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18th International Conference on High Pressure science and Technology

作者： E.Reny s.yamanaka C.Cros M.Pouchard Department of Applied Chemistry Faculty of EngineeringHiroshima UniversityHigashi Hiroshima 739-8527Japan Japan Society for the Promotion of Science (JSPS Japan Department of Applied Chemistry Faculty of EngineeringHiroshima UniversityHigashi Hiroshima 739-8527 CRESTJapan Science and Technology Corporation (JSTJapan Institut de Chimie de la Matiere Condensee de Bordeaux 33608 Pessac cedexFrance Institut de Chimie de la Matiere Condensee de Bordeaux 33608 Pessac cedexFrance

＜正＞The network of type I silicon clathrate structures is an arrangement of fullerene-like si20（Ih） and si24（D6d） polyhedra connected via their pentagonal and hexagonal faces. These compounds crystallise in a cubic cell （Pm3n） where the two si20 dodecahedra occupy the summits and the centre of the cube while six si24 tetradekaidecahedra are situated on the faces. In the centre of these cages can be found guest atoms which are usually alkali or alkaline-earth elements （M）.（1,2）The corresponding ideal formula is therefore M8si46. A representation of the ideal structure can be seen in figure 1. Up to recently, silicon clathrates could only be synthesised by two means: melting of stoichiometric mixture of the elements or thermal degradation of alkali or alkaline earth silicides under vacuum or argon flow. However, some compositions couldn’t be obtained in either ways. Recently, we attempted with great success the synthesis of clathrates using a High Pressure High Temperature （HPHT） technique. For example, two years ago, was successfully obtained for the first time, Ba8si46 exhibiting superconducting properties with a Tc = 8K, highest ever obtained for sp3 silicon networks.（3） The increasing interest of the scientific community for clathrates, resulting mainly from the observed or speculated physical properties of such materials （superconductivity（3）, peculiar mechanical properties（4）, possible thermoelectric applications due to the guest atom rattling（5） etc.）, led us to explore the high pressure high temperature synthesis routein order to attempt the synthesis of other new silicon clathrates. We report in this presentation synthesis by HPHT of the first silicon clathrate compound doped with an electronegative element（6） Actually during the synthesis, the clathrate phase formation is in concurrence with other compounds as silicon iodides of type silx. However it is possible to ’help’ the reaction by the addition of a crystalline seed to the starting

关键词： High Pressure High Temperature synthesis silicon Clathrate Iodine.

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Electrical Conductivity Measurment and Thermal Conductivity Analysis on(sr,Ba)MoO3 and(sr,Ba)MoO4

Electrical Conductivity Measurment and Thermal Conductivity ...

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作者： s.yamanaka M.Uno K.Kurosaki H.Muta Division of sustainable Energy and Environmental Engineering Graduate School of EngineeringOsaka University Research Institute of Nuclear Engineering University of Fukui

INTRODUCTION:The behavior of fission products and the properties of their compounds are very important for evaluation of the fuel *** gray oxide phase of(sr,Ba)-(U,Pu,Zr,RE,Mo)-O compounds have been observed as the oxide *** our previous study,we performed thermal conductivity characterizations on the(sr,Ba)-Mo-O ternary compounds and revealed that the thermal conductivities of(sr,Ba)MoO are approximately 10 times higher than those of

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评估化学品急性毒性的一种简便方法

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实验动物与比较医学 1992年第4期23卷 222-222页

作者： s.yamanaka 薄志坚

本文提出了一种对化学品进行经口和经皮急性毒性评价的新方法。其特点是动物使用量少,每个剂量组、每种性别仅需3只大鼠或小鼠。首先以2000mg/kg的剂量投药,仔细观察体征,以得到相应的中毒体征发生率与死亡率。如果没有动物死亡,则停止... 详细信息

本文提出了一种对化学品进行经口和经皮急性毒性评价的新方法。其特点是动物使用量少,每个剂量组、每种性别仅需3只大鼠或小鼠。首先以2000mg/kg的剂量投药,仔细观察体征,以得到相应的中毒体征发生率与死亡率。如果没有动物死亡,则停止试验,如果有动物死亡,再分别以200mg/kg和20mg/kg的剂量进行试验。从而得出LDsub>50sub>值的范围(LDsub>50sub>>20mg/kg;LDsub>50sub>在20～200mg/kg之间等)。对多种化学品试验的结果表明,这种方法得到的LDsub>50sub>与文献中报道的值非常一致,且两个不同实验室进行同一试验的结果差别极小。另外,作者用经典方法测定LDsub>50sub>试验得到的数据显示,LDsub>50sub>大约为MNLD（最大无死亡剂量）的2～2.5倍。

关键词：急性毒性大鼠经口动物保护数据显示靶器官法常 welfare 评价方法评价程序

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Influence of image classification accuracy on saliency map estimation

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CAAI Transactions on Intelligence Technology 2018年第3期3卷 140-152页

作者： Taiki Oyama Takao yamanaka Department of Information and Communication sciences Sophia University 7-1 Kioi-cho Chiyoda-ku Tokyo 102-0094 Japan

saliency map estimation in computer vision aims to estimate the locations where people gaze in images. since people tend to look at objects in images, the parameters of the model pre-trained on ImageNet for image classification are useful for the saliency map estimation. However, there is no research on the relationship between the image classification accuracy and the performance of the saliency map estimation. In this study, it is shown that there is a strong correlation between image classification accuracy and saliency map estimation accuracy. The authors also investigated the effective architecture based on multi-scale images and the up-sampling layers to refine the saliencymap resolution. The model achieved the state-of-the-art accuracy on the PAsCAL-s, OsIE, and MIT1003 datasets. In the MIT saliency benchmark, the model achieved the best performance in some metrics and competitive results in the other metrics.

关键词：计算机视觉图像处理发展现状计算机技术

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site effects by generalized inversion technique using strong motion recordings of the 2008 Wenchuan earthquake

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Earthquake Engineering and Engineering Vibration 2013年第2期12卷 165-184页

作者： Ren Yefei Wen Ruizhi Hiroaki yamanaka Toshihide Kashima Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake Administration Tokyo Institute of Technology Building Research Institute

The generalized inversion of s-wave amplitude spectra from the free-field strong motion recordings of the China National strong Motion Observation Network system （NsMONs） are used to evaluate the site effects in the Wenchuan area. In this regard, a total of 602 recordings from 96 aftershocks of the Wenchuan earthquake with magnitudes of M3.7-M6.5 were selected as a dataset. These recordings were obtained from 28 stations at a hypocenter distance ranging from 30 km to 150 km. The inversion results have been verified as reliable by comparing the site response at station 62WUD using the Generalized Inversion Technique （GIT） and the standard spectral Ratio method （ssR）. For all 28 stations, the site predominant frequency F and the average site amplification in different frequency bands of 1.0-5.0 Hz, 5.0-10.0 Hz and 1.0-10.0 Hz have been calculated based on the inversion results. Compared with the results from the horizontal-to-vertical spectral ratio （HVsR） method, it shows that the HVsR method can reasonably estimate the site predominant frequency but underestimates the site amplification. The linear fitting between the average site amplification for each frequency band and the V20 （the average uppermost-20 m shear wave velocity） shows good correlation. A distance measurement called the asperity distance DAspt is proposed to reasonably characterize the source-to-site distance for large earthquakes. Finally, the inversed site response is used to identify the soil nonlinearity in the main shock and aftershocks of Wenchuan earthquake. In ten of the 28 stations analyzed in the main shock, the soil behaved nonlinearly, where the ground motion level is apparently beyond a threshold ofPGA 〉 300 cm/s^2 or PGV 〉 20 cm/s, and only one station coded 51sFB has evidence of soil nonlinear behavior in the aftershocks.

关键词： generalized inversion technique site effect Wenchuan earthquake soil nonlinearity predominant frequency site amplification

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Effectiveness of impedance monitoring during radiofrequency ablation for predicting popping

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World Journal of Gastroenterology 2012年第41期18卷 5870-5878页

作者： Hiroya Iida Tsukasa Aihara shinichi Ikuta Naoki yamanaka Department of surgery Meiwa Hospital4-31 Agenaruo-choNishinomiyaHyogo 663-8186Japan

AIM： To retrospectively evaluate the effectiveness of impedance monitoring for predicting popping during radiofrequency ablation （RFA） using internally cooled electrodes. METHODs： We reviewed 140 patients （94 males, 46 females; age range 73.0 ＋ 11.1 year） who underwent RFA between February 2006 and November 2008 with a modified protocol using a limited power delivery rather than a conventional one to avoid popping. All the patients provided their written informed consent, and the study was approved by the institutional review board. Intraprocedural impedances were measured for the study subjects, and the tumors were classified into three types according to the characteristics of their impedance curves： increasing, flat, or decreasing. The tumors were further sorted into seven subtypes （A-G） depending on the curvature of the impedance curve＇ s increase or decrease. Relative popping rates were determined for the three types and seven subtypes. A chi-square test was performed to estimate statistical ***： A total of 148 nodules treated by RFA were analyzed. The study samples included 132 nodules of hepatocellular carcinoma, 14 nodules of metastatic liver cancer, and two nodules of intrahepatic cholangio- carcinoma. The numbers of nodules with each imped- ance curve type were as follows： 37 increasing-type nodules, 43 fiat-type nodules, and 68 decreasing-type nodules. Popping occurrence rates were 24.3%, 46.5% and 64.7%, respectively. Flat-type nodules exhibited a significantly higher rate of popping compared to increasing-type nodules （P = 0.039）. Decreasing-type nodules exhibited a significantly higher rate of popping compared to increasing-type nodules （P 〈 0.0001）. No- tably, nodules that showed a sharp decrease in imped- ance in the latter ablation period （subtype E） exhibited a significantly higher rate of popping compared to other subtypes. CONCLUsION： Intraprocedural impedance monitoring can be a useful tool to predict the occurrence of pop- ping

关键词： Radiofrequency ablation Internally cooledelectrode Popping Liver Complication

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Augmentation of tumor necrosis factor family-induced apoptosis by E3330 in human hepatocellular carcinoma cell lines via inhibition of NFκB

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World Journal of Gastroenterology 2005年第40期11卷 6258-6261页

作者： Yukiko saitou Katsuya shiraki Takenari yamanaka Kazumi Miyashita Tomoko Inoue Yutaka yamanaka Yumi Yamaguchi Naoyuki Enokimura Norihiko Yamamoto Keiichi Itou Kazushi sugimoto Takeshi Nakano First Department of Internal Medicine

AIM- To investigate the reduction of cell viability in human hepatocellular carcinoma （HCC） cell lines induced by inhibition of nuclear factor kB （NFkB）. METIIOI）s： HLE, sKHep1, and HepG2 were incubated and E3330 was used to compare the stimulation of some chemotherapeutic drugs with that of TNF family, Fas ligand, TNF（x and TNF-related apoptosis-inducing ligand （TRAIL） at the point of the reduction of cell viability by inhibiting NFkB. REsULTs： E3330 decreased NFKB levels in HLE cells stimulated by TNF and TRAIL. The cytotoxicity of the combination of TRAIL, TNFa, Fas ligand, and E3330 increased synergistically in a dose-dependent manner compared to either E3330 alone in all HCC cell lines by MTT assay. However, the combination of some chemotherapeutic drugs and E3330 did not decrease the cell viability. CONCLUsION： Inhibition of NFd3 sensitizes human HCC cell lines to TNF-mediated apoptosis including TRAIL, and TRAIL-based tumor therapy might be a powerful potential therapeutic tool in the treatment of human HCC.

关键词： E3330 NFkB inhibitor Cytotoxicity TRAIL TNFa Fas ligand Doxorubicin Camptotecin

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Inverse correlation between reactive oxygen species in unwashed semen and sperm motion parameters as measured by a computer-assisted semen analyzer

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Asian Journal of Andrology 2017年第3期19卷 350-354页

作者： Teppei Takeshima Yasushi Yumura Kengo Yasuda Hiroyuki sanjo shinnosuke Kuroda Hiroyuki yamanaka Akira Iwasaki Department of Urology Reproductive Center Yokohama City University Medical Center Yokohama Kanagawa Japan YMRAC Urology Office Yokohama Kanagawa Japan.

This study investigated the correlation between sperm motion parameters obtained by a computer-assisted semen analyzer and levels of reactive oxygen species in unwashed semen. In total, 847 patients, except for azoospermic patients were investigated. At the time of each patient＇s first consultation, semen parameters were measured using sMAsTM or Cellsoft 3000TM, and production of reactive oxygen species was measured using a computer-driven LKB Wallac Luminometer 1251 Analyzer. The patients were divided into two groups： reactive oxygen species - positive and negative. The semen parameters within each group were measured using one of the two computer-assisted semen analyzer systems and then compared. Correlations between reactive oxygen species levels and sperm motion parameters in semen from the reactive oxygen species - positive group were also investigated. Reactive oxygen species were detected in semen samples of 282 cases （33.3%）. sperm concentration （P 〈 0.01; P 〈 0.01）, motility （P 〈 0.01; P 〈 0.05）, and progressive motility （P 〈 0.01; P 〈 0.01） were markedly lower in the reactive oxygen species - positive group than in the reactive oxygen species - negative group. Among the sperm motion parameters in the reactive oxygen species - positive group, sperm concentration （P 〈 0.01; P 〈 0.01）, motility （P 〈 0.05; P 〈 0.01）, mALH （P 〈 0.05; P 〈 0.01）, and progressive motility （P 〈 0.05; P 〈 0.01） also showed inverse correlations with the logarithmic transformed reactive oxygen species levels. Therefore, this study demonstrated that excessive reactive oxygen species in semen damage sperm concentration, motility, and other sperm motion parameters.

关键词： oxidative stress reactive oxygen species semen analysis sperm motility

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Plasmid DNA encoding neutralizing human monoclonal antibody without enhancing activity protects against dengue virus infection in mice

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Asian Pacific Journal of Tropical Medicine 2021年第7期14卷 299-308页

作者： surachet Benjathummarak Atsushi yamanaka Thanyaluk Krasae Chonlatip Pipattanaboon subenya Injampa Pannamthip Pitaksajjakul Pongrama Ramasoota Department of social and Environmental Medicine Faculty of Tropical MedicineMahidol UniversityBangkokThailand Center of Excellence for Antibody Research(CEAR) Faculty of Tropical MedicineMahidol UniversityBangkokThailand Mahidol-Osaka Center for Infectious Diseases(MOCID) Faculty of Tropical MedicineMahidol UniversityBangkokThailand Mahidol-Osaka Center for Infectious Diseases Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan Laboratory Animal science Unit Faculty of Tropical MedicineMahidol UniversityBangkokThailand Department of Microbiology Faculty of MedicineKhon Kaen UniversityThailand Faculty of Medicine King Mongkut’s Institute of Technology LadkrabangBangkokThailand

Objective: To evaluate the expression of DNA plasmid-harboring modified antibody gene that produces neutralizing human monoclonal antibodies against four serotypes of dengue virus(DENV) without enhancing activity in BALB/c mice. Methods: We constructed pFUsE-based vectors(pFUsE1 G7 C2hVH and pFUsE1 G7 C2hVL) containing genes encoding the variable domains of the heavy or light chain of the anti-dengue virus antibody 1 G7 C2, a human IgG1 that has been characterized for its neutralizing activity to DENV-1-4. Leucine(L) at positions 234 and 235 on the Fc CH2 domain in pFUsE1 G7 C2hVH was mutated to alanine(A)(LALA mutation) by site direct mutagenesis, and the new plasmid was termed pFUsE1 G7 C2hVHLALA. An equal amount of pFUsE1 G7 C2hVL and 1 G7 C2hG1-LALA plasmids were co-transfected into Chinese hamster ovary cells(CHO-K1) and a single dose of 100 μg 1 G7 C2hG1-LALA plasmid was intramuscularly injected, followed by electroporation in BALB/c mice. The secreted 1 G7 C2hG1-LALA antibodies in cell culture supernatant and mouse serum were examined for their biological functions, neutralization and enhancing activity. Results: The co-transfection of heavy-and light-chain 1 G7 C2hG1-LALA plasmids in CHO-K1 cells produced approximately 3 900 ng/mL human IgG and neutralized 90%-100% all four DENV, with no enhancing activity. Furthermore, the modified human IgG was produced more than 1 000 ng/mL in mouse serum on day 7 post plasmid injection and showed cross-neutralization to four DENV serotypes. subsequently, antibody production and neutralization decreased rapidly. Nevertheless, the secreted neutralizing 1 G7 C2hG1-LALA in mouse serum demonstrated complete absence of enhancing activities to all DENV serotypes. Conclusions: These findings reveal that a new modified 1 G7 C2h G1-LALA expressing plasmid based on gene transfer is a possible therapeutic antibody candidate against DENV infection.

关键词： Dengue virus LALA mutation Antibodydependent enhancement(ADE) Antibody plasmid Electroporation

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Diagnostic tests for hepatitis C: Recent trends in electrochemical immunosensor and genosensor analysis

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World Journal of Gastroenterology 2014年第42期20卷 15476-15491页

作者： Carolina V Uliana Carla s Riccardi Hideko yamanaka Department of Chemistry Federal University of Sao Carlos Department of Physical Chemistry Institute of Chemistry Sao Paulo State University Department of Analytical Chemistry Institute of Chemistry of Araraquara Sao Paulo State University (UNESP)

Hepatitis C is a liver disease that is transmitted through contact with the blood of an infected person. An estimated 150 million individuals worldwide have been chronically infected with the hepatitis C virus(HCV). Hepatitis C shows significant genetic variation in the global population, due to the high rate of viral RNA mutation. There are six variants of the virus(HCV genotypes 1, 2, 3, 4, 5, and 6), with 15 recorded subtypes that vary in prevalence across different regions of the world. A variety of devices are used to diagnose hepatitis C, including HCV antibody test, HCV viral load test, HCV genotype test and liver biopsy. Rapid, inexpensive, sensitive, and robust analytical devices are therefore essential for effective diagnosis and monitoring of disease treatment. This review provides an overview of current electrochemical immunosensor and genosensortechnologies employed in HCV *** are a limited number of publications showing electrochemical biosensors being used for the detection of *** to their simplicity,specificity,and reliability,electrochemical biosensor devices have potential clinical applications in several viral infections.

关键词： Hepatitis C virus Immunosensors Genosensors Electrochemical detection Diagnostic tests

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