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地幔置换作用:华北两类橄榄岩及其透辉石微量元素对比证据

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地球科学（中国地质大学学报） 2003年第3期28卷 235-240页

作者：郑建平路凤香余淳梅 o’reilly s y 中国地质大学地球科学学院湖北武汉430074 澳大利亚Macquarie大学地球与行星科学系

在华北地块东部 ,河南鹤壁新生代玄武岩中的耐熔橄榄岩捕虏体被认为是克拉通地幔的残留 ;山东山旺饱满橄榄岩捕虏体被认为是新生代玄武岩所捕获的新生地幔物质 ,对它们全岩的常量、微量元素 ,组成单矿物的常量元素和透辉石微量元素进行... 详细信息

在华北地块东部 ,河南鹤壁新生代玄武岩中的耐熔橄榄岩捕虏体被认为是克拉通地幔的残留 ;山东山旺饱满橄榄岩捕虏体被认为是新生代玄武岩所捕获的新生地幔物质 ,对它们全岩的常量、微量元素 ,组成单矿物的常量元素和透辉石微量元素进行了对比 .结果显示代表古老岩石圈的鹤壁克拉通型地幔和代表新生岩石圈的山旺“大洋型”地幔分别相当于原始地幔经历 15 %～ 2 5 %和 1%～ 5 %熔融的产物 .它们在熔融之后又都遭受了硅酸盐质碳酸岩熔体的交代改造作用 ,但前者明显强于后者 .古老岩石圈橄榄岩的固相线温度受地幔熔 /流体的长期交代而降低 .由于早中生代时华北地块受扬子地块碰撞的地幔热扰动和软流圈上涌影响 ,促使橄榄岩熔融 .所融出的基性岩浆主要垫托在地壳底部 ,形成壳 -幔过渡带并实现大规模的壳 -幔物质和热交换 .第三纪以后的热沉降使抬升的软流圈物质冷却垫托在岩石圈底部构成新增生的岩石圈 .因此 ,发生于东部的中、新生代 (相对于古生代 )岩石圈减薄不是软流圈抬升所引起的简单岩石圈厚度变小 ,而是伴随着新生地幔物质对古老地幔的置换过程 .

关键词：地幔置换作用橄榄岩透辉石微量元素新生代玄武岩橄榄岩捕虏体交代改造作用硅酸盐质碳酸岩熔体

Formation history and protolith characteristics of granulite facies metamorphic rock in Central Cathaysia deduced from U-Pb and Lu-Hf isotopic studies of single zircon grains

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Chinese science Bulletin 2005年第18期50卷 2080-2089页

作者： yU Jinhai ZHoU Xinmin y. s. o'reilly ZHAo Lei W. L. Griffin WANG Rucheng WANG Lijuan CHEN Xiaomin state Key Laboratory for Mineral Deposits Research Department of Earth Sciences Nanjing University Nanjing 210093 China GEMoC ARC National Key Centre Department of Earth and Planetary Sciences Macquarie University Sydney N.S.W. 2109 Australia

The petrochemical as well as zircon U-Pb and Lu-Hf isotopic studies of granulite facies metamorphic rock from the Taoxi Group in eastern Nanling Range, Central Cathaysia indicate that its protolith is the sedimentary rock with low maturation index. The clastic materials are mostly from middle Neoproterozoic (~736 Ma) granitoid rocks with minor Neoarchaean and Paleoproterozoic rocks. The timing of this Neoproterozoic magmatism is in agreement with the second period of magmatism widespread surrounding the yangtze Block. Hf isotopic data indicate that the Neoproterozoic granitoids resulted from the recycled Paleoproterozoic mantle-derived crustal materials. The sedimentary rock was deposited in Late Neoproterozoic Era, and carried into low crust in Early Paleozoic. The partial melting of the meta-sedimentary rock took place at about 480 Ma and subsequently granulite facies metamorphism occurred at ca. 443 Ma. The zircons forming during this time interval (Early Paleozoic) show large Hf isotope variations, and their -Hf(t) values increase from -13.2 to +2.36 with decreasing age, suggesting the injection of mantle-derived materials during partial melting and metamorphism processes in the Early Paleozoic. Calculation results show that this metamorphic rock, if evolved to Mesozoic, has similar isotopic composition to the nearby Mesozoic high si peraluminous granites, implying that this kind of granulite facies metamorphic rock is probably the source material of some Mesozoic peraluminous granitoids in eastern Nanling Range.

关键词：麻粒岩锆石同位素变质结构沉积岩石

Intrumer:A Multi Module Distributed Explainable IDs/IPs for securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.K.B.sangeetha Department of Computer science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDs,have been developed to tackle these ***,most conventional Intrusion Detection system(IDs)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDsmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDs datasets CICIDs 2017,Honeypots,and NsL-KDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

华南晚古生代岩浆活动的新发现:岛弧还是陆内造山?

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科学通报 2012年第31期57卷 2964-2971页

作者：于津海刘潜胡修棉王勤 o'reilly suzanne y 南京大学地球科学与工程学院内生金属矿床成矿机制研究国家重点实验室南京210093 GEMoC ARC National Key Centre Department of Earth and Planetary SciencesMacquarie UniversitySydneyN.S.W.2109Australia

在福建省周宁县五凤楼村发现了一个形成于313±4Ma的片麻状花岗岩.该岩石具有高的K2o和Al2o3含量和低的sio2和Na2o含量,其A/CNK比值高达1.22,指示其源区为经过化学风化的沉积岩,因此属于s型花岗岩.所含锆石为柱状自形形态,其U-Pb年龄变... 详细信息

在福建省周宁县五凤楼村发现了一个形成于313±4Ma的片麻状花岗岩.该岩石具有高的K2o和Al2o3含量和低的sio2和Na2o含量,其A/CNK比值高达1.22,指示其源区为经过化学风化的沉积岩,因此属于s型花岗岩.所含锆石为柱状自形形态,其U-Pb年龄变化于326～301Ma(加权平均年龄为313±4Ma),具有负的?Hf(t)值(?8.35～?1.74)和1.43～1.84Ga的二阶段Hf模式年龄.这是首次在华南发现有确凿同位素年代学证据的晚石炭世s型花岗质岩浆活动.该s型花岗岩最可能形成于陆内造山阶段,源岩主要为古元古代晚期生长的地壳.结合前人对岩相古地理、古生代盆地性质、早二叠世火山作用以及晚古生代-早中生代沉积岩中碎屑锆石的U-Pb-Hf同位素资料,本文推断华夏东部可能曾经存在一个晚古生代造山带.从晚石炭世(340～310Ma)的挤压造山阶段演化到早二叠世(285～270Ma)的后造山或板内伸展阶段,华南东部经历了一个较为完整的晚古生代造山旋回,所形成的晚古生代岩浆岩是陆内造山作用的产物,而不是岛弧岩浆作用产物.

关键词： s型花岗岩锆石U-Pb年龄锆石Hf同位素晚古生代造山作用华南东部

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

雷州半岛英峰岭玄武岩中的铁铝榴石巨晶及母岩浆成因

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科学通报 2001年第6期46卷 492-497页

作者：于津海 s.y. o'reilly 南京大学地球科学系内生矿床成矿机制研究国家重点实验室南京210093 GEMoC Department of Earth and Planetary sciences Macquarie University

英峰岭火山岩中的石榴石巨晶以富铁(>20%)、低镁(5.88%～10.87%)和高钙(6.92%～8.16%)为特征. 成分明显变化, 随着Mg#减小, 石榴石中的Ni, V, sc, Co和重稀土含量逐渐降低, 而Zr, Hf, Ga, y, sr, Nb, Zn和轻、中稀土含量逐渐升高. 石榴... 详细信息

英峰岭火山岩中的石榴石巨晶以富铁(>20%)、低镁(5.88%～10.87%)和高钙(6.92%～8.16%)为特征. 成分明显变化, 随着Mg#减小, 石榴石中的Ni, V, sc, Co和重稀土含量逐渐降低, 而Zr, Hf, Ga, y, sr, Nb, Zn和轻、中稀土含量逐渐升高. 石榴石母岩浆是一种高度演化的残余岩浆, 强烈亏损Ti, sr, Hf, Nb和重稀土元素. 母岩浆是由石英拉斑质玄武岩浆经60%以上的单斜辉石、石榴石、斜长石和钛铁矿的分离结晶形成. 这种母岩浆没有喷出地表, 而是滞留于地幔结晶成巨晶堆晶岩. 巨晶与寄主岩是非平衡的.

关键词：铁铝榴石巨晶地球化学雷州半岛英峰岭玄武岩母岩浆石榴分离结晶

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex David J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New york Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and ophthalmology(ARVo).

关键词： neural visual Times

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.V.P.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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oncology research 2025年第1期33卷 67-81页

作者： Xiang Li Wenke Jin Lifeng Wu Huan Wang Xin Xie Wei Huang B o Liu state Key Laboratory of southwestern Chinese Medicine Resources School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

Background:Triple-negative breast cancer (TNBC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (PPI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways.Methods:Here, we employed Naive Bayes, Decision Tree, and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC, aiming to uncover novel therapeutic targets. Meanwhile, the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay, and the interaction relationship was verified by molecular docking and Co-IP experiments after intersection. Colony formation, cellular immunofluorescence, cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) tests were used to predict the clinical therapeutic effects of manipulating candidate PPI.Results:By developing three PPI classification models and analyzing over 13,000 datasets, we identified 3733 previously unknown autophagy-related PPIs. our network analysis revealed the central role of Beclin 2 in autophagy regulation, uncovering its interactions with 39 newly identified proteins. Notably, the Co-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1, which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay results. subsequently, investigations showed that overexpressing Beclin 2 increased Ubiquilin 1, promoted autophagy-dependent cell death, and inhibited proliferation and metastasis in MDA-MB-231 cells.

关键词： Artificial intelligence (AI) Autophagy Beclin 2 Protein-protein interactions (PPI) Triple-negative breast cancer (TNBC) Ubiquilin 1