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A comprehensive review of phytochemical approaches in treatment of acute myeloid leukemia:Associated pathways and molecular mechanisms

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Chinese Herbal Medicines 2025年第1期17卷 41-55页

作者： Mouvanal sajana t.s.Gopenath Basalingappa M.Kanthesh Division of Molecular Biology School of Life SciencesJSS AHER Department of Biotechnology and Bioinformatics School of Life SciencesJSS AHER

Acute myeloid leukemia(AML) is a type of cancer that affects the blood and bone *** review conducts a thorough analysis of AML, addressing its genetic *** examination extends to the current therapeutic approaches employed for AML,shedding light on their efficacy and the notable side effects experienced by patients undergoing these treatments,leading to a low overall survival ***,exploring alternative treatments,such as phytochemicals,is ***,the review explores the complex landscape of phytochemicals,categorizing them based on their diverse properties,which include alkaloids,phenols,terpenoids,organo-sulfur compounds,and other compounds,including quinones,and elucidating their mechanisms of *** emphasis is placed on their involvement in critical signaling pathways,with a particular focus on how these phytochemicals impact AML when evaluated across a spectrum of cell *** in-depth exploration aims to uncover potential targets within the molecular landscape of AML where phytochemicals can exert their therapeutic *** review investigates the potential role of plant-derived phytochemicals as adjunctive therapies for *** exploration encompasses the identification of specific phytochemicals that exhibit promising anti-leukemic properties and evaluates their potential in clinical *** conventional treatments,the review explores the integration of complementary and alternative medicine as a holistic approach to managing *** examination encompasses the synergy between conventional therapies and alternative interventions,exploring how these combined strategies may enhance overall therapeutic outcomes and mitigate side *** a forward-looking perspective,the overarching goal is to contribute to the evolving landscape of AML treatment by considering innovative approaches that harness the therapeutic potential of phytochemicals,both independently and in conjunction with establishe

关键词： cell death complementary and alternative medicine leukemia phytochemicals signaling pathways therapeutic targets

the impact of alpha-fetoprotein(AFp),child-turcotte-pugh(Ctp)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NAssER MULLA YOUsEF KAtIB AsIM M.ALMUGHAMsI DUAA s.ALKHAYAt MOHAMED MOsAAD sAMIR t.ALFOtIH RAWAN ALAOFI Department of Internal Medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King salman bin Abdulaziz Medical City Madinah42311Saudi Arabia prince Mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in saudi *** study aimed to investigate the patterns of HCC and the effect of tNM staging,Alfa-fetoprotein(AFp),and Child-turcotte pugh(Ctp)on patients’overall survival(Os).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:the mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in Os among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in Os(p-value=0.027).AFp was>400 ng/ml in 45%of the *** was a statistically significant difference in the Os in terms of AFp levels(p-value=0.021).A statistically significant difference was also observed between the Ctp score and Os(p-value=0.02).Ctp class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in Os among viral and non-viral HCC patients(p-value=0.008).Conclusions:the most common predictors for Os were the underlying cause of HCC,AFp,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFp>400 ng/mL,and a Ctp score class C were all negatively associated with Os.

关键词： Hepatocellular carcinoma pattern Alpha-fetoprotein(AFp) Child-turcotte-pugh progression free survival

Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece tüsüzÖnata ÖnerÖzdemir Division of pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,parasites living in the human intestine constitute the human intestinal *** refers to composi-tional and quantitative changes that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis,treatment strategies targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMt)is the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(t helper 1/t helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMt in allergic diseases will be discussed with current data.

关键词： Microbiota Dysbiosis Faecal microbiota transplantation Allergic diseases

Magnetosymbiosis discovery:new perspectives in magnetotaxis research

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Journal of Oceanology and Limnology 2025年第1期43卷 177-186页

作者： Caroline L.MONtEIL Christopher t.LEFEVRE Aix-Marseille Université CEACNRSInstitute of Biosciences and Biotechnologies of Aix-MarseilleSaint-Paul-lez-Durance 13115France

Magnetotactic bacteria have been the only known magnetoreceptive microorganisms for *** if the existence of magnetotactic protists was suggested in 1986,this is only 30 years later that magnetotaxis was extended to the domain of Eukaryota,thanks to the characterization of magnetotactic symbiotic assemblies composed of a flagellated protist and bacteria biomineralizing magnetic *** mutualistic ectosymbiosis relies on a collective magnetotaxis coupled to a hydrogen-based *** new form of cooperation challenges our view of magnetic biomineralization in prokaryotes and magnetoreception in *** this review,we present how magnetosymbiosis was discovered and how cooperation ***,we discuss the future research and the new perspectives such discovery brought to the field of magnetotaxis.

关键词： magnetotaxis biomineralization symbiosis magnetotactic

dp/dt_(max):An underestimated prognostic factor in large animal infarction model

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Animal Models and Experimental Medicine 2025年第1期8卷 171-178页

作者： Rita Garamvölgyi Dénes Kőrösi Ottótátrai Emőke Bodor Dániel Fajtai Kornélia Farkas András Vorobcsuk Doctoral school in Animal science Hungarian University of Agriculture and Life SciencesKaposvárHungary Department of Cardiology Kaposi Moritz Teaching HospitalKaposvárHungary Medicopus Nonprofit Ltd. KaposvárHungary Institute of Bioanalysis Medical SchoolUniversity of PécsPécsHungary Doctoral school of Clinical Medicine University of PécsPécsHungary

the present study aims to establish a reproducible large animal experimental unit using a minipig model to monitor cardiac function changes.A 90-min closed-chest bal-loon occlusion of the left anterior descending branch of the coronary artery was used to induce myocardial infarction in pannon *** monitor the cardiac function,measurements were made by cardiac magnetic resonance imaging(cMRI),invasive pressure monitoring,and a pulse index Continuous Cardiac Output(piCCO)hemo-dynamic system at 0,72,and 720 h during the follow-up ***-diastolic and end-systolic volumes(EDV,EsV),left ventricular ejection fraction(LVEF)obtained by cMRI evaluation,global ejection fraction and aortic dp/dt_(max)obtained by the invasive method,were recorded and *** 72-and 720-h EDV data showed a signifi-cant increase(p=0.012,pared to baseline,and the Day 30 data showed a significant increase compared to Day 3(p=0.022).the EsV 72 h after the infarction showed a significant increase(p=0.001)compared to baseline,which did not change significantly by Day 30(p=0.781)compared to Day *** and EsV were signifi-cantly negatively correlated with aortic dp_(max),and EsV was significantly correlated with *** LVEF and dp_(max),a significant(pp=0.002)worsening was demonstrated at Day 3 compared to baseline,which was no longer statistically de-tectable for LVEF at Day 30(p=0.141),while the difference for dp_(max)was maintained(p=0.002).the complementary use of piCCO hemodynamic measurements in large animal models makes the previously used methodologies more robust and reliable.

关键词： dp/dt_(max) hemodynamic measurements infarction model minipig piCCO

Leveraging ROtI map derived from Indonesian GNss receiver network for advancing study of Equatorial plasma Bubble in southeast/East Asia

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Earth and planetary physics 2025年第1期9卷 101-116页

作者： prayitno Abadi Ihsan N.Muafiry teguh N.pratama Angga Y.putra suraina Gatot H.pramono sidik t.Wibowo Febrylian F.Chabibi Umar A.Ahmad Wildan p.tresna Asnawi Research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia school of Electrical Engineering Telkom UniversityBandungIndonesia Directorate of Laboratory Management Facilities and science and technology park Indonesian National Research and Innovation Agency(BRIN)PontianakIndonesia Geophysics Laboratory Master Program in PhysicsUniversitas Gadjah Mada(UGM)YogyakartaIndonesia Research Center for space Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Research Center for photonics Indonesian National Research and Innovation Agency(BRIN)Tangerang SelatanIndonesia Department of Earth and planetary sciences Hokkaido UniversitySapporoJapan

this paper highlights the crucial role of Indonesia’s GNss receiver network in advancing Equatorial plasma Bubble(EpB)studies in southeast and East Asia,as ionospheric irregularities within EpB can disrupt GNss signals and degrade positioning *** by the Indonesian Geospatial Information Agency(BIG),the Indonesia Continuously Operating Reference station(Ina-CORs)network comprises over 300 GNss receivers spanning equatorial to southern low-latitude ***-CORs is uniquely situated to monitor EpB generation,zonal drift,and dissipation across southeast *** provide a practical tool for EpB research,by sharing two-dimensional rate of total Electron Content(tEC)change index(ROtI)derived from this *** generate ROtI maps with a 10-minute resolution,and samples from May 2024 are publicly available for further scientific *** preliminary findings from the ROtI maps of Ina-CORs are ***,the Ina-CORs ROtI maps reveal that the irregularities within a broader EpB structure persist longer,increasing the potential for these irregularities to migrate farther ***,we demonstrate that combined ROtI maps from Ina-CORs and GNss receivers in East Asia and Australia can be used to monitor the development of ionospheric irregularities in southeast and East *** have demonstrated the combined ROtI maps to capture the development of ionospheric irregularities in the southeast/East Asian sector during the G5 Geomagnetic storm on May 11,*** observed simultaneous ionospheric irregularities in Japan and Australia,respectively propagating northwestward and southwestward,before midnight,whereas southeast Asia’s equatorial and low-latitude regions exhibited irregularities *** sharing ROtI maps from Indonesia and integrating them with regional GNss networks,researchers can conduct comprehensive EpB studies,enhancing the understanding of EpB behavior across southeast and East Asia and contributing significantly to ionosphe

关键词： Equatorial plasma Bubble(EpB) GNss receivers’network Indonesia Continuously Operating Reference station(Ina-CORs) ionospheric map Rate of tEC change index(ROtI)map

Vegetation dynamics at the southern edge of the siberian mountain taiga

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Journal of Mountain science 2025年第2期22卷 451-465页

作者： IM sergei t KHARUK Viacheslav I pEtROV Il'ya A sHUsHpANOV Alexander s DVINsKAYA Maria L ONDAR sergei O V.N.sukachev Institute of Forest Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of ScienceKrasnoyarsk 660036Russia Institute of Ecology and Geography Institute of Space and Information TechnologiesSiberian Federal UniversityKrasnoyarsk 660041Russia Laboratory of Biodiversity and Ecology Tomsk State UniversityTomsk 634050Russia Institute of space Research and High technologies Reshetnev Siberian State University of Science and TechnologyKrasnoyarsk 660014Russia Department of Biology and Ecology Tuvan State UniversityKyzyl 667000Russia

the growth,survival,and mortality of conifer species in response to the hydrothermal regime have received considerable *** is expected that the highest sensitivity of trees to the warming-drying climate will occur mainly at the edges of the species *** focused on the responses to climate change of the drought-resistant larch(Larix sibirica)and the moisture-sensitive siberian pine(pinus sibirica)along the elevation gradient in the tannu-Ola Ridge,the southern margin where those two species coexist in siberia by using satellite data(MODIs,Landsat,and microwave),the indexes of gross(Gpp)and net(Npp)primary productivity,and tree radial growth index(GI).We found that since the warming restart in the 2000s,the area of larch-dominated forests increased by~150%while the area of pine-dominated forests decreased by~10%.the siberian pine has retreated at low elevations(sed its area at higher *** contrast,the area of larch stands increased in both the uphill and downhill ***(Betula spp.)also increased its area at low elevations(about+120%).since 2001,the forested area increased by~5%.A shrubification,i.e.,an increase in the area of shrubs,was observed at high *** uphill rate of timberline and shrubline migration was about 0.3 m/*** the 2000s,vegetation Npp has increased by 13%.A notable correlation between Npp and the GI of larch and pine was found(r=0.5-0.7).At lower elevations,Npp positively correlated with precipitation and soil moisture,while air temperature and VpD(vapor pressure deficit)increase inhibited *** high elevations,the effects of these variables on productivity *** continuous decline of the siberian pine forest indicates an inevitable retreat of this species at low elevations and its replacement by larch and birch.

关键词： trees range changes Mountain taiga siberian larch siberian pine timberline shrubification tree uphill migration Forest population dynamics Ecological resilience Habitat suitability

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.AsGHAR Z.ABBAs Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(pDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the peclet number, the schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： analytical solution Cattaneo-Christov heat and mass flux chemical reaction gyrotactic microorganism hybrid nanofluid O368 oscillating curved stretchable sheet

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:traumatic brain injury(tBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage