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Acta Pharmaceutica sinica B 2021年第8期11卷 2505-2536页

作者： sonal V.Bhujbal Biplob Mitra Uday Jain Yuchuan Gong Anjali Agrawal shyam Karki Lynne s.taylor sumit Kumar Qi(Tony)Zhou Department of Industrial and Physical Pharmacy College of PharmacyPurdue University Oral Product Development Bristol Myers Squibb Material science and Engineering Bristol Myers Squibb

Amorphous solid dispersions(AsDs)are popular for enhancing the solubility and bioavailability of poorly water-soluble *** approaches have been employed to produce AsDs and novel techniques are *** review provides an updated overview of manufacturing techniques for preparing *** physical stability is a critical quality attribute for AsD,the impact of formulation,equipment,and process variables,together with the downstream processing on physical stability of AsDs have been *** strategies are proposed to identify suitable manufacturing methods,which may aid in the development of AsDs with satisfactory physical stability.

关键词： Amorphous solid dispersions stability Drug delivery Manufacturing solvent evaporation Melting process Co-precipitation Downstream processing selection criteria

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AZ41镁合金超塑性成形特性

Transactions of Nonferrous Metals society of China 2021年第3期31卷 648-654页

作者： s.taylor G.D.WEsT E.MOGIRE F.TANG H.R.KOTADIA WMG the University of WarwickCoventry CV47ALUK Buehler WMG Materials Engineering Centrethe University of WarwickCoventry CV47ALUK

研究AZ41镁合金在热轧(无后续热变形)条件下的显微组织变化,以确定其在超塑性成形工艺中的适用性,并确定最佳成形参数。采用高温拉伸试验和热气体胀形试验对材料在不同应变速率(1×10^(−1)~1×10^(−3) s^(−1))和温度(350~450℃)下的成... 详细信息

研究AZ41镁合金在热轧(无后续热变形)条件下的显微组织变化,以确定其在超塑性成形工艺中的适用性,并确定最佳成形参数。采用高温拉伸试验和热气体胀形试验对材料在不同应变速率(1×10^(−1)~1×10^(−3) s^(−1))和温度(350~450℃)下的成形性进行评估。利用GOM Aramis相机进行圆形网格分析,了解峰值应变和材料减薄与工业成形过程的关系。通过成形后EBsD和sTEM分析材料成形性的机制,发现存在明显动态再结晶。最佳成形参数为450℃和1×10^(−3) s^(−1),此时的峰值伸长率达520%。在1×10^(−2) s^(−1)下,450℃和400℃时的工业相关伸长率分别为195%和170%。

关键词：镁超塑性成形超塑性电子背散射衍射(EBsD) AZ41镁合金

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等离子生长氧化硅的电性能

微电子学 1989年第1期19卷 53-55页

作者： s.taylor 陈凌云

在400℃及低于400℃的温度下用氧/氯等离子气体在硅上生长了氧化物。研究了氧化物的电击穿强度和低温热退火后的界面及体内特性。业已表明,对于器件应用来讲,等离子生长氧化物的电性能是绰绰有余的。

关键词：等离子氧化硅电性能氧化硅薄膜

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内燃机原理

内燃机原理

Use of donepezil for neurocognitive recovery after brain injury in adult and pediatric populations:a scoping review

1952年

作者： C.Fayette taylor Edward s.taylor 宁榥董寿莘樊恭烋曹传钧陈启民译

来源：汇雅图书（南通市图书馆... 评论

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Neural Regeneration Research 2024年第8期19卷 1686-1695页

作者： Avery L.Miller Nathan K.Evanson J.Michael taylor University of Cincinnati College of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurology and Rehabilitation Medicine University of CincinnatiCincinnatiOHUSA Division of Pediatric Rehabilitation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacologic options for the treatment of cognitive deficits associated with traumatic brain injury in pediatric *** inhibitors such as donepezil have been evaluated in adult patients after traumatic brain injury,but relatively less is known about the effect in pediatric *** goal of this review is to identify knowledge gaps in the efficacy and safety of acetylcholinesterase inhibito rs as a potential a djuvant treatment fo r neurocognitive decline in pediatric patients with traumatic brain *** queried PubMed to identify literature published from database inception thro ugh June 2023 desc ribing the use of donepezil in young adult traumatic brain injury and pediatric patients with predefined *** on preselected search criteria,340 unique papers we re selected for title and abstra ct ***-two reco rds were reviewed in full after eliminating preclinical studies and pape rs outside the scope of the *** adult traumatic brain injury,we review results from 14 papers detailing 227 subjects where evidence suggests donepezil is well tole rated and shows both objective and patient-reported efficacy for reducing cognitive *** children,3 pape rs report on 5 children recovering from traumatic brain injury,showing limited *** additional 15 pediatric studies conducted in populations at risk for cognitive dysfunction provide a broader look at safety and efficacy in 210 patients in the pediatric age *** its promise for efficacy in adults with traumatic brain injury and tole rability in pediatric patients,we believe further study of donepezil for children and adolescents with traumatic brain injury is warranted.

关键词： acetylcholinesterase inhibitor adult cognition donepezil pediatrics traumatic brain injury

CHARTING TTHE ROAD AHEAD

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Beijing Review 2024年第31期67卷 18-19页

作者： Jon taylor University of Texas at san Antonio

The Communist Party of China(CPC)recently concluded the long-anticipated Third Plenary session of the 20th CPC Central *** meeting brought together the Party's top leadership to discuss and articulate China's policy g... 详细信息

关键词： policy goals strategic

The secondary injury cascade after spinal cord injury: an analysis of local cytokine/chemokine regulation

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Neural Regeneration Research 2024年第6期19卷 1308-1317页

作者： Daniel J.Hellenbrand Charles M.Quinn Zachariah J.Piper Ryan T.Elder Raveena R.Mishra taylor L.Marti Phoebe M.Omuro Rylie M.Roddick Jae sung Lee William L.Murphy Amgad s.Hanna Department of Neurosurgery University of Wisconsin-Madison School of Medicine and Public Health Department of Biomedical Engineering University of Wisconsin-Madison Department of Orthopedics and Rehabilitation University of Wisconsin-Madison Department of Materials science and Engineering University of Wisconsin-Madison Forward BIO Institute University of Wisconsin-Madison

After spinal cord injury, there is an extensive infiltration of immune cells, which exacerbates the injury and leads to further neural degeneration. Therefore, a major aim of current research involves targeting the immune response as a treatment for spinal cord injury. Although much research has been performed analyzing the complex inflammatory process following spinal cord injury, there remain major discrepancies within previous literature regarding the timeline of local cytokine regulation. The objectives of this study were to establish an overview of the timeline of cytokine regulation for 2 weeks after spinal cord injury, identify sexual dimorphisms in terms of cytokine levels, and determine local cytokines that significantly change based on the severity of spinal cord injury. Rats were inflicted with either a mild contusion, moderate contusion, severe contusion, or complete transection, 7 mm of spinal cord centered on the injury was harvested at varying times post-injury, and tissue homogenates were analyzed with a Cytokine/Chemokine 27-Plex assay. Results demonstrated pro-inflammatory cytokines including tumor necrosis factor α, interleukin-1β, and interleukin-6 were all upregulated after spinal cord injury, but returned to uninjured levels within approximately 24 hours post-injury, while chemokines including monocyte chemoattractant protein-1 remained upregulated for days post-injury. In contrast, several anti-inflammatory cytokines and growth factors including interleukin-10 and vascular endothelial growth factor were downregulated by 7 days post-injury. After spinal cord injury, tissue inhibitor of metalloproteinase-1, which specifically affects astrocytes involved in glial scar development, increased more than all other cytokines tested, reaching 26.9-fold higher than uninjured rats. After a mild injury, 11 cytokines demonstrated sexual dimorphisms; however, after a severe contusion only leptin levels were different between female and male rats. In conclus

关键词： astrocytes chemokines cytokines inflammation macrophages microglia secondary damage spinal cord injury

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan Mark J.taylor Julia Gauglitz Achim Hoerauf Yasuaki sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool school of Tropical Medicine LiverpoolUK Department of Computer science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany school of Global Humanities and social sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda school of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 september, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (AsMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free AsMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

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X线检查剂量调查：我们的结果有多准确？

国际医学放射学杂志 2019年第6期 750-750页

作者： s.taylor A.V.Muylem N.Howarth P.A.Gevenois D.Tack 王春节 Department of Radiology H?pital Ambroise Paré

摘要目的明确常用X线检查中剂量-面积-产物(DAP)的变化情况具有诊断参考水平(DRL)。方法用1～2年的时间从2家制造商的设备上收集3个中心获得的胸腹

关键词： DAP 变异性