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3D Printing of Tough Hydrogel scaffolds with Functional surface structures for Tissue Regeneration

Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke yao Gaoying Hong Ximin yuan Weicheng Kong Pengcheng Xia yuanrong Li yuewei Chen Nian Liu Jing He Jue shi Zihe Hu yanyan zhou Zhijian Xie yong He state Key Laboratory of Fluid Power and Mechatronic systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China state Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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An Inverse Approach for Extracting Elastic-plastic Properties of Thin Films from small scale sharp Indentation

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Journal of Materials science & Technology 2012年第7期28卷 626-635页

作者： Z.s. Ma y.C. zhou s.G. Long C.s. Lu Key Laboratory of Low Dimensional Materials ~ Application Technology of Ministry of Education Xiangtan Uni-versity Xiangtan 411105 China Faculty of Materials Optoelectronics and Physics Xiangtan University Xiangtan 411105 China Department of Mechanical Engineering Curtin University of Technology Perth WA 6845 Australia

An inverse method for extracting the elastic-plastic properties of metallic thin films from instrumented sharp indentation has been proposed in terms of dimensional analysis and finite element modeling. A wide range of materials with different elastic modulus, yield strength, and strain-hardening exponent were *** to the Nix-Gao model for the depth dependence of hardness H,the relationship between elastic modulus E and indentation depth h can be expressed as By combiningthese two formulas, we find that there is a relationship between yield stress and indentation depth h：where σyO is the yield strength associated with the strain-hardening exponent n, the true hardness Ho and the true elastic modulus *** constant, whichis only related to n, and hH and hE are characteristic lengths for hardness and elastic modulus. The results obtained from inverse analysis show that the elastic-plastic properties of thin films can be uniquely extracted from the solution of this relationship when the indentation size effect has to be taken into account.

关键词： Indentation Elastic-plastic properties Metal thin films Inverse analysis

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selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide

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science China Life sciences 2025年

作者： Xiaonan Wang Ning zhou Xuejiao J.Gao Zijing Zhu Minmin sun Qian Wang Haolin Cao Xuetong Wu Caiyu zhou Qingkang Zheng ye yuan yuan Liu Lei Chen Jing Jiang Pengcheng Bu Lizeng Gao CAs Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences school of Life sciences University of Chinese Academy of Sciences College of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Epigenetic Regulation and Intervention Institute of Biophysics Chinese Academy of Sciences Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science

Alternative treatment for the highly prevalent Helicobacter pylori infection is imperative due to rising antibiotic resistance. We unexpectedly discovered that the anti-H. pylori component in garlic is hydrogen polysulfide（H2s_n, n≥2）, not organic polysulfides. studies on the mechanism of action（MoA） show that H2s_nspecifically inactivates H. pylori glucose-6-phosphate dehydrogenase（G6PDH） by interfering with electron transfer from glucose-6-phosphate（G6P） to nicotinamide adenine dinucleotide phosphate（NADP+）. However, low H2s_nyield makes garlic derivatives hard to be a reliable donor of H2s_nto treat H. pylori infection. To address this challenge, we established a polysulfide transformation process from garlic organosulfur compounds into Fe3s4that generates H2s_nwith a 25–58 times increase in *** chitosan encapsulation, we designed a gastric-adaptive H2s_nmicroreactor（GAPsR） that eradicates H. pylori with 250 times higher efficiency under gastric conditions. A single GAPsR achieves more rapid H. pylori eradication than combined antibiotics therapy without disturbing the gut microbiota. These findings indicate a distinct MoA transformation mediated by polysulfide as an alternative candidate to treat H. pylori infection.

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Experimental demonstration of 220-GHz terahertz signals wireless transmission over 4.6 km

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science China(Information sciences) 2025年第1期68卷 386-388页

作者： yi WEI Jianjun yU Mingxu WANG Xiongwei yANG Qiutong ZHANG Jingwen TAN Bing ZHANG ying WU yang HAN Peng TIAN Wen zhou Kaihui WANG Feng ZHAO state Key Laboratory of AsIC and system Key Laboratory for Information Science of Electromagnetic Waves (MoE)School of Information Science and Technology Fudan University school of Electronic Engineering Xi'an University of Posts and Telecommunications

The advancement of terahertz (THz) communication technology drives the evolution of wireless communication systems,offering novel pathways and technical means for the development of future 6G communication *** wireless communication systems are often constrained by bandwidth limitations of electronic devices in high frequency ***,THz communication technology leverages the characteristics of electromagnetic waves to transcend these limitations,enabling communication athigher frequencies and wider bandwidths.

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EFFECT OF Mo AND Mo_2C ON THE MICROsTRUCTURE AND PROPERTIEs OF THE CERMETs BAsED ON Ti(C,N)

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Acta Metallurgica sinica(English Letters) 2008年第3期21卷 211-219页

作者： s.Q. zhou W. Zhao W.H. Xiong y.N. zhou school of Materials science and Engineering Huazhong University of Science and Technology Wuhan 430074 China The University of Waterloo Waterloo ON N2L3G1 Canada

Effect of Mo and Mo2 C on the microstructure and properties of Ti（C,N）-based cermets was investigated in this article. The results have indicated that the weight percentage of Mo from 5 to 10 can reduce Ti（C,N） grain diameter and thickness of the rim, and Ti（C,N） grain can be wetted by Ni-Cu-Mo liquid so as to get small contiguity of Ti（C,N） grain. In that way, the transverse rupture strength of Ti（C,N）-based cermets has reached 1800-1900 MPa; the fracture toughness has been due to 16-18 MPa.m1/2. But 15 wt pct Mo was not more effective on Ti（C,N）-based cermets, because the thickness of the rim becomes larger. In the circumstance of Mo2 C, 5 wt pct Mo2 C was good for microstructure and properties of Ti（C,N）-based cermets, but 11 wt pct Mo2C has resulted in larger contiguity of Ti（C,N） grain and big Ti（C,N） grain diameter so as to reduce transverse rupture strength and fracture toughness. so that, the effect of Mo on Ti（C,N）-based cermets is better than Mo2C.

关键词： Cermet Transverse rupture strength (TRs) Contiguity Fracture toughness

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Effect of post-bond heat treatment on the microstructure and high temperature mechanical property of a TLP bonded γ'-strengthened co-based single crystal superalloy

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Journal of Materials science & Technology 2021年第21期80卷 244-258页

作者： s.y.Wang y.sun C.y.Cui X.F.sun y.Z zhou y.M.Ma H.L.An Institute of Metal Research Chinese Academy of SciencesShenyang 110016China school of Materials science and Engineering University of Science and Technology of ChinaHefei 230026China Harbin Welding Institute China Academy of Machinery Science and TechnologyHarbin 150028China

Post-bond heat treatment(PBHT) applied to a transient liquid phase(TLP) bonding joint is an effective approach to remove the brittle borides and improve its ***,we proposed two types of PBHT strategies to obtain a TLP bonded γ'-strengthened Co-based single crystal superalloy,and the microstructural characteristics and tensile properties of the two heat treated joints were compared to identify the optimal PBHT *** evolution of the brittle boride in the joint after the PBHT was studied by using in-situ *** experimental results allowed to provide a theoretic model to quantitatively evaluate the distribution of the brittle phase after the optimal PBHT and analyze the joint fractures to understand the failure *** obtained results revealed that a post-bond solid solution treatment performed to the joint at a high temperature(over 1275℃) could decrease the area fraction of the boride from 7.2 % to 1.4 % and increase the elongation from 1.9 % to 7.8 %.This work emphasizes the relevance of solid solution temperature when a PBHT strategy is applied.

关键词： Transient liquid phase(TLP) γ'-strengthened co-based single crystal superalloy Heat treatment sequence Brittle boride Tensile property

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公众人工智能价值敏感性的测度解析

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自然辩证法通讯 2025年第1期47卷 18-27页

作者：张学义周洲郑宇涵东南大学哲学与科学系江苏省道德发展智库

“价值敏感性”源于巴迪亚·弗里德曼的“价值敏感性设计”概念，指在技术设计、研发、生产和使用中具有伦理意蕴的价值感知能力。课题组创新性地应用“三方方法论”，通过多指标多因素结构方程模型(MIMIC)测量公众对人工智能的价值敏... 详细信息

“价值敏感性”源于巴迪亚·弗里德曼的“价值敏感性设计”概念，指在技术设计、研发、生产和使用中具有伦理意蕴的价值感知能力。课题组创新性地应用“三方方法论”，通过多指标多因素结构方程模型(MIMIC)测量公众对人工智能的价值敏感性，评估现有技术是否支持价值敏感设计目标。研究发现：(1)公众对人工智能的价值敏感排序为：透明性、算法公正、劳动就业保障、责任归属等，说明这些价值需在技术设计阶段予以重视；(2)信息安全和生态失衡未引起广泛关注；(3)性别和职业对价值敏感性无显著影响，但年龄和学历差异显著。

关键词：人工智能价值敏感性多指标多因素模型伦理治理

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Impregnating photo-stable gold precursor onto uncalcined Ts-1 to boost catalytic hydro-oxidation of propane

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science China Chemistry 2025年

作者： Zhihua Zhang Erchuan yang Fan Liu Kesheng Xu yuxia Zhong Jinwei sun shudong shi Xuezhi Duan Xinggui zhou state Key Laboratory of Chemical Engineering East China University of Science and Technology

Immobilizing highly dispersed Au nanoparticles onto titanium silicalite-1 (Ts-1) by a simple impregnation method under light is still a challenging *** this work,a high photostable Au precursor protected by thiol ligands was firstly synthesized,and the as-prepared Au precursor displayed excellent stability under light for over 30 days,while the Au precursor without thiol ligands formed precipitates after just 2 h under ***,the Au precursor protected by thiol ligands was immobilized on the external surface of uncalcined Ts-1 (i.e.,Ts-1-B) by the incipient wetness impregnation method (IWI method) to prepare Au/Ts-1-B *** activity of as-prepared Au/Ts-1-B catalyst in the hydro-oxidation of propane to acetone was 1.4 times higher than that of the catalyst prepared by the deposition-precipitation urea method (DPU method).The structures of the Au/Ts-1-B catalysts prepared by different methods were analyzed by multiple *** to the Au/Ts-1-B catalyst prepared by the DPU method,the Au/Ts-1-B catalyst synthesized by the IWI method exhibited a narrower size distribution of Au nanoparticles and had more small Au particles (s the main reason for its superior ***,the effects of gold loadings,reaction temperature and si/Ti molar ratio on the catalytic performance of the Au/Ts-1-B catalyst prepared by the IWI method were also *** addition,the Au/Ts-1-B catalyst prepared by the IWI method also exhibited excellent stability for over 140 h.

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Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

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science China Life sciences 2025年

作者： Lu Gan yi yang Bin Zhao Kai yu Kehua Guo Fang Fang Zhiguang zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services school of Computer science and Engineering Central South University Institute of Environmental Medicine Karolinska Institute National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend st, a higher intake of starch and carbohydrate from starchy vegetables was associated with an increased risk of T2D(highest vs. lowest quantile, HR [95%CI]=1.31 [1.16–1.48] and 1.19 [1.09–1.31], respectively, both P for trend serving of refined grains or starchy vegetables with an equal amount of whole grains or non-starchy vegetables was associated with 4% to 10% lower risk of T2D(all P values served associations were generally similar across population subgroups, including individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

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MECHANICAL PROPERTIEs OF Ti_3siC_2 AT HIGH TEMPERATURE

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Acta Metallurgica sinica(English Letters) 2004年第4期17卷 465-470页

作者： y.W.Bao y.C.zhou shenyang National Laboratory for Materials science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 ChinaShenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Creep and stress relaxation behavior, the elastic modulus and fracture toughness of machinable Ti3siC2 at various temperatures from 20 to 1250℃ were investigated by means of three-point bending tests. The experiments were performed respectively at: (i) fixed stress and changed temperatures, and (ii) fixed temperature and changed stresses. A creep resistance parameter that represents the probability of creep deformation in a given condition was defined as a function of both applied stress and the threshold stress, varying in a range from 0 to 1. Elastic modulus at high temperatures was measured through comparing relative slopes of loading curves in cyclic loading curve. The fracture toughness measured by sENB method showed a stable value in the range of 25-1000℃, but over 1000℃, it declined abruptly from -6.7MPa·m1/2 to -2.0MPa·m1/2 at 1200℃.

关键词： high-temperature Ti3siC2 creep stress relaxation fracture toughness

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