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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.v.P.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Convergence of COvID-19 and recurrent stroke:In-hospital mortality risks explored

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World Journal of virology 2025年第1期14卷 5-8页

作者： Basavraj s Nagoba shree v Dhotre Ajay M Gavkare sachin s Mumbre Pradnya s Dhotre Department of Microbiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of Microbiology Ashwini Rural Medical CollegeSolapur 413001India Department of Community Medicine Ashwini Rural Medical CollegeSolapur 413001India Department of Biochemistry Ashwini Rural Medical CollegeSolapur 413001India

This editorial comments on the article by Desai et al,which investigates the impact of coronavirus disease 2019(COvID-19)on in-hospital mortality among patients with recurrent stroke using data from the 2020 National Inpatient *** findings reveal significantly higher mortality rates in COvID-19-positive patients compared to non-COvID-19 patients,particularly among middle-aged individuals,males,and ethnic *** editorial explores the underlying mechanisms contributing to these outcomes and discusses the clinical implications for targeted management strategies in high-risk *** results emphasize the need for comprehensive approaches to mitigate the heightened risks faced by recurrent stroke patients during the COvID-19 pandemic.

关键词： Recurrent stroke COvID-19 In-hospital mortality Nationwide analysis stroke admissions Infectious diseases Chronic health conditions Hypercoagulability

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Controversies in fecal incontinence

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World Journal of Gastroenterology 2025年第3期31卷 113-119页

作者： Andreia Albuquerque satish s C Rao school of Medicine and Biomedical sciences Fernando Pessoa UniversityGondomar 4420-096PortoPortugal Precancerous Lesions and Early Cancer Management Research Group RIsE@CI-IPO(Health Research Network) Portuguese Oncology Institute of PortoPorto 4200-072Portugal Division of Gastroenterology and Hepatology Department of Internal MedicineAugusta UniversityAugustaGA 30912United States

Fecal incontinence is a common condition that can significantly impact patients’quality of *** anal sphincter injury and anorectal surgeries are common *** ultrasound and anorectal manometry are important diagnostic tools for evaluating *** are various treatment options,including diet,lifestyle modifications,drugs,biofeedback therapy,tibial and sacral nerve neuromodulation therapy,and *** this editorial,we will discuss current controversies and novel approaches to fecal *** for asymptomatic anal sphincter defects after obstetric anal sphincter injury and in patients with inflammatory bowel disease is not generally recommended,but may be helpful in selected *** Garg incontinence score is a new score that includes the assessment of solid,liquid,flatus,mucous,stress and urge fecal *** tests such as translumbosacral anorectal magnetic stimulation and novel therapies such as translumbosacral neuromodulation therapy are promising diagnostic and treatment options,for both fecal incontinence and *** biofeedback therapy can overcome some limitations of the office-based *** muscle-derived cell implantation of the external anal sphincter has been further studied as a possible treatment *** neuromodulation may be useful in scleroderma,congenital fecal incontinence and inflammatory bowel disease but merits further study.

关键词： Fecal incontinence Endoanal ultrasound Anal sphincter defects Biofeedback Neuropathy sacral neuromodulation

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第01期 81-100页

作者： s.sAURABH R.KIRAN D.sINGH R.vAIsH v.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Improved strength and ductility of high alloy containing Al–12Zn–3Mg–2.5Cu alloy by combining non-isothermal step rolling and cold rolling

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International Journal of Minerals,Metallurgy and Materials 2017年第2期24卷 179-185页

作者： v.v.Ravikumar s.Kumaran Department of Metallurgical and Materials Engineering National Institute of TechnologyTamil Nadu 620015India

Al-12Zn-3Mg-2.5Cu alloy was prepared using a liquid metallurgy route under the optimized conditions. A sample cut from the ingot was rolled non-isothermally from 400℃ to 100℃ in 100℃ steps, with 15% reduction in thickness; it was then cold rolled isothermally at room temperature for 85% reduction. The cold-rolled alloys were characterized by electron microscopy, hardness test, and tensile test to elucidate their structural evolution and evaluate their mechanical behavior. In the results, the cast alloy consists of a-aluminum and various intermetallic compounds. These compounds are segregated along the grain boundaries, which makes the alloy difficult to roll at room tem- perature. The combined effect of non-isothermal step rolling and cold rolling results in the nano/microsized compounds distributed uniformly in the matrix. The hardness is substantially increased after rolling. This increase in hardness is attributed to the ultra-fine grain size, fine-scale intermetallic compounds, and structural defects （e.g., dislocations, stacking faults, and sub-grains）. The ultimate tensile strength of the rolled alloy is approximately 628 MPa with 7% ductility.

关键词： aluminum zinc magnesium copper alloys non-isothermal cold rolling mechanical properties intermetallic compounds struc-ture defects

The detailed corrosion performance of bioresorbable Mg-0.8Ca alloy in physiological solutions

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Journal of Magnesium and Alloys 2022年第5期10卷 1326-1350页

作者： A.s.Gnedenkov s.L.sinebryukhov v.s.Filonina v.s.Egorkin A.Yu.Ustinov v.I.sergienko s.v.Gnedenkov Institute of Chemistry of FEB RAs 159 Pr.100-letiya VladivostokaVladivostok690022Russia

The electrochemical behaviour of biodegradable magnesium alloy Mg-0.8Ca was evaluated in a mammalian cell culture medium(MEM)and Na Cl solutions(0.9 wt.%, 0.3 wt.%) using traditional(EIs, PDP, OCP) and local scanning electrochemical(svET, sIET with p H-selective microelectrode) methods at the micro-and meso-level. Corrosion rates of samples in two different media were determined using weight loss tests. The influence of testing media components, alloy composition and microstructure on the material’s degradation process was *** svET/sIET test parameters were optimized for in vitro investigation of the bioresorbable material surface. The mechanism of the alloy’s bioresorption was suggested. The effect of microsized phases on the corrosion behaviour of the alloy was proved using complementary in situ monitoring and sKPFM measurements. The rapid degradation rate of the alloy is related to the presence of local microgalvanic cells formed by cathodic α-magnesium matrix and anodic Mg_(2)Ca phase. The highest corrosion activity was revealed in the first 12 min of sample exposure to MEM, followed by stabilization of corrosion process due to the material’s passivation. Using sEM-EDX analysis, micro-Raman spectroscopy and XPs analysis the composition of the corrosion products was determined. Degradation in MEM proceeds with a formation of magnesium-and-carbonate substituted hydroxyapatite-containing film on the sample’s surface. The low possibility of application of Mg-0.8Ca alloy without coating protection in implant surgery was highlighted.

关键词： Magnesium-calcium alloy Biodegradation Corrosion rate Electrochemistry Weight loss Minimum essential medium

Hydroxyapatite-containing PEO-coating design for biodegradable Mg-0.8Ca alloy: Formation and corrosion behaviour

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Journal of Magnesium and Alloys 2023年第12期11卷 4468-4484页

作者： A.s.Gnedenkov s.L.sinebryukhov v.s.Filonina s.v.Gnedenkov Institute of Chemistry of FEB RAs 159 Pr.100-letiya VladivostokaVladivostok690022Russian Federation

In this study, the biocompatible protective coating was formed using plasma electrolytic oxidation(PEO) on bioresorbable Mg-0.8Ca alloy. The composition of the formed coating was studied using XRD, sEM-EDX analysis, and micro-Raman spectroscopy. The uniform distribution of hydroxyapatite over the thickness of protective PEO-layer was established. Using traditional(EIs, PDP, OCP) and local scanning electrochemical methods(svET, sIET with H^(+)-selective microelectrode), the level of protective properties of PEO-layer in a biological environment(mammalian cell culture medium, MEM) was determined. It was established that modification of Mg-0.8Ca alloy surface by PEO contributes to a significant increase in the corrosion resistance of the surface layer, making it possible to control the process of material‘s biodegradation. The maximum local electrochemical activity was recorded after 72 h of testing, while for the uncoated sample,intense corrosion degradation was recorded in the first 12 min of exposure to the cell culture medium. Formation of the PEO-coating results in a twofold decrease in the corrosion current density(2.8·10^(-6)A cm^(-2)) and an increase in the impedance modulus measured at a low frequency(1.7·10^(4)Ω cm^(2)) in comparison with the uncoated material(9.5·10^(-6)A cm^(-2);8.1·10^(3)Ω cm^(2)). The mechanism of material bioresorption was established and a model for biodegradation process of Mg-0.8Ca alloy with hydroxyapatite-containing PEO-coating in MEM was proposed. Analysis of these results and comparing with others obtained by various scientific groups indicate the prospects for application of biocompatible PEO-coating on Mg-Ca alloy in implant surgery.

关键词： Magnesium-calcium alloy Biodegradation Implant surgery Plasma electrolytic oxidation Electrochemistry Minimum essential medium Hydroxyapatite

Modelling Magnetoresistance Effect in Limited Anisotropic semiconductors

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Chinese Physics Letters 2017年第7期34卷 212-214页

作者： Filippov v.v. Mitsuk s.v. Lipetsk state Pedagogical University of P. P. semenov-Tyan-shansky Lipetsk 398020 the Russian Federation Lipetsk state Technical University Lipetsk 398600 the Russian Federation

A macroscopic model of the magnetoresistance effect in fimited anisotropic semiconductors is built. This model allows us to solve the problem of measurement of physical magnetoresistance components of crystals and films. Based on a unified mathematical model the method is worked out enabling us to measure tensor components of the specific electrical resistance and the relative magnetoresistance of anisotropic semiconductors simultaneously.

关键词： Modelling Magnetoresistance Effect in Limited Anisotropic semiconductors