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Trace element characteristics in the diopsides of peridotite xenoliths: a laser ablation-inductively coupled plasma-mass spectrometry study

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Chinese science Bulletin 1998年第7期43卷 579-583页

作者： shaohai Chen Xinghua Zhou s. y. o’reilly W. L. Griffin Guohui Zhang M. Zhang Chinese Acad sci Inst Geol Lab Lithosphere Tecton Evolut Beijing 100029 Peoples R China Macquarie Univ Sch Earth Sci GEMOC Sydney NSW 2109 Australia

Among the various xenoliths entrained by the Cenozoic Hannuoba basalts, peridotite is the most abundant one. The trace elements of the diopsides from the peridotite xenoliths were analysed by LA-ICP-Ms. The overall depletion and some heterogeneity of the continental mantle beneath northern North China Craton were indicated by the characteristics of the trace elements. The ∑REE amount in diopside correlates with the Cr/(Cr+Al) ratio of diopside which is indicative of xenolith’s partial melting degree. As the peridotite hosts and pyroxenite veins show similar REE distribution patterns, the composite xenoliths are probably formed by mantle deformation, rather than by the late metasomatism of mantle fluids/melts.

关键词： LA-ICP-Ms diopside trace elements.

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing sMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller school of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

spinal muscular atrophy(sMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of sMA was understood in 1995 when loss or impairment of the survival motor neuron 1(sMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,sMN2,which can produce low levels(approximately 10%)of the full-length functional sMN protein,has led to the generation of sMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,sMN2 copy number is used as a proxy for the prediction of disease severity,with higher sMN2 copy number typically being associated with reduced severity of sMA,although this relationship is not absolute:some individuals with low sMN2 copy number have less severe sMA phenotypes and vice ***,the etiology of sMA is further complicated by other factors,such as non-typical nucleotide variants and sMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Zircon U-Pb and Hf isotopes of volcanic rocks from the Batamayineishan Formation in the eastern Junggar Basin

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Chinese science Bulletin 2010年第36期55卷 4150-4161页

作者： sU yuPing ZHENG JianPing GRIFFIN William L TANG Huayun o'reilly suzanne y LIN Xiangyang Faculty of Earth sciences China University of Geosciences Wuhan 430074 China National Key Centre for Geochemical Evolution and Metallogeny of Continents ( GEMoC) Macquarie University Sydney NSW 2109 Australia

内部结构的研究被进行从 Batamayineishan 形成调查 U-Pb 年龄，踪迹元素和玄武岩的锆石的 Hf 同位素。暗岩从练习井圣罐头被获得 1 在 Junggar 盆以内在东方 Luliang 上高举。跟踪所有样品是 magmatic 的锆石表演的元素数据，与类似的 ... 详细信息

内部结构的研究被进行从 Batamayineishan 形成调查 U-Pb 年龄，踪迹元素和玄武岩的锆石的 Hf 同位素。暗岩从练习井圣罐头被获得 1 在 Junggar 盆以内在东方 Luliang 上高举。跟踪所有样品是 magmatic 的锆石表演的元素数据，与类似的 REE 模式，包括积极 Ce (Ce=5.06134 ) ，而是否定 Eu (Eu=0.06 ? 0.55 ) 在重稀土元素元素的异例和丰富。在 25 谷物之中，一致年龄被细分进三个组；300.4 整潲祺潧整的年龄？

关键词：准噶尔盆地东部岛弧火山岩形成年龄 Hf同位素锆石 Pb 碰撞后构造环境岩石圈地幔

Grenvillian orogeny in the southern Cathaysia Block:Constraints from U-Pb ages and Lu-Hf isotopes in zircon from metamorphic basement

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Chinese science Bulletin 2008年第19期53卷 3037-3050页

作者： WANG LiJuan yU JinHai s.y. o'reilly W.L. GRIFFIN sUN Tao WEI Zhenyang JIANG shaoyong sHU Liangshu state Key Laboratory for Mineral Deposits Research Department of Earth Sciences Nanjing University Nanjing 210093 China GEMoC National Key Centre Department of Earth and Planetary Science Macquarie University Sydney NSW 2109 Australia

Metamorphic basement rocks in the Cathaysia Block are composed mainly of meta-sediments with different ages. New zircon U-Pb geochronological results from the meta-sedimentary rocks exposed in the Zengcheng and Hezi areas, southern Cathaysia Block, show that they consist dominantly of early Neoproterozoic (1.0―0.9 Ga) materials with minor Paleo- to Mesoproterozoic and late Neoproterozoic (0.8―0.6 Ga) components, suggesting that the detritus mostly come from a Grenvillian orogen. The youngest detrital zircon ages place a constraint on the deposition time of these sediments in Late Neoproterozoic. Zircon Hf isotopic compositions indicate that the Grenvillian zircons were derived from the reworking of Mesoproterozoic arc magmatic rocks and Paleoproterozoic continental crust, implying an arc-continent collisional setting. single-peak age spectra and the presence of abundant euhedral Grenvillian zircons suggest that the sedimentary provenance is not far away from the sample location. Thus, the Grenvillian orogen probably preexisted along the southern margin of the Cathaysia Block, or very close to the south. similarity in the ages of Grenvillian orogeny and the influence of the assembly of Gondwana in south China with India and East Antarctic are discussed, with suggestion that south China was more likely linked with the India-East Antarctica continents in Early Neoproterozoic rather than between western Laurentia and eastern Australia.

关键词：华夏古大陆格伦维尔期锆石同位素新元古代

ENERGy EMBoDIED IN,AND TRANsMITTED THRoUGH,WALLs oF DIFFERENT TyPEs WHEN ACCoUNTING FoR THE DyNAMIC EFFECTs oF THERMAL MAss

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Journal of Green Building 2020年第4期15卷 43-66页

作者： Aidan reilly oliver Kinnane Richard o’Hegarty UCD school of Architecture Planning and Environmental PolicyCollege of Engineering and ArchitectureUniversity College DublinIreland

Embodied energy is a measure of the energy used in producing,transporting and assembling the materials for a *** energy is the energy used to moderate the indoor environment to make it functional or comfortable-primarily,to heat or cool the *** many building geometries,the walls make the most significant contribution to the embodied energy of the building,and they are also the path of greatest heat loss or gain through the fabric,as they often have a greater surface area than the roof or *** insulation reduces the heat flow through the wall,reducing the energy used during operation,but this adds to the embodied *** operational energy is not only a function of the wall buildup,but also depends on the climate,occupancy pattern,and heating strategy,making an optimisation for minimum overall energy use *** study presents a comparison of typical wall construction types and heating strategies in a temperate maritime *** transient energy ratio method is a means to abstract the heat flow through the walls(operational energy for heating),allowing assessment of the influence of walls in isolation(*** a general sense,without being restricted to particular building geometries).Three retrofit scenarios for a solid wall are *** very low U-values,overall energy use can increase as the embodied energy can exceed the operational energy;current best practice walls coupled with low building lifetimes mean that this point may be reached in the near *** uncertainty is present in existing embodied energy data,and given its contribution to total energy use,this is a topic of urgent concern.

关键词： energy use lifetime energy use embodied energy operational energy thermal mass heating intermittent occupancy transient energy ratio uncertainty

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber