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有效改善自动化精加工作业

现代制造 2015年第47期 90-92页

作者： Tom s.wood 科尔摩根Kollmorgen

许多制造过程要求进行力控磨光或精加工作业，这些作业通常是由人工操作员来完成的，因为人手具有完成这些作业所必需的柔顺性，而这正是机床基于位置的“僵硬”控制所欠缺的。

关键词：精加工作业自动化制造过程操作员柔顺性磨光机床

贡布里希《艺术与错觉:图画再现的心理学研究》书评

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美育研究

美育研究 2024年第1期 195-202页

作者：克里斯托弗·s.伍德杨莹莹(译) 纽约大学德语系美国纽约10012 华中师范大学美术学院湖北武汉430079

“制作先于匹配”(Making precedes matching),通过这一著名的,可以看成《艺术与错觉》(Art and Illusion,1960)一书1缩影的准则,恩斯特·贡布里希(Ernst Gombrich)指明,在艺术家动念去模仿他们的眼前之物之前,他们已经在利用他们继承... 详细信息

“制作先于匹配”(Making precedes matching),通过这一著名的,可以看成《艺术与错觉》(Art and Illusion,1960)一书1缩影的准则,恩斯特·贡布里希(Ernst Gombrich)指明,在艺术家动念去模仿他们的眼前之物之前,他们已经在利用他们继承而来的图式作画,这些图式体现了刻画现实的传统惯例的力量。在某个时刻,某个艺术家将他对世界的视觉观察与某个绘画图式相对照,在此基础上他径直修正了图式。

关键词：贡布里希绘画图式视觉观察《艺术与错觉》恩斯特心理学研究

脉络膜黑素瘤蛋白表达错配修复的改变和微卫星不稳性

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美国医学会眼科杂志（中文版） 2006年第4期18卷 253-253页

作者： Mahmoud R. Hussein, MscPath Anna K Haemel Daniel M. Albert Gary s.wood 刘亮（译）

目的：通过蛋白质微卫星不稳性（MsI）和错配修复（MMR）的改变证明脉络膜黑素瘤基因组的不稳定性，评估这些变化对肿瘤的临床病理特征有无关联。

关键词：错配修复不稳性微卫星黑素瘤脉络膜蛋白表达临床病理特征不稳定性

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Integration of Core Data, Well Logs and seismic Attributes for Identification of the Low Reservoir Quality Units with Unswept Gas in the Carbonate Rocks of the World's Largest Gas Field

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Journal of Earth science 2017年第5期28卷 857-866页

作者： Mohammad Ali Faraji Ali Kadkhodaie Reza Rezaee David A.wood Department of Geology College of Science University of Tehran Earth science Department Faculty of Natural Science University of Tabriz Department of Petroleum Engineering Curtin University DWA Energy Limited

Tight zones of the gas bearing Kangan and Dalan formations of the south Pars gas field contain a considerable amount of unswept gas due to their low porosity, low permeability and isolated pore types. The current study, integrates core data, rock elastic properties and 3D seismic attributes to delineate fight and low-reservoir-quality zones of the south Pars gas field. In the first step, the dynamic reservoir geomechanical parameters were calculated based on empirical relationships from well log data. The log-derived elastic moduli were validated with the available laboratory measurements of core data. Cross plots between estimated porosity and elastic parameters based on Young＇s modulus indicate that low porosity zone coincide with high values of Young＇s module. The results were validated with petro- graphic studies of the available thin sections. The core samples with low porosity and permeability are correlated with strong rocks with tight matrix frameworks and high elastic values. subsequently, rock elastic properties including Young＇s modulus and Poisson＇s ratio along with porosity were estimated by using neural networks from a collection of 3D post-stack seismic attributes, such as acoustic impedance （ALl）, instantaneous phase of AI and apparent polarity. Distinguishing low reservoir quality areas in pay zones with unswept gas is then facilitated by locating low porosity and high elastic modulus values. An- hydrite zones are identified and eliminated as non-pay zones due to their characterization of zero porosi- ty and high Young modulus values. The methodology described has applications for unconventional re- servoirs more generally, because it is able to distinguish low porosity and permeability zones that are po- tentially productive from those unprospective zones with negligible reservoir quality.

关键词： tight zones unswept gas elastic parameters reservoir quality seismic attributes south Pars gas field.