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A MATHEMATICAL THEORY FOR LEs CONVERGENCE

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Acta Mathematica scientia 2012年第1期32卷 237-258页

作者： H.Lim T.Kaman V.Mahadeo J.Glimm s.dutta D.H.sharp B.Plohr Department of Applied Mathematics and statistics Stony Brook University College of st.Catherine Los Alamos National Laboratory

Practical simulations of turbulent processes are generally cutoff, with a grid resolution that stops within the inertial range, meaning that multiple active regions and length scales occur below the grid level and are not resolved. This is the regime of large eddy simulations （LEs）, in which the larger but not the smaller of the turbulent length scales are resolved. solutions of the fluid Navier-stokes equations, when considered in the inertial regime, are conventionally regarded as solutions of the Euler equations. In other words, the viscous and diffusive transport terms in the Navier-stokes equations can be neglected in the inertial regime and in LEs simulations, while the Euler equation becomes fundamental. For such simulations, significant new solution details emerge as the grid is refined. It follows that conventional notions of grid convergence are at risk of failure, and that a new, and weaker notion of convergence may be appropriate. It is generally understood that the LEs or inertial regime is inherently fluctuating and its description must be statistical in nature. Here we develop such a point of view systematically, based on Young measures, which are measures depending on or indexed by space time points. In the Young measure du（ξ）x,t, the random variable ξ of the measure is a solution state variable, i.e., a solution dependent variable, representing momentum, density, energy and species concentrations, while the space time coordinates, x, t, serve to index the *** evidence suggests that convergence via Young measures is suifficiently weak to encompass the LEs/inertial regime; numerical and theoretical evidence suggests that this notion may be required for passive scalar concentration and therm degrees of freedom. Our objective in this research is twofold： turbulent simulations without recourse to ad- justable parameters （calibration） and extension to more complex physics, without use of additional models or parameters, in both cases with

关键词： numerical methods turbuent mixing

不同来源的芦荟对酪氨酸酶的抑制作用(英文)

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中国天然药物 2013年第6期11卷 616-620页

作者： s.dutta Gupta s.K.Masakapalli Department of Agricultural and Food Engineering Indian Institute of Technology Kharagpur Department of Plant sciences University of Oxford

In this study, lyophilized and methanolic extracts of aloe gel from different germplasms were evaluated for their potential to inhibit mushroom tyrosinase activity. The results showed potent inhibitory effect of Aloe vera gel extracts on L-dihydroxyphenylalanine(L-DOPA) oxidation catalyzed by tyrosinase in a dose-dependent manner. significant differences in % inhibition of tyrosinase among the extraction methods and the germplasms were observed. The relative performance of the germplasms was evaluated with the help of posthoc multicomparison test. The methanolic extract was more effective than the lyophilized crude gel in all the germplasms. The inhibitory effect of the lyophilized gel and methanolic extract tested from five germplasms followed the order: RM > TN > s24 > OR > RJN. The germplasm RM showed the highest tyrosinase inhibition, and the maximum % inhibition noted was 26.04% and 41.18%, respectively for the lyophilized and methanolic extracts at 6 mg·mL–1concentration. Lineweaver-Burk plots of the different concentrations of L-DOPA in the absence and presence of lyophilized gel extract showed competitive inhibition of mushroom tyrosinase in all the germplasms. This study suggests that the germplasm RM could potentially be used for the isolation and identification of the effective tyrosinase inhibitory component, and ascertains the critical role of selecting the best source of germplasm for natural product isolation and characterization.

关键词： Aloe vera L.gel Tyrosinase inhibitor L-DOPA Inhibition kinetics Germplasm sourcing

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钢芯铝线的新弛度-张力计算法

电力建设 1984年第9期 54-59页

作者： J.s.Barrett s.dutta O.Nigol 潘忠华安大略水电局研究部安大略水电局研究部安大略水电局研究部加拿大加拿大加拿大

序言一个新的弛度-张力计算机程序的产生,取决于改变架空线路运行条件以及设计工程师需要更加逼真的设计标准。改变运行条件的实际例子是运行温度的提高,以及架空导线因使用更为有效的振动控制措施而可提高导线张力。此外,现已有足够多... 详细信息

序言一个新的弛度-张力计算机程序的产生,取决于改变架空线路运行条件以及设计工程师需要更加逼真的设计标准。改变运行条件的实际例子是运行温度的提高,以及架空导线因使用更为有效的振动控制措施而可提高导线张力。此外,现已有足够多的蠕变数据可供在计算机程序中判断导线蠕变的

关键词：蠕变参数钢芯铝线应变曲线计算机程序线张力蠕变曲线导线长度弹性应变蠕变量方程式方程累加法弛度蠕变方程

Congruent Feature selection Method to Improve the Efficacy of Machine Learning-Based Classification in Medical Image Processing

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Computer Modeling in Engineering & sciences 2025年第1期142卷 357-384页

作者： Mohd Anjum Naoufel Kraiem Hong Min Ashit Kumar dutta Yousef Ibrahim Daradkeh Department of Computer Engineering Aligarh Muslim UniversityAligarh202002India College of Computer science King Khalid UniversityAbha61413Saudi Arabia school of Computing Gachon UniversitySeongnam13120Republic of Korea Department of Computer science and Information systems College of Applied SciencesAlMaarefa UniversityRiyadh13713Saudi Arabia Department of Computer Engineering and Information College of Engineering in Wadi AlddawasirPrince Sattam bin Abdulaziz UniversityAl-Kharj16273Saudi Arabia

Machine learning(ML)is increasingly applied for medical image processing with appropriate learning *** applications include analyzing images of various organs,such as the brain,lung,eye,etc.,to identify specific flaws/diseases for *** primary concern of ML applications is the precise selection of flexible image features for pattern detection and region *** of the extracted image features are irrelevant and lead to an increase in computation ***,this article uses an analytical learning paradigm to design a Congruent Feature selection Method to select the most relevant image *** process trains the learning paradigm using similarity and correlation-based features over different textural intensities and pixel *** similarity between the pixels over the various distribution patterns with high indexes is recommended for disease ***,the correlation based on intensity and distribution is analyzed to improve the feature selection ***,the more congruent pixels are sorted in the descending order of the selection,which identifies better regions than the ***,the learning paradigm is trained using intensity and region-based similarity to maximize the chances of ***,the probability of feature selection,regardless of the textures and medical image patterns,is *** process enhances the performance of ML applications for different medical image *** proposed method improves the accuracy,precision,and training rate by 13.19%,10.69%,and 11.06%,respectively,compared to other models for the selected *** mean error and selection time is also reduced by 12.56%and 13.56%,respectively,compared to the same models and dataset.

关键词： Computer vision feature selection machine learning region detection texture analysis image classification medical images

La3+ substitution-adjusted magnetic and optical properties with enhanced photocatalytic activity and stability of copper zinc nickel ferrites for wastewater treatment applications

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Journal of Rare Earths 2025年第2期43卷 319-328页

作者： N.s.Al-Bassami General studies Department Jubail Industrial College

Copper-zinc-nickel（Cu-Zn-Ni） ferrite nanoparticles are used for wastewater treatment ***,low degradation efficiency and stability are two main issues that make them unsuitable for actual production *** this paper,the citrate-nitrate auto-combustion method was applied for the formation of Cu0.5Zn0.25Ni0.25LaxFe2-xO4;（0≤x≤0.1;step 0.02）(CZNL) *** the substitution process entails the replacement of a small ion with a larger one,the lattice constant and crystallite size does not exhibit a consistent incremental *** behavior is justified and *** size of all the CZNL ferrite nanoparticles is in the range of 8-12 nm,and the lattice constant is in the range of 8.6230 to 8.4865 *** morphological analysis conducted using field emission-scanning electron microscopy（FE-sEM） reveals that the CZNL exhibits agglomerated spherical *** energy dispersive X-ray spectrameter（EDAX） analysis was employed to confirm the elemental composition of CZNL *** the process entails the substitution of Fe3+magnetic ions with nonmagnetic ions La3+,the magnetic parameters of CZNL nanoferrites show a general decreasing trend as *** 20 K,saturation magnetization Ms shows an overall drop in its values from 59.302 emu/g at x=0.0-41.295 emu/g at x=0.1,the smallest value of 37.87 emu/g is recorded at x=*** highest coercivity（Hc=125.9 Oe） and remanence（Mr=13.32 emu/g） are recorded for x=0.08 and x=0.04 nanoferrite,*** band gap of all the CZNL nanoferrites was determined using the Kubelka-Munk function and Tauc plot for direct permitted *** doping modifies the band gap（within 1.86-1.75 eV）,increases light absorption,induces efficient e/h separation and charge migration to *** nanoferrite Cu0.5Zn0.25Ni0.25La0.06Fe1.94O4achieves a degradation efficiency of 97.3% for methylene blue（MB） dye removal after just 60 *** five recycling processes,the nanoc

关键词： Copper-zinc-nickel Ferrite Photocatalytic properties Rare earths Wastewater treatment

Reasons for discontinuing tirzepatide in randomized controlled trials:A systematic review and meta-analysis

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World Journal of Diabetes 2025年第4期16卷 284-296页

作者： Abul Bashar Mohammad Kamrul-Hasan Joseph M Pappachan Deep dutta Lakshmi Nagendra Mohammad shafi Kuchay Nitin Kapoor Department of Endocrinology Mymensingh Medical CollegeMymensingh 2200DhakaBangladesh Faculty of science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Department of Endocrinology KMC Medical CollegeManipal UniversityManipal 576104India Department of Endocrinology CEDAR Superspeciality HealthcareDwarka New Delhi 110075India Department of Endocrinology JSS Medical CollegeJSS Academy of Higher Education&ResearchMysore 570015India Department of Endocrinology and Diabetes Medanta the Medicity HospitalGurugram 122001HaryanaIndia Department of Endocrinology Diabetes and MetabolismChristian Medical College and HospitalVellore 632004Tamil NaduIndia Non-Communicable Disease Unit Melbourne School of Population and Global HealthUniversity of MelbourneCarlton 3053VictoriaAustralia

BACKGROUND Despite therapeutic benefits,discontinuation of tirzepatide is common in randomized controlled trials(RCTs)due to adverse events(AEs)and other *** previous systematic reviews have explored the reasons for discontinuing tirzepatide in the *** To explore the reasons for permanent discontinuation of tirzepatide vs controls[placebo,insulin,and glucagon-like peptide-1 receptor agonists(GLP-1Ras)]in *** Relevant RCTs were systematically searched using related terms through multiple databases such as MEDLINE(via PubMed),scopus,Cochrane Central Register,and *** from their inception until June 20,*** web was used to conduct meta-analysis using random-effects *** were presented as risk ratios(RR)with 95%confidence intervals(CI).REsULTs seventeen RCTs(n=14645),mostly having low risks of bias,were *** to placebo,the risk of permanent discontinuation of the study drug was substantially lower with tirzepatide 10 mg(RR:0.69,95%CI:0.51-0.93,P=0.02)and similar with tirzepatide 5 mg(RR:0.74,95%CI:0.47-1.17,P=0.20)and 15 mg(RR:0.94,95%CI:0.68-1.31,P=0.71).Tirzepatide had identical discontinuation risks when compared to insulin at 5 mg(RR:0.96,95%CI:0.75-1.24,P=0.77)and 10 mg(RR:1.19,95%CI:0.77-1.82,P=0.44)doses,whereas such risk was higher with tirzepatide 15 mg than insulin(RR:1.31,95%CI:1.03-1.67,P=0.03).Compared to GLP-1RA,the permanent discontinuation risk was similar with tirzepatide 5 mg(RR:0.98,95%CI:0.70-1.37,P=0.90)but was higher with tirzepatide 10 mg(RR:1.40,95%CI:1.03-1.90,P=0.03)and 15 mg(RR:1.70,95%CI:1.27-2.27,P=0.0004).Tirzepatide,at all doses,had higher risks of AE-related discontinuation than insulin;such risks were only greater with higher doses of tirzepatide than with placebo or *** risk due to withdrawal by the study subjects was lower with tirzepatide than with placebo or *** to the placebo,tirzepatide(all doses)conferred a lower risk of study drug di

关键词： Tirzepatide Drug adherence study drug discontinuation Adverse events Withdrawal by the study subjects

Renal effects and safety of tirzepatide in subjects with and without diabetes:A systematic review and meta-analysis

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World Journal of Diabetes 2025年第2期16卷 270-283页

作者： ABM Kamrul-Hasan shinjan Patra Deep dutta Lakshmi Nagendra AFM Muntahi-Reza sanja Borozan Joseph M Pappachan Department of Endocrinology Mymensingh Medical CollegeMymensingh 2200DhakaBangladesh Department of Endocrinology and Metabolism All India Institute of Medical Sciences NagpurNagpur 441108MaharashtraIndia Department of Endocrinology CEDAR Superspeciality ClinicsDwarkaNew Delhi 110075India Department of Endocrinology JSS Medical CollegeJSS Academy of Higher Education&ResearchMysore 570015India Department of Urology Bangabandhu Sheikh Mujib Medical UniversityDhaka 1000Bangladesh Department of Endocrinology Clinical Centre of MontenegroPodgorica 81000Montenegro Faculty of Medicine University of MontenegroPodgorica 81000Montenegro Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS Trust&Manchester Metropolitan UniversityPreston PR29HTUnited Kingdom Faculty of science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Department of Endocrinology Kasturba Medical CollegeManipal UniversityManipal 576104India

BACKGROUND Type 2 diabetes(T2D),as well as obesity,are risk factors for chronic kidney disease(CKD)and end-stage renal *** renal impacts of glucose-lowering and weight-lowering drugs and their potential benefits in preventing CKD often guide clinicians in choosing them *** limited data based on randomized controlled trials(RCTs)is currently available on the renal effects and safety profile of *** To explore the renal benefits and safety of tirzepatide vs *** RCTs involving patients receiving tirzepatide for any indication in the intervention arm and placebo or active comparator in the control arm were searched through multiple electronic *** co-primary outcomes were percent change from baseline(CFB)in urine albumin-to-creatinine ratio(UACR)and absolute CFB in estimated glomerular filtration rate(eGFR;in mL/min/1.73 m^(2));the secondary outcome was tirzepatide’s renal safety *** web was used to conduct meta-analysis using random-effects *** were presented as mean differences(MD)or risk ratios with 95%confidence *** Fifteen RCTs(n=14471)with mostly low risk of bias(RoB)were *** 26-72 weeks,tirzepatide 10 mg[MD-26.95%(-40.13,-13.76),Psuperior to placebo in percent reductions of ***,at all doses,outperformed insulin in percent reductions of *** to the placebo,the percent UACR reduction was greater in subjects with T2D than those with obesity but without T2D(MD-33.25%vs-7.93%;P=0.001).The CFB in eGFR with all doses of tirzepatide was comparable[5 mg:MD 0.36(-1.41,2.14);10 mg:MD 1.17(-0.22,2.56);15 mg:MD 1.42(-0.04,2.88)];P>0.05 for all vs ***(pooled and separate doses)did not increase the risks of adverse renal events,urinary tract infection,nephrolithiasis,acute kidney injury,and renal cancer compared to the placebo,insulin,and glucagon-like peptide-1 receptor ***

关键词： Tirzepatide Type 2 diabetes Obesity Urine albumin creatinine ratio Estimated glomerular filtration rate Renal safety Acute kidney injury Chronic kidney disease

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAURABH R.KIRAN D.sINGH R.VAIsH V.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： bio-inspired composite plate finite element method (FEM) Green-Lagrange helicoidal inverse hyperbolic shear deformation theory (IHsDT) nonlinear O322

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral