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Evaluating the Efficiency of Cadmium Removal by Alginate Hydrogels from Water Using 5,7-Dibromo-8-hydroxyquinoline as a Complexing Reagent

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Precision Chemistry 2023年第9期1卷 538-547页

作者： Abhijit B.Phalke Varuna s.Watwe sunil D.Kulkarni Preeti s.Kulkarni Post graduate and Research Center Department of ChemistryMES Abasaheb Garware CollegePune 411004 MaharashtraIndia Affiliated with savitribai Phule Pune University(Formerly University of Pune) Pune 411007 MaharashtraIndia

Cadmium toxicity in wastewater is a rising concern due to industries like batteries,metallurgy,electroplating,plastic stabilizers,and *** quantitative detection of Cd^(2+)and its remediation from wastewater samples are of major concern from an environmental point of *** the present work,an effective spectrophotometric method has been reported using 5,7-dibromo-8-hydroxyquinoline(DBHQ)as a complexing agent for Cd^(2+).this method has advantages like using recyclable,less toxic solvents and easy sample *** limit of detection,limit of quantification,and sensitivity of the proposed method were found to be 33.30,36.70 mg L^(−1),and 2×10^(−3),*** DBHQ method was validated using atomic absorption spectroscopy,and the recovery percentage was more than 98%.these results indicate that DBHQ can be effectively used for monitoring Cd^(2+)in aqueous *** method developed was further employed for monitoring Cd^(2+)adsorption on calcium alginate(AL)*** adsorption studies were done to optimize parameters of Cd^(2+)removal using AL hydrogels,and the data obtained were used for kinetic and thermodynamic *** studies indicated that the pseudo-first-order model showed better fitting,and thermodynamic studies showed Freundlich-like *** maximum adsorption capacity of Cd^(2+)on AL hydrogels was found to be 56.45 mg g^(−1).the validation studies of DBHQ were performed using statistical analysis methods like t-tests and one-way variance.

关键词： cadmium toxicity 5 7-dibromo-8-hydroxyquinoline spectrophotometric method adsorption studies wastewater remediation calcium alginate hydrogels

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surveillance for gastrointestinal malignancies

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World Journal of gastroenterology 2012年第33期18卷 4507-4516页

作者： Ashish K tiwari Heather s Laird-Fick Ramesh K Wali Hemant K Roy Department of Internal Medicine Michigan State University East Lansing MI 48824 United States Department of Internal Medicine North Shore University Health System Evanston IL 60021 United States

gastrointestinal (gI) malignancies are notorious for frequently progressing to advanced stages even in the absence of serious symptoms, thus leading to delayed diagnoses and dismal prognoses. secondary prevention of gI malignancies through early detection and treatment of cancer-precursor/premalignant lesions, therefore, is recognized as an effective cancer prevention strategy. In order to efficiently detect these lesions, systemic application of screening tests (surveillance) is needed. However, most of the currently used non-invasive screening tests for gI malignancies (for example, serum markers such as alpha-fetoprotein for hepatocellular carcinoma, and fecal occult blood test, for colon cancer) are only modestly effective necessitating the use of highly invasive endoscopy-based procedures, such as esophagogastroduodenoscopy and colonoscopy for screening purposes. Even for hepatocellular carcinoma where non-invasive imaging (ultrasonography) has become a standard screening tool, the need for repeated liver biopsies of suspicious liver nodules for histopathological confirmation can't be avoided. the invasive nature and high-cost associated with these screening tools hinders implementation of gI cancer screening programs. Moreover, only a small fraction of general population is truly predisposed to developing gI malignancies, and indeed needs surveillance. to spare the average-risk individuals from superfluous invasive procedures and achieve an economically viable model of cancer prevention, it's important to identify cohorts in general population that are at substantially high risk of developing gI malignancies (riskstratification), and select suitable screening tests for surveillance in these cohorts. We herein provide a brief overview of such high-risk cohorts for different gI malignancies, and the screening strategies that have commonly been employed for surveillance purpose in them.

关键词： gastrointestinal malignancies surveillance screening Biomarkers Cancer prevention

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Inhibiting tau-induced elevated nsMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

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translational Neurodegeneration 2023年第1期12卷 70-89页

作者： Carolyn tallon Benjamin J.Bell Medhinee M.Malvankar Pragney Deme Carlos Nogueras-Ortiz Erden Eren Ajit g.thomas Kristen R.Hollinger Arindom Pal Maja Mustapic Meixiang Huang Kaleem Coleman tawnjerae R.Joe Rana Rais Norman J.Haughey Dimitrios Kapogiannis Barbara s.slusher Johns Hopkins Drug Discovery Johns Hopkins University School of MedicineBaltimoreMD 21205USA Neurology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Cell Biology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Oncology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Medicine Johns Hopkins University School of MedicineBaltimoreMD 21205USA Pharmacology and Molecular sciences Johns Hopkins University School of MedicineBaltimoreMD 21205USA Psychiatry and Behavioral science Johns Hopkins University School of Medicine855 N.Wolfe StreetRangos 278BaltimoreMD 21205USA Intramural Research Program Laboratory of Clinical InvestigationNational Institute on AgingNational Institutes of Health251 Bayview BlvdSte 8C228BaltimoreMD 21224USA Johns Hopkins University school of Medicine 600 N.Wolfe StreetPathology 517BaltimoreMD 21287USA

Background Cognitive decline in Alzheimer’s disease(AD)is associated with hyperphosphorylated tau(ptau)propagation between neurons along synaptically connected networks,in part via extracellular vesicles(EVs).EV biogenesis is triggered by ceramide enrichment at the plasma membrane from neutral sphingomyelinase2(nsMase2)-mediated cleavage of *** report,for the first time,that human tau expression elevates brain ceramides and nsMase2 *** to determine the therapeutic benefit of inhibiting this elevation,we evaluated PDDC,the first potent,selective,orally bioavailable,and brain-penetrable nsMase2 inhibitor in the transgenic Ps19 AD mouse ***,we directly evaluated the effect of PDDC on tau propagation in a mouse model where an adeno-associated virus(AAV)encoding P301L/s320F double mutant human tau was stereotaxically-injected unilaterally into the *** contralateral transfer of the double mutant human tau to the dentate gyrus was *** examined ceramide levels,histopathological changes,and ptau content within EVs isolated from the mouse *** similar to human AD,the Ps19 mice exhibited increased brain ceramide levels and nsMase2 activity;both were completely normalized by PDDC *** Ps19 mice also exhibited elevated tau immunostaining,thinning of hippocampal neuronal cell layers,increased mossy fiber synaptophysin immunostaining,and glial activation,all of which were pathologic features of human *** treatment reduced these *** plasma of PDDC-treated Ps19 mice had reduced levels of neuronal-and microglial-derived EVs,the former carrying lower ptau levels,compared to untreated *** the tau propagation model,PDDC normalized the tau-induced increase in brain ceramides and significantly reduced the amount of tau propagation to the contralateral *** PDDC is a first-in-class therapeutic candidate that normalizes elevated brain ceramides and nsMase2 activity,leading to the slo

关键词： Alzheimer’s disease Extracellular vesicles Neutral sphingomyelinase 2 tau Ceramide

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人体肢体隐性发汗及其降温效应机理的热物理分析

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中国生物医学工程学报 2004年第2期23卷 163-168页

作者：朱光明刘伟杨昆 t.F.Zeng 华中科技大学能源与动力工程学院武汉430074 Department of Mechanical and Aerospace Engineering North Carolina state University

立人体皮肤组织内汗液流动和传热的数学模型 ,把Darcy定律引入到对汗液迁移的数学描述 ,从热物理的角度解释人体隐性发汗的机理 ,定量分析隐性发汗对肢体的降温效应。

关键词：人体肢体隐性发汗多孔介质模型

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side effects of budesonide in liver cirrhosis due to chronic autoimmune hepatitis: Influence of hepatic metabolism versus portosystemic shunts on a patient complicated with HCC

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World Journal of gastroenterology 2003年第12期9卷 2681-2685页

作者： Andreas geier Carsten gartung Christoph g.Dietrich Hermann E.Wasmuth Patrick Reinartz siegfried Matern Department of Intemal Medicine Ⅲ University of Technology (RWTH) AachenAachenGermany Nuclear Medicine University of Technology (RWTH) AachenAachenGermany Department of Internal Medicine Ⅲ University of Technology (RWTH) AachenAachenGermany

AIM:to investigate the systemic availability of budesonide in a patient with Child A cirrhosis due to autoimmune hepatitis (AIH) and primary hepatocellular carcinoma,who developed serious side effects. MEtHODs:serum levels of budesonide,6β-OH-budesonide and 16α-OH-prednisolon were measured by HPLC/Ms/Ms; portosystemic shunt-index (sI) was determined by 99mtc nuclear *** values were compared with a matched control patient without side effects. REsULts:serum levels of budesonide were 13-fold increased in the index *** ratio between serum levels of the metabolites 6β-OH-budesonide and 16α-OH- prednisolone,respectively,and serum levels of budesonide was diminished (1.0 vs.4.0 for 6β-OH-budesonide,4.2 vs. 10.7 for 16α-OH-prednisolone).Both patients had portosystemic sI (5.7 % and 3.1%) within the range of healthy ***:serum levels of budesonide Vary uP to 13-fold in AIH Patients with Child A eirrhosis in the absenee ofrelevant Portosystemic *** hePatiemetabolism,as indicated by redueed metabolite-to-drugratio,rather than Portosystemie shunting may explainsystemic side effects of this drug in cirrhosis

关键词： Portasystemic shunt, surgical Aged Anti-Inflammatory Agents Budesonide Carcinoma, Hepatocellular Female Hepatitis, Autoimmune Humans Liver Liver Neoplasms Research support, Non-U.s. gov't

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Optimal hydraulic design of new-type shaft tubular pumping system

Optimal hydraulic design of new-type shaft tubular pumping s...

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the 26th IAHR symposium on Hydraulic Machinery and systems

作者： H g Zhu R t Zhang and J R Zhou College of Hydraulic science and Engineering Yangzhou University Yangzhou 225009 China

Based on the characteristics of large flow rate,low-head,short annual operation time and high reliability of city flood-control pumping stations,a new-type shaft tubular pumping system featuring shaft suction box,siphon-type discharge passage with vacuum breaker as cutoff device was put forward,which possesses such advantages as simpler structure,reliable cutoff and higher energy *** to the design parameters of a city flood control pumping station,a numerical computation model was set up including shaft-type suction box,siphon-type discharge passage,pump impeller and guide *** using commercial CFD software Fluent,RNg κε turbulence model was adopted to close the three-dimensional time-averaged incompressible N-s *** completing optimal hydraulic design of shaft-type suction box,and keeping the parameters of total length,maximum width and outlet section unchanged,siphon-type discharge passages of three hump locations and three hump heights were designed and numerical analysis on the 9 hydraulic design schemes of pumping system were *** computational results show that the changing of hump locations and hump heights directly affects the internal flow patterns of discharge passages and hydraulic performances of the system,and when hump is located 3.66D from the inlet section and hump height is about 0.65D （D is the diameter of pump impeller）,the new-type shaft tubular pumping system achieves better energy performances.A pumping system model test of the optimal designed scheme was carried *** result shows that the highest pumping system efficiency reaches 75.96%,and when at design head of 1.15m the flow rate and system efficiency were 0.304m 3 /s and 63.10%,***,the validity of optimal design method was verified by the model test,and a solid foundation was laid for the application and extension of the new-type shaft tubular pumping system.

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用干热成像的热释电陶瓷

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压电与声光 1978年第3期 69-72页

作者： s.g.Porter 娄子勤普莱赛公司

研究了以锆钛酸铅为基的热释电陶瓷,它可用于热成像和单元探测器。采用局部化学共沉淀和热压技术,能够获得晶粒小于1微米的均匀、无孔陶瓷。它坚实、稳定、电阻率可以控制,因而是硫酸三甘肽(t.g.s)的富有吸引力的代替物。最近用黑化的2... 详细信息

研究了以锆钛酸铅为基的热释电陶瓷,它可用于热成像和单元探测器。采用局部化学共沉淀和热压技术,能够获得晶粒小于1微米的均匀、无孔陶瓷。它坚实、稳定、电阻率可以控制,因而是硫酸三甘肽(t.g.s)的富有吸引力的代替物。最近用黑化的20微米厚的靶测得光导摄像管响应度为6微安/瓦和1线对/毫米时的最小可分辨温度为1.2°K。可靠的单元探测器的典型响应度为120伏/瓦,而10赫时噪声等效功率为1.5×10瓦/赫。

关键词：热释电热成像长波红外成像

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斑岩铜矿热液流体的K-Mg同位素示踪

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中国科学：地球科学 2020年第2期50卷 245-257页

作者：李伟强赵书高王小敏李石磊王国光杨涛金章东南京大学内生金属矿床成矿机制研究国家重点实验室南京210046 中国科学院地球环境研究所黄土与第四纪地质国家重点实验室西安710061

文章系统分析了德兴斑岩铜矿热液蚀变岩的K-Mg同位素组成,发现蚀变斑岩和围岩的K-Mg同位素组成变化显著,其中δ41K值为-1.02~0.38‰,δ26Mg值为-0.49~0.32‰.除少量蚀变岩具有异常低的K-Mg同位素值外,大多数蚀变岩的K-Mg同位素值都高于... 详细信息

文章系统分析了德兴斑岩铜矿热液蚀变岩的K-Mg同位素组成,发现蚀变斑岩和围岩的K-Mg同位素组成变化显著,其中δ41K值为-1.02~0.38‰,δ26Mg值为-0.49~0.32‰.除少量蚀变岩具有异常低的K-Mg同位素值外,大多数蚀变岩的K-Mg同位素值都高于相应的上陆壳基线值.这指示了在热液蚀变过程中,蚀变产物尤其是层状硅酸盐矿物优先富集重的K-Mg同位素.德兴斑岩铜矿蚀变岩的K-Mg同位素值与其K-Mg含量以及矿物学特征之间无相关性,可能指示了具有不同物理化学性质或同位素组成的流体作用.基于蚀变岩的K-Mg同位素特征,在德兴斑岩矿床中识别出了至少三种不同的热液流体.研究显示K-Mg同位素可用于示踪复杂热液体系中的不同地质流体.

关键词：斑岩铜矿蚀变岩 K-Mg同位素热液流体

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BioCluster:tool for Identification and Clustering of Enterobacteriaceae Based on Biochemical Data

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genomics, Proteomics & Bioinformatics 2015年第3期13卷 192-199页

作者： Ahmed Abdullah s.M.sabbir Alam Munawar sultana M.Anwar Hossain Department of Microbiology University of Dhaka

Presumptive identifcation of different Enterobaeteriaeeae species is routinely achieved based on biochemical properties. traditional practice includes manual comparison of each biochem- ical property of the unknown sample with known reference samples and inference of its identity based on the maximum similarity pattern with the known samples. this process is labor- intensive, time-consuming, error-prone, and subjective. therefore, automation of sorting and sim- ilarity in calculation would be advantageous. Here we present a MAtLAB-based graphical user interface （gUI） tool named BioCluster. this tool was designed for automated clustering and iden- tification of Enterobacteriaceae based on biochemical test results. In this tool, we used two types of algorithms, i.e., traditional hierarchical clustering （HC） and the Improved Hierarchical Clustering （IHC）, a modified algorithm that was developed specifically for the clustering and identification of within this species. IHC takes into account the variability in result of 1-47 biochemical tests family. this tool also provides different options to optimize the clus- tering in a user-friendly way. Using computer-generated synthetic data and some real data, we have demonstrated that BioCluster has high accuracy in clustering and identifying enterobacterial species based on biochemical test data. this tool can be freely downloaded at http：//***/ biocluster/.

关键词： Bacterial identification Enterobacteriaceae Biochemical properties Clustering tool Identification tool Hierarchy algorithm

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Impacts of Forest Harvest on Active Carbon and Microbial Properties of a Volcanic Ash Cap soil in Northern Idaho

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Open Journal of soil science 2015年第1期5卷 11-19页

作者： Deborah s. Page-Dumroese Matt D. Busse steven t. Overby Brian D. gardner Joanne M. tirocke UsDA Forest service Rocky Mountain Research Station Moscow USA UsDA Forest service Pacific Southwest Research Station Davis USA UsDA Forest service Rocky Mountain Research Station Flagstaff USA UsDA Natural Resource Conservation service Moscow USA

soil quality assessments are essential for determining impacts on belowground microbial community structure and function. We evaluated the suitability of active carbon (C), a rapid field test, as an indicator of soil biological quality in five paired forest stands (clear cut harvested 40 years prior and unharvested) growing on volcanic ash-cap soils in northern Idaho. Active C was compared with several traditional measures of soil microbial properties (microbial biomass, respiration, fungal hyphal biomass, bacterial number and biomass and PLFA community structure). Despite the significant differences in forest vegetation between paired stands, no differences in active C and only a few significant differences in microbial properties were detected. total bacteria (microscope counts) and PLFA signatures (gram positive bacteria, gram negative bacteria, actinomycetes) were significantly higher in the managed stands. Our results indicate that either mineral soil biological properties in managed stands were relatively unaffected at the time of harvest or some biological recovery occurred 40 years later. Additionally, volcanic ash-cap soils in moist ecosystems could be highly resilient to the impacts of harvest operations and therefore few significant biological changes could be detected.

关键词： soil Quality Forest soil soil Monitoring soil Organic Matter

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