively ignored by health professionals and the global media. In recent years, however, the discovery of important diagnostic and pathogenic milestones led CD from obscurity to global prominence. In addition, interestingly, people feeding themselves with glutenfree products greatly outnumber patients affected by CD, fuelling a global consumption of gluten-free foods with approximately $2.5 billion in United states sales each year. The acknowledgment of other medical conditions related to gluten that has arisen as health problems, providing a wide spectrum of gluten-related disorders. In february 2011, a new nomenclature for gluten-related disorders was created at a consensus conference in London. In this review, we analyse innovations in the field of research that emerged after the creation of the new classification, with particular attention to the new European society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines for CD and the most recent research about non-celiac gluten sensitivity.

关键词： Celiac disease Wheat allergy Gluten sensitivity Non-celiac gluten sensitivity Gluten-free diet Gluten Anti-gliadin antibodies