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sARs-CoV2 Nsp3 protein triggers cell death and exacerbates amyloid β42-mediated neurodegeneration

Neural Regeneration Research 2024年第6期19卷 1385-1392页

作者： Aditi singh Anuradha Venkatakrishnan Chimata Prajakta Deshpande soumya Bajpai Anjali sangeeth Mrigendra Rajput Amit singh Department of Biology University of DaytonDaytonOHUSA Premedical Program University of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA The Integrative science and Engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

Infection caused by the severe acute respiratory syndrome coronavirus 2(sARs-CoV2)virus,responsible for the coronavirus disease 2019(COVID-19)pandemic,induces symptoms including increased inflammatory response,severe acute respiratory syndrome(sARs),cognitive dysfunction like brain fog,and cardiovascular ***-term effects of sARs-CoV2 COVID-19 syndrome referred to as post-COVID-19 syndrome on age-related progressive neurodegenerative disorders such as Alzheimer's disease remain *** the targeted misexpression of individual sARs-CoV2 proteins in the retinal neurons of the Drosophila melanogaster eye,we found that misexpression of nonstructural protein 3(Nsp3),a papain-like protease,ablates the eye and generates dark necrotic *** misexpression of Nsp3 in the eye triggers reactive oxygen species production and leads to apoptosis as shown by cell death reporters,terminal deoxynucleotidyl transferase(TdT)dUTP Nick-end labeling(TUNEL)assay,and dihydroethidium ***,Nsp3 misexpression activates both apoptosis and autophagy mechanism(s)to regulate tissue *** expression of sARs-CoV2 Nsp3 in murine neuroblastoma,Neuro-2a cells,significantly reduced the metabolic activity of these cells and triggers cell *** of sARs-CoV2 Nsp3 in an Alzheimer's disease transgenic fly eye model(glass multiple repeats[GMR]>amyloidβ42)further enhances the neurodegenerative rough eye phenotype due to increased cell *** findings suggest that sARs-CoV2 utilizes Nsp3 protein to potentiate cell death response in a neurodegenerative disease background that has high pre-existing levels of neuroinflammation and cell death.

关键词： Alzheimer's disease apoptosis autophagy COVID-19 Drosophila necrosis Neuro-2a cells neurodegeneration post COVID-19 syndrome sARs-CoV2

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Automated Time Based Multi-Criteria Bug Triage Approach:Developer Working Efficiency and social Network Based Developer Recommendation

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Journal of shanghai Jiaotong university(science) 2024年第3期29卷 566-578页

作者： YADAV Asmita singh Kumar sandeep Krishna Engineering College Ghaziabad 201007India JIIT Noida 201309India

In software development projects,bugs are common *** report bugs in open source *** is a need to develop high quality developer prediction model that considers developer work satisfaction,keep within limited development cost,and improve bug resolution *** address and resolve bug report as soon as possible is the main focus of triager when a new bug is ***,developer work efficiency is an important factor in *** address these issues,a proposed approach recommends a set of developers that could potentially share their knowledge with each other to fix new bug *** proposed approach is called developer working efficiency and social network based developer recommendation(Dwesn).It is a composite model that builds developers'profile by using developer average bug fixing time,work efficiency to fix variety of bugs,as well as the developer's social interactions with other developers.A similarity measure is applied between new bug and bugs in corpus to extract the list of capable developers from the *** proposed approach only selects those developers who are active and less loaded with *** developer with the highest profile score is assigned the *** evaluated our approach on the subset of five large open-source projects including Mozilla,Netbeans,Eclipse,Firefox and OpenOffice,and compared it with the *** results demonstrate that combination of developers'efficiency with their average bug fixing time and interactions in their social network gives good accuracy and efficiently reduces bug tossing *** approach shows an improvement in prediction accuracy,precision,recall,F-score and reduced bug tossing length up to 93.89%,93.12%,93.46%,93.27%and 93.25%,*** proposed approach achieved a 93%hit ratio and 93.34%mean reciprocal rank,indicating that our proposed triager is able to efficiently assign bugs to correct developers.

关键词： open-source repository bug report bug assignment tossing length bug triager developer social network developer recommendation

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Dual PPAR delta/gamma agonist offer therapeutic potential for Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1175-1176页

作者： Ian steinke Meenakshi singh Rajesh Amin Department of Drug Discovery and Development Auburn UniversityAuburn AlabamaALUSA

The increasing incidence of Alzheimer's disease(AD)in the aging population,indicates the critical need for the development of novel targeted molecular therapies for ameliorating AD ***,clinical and preclinical evidence demonstrates that peroxisomal proliferator activating receptors(PPAR)agonists regulate energy and lipid homeostasis in models of diabetes,as well as improve spatial memory in animal models of AD(Khan et al.,2019).

关键词： Alzheimer clinical homeostasis

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Analytical solutions fractional order partial differential equations arising in fluid dynamics

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 458-468页

作者： sidheswar Behera Jasvinder singh Pal Virdi Department of Physics Veer Surendra Sai University of TechnologyOdishaIndia

This article describes the solution procedure of the fractional Pade-Ⅱ equation and generalized Zakharov equation(GsEs)using the sine-cosine ***-Ⅱ is an important nonlinear wave equation modeling unidirectional propagation of long-wave in dispersive media and GsEs are used to model the interaction between one-dimensional high,and low-frequency *** of trigonometric and hyperbolic function solutions in fractional calculus are *** simulations of the numerical solutions are flaunted by MATLAB.

关键词： the sine-cosine method He's fractional derivative analytical solution fractional Pade-Ⅱequation fractional generalized Zakharov equation

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Review of Electrochemical sensors and Biosensors Based on First-Row Transition Metals,Their Oxides,and Noble Metals Nanoparticles

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Journal of Analysis and Testing 2024年第2期8卷 143-159页

作者： Kulveer singh Kuldeep Kumar Maurya Manisha Malviya Department of Chemistry Indian Institute of Technology(Banaras Hindu University)Varanasi221005India

The use of electrochemical sensors for sensitive disease diagnosis and detecting various species with pharmacological,therapeutic,industrial,food-related,and environmental origins is now widely accepted.A catalytic or binding event resulting from the sensor’s electroactive component recognizing its analyte creates an electrical signal proportionate to the analyte concentration,which is then monitored by a *** development of morphologically distinct metal and metal oxide nanoparticles formed from first-row transition elements(Mn,Cr,Fe,Co,Ti,Ni,Cu,Zn)and noble metals(Pt,Au,Ag,Pd)is described in this *** effect of these metal nanoparticles has been studied using Tetracyanoquinodimethane(TCNQ),Ferrocene,and other organic compounds as electroactive species using carbon paste-modified *** sensors,mostly based on ferrocene,are exceedingly sensitive,selective,affordable,and for detecting numerous biomolecules like glucose,dopamine,NADH,ascorbic acid,and a few dyes and are simple to *** recent decades,charge transfer organic species-based chemosensors have become a prominent study *** paper outlines current developments in electrochemical biosensors based on transition metal nanoparticles,covering glucose,ascorbic acid,uric acid,and other inorganic and organic *** importance of transition metal and transition metal oxide nanoparticles as potential electrode modifiers for developing sensors is highlighted.A discussion of the present problem and possible solutions,and plausible future directions marks the review’s conclusion.

关键词： Electrochemical sensing Amperometry Cyclic voltammetry square wave voltammetry Linear sweep voltammetry

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Comparative measurement of CO_(2),CH_(4)and CO at two traffic interjunctions having inflated vehicular flow in Delhi

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Journal of Environmental sciences 2024年第7期141卷 314-329页

作者： Komal Daya soni Khem singh shankar G.Aggarwal CsIR-National Physical Laboratory Dr.K.S.Krishnan MargNew Delhi 110012India Academy of scientific&Innovative Research(AcsIR) Ghaziabad 201002India

Vehicular emissions are considered one of the major anthropogenic sources of greenhouse gases and poor air quality in metropolitan *** study aims to see the correlation of CO_(2),CH_(4),and CO through monitoring over a period from December 2020 to October 2021 covering three seasons’winter,summer,and monsoon at two different traffic locations of Delhi having different traffic volumes,road patterns,and traffic *** annual average morning concentration of CO_(2),CH_(4)and CO was found(533±105),(7.3±3.1),(10.7±3.0)ppm at Najafgarh and(480±70),(5.2±1.8),(7.8±2.8)ppm at Rajendra Place,respectively.A relationship between concentration of all three gases and meteorological parameters such as temperature,humidity,wind speed and wind direction has also been investigated using Pearson correlation coefficient and pollution rose diagram.A comparable pattern in concentration was observed for all three gases in spatial(location)and temporal(diurnal)*** concentration trend of CO_(2)in different seasons is winter>summer>monsoon,while in the case of CH_(4)winter=summer>monsoon but not any seasonal trend was noted in CO *** is observed that CO_(2)has a good relation with CO(a tracer for vehicular emission)in terms of diurnal variation,whereas,CH_(4)does not represent a relation with CO and CO_(2)diurnally,suggesting that vehicles are the source of CO_(2)but not much contributing to other greenhouse gases like CH_(4).

关键词： Vehicular emission Greenhouse gases Harmful pollutants Meteorological parameters

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Photo-activated microtubule targeting drugs: Advancing therapies for colorectal cancer

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World Journal of Gastroenterology 2024年第26期30卷 3257-3260页

作者： Naresh singh samantha sharma Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202United States

Over the years immunotherapy has demonstrably improved the field of cancer ***,achieving long-term survival for colorectal cancer(CRC)patients remains a significant unmet *** immunotherapies incor-porating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative ***,substantial gaps remain in the current therapeutic armamentarium for *** recent years,there has been a surge of interest in exploring novel treatment strategies,including the application of light-activated drugs in conjunction with optical *** approach holds promise for achie-ving localized and targeted delivery of cytotoxic agents,such as microtubule-targeting drugs,directly to cancerous cells within the colon.

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Trigonometric tension B-spline collocation approximations for time fractional Burgers’equation

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Journal of Ocean Engineering and science 2024年第5期9卷 508-516页

作者： Brajesh Kumar singh Mukesh Gupta school of Physical and Decision sciences Department of MathematicsBabasaheb Bhimrao Ambedkar University Lucknow 226025(UP)INDIA

This manuscript’s aim is to form and examine the numerical simulation of Caputo-time fractional nonlinear Burgers’equation via collocation approach with trigonometric tension B-splines as base ***,L 1 discretization formula is utilized for the time fractional derivative and after linearizing the nonlinear term,the trigonometric tension B-spline interpolants are utilized to get a system of simultaneous linear equations that are solved via Gauss elimination ***,numerical approximation at the desired time level is *** is demonstrated via von-Neumann approach that proposed scheme produces stable *** results of six different test examples having their analytical solutions are compared with the results in the literature to validate the accuracy and efficiency of the scheme.

关键词： Fractional Burgers’equation Trigonometric tension B-spline Collocation scheme Gauss elimination method

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Modulatory role of plant-derived metabolites on host-microbiota interactions:personalized therapeutics outlook

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BIOCELL 2024年第8期48卷 1127-1143页

作者： POOJA YADAV NAR singh CHAUHAN Department of Biochemistry Maharshi Dayanand University RohtakRohtakHaryanaIndia

A diverse array of microbes in and on the human body constitute the *** micro-residents continuously interact with the human host through the language of metabolites to dictate the host’s physiology in health and *** biotic and abiotic component ensuring a balanced host-microbiota interaction are potential microbiome therapeutic agents to overcome human *** metabolites are continually being used to treat various *** metabolites target the host’s metabolic machinery and host-gut microbiota interactions to overcome human *** the paramount therapeutic significance of the factors affecting host-microbiota interactions,a comprehensive overview of the modulatory role of plant-derived metabolites in host-microbiota interactions is *** current review puts an effort into comprehending the role of medicinal plants in gut microbiota modulation to mitigate various human *** would develop a holistic understanding of hostmicrobiota interactions and the role of effectors in health and diseases.

关键词： Microbiome therapeutics Human gut microbiota Host-microbiota interactions Personalized therapeutics Plant metabolites Human health and diseases

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Effect of random movement and cooperative hunting in the prey-predator system:A dynamical approach

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International Journal of Biomathematics 2024年第3期17卷 211-240页

作者： shivam Teekam singh Mukesh Kumar Department of Mathematics Graphic Era Deemed to be University 566/6 Bell RoadSociety AreaClenent Town DehradunUttarakhand 248002India Department of Computer science and Engineering Graphic Era Deemed to be University 566/6 Bell RoadSociety AreaClement Town DehradunUttarakhand 248002India

self-diffusion prerequisite is obtained as the spreading approach of biological *** hunting is a common behavior in predator populations that promotes predation and the coexistence of the prey-predator *** the other side,the Allee effect among prey may cause the system to become *** this paper,a difusive prey predator system with cooperative hunting and the weak Allee effect in prey populations is *** linear stability and Hopf-bifurcation analysis had been used to examine the system's *** the spatial stability of the system,the conditions for Turing instability have been *** multiple-scale analysis has been used to derive the amplitude equations of the *** stability analysis of these amplitude equations leads to the formation of Turing ***,numerical simulations are used to analyze spatial patterns forming in 1-D and *** studies indicate that the model can generate a complex pattern structure and that self-diffusion has a drastic impacton species distribution.

关键词： Prey predator system hunting cooperation Allee effect Hopf-bifurcation diffusive instability amplitudeequation

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