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Viral and nonviral nanocarriers for in vivo CRIsPR-based gene editing

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Nano Research 2024年第10期17卷 8904-8925页

作者： Zhongyuan Guo Audrey t.Zhu Ronnie H.Fang Liangfang Zhang Aiiso Yufeng Li Family Department of Chemical and Nano engineering University of California San DiegoLa JollaCA 92093USA Division of Host-Microbe systems and therapeutics Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA

the continued development of clustered regularly interspaced short palindromic repeats(CRIsPR)technology has the potential to greatly impact clinical medicine,particularly for disease diagnosis and *** high demand for the in vivo delivery of CRIsPR-based therapies,significant challenges *** include rapid degradation by enzymes,inefficient disease site targeting,and the risk of undesired off-target *** platforms,with their tailorable properties,have been engineered to efficiently package CRIsPR payloads in various formats,including as plasmid DNA,mRNA,and ribonucleoprotein complexes,for in vivo *** them,recombinant adeno-associated viruses,virus-like particles,and lipid nanoparticles have displayed exceptional *** review will discuss the development of these and other nanocarriers for in vivo CRIsPR-based genome editing.

关键词： clustered regularly interspaced short palindromic repeats(CRIsPR) in vivo gene editing nanocarriers recombinant adeno-associated viruses(rAAVs) virus-like particle(VLP) lipid nanoparticle(LNP)

Astrocytes dynamically regulate the blood-brain barrier in the healthy brain

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Neural Regeneration Research 2024年第4期19卷 709-710页

作者： AgnėPociūtė Augustas Pivoriūnas Alexei Verkhratsky Department of stem Cell Biology State Research Institute Centre for Innovative MedicineVilniusLithuania Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Centre for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain Department of Forensic Analytical toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina

the blood-brain barrier(BBB)(discovered and defined by Max Lewandowsky and Lina stern,and not,as it is universally,and yet erroneously believed,by Paul ehrlich(Verkhratsky and Pivoriunas,2023))that separates the nervous system from the circulation is evolutionarily conserved from arthropods to *** primeval BBB of the invertebrates and some early vertebrates was made solely by glial cells and secured(in invertebrates)by septate junctions.

关键词： ehrlich barrier blood

elevation transition of aquatic insects closely matches a thermal feature in the Yungas of Northwestern Argentina

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Journal of Mountain science 2024年第2期21卷 433-448页

作者： Alexandra BUItRAGO-GUACANAMe Carlos MOLINeRI Andrés LIRA-NORIeGA Daniel Andrés DOs sANtOs Neotropical Biodiversity Institute(CONICet-UNt) UNT-DomesHorco Molle S/N4107 TucumánArgentina CONACYt Research Fellow Network of Advanced Molecular StudiesInstitute of Ecology A.COld Road to Coatepec 351El HayaCP 91073XalapaVeracruzMexico Biostatistics Chair Faculty of Natural Sciences and IMLNational University of TucumánSan Miguel de TucumánMiguel Lillo 2054000 TucumánArgentina

temperature is a key factor that shapes the distribution of *** knowledge about how species respond to temperature is relevant to devise strategies for addressing the impacts of climate *** insects are particularly vulnerable to climate change,yet there is still much to learn about their ecology and *** the Yungas ecoregion of Northwestern Argentina,cold-and warm-adapted species of the orders ephemeroptera,Plecoptera,and trichoptera(ePt)are segregated by *** modeled the ecological niche of south American ePt species in this region using available data and projected their potential distribution in geographic *** were grouped based on their ecogeographic similarity,and we analyzed their replacement pattern along elevation gradients,focusing on the ecotone where opposing thermal preferences *** this interface,we identified critical points where the combined incidence of cold and warm assemblages maximizes,indicating a significant transition *** found that the Montane Cloud Forest holds the interface,with a particularly greater suitability at its lower *** main axis of the interface runs in a N-s direction and falls between 14°C-16°C mean annual *** probability of a particular location within a basin being classified as part of the interface increases as Kira’s warmth index approaches a score around *** the interface is critical for defining the thermal limits of species distribution and designing biomonitoring *** in the location of thermal constants related to mountainous ecotones may cause vertical displacement of aquatic insects and vegetation *** have recognized significant temperature thresholds that serve as indicators of suitability for the *** global warming is anticipated to shift these indicators,we suggest using them to monitor the imprints of climate change on mountain ecosystems.

关键词： Austral Yungas ecological Niche Model ephemeroptera Kira’s warmth index Plecoptera trichoptera

Conservation laws,Lie symmetries,self adjointness,and soliton solutions for the selkov–schnakenberg system

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Communications in theoretical Physics 2024年第2期76卷 29-44页

作者： Kashif Ali Aly R seadawy syed t R Rizvi Noor Aziz Department of Mathematics COMSATS University IslamabadLahore CampusPakistan Mathematics Department Faculty of ScienceTaibah UniversityAl-Madinah Al-Munawarah41411Saudi Arabia

In this article,we explore the famous selkov–schnakenberg(ss)system of coupled nonlinear partial differential equations(PDes)for Lie symmetry analysis,self-adjointness,and conservation ***,miscellaneous soliton solutions like dark,bright,periodic,rational,Jacobian elliptic function,Weierstrass elliptic function,and hyperbolic solutions of the ss system will be achieved by a well-known technique called sub-ordinary differential *** these results are displayed graphically by 3D,2D,and contour plots.

关键词： selkov-schnakenberg system Lie symmetry analysis conservation laws adjointness integrability

A study of the Comets with Large Perihelion Distances C/2019 L3(AtLAs)and C/2019 O3(Palomar)

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Research in Astronomy and Astrophysics 2024年第9期24卷 199-213页

作者： Alberto s.Betzler Centro de Ciencia e tecnologia em energia e sustentabilidade Universidade Federal do Recôncavo da BahiaFeira de SantanaBahia44.085-132Brazil

this work analyzes the photometric data of the Oort spike comets C/2019 L3(AtLAs)and C/2019 O3(Palomar)obtained between 2016 and 2023 by the AtLAs network and the Belgian Olmen *** comets Palomar and AtLAs have a typical and unusually high activity level,respectively,based on the Afρparameter corrected to phase angle zero at *** absolute magnitude of comets AtLAs and Palomar in the o-band is 4.71±0.05 and 4.16±0.02 *** cometary activity of comets AtLAs and Palomar probably began at r>13 au before perihelion and will end at r>14 au after perihelion,which means that they could remain active until the second half of *** nucleus of comet AtLAs has a minimum radius of 7.9 km,and the nucleus of comet Palomar could be a little *** c-o colors of the comets AtLAs and Palomar are redder and bluer,respectively,at perihelion than the solar twin YBP *** comets showed a bluish trend in the coma color with decreasing heliocentric *** Palomar probably had two outbursts after its perihelion,each releasing about 10^(8)kg of *** slopes of the photometric profile of the comae of these comets were between 1and 1.5,indicating a steady state during the observation campaign.

关键词： individual C/2019 L3(AtLAs) C/2019 O3(Palomar) techniques:photometric methods:data analysis

Improved state-space Modelling for Microgrids Without Virtual Resistances

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Journal of Modern Power systems and Clean energy 2024年第2期12卷 584-596页

作者： Paranagamage s.A.Peiris shaahin Filizadeh Dharshana Muthumuni Department of electrical and Computer engineering University of ManitobaWinnipegMBR3T 5V6Canada Manitoba HVDC Research Center 211 Commerce DriveWinnipegMBR3P 1A3Canada Ieee

Power converters and their interfacing networks are often treated as modular state-space blocks for small-signal stability studies in microgrids;they are interconnected by matching the input and output states of the network and *** resistors have been widely used in existing models to generate a voltage for state-space models of the network that require voltage *** paper accurately quantifies the adverse impacts of adding the virtual resistance and proposes an alternative method for network modelling that eliminates the requirement of the virtual resistor when interfacing converters with *** proposed nonlinear method allows initialization,time-domain simulations of the nonlinear model,and linearization and eigenvalue generation.A numerically linearized small-signal model is used to generate eigenvalues and is compared with the eigenvalues generated using the existing modelling method with virtual *** of the existing method and improvements offered by the proposed modelling method are clearly *** transient(eMt)simulations using detailed switching models are used for validation of the proposed modelling method.

关键词： Low-voltage converter state-space modelling dynamic phasor time-domain simulation eigenvalue analysis

exploring the electromagnetic shielding behavior of lanthanum doped calcium nanoferrites

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Journal of Rare earths 2024年第11期42卷 2128-2136页

作者： e.Ahilandeswari K.sakthipandi R.Rajesh Kanna G.Rajkumar B.Ganesh Babu s.Arunmetha Aslam Hossain P.sakthivel V.Rajendran M.srinidhi Raghavan Department of Physics SRM TRP Engineering College Department of electronics and Communication engineering M. Kumarasamy College of Engineering Department of Physics Easwari Engineering College Department of Mechanical engineering SRM TRP Engineering College Centre for Advanced energy studies Department of Electronics and Communication EngineeringKoneru Lakshmaiah Education Foundation smart Materials Research Institute Southern Federal University Centre for Materials science Department of PhysicsScience and HumanitiesFaculty of EngineeringKarpagam Academy of Higher Education Centre for Nanotechnology Academy of Maritime Education and Training (Deemed to be University) Department of Chemistry and Centre for Nano-Materials and Displays B.M.S. College of Engineering

the present study focuses on the synthesis and characterization of lanthanum(La3+)-doped calcium nanoferrites(CaLaxFe2-xO4:x=0.025,0.050,0.075 and 0.100) using the sonochemical *** techniques were employed to analyze the effect of La3+infusion,Raman spectroscopy confirms the presence of active A1g,t2gand egmodes in the CaLaxFe2-xO4nanoferrite,indicating the formation of an active ferrite *** introduction of La3+doping results in a significant increase in the band gap energy,rendering the nanoferrites insulating（3.23-3,57 eV）.At higher frequencies,the impedance studies reveal minimal losses and better AC conductivity,pointing to improved dielectric *** higher frequencies,the Q-factor of La-doped calcium nanoferrites shows lower electromagnetic *** M-H curve exhibits ferromagnetic behavior,with La3+-doped calcium nano ferrites displaying a saturation magnetization ranging from 12.72 to 18.10 emu/*** incorporation of La3+also induces enhanced electrical polarization,leading to notable dielectric loss and increased absorption of electromagnetic ***,these CaLaxFe2-xO4nanoferrites demonstrate potential as effective microwave absorbers across a wide frequency range,with significant shielding absorption observed at 8.8-9.1 GHz.

关键词： Dielectric Magnetism Microwave absorption Nanoferrites Rare earths structural properties

Prompt neutron emission in ^(250)No spontaneous fission associated with ground and isomeric state decays

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Chinese Physics C 2024年第6期48卷 112-117页

作者： R.s.Mukhin A.V.Isaev A.V.Andreev M.L.Chelnokov V.I.Chepigin H.M.Devaraja I.N.Izosimov A.A.Kuznetsova O.N.Malyshev A.G.Popeko Yu.A.Popov A.Rahmatinejad B.sailaubekov t.M.shneidman e.A.sokol A.I.svirikhin M.s.tezekbayeva M.A.Bychkov A.V.Yeremin O.Dorvaux B.Gall K.Kessaci K.Hauschild A.Lopez-Martens Joint Institute for Nuclear Research Dubna141980Russia Dubna state University Dubna141982Russia Institute of Nuclear Physics Almaty050032Kazakhstan L.N.Gumilyov eurasian National University Astana010008Kazakhstan Kazan Federal University Kazan420008Russia Universitéde strasbourg CNRSStrasbourg67000France IJCLab IN2P3-CNRSUniversitéParis-SaclayOrsay91400France

the complete-fusion reaction^(204)Pb(^(48)Ca,2n)^(250)No was used to study two activities of^(250)No with distinct half-lives.A total of 1357 events were observed in the sFiNx neutron detection *** average number of neutrons emitted per spontaneous fission of^(250)No was determined to be(4.1±0.1).the unusually symmetrical shape of the prompt neutron multiplicity distribution was restored and presented for the first *** tests were performed to compare the prompt neutron multiplicity distributions associated with the ground state and K-isomer state decays.

关键词： spontaneous fission prompt neutrons actinide

On the interaction phenomena to the nonlinear generalized Hietarinta-type equation

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Journal of Ocean engineering and science 2024年第1期9卷 89-97页

作者： Usman Younas t.A.sulaiman Jingli Ren A.Yusuf state Key Laboratory of Power Grid environmental Protection/Henan Academy of Big Data Zhengzhou UniversityZhengzhou 450001China Faculty of science Federal University DutseJigawaNigeria Department of Computer engineering Biruni University IstanbulTurkey

In this paper,we describe the nonlinear behavior of a generalized fourth-order Hietarinta-type equa-tion for dispersive waves in(2+1)*** various wave formations are retrieved by using Hirota’s bilinear method(HBM)and various test function *** Hirota method is a widely used and robust mathematical tool for finding soliton solutions of nonlinear partial differential equa-tions(NLPDes)in a variety of disciplines like mathematical physics,nonlinear dynamics,oceanography,engineering sciences,and others requires bilinearization of nonlinear *** different wave structures in the forms of new breather,lump-periodic,rogue waves,and two-wave solutions are *** addi-tion,the physical behavior of the acquired solutions is illustrated in three-dimensional,two-dimensional,density,and contour profiles by the assistance of suitable *** on the obtained results,we can assert that the employed methodology is straightforward,dynamic,highly efficient,and will serve as a valuable tool for discussing complex issues in a diversity of domains specifically ocean and coastal *** have also made an important first step in understanding the structure and physical be-havior of complex structures with our findings *** believe this research is timely and relevant to a wide range of engineering *** results obtained are useful for comprehending the fundamental scenarios of nonlinear sciences.

关键词： Hirota’s bilinear method Lump-periodic solutions Breather waves Rouge waves Multi-waves