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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena stanojevic Ivana stevanovic Milica Ninkovic Tihomir v.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invas.v. approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progress.v. loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invas.v. brain stimulation Parkinson's disease purinergic signalling

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Allowed spatial Transitions and Cancellation of the Richardson-Langmuir Ban

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Non-Metallic Material science 2021年第1期3卷 15-23页

作者： Ordin s.v. Ioffe Institute RAs. Russia

The ancient emission formulas of Langmuir and Richardson entered the calculations of subtle effects in semiconductor devices as basic ***,in the physics of semiconductor devices,these models have long played a purely decorative role,since they can describe in the most rough approximation only individual sections of the I-v *** it is precisely the fact that these formulas are basic when describing the barrier current-voltage characteristics(CvC)and prevented the consideration and use of thermoelectric effects in materials on a ***,as these basic emission models actually imposed a ban on the MEAsURABILITY of local thermoelectric effects,the existence of which has already been proven both phenomenologically and *** quantum transition technique is based on classical *** it can also be used to correct these classic *** calculation of the spatial transition of electrons over the potential barrier,taking into account the polarity of the kinetic energy,gives currents that are significantly higher than the currents of Langmuir and Richardson,including in the initial section of the I-v ***,ballistic currents are concentrated at energy levels close to the *** effect of condensation of electrons flowing down the barrier transforms the"anomalous"seebeck coefficients into normal MEAsURABLE Local Thermal EMF,including in p-n junctions.

关键词： Potential barrier Ballistic model spatial transition of electrons Electron condensation Local Thermo-EMF p-n junctions

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Current impact in the treatment of advanced hepatocellular carcinoma:The challenge remains

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 479-483页

作者： Angelo A de Mattos Cristiane v Tovo Isadora Z Bombassaro Luis F Ferreira Department of Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil school of Electronics Electrical Engineering and Computer ScienceQueen’s University of BelfastBelfast BT95BNBelfastUnited Kingdom

Hepatocellular carcinoma remains a significant cause of mortality worldwide,particularly among patients with liver *** most cases,surveillance in cirrhotic patients is neglected,leading to a diagnosis when the neoplasm is at an advanced *** this context,Zhou et al carried out a network metaanalysis to demonstrate the effectiveness of hepatic arterial infusion chemotherapy,concluding that it is a superior approach compared to sorafenib and transarterial chemoembolization in the treatment of advanced hepatocellular ***,the meta-analysis in question lacks methodological rigor,preventing the authors from making more definitive ***,we understand that transarterial chemoembolization,when properly indicated,is a highly effective therapeutic option,and that sorafenib,given the results of new therapies based on immune checkpoint inhibitors,is no longer the recommended drug for the treatment of these ***,we believe the use of hepatic arterial infusion chemotherapy is increasingly limited and lacks strong scientific support.

关键词： Hepatocellular carcinoma Meta-analysis Treatment Liver diseases Liver neoplasms

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Quantum Fast Algorithm Computational Intelligence PT I:sW/HW smart Toolkit

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Artificial Intelligence Advances 2019年第1期1卷 18-43页

作者： Ulyanov s.v. state University"Dubna" Universitetskaya Str.19DubnaMoscow Region141980Russia

A new approach to a circuit implementation design of quantum algorithm gates for quantum mass.v. parallel fast computing implementation is *** main attention is focused on the development of design method of fast quantum algorithm operators as superposition,entanglement and interference which are in general time-consuming operations due to the number of products that have to be ***&HW support sophisticated smart toolkit of supercomputing accelerator of quantum algorithm simulation is *** method for performing Grover’s interference without product operations as Benchmark *** background of developed information technology is the"Quantum/soft Computing Optimizer"(QsCOptKBTM)software based on soft and quantum computational intelligence *** genetic and quantum fuzzy inference algorithm gate design *** quantum information technology of imperfect knowledge base self-organization design of fuzzy robust controllers for the guaranteed achievement of intelligent autonomous robot the control goal in unpredicted control situations is described.

关键词： Quantum algorithm gate superposition Entanglement Interference Quantum simulator

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多变量预后模型改善结直肠癌复发预测：PROsPe CT试验

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国际医学放射学杂志 2025年第1期 115-116页

作者： v.Goh s.Mallett v.Boulter R.Glynne-Jones s.Khan s.Lessels 李晗

摘要目的改善预后预测以指导个性化治疗的需求仍未能解决。通过前瞻性研究CT、遗传和免疫组织化学标志物，以改善对结直肠癌复发的预测。方法该多中心试验（Is

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Bridging the gap:The role of technological advances in shaping gastrointestinal oncological outcomes

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 29-37页

作者： Nuno J G Rama Inês sousa Division of Colorectal surgical Leiria Hospital CentreLeiria 2410-021Portugal Department of surgical Leiria Hospital CentreLeiria 2410-021Portugal

Gastrointestinal(GI)cancers are highly prevalent and considered a major global health *** approach has undergone a remarkable transformation over the past years due to the development of new technologies that enabled better outcomes regarding their diagnosis and *** include artificial intelligence,robotics,next-generation sequencing and personalized ***,the integration of these advances into everyday clinical practice remains complex and challenging as we are still trying to figure out if these innovations tangibly improve oncological outcomes or if the current state of art should remain as the gold standard for the treatment of these ***,there are also some issues regarding ethical subjects,data privacy,finances and *** surgery concept has evolved considerably over the past decades,especially for oncological *** aims to customize medical treatments and to operate on those patients who most likely will benefit from a specific surgical *** the future,to improve GI oncological outcomes,a delicate balance between technological advances adoption and evidence-based care should be *** we move forward,the question will be to harness the power of innovation while keeping up the highest standards of patient care.

关键词： Technology Innovation Gastrointestinal oncology Outcomes Artificial intelligence Precision surgery

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Influence of structural factors on the strength properties of aluminum alloys under shock wave loading

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Matter and Radiation at Extremes 2018年第4期3卷 145-158页

作者： s.v.Razorenov Institute of Problems of Chemical Physics RAs ChernogolovkaRussia National Research Tomsk state University TomskRussia

The results of measurements of the strength characteristics-Hugoniot elastic limit and spall strength of aluminum and aluminum alloys in different structural states under shock wave loading are ***-crystals and polycrystalline technical grade aluminumА1013 and aluminum alloysА2024,АА6063Т6,А1421,A7,А7075,А3003,A5083,АА1070 in the initial coarse-grained state and ultrafine-grained or nanocrystalline structural state were *** refinement of the grain structure was carried out by different methods of s.v.re plastic deformation such as Equal Chanel Angular Pressing,Dynamic Channel Angular Pressing,High-Pressure Torsion and Accumulative *** strength characteristics of shock-loaded samples in different structural states were obtained from the analysis of the evolution of the free surface velocity histories recorded by means of laser Doppler velocimeter *** strain rates before spall fracture of the samples were in the range of 10^(4)-10^(5 )s^(-1),the maximum pressure of shock compression did not exceed 7 *** results of these studies clearly demonstrate the influence of structural factors on the resistance to high-rate deformation and dynamic fracture,and it is much less than under the static and quasi-static loading.

关键词： Aluminum alloys shock wave loading Ultrafine-grained structure Dynamic strength properties

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Links of Terrestrial Environment with solar Activity and solar and Planetary Orbital Motion

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Atmospheric and Climate sciences 2025年第1期15卷 72-105页

作者： valentina v. Zharkova Irina vasilieva Department of MPEE Faculty of Engineering and Environment University of Northumbria Newcastle upon Tyne UK Zvs Research Enterprise Ltd. London UK Department of solar Physics Main Astronomical Observatory Kyiv Ukraine

In this paper we emphasize statistical links between solar activity and orbital motion with various terrestrial phenomena: terrestrial temperature, sea levels, ice areas, frequencies of volcanic eruptions, and Oceanic Nino Index (ONI). solar activity links. The solar activity indices are expressed through the averaged sunspot numbers ssN and the summary curve of eigen vectors of the solar background magnetic field (sBMF). The terrestrial temperature (GLB dataset), global sea level, and volcanic eruption frequencies are shown from the wavelet analysis to have a clear link to the sBMF index, which has the same significant period of 21.4 years. The ice and snow areas in the Northern hemisphere are found to vary with a period of 10.7 years equal to the usual sunspot activity cycle while in the southern hemispheres, no links to solar activity are detected. solar orbital motion links. The variations of total solar irradiance (TsI) measured from the abundance of 14C isotope during the Holocene are shown to have a similar period of 2200-2300 years (Hallstatt’s cycle) as the solar inertial motion (sIM) induced by the gravitation of large planets, In the current millennium the amount of TsI deposited on Earth in the March-september to Northern hemisphere is ≈1.2% higher than in the september to March in the southern hemisphere. The wavelet analysis of ONI revealed the two significant periods of 4.5 and 12 years. The first one is shown to have a link to the lunar perigee period variations while the second period is linked to the Jupiter period of revolution about the sun whose gravitation seems to trigger terrestrial tectonic processes leading to volcanic eruptions. The ONI variation is noticeably linked to the occurrence of underwater volcanic eruptions (correlation of 25%), which, in turn, are linked to the tidal forces of Jupiter, the Moon and the sun in its inertial motion. Joint effects of the solar activity and the solar and planetary orbital motion are likely to govern

关键词： Terrestrial Temperature Terrestrial sea Level Terrestrial Ice Areas El Nino southern Oscillation volcanic Eruptions Underwater volcanic Eruptions solar Magnetic Field solar Activity solar Inertial Motion Correlation Jupiter Revolution Period Lunar Perigee Period

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Reconstruction of pile-up events using a one-dimensional convolutional autoencoder for the NEDA detector array

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Nuclear science and Techniques 2025年第2期36卷 62-70页

作者： J.M.Deltoro G.Jaworski A.Goasduff v.González A.Gadea M.Palacz J.J.valiente-Dobón J.Nyberg s.Casans A.E.Navarro-Antón E.sanchis G.de Angelis A.Boujrad s.Coudert T.Dupasquier s.Ertürk O.stezowski R.Wadsworth Department of Electronic Engineering University of ValenciaBurjassotValenciaSpain Heavy Ion Laboratory University of Warsaw02-093 WarsawPoland Istituto Nazionale di Fisica Nucleare Laboratori Nazionali di LegnaroLegnaroItaly Instituto de Física Corpuscular CSIC-Universidad de Valencia46980 PaternaValenciaSpain Department of Physics and Astronomy Uppsala UniversityUppsalaSweden GANIL CEA/DRF-CNRS/IN2P3Bvd.Henri Becquerel14076 CaenFrance CNRs IN2P3IPN LyonUniversitéLyon 169622 VilleurbanneFrance Department of Physics Nigde Omer Halisdemir University51240 NigdeTurkey Department of Physics University of YorkHeslingtonYork YO105DDUK

Pulse pile-up is a problem in nuclear spectroscopy and nuclear reaction studies that occurs when two pulses overlap and distort each other,degrading the quality of energy and timing *** methods have been used for pile-up rejection,both digital and analogue,but some pile-up events may contain pulses of interest and need to be *** paper proposes a new method for reconstructing pile-up events acquired with a neutron detector array(NEDA)using an one-dimensional convolutional autoencoder(1D-CAE).The datasets for training and testing the 1D-CAE are created from data acquired from the *** new pile-up signal reconstruction method is evaluated from the point of view of how similar the reconstructed signals are to the original ***,it is analysed considering the result of the neutron-gamma discrimination based on charge comparison,comparing the result obtained from original and reconstructed signals.

关键词： 1D-CAE Autoencoder CAE Convolutional neural network(CNN) Neutron detector Neutron-gamma discrimination(NGD) Machine learning Pulse shape discrimination Pile-up pulse

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spatio-Temporal Change of Atmospheric Precipitation on Territory of North-West of Ukraine

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Journal of Atmospheric science Research 2019年第4期2卷 1-4页

作者： Budnik s.v. The Central Geophysical Observatory of a Name of B.sreznevskogo the state Emergency service of Ukraine KievUkraine

The direction of the trend of precipitation over time is an important characteristic for both theoretical and practical *** presented study is devoted to the analysis of changes in the territory of the trend of precipitation over the year over *** the present stage of climate change in the north-west of Ukraine,there is a general tendency to increase rainfall over the *** trend is not the same across the territory and depends on the height and latitude of the *** amount of precipitation varies both in space and in time,however,the distribution of the characteristics of the rains themselves(intensity,duration and others)continue to remain similar throughout the *** revealed features of changes in the amount of precipitation in space and time can be useful in studying the unevenness of wetting,forecasting floods,changes in erosion activity,etc.

关键词： Precipitation characteristics Trend territory Meteorological station Long-term observations

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