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Impact of medical and surgical intervention on survival in patients with cholangiocarcinoma

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World Journal of Gastrointestinal surgery 2013年第6期5卷 178-186页

作者： Amanda K Arrington Rebecca A Nelson Ann falor Carrie Luu Rebecca L Wiatrek Marwan fakih Gagandeep singh Joseph Kim Division of surgical Oncology City of Hope Comprehensive Cancer CenterDuarteCA 91010United States Department of Biostatistics City of Hope Comprehensive Cancer CenterDuarteCA 91010United States Department of surgery Harbor-UCLA Medical CenterTorranceCA 90509United States Department of Medical Oncology City of Hope Comprehensive Cancer CenterDuarteCA 91010United States

AIM:To examine surgical and medical outcomes for patients with cholangiocarcinoma using a populationbased cancer ***:Using the California Cancer Registry's Cancer surveillance Program,patients with intrahepatic cholangiocarcinoma treated in Los Angeles County from 1988 to 2006 were identified and evaluated for clinical and pathologic factors and therapies received(surgery,radiation,and chemotherapy).The surgical cohort was further categorized into three treatment groups:patients who received adjuvant chemotherapy,adjuvant chemoradiation,or underwent surgery alone(no chemotherapy or radiation administered).survival was assessed by Kaplan-Meier method;and Cox proportional hazard modeling was used in multivariate ***:Of 825 patients,60.2% received no *** the remaining 328 patients,18.5% chemotherapy only,7.4% chemoradiation,and 13.8% underwent *** male patients underwent surgical resection(P = 0.004).surgical patients were younger than the patients receiving chemotherapy or chemoradiation(P surgical cohort(n = 114),60.5% underwent surgery alone while 39.5% underwent surgery plus adjuvant therapy(chemotherapy n = 20;chemoradiation,n = 21)(P survival for all patients in the study was 6.6 *** survival was highest for patients who underwent surgery(23 mo),whereas both chemotherapy(9 mo) and chemoradiation(8 mo) alone were each less effective(P sis,extent of disease,receipt of surgery,and administration of chemotherapy(with/without surgery) were independent predictors of overall ***:This study demonstrates that surgery is a critical treatment *** treatment has yet to be standardized,but play a role in optimal therapy for cholangiocarcinoma.

关键词： Cholangiocarcinoma Chemotherapy surgery survival Therapies

Primary Malignant Melanoma of Female Urethra:A Case Report and Review of Literature

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Journal of Oncology Research 2019年第3期1卷 13-16页

作者： shashank Agrawal Tak GR Aditya Parikh Arvind Prakash Ganpule Abhishek Gajendra singh Ravindra Bhalchandra sabnis Mahesh Ramanlal Desai MBBs MSDNB(UROLOGY MBBs MSDNBMNAMS(Vice Chairman MBBs MSM.chDNB MBBs MSMch(Chairman MBBs MSFRCSFRCS(Medical Director

We report a very rare case report of female diagnosed with primary malignant melanoma.A 65 years old diabetic elderly postmenopausal female presented with a history of intermittent blood spots on undergarments for few *** examination revealed a single,tan colored,soft chestnut size and polypoidal non ulcerated mass lesion protruding through the urethral *** biopsy revealed poorly differentiated epithelial malignancy and immuno-histological analysis revealed positive with HMB 45 and protein s-100 suggestive of *** work up for the malignancy was *** urethrectomy with Mitrofanoff procedure with inguinal lymph node dissection was *** examination was suggestive of malignant melanoma of *** we discuss the clinicopathological features and management option possible in this scenario.

关键词： Female urethra melanoma

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髌骨肿瘤和肿瘤样病变:多中心经验

国际医学放射学杂志 2009年第3期 301-301页

作者： J.singh s.L.James H.M.Kroon K.Woertler s.E.Anderson A.M.Davies 尚全良 Department of Radiology The Royal Orthopaedic HospitalBristol Road SouthNorthfieldBirminghamUK

对在欧洲4个骨肿瘤中心登记的59例髌骨病变的病人进行了复习,其中46%是非肿瘤,39%是良性肿瘤,15%是恶性肿瘤。最常见的良性肿瘤是骨巨细胞瘤(11例),年轻人以良性肿瘤居多。40岁以下病人中髌骨病变有骨巨细胞瘤、成软骨细胞瘤、动脉瘤样... 详细信息

对在欧洲4个骨肿瘤中心登记的59例髌骨病变的病人进行了复习,其中46%是非肿瘤,39%是良性肿瘤,15%是恶性肿瘤。最常见的良性肿瘤是骨巨细胞瘤(11例),年轻人以良性肿瘤居多。40岁以下病人中髌骨病变有骨巨细胞瘤、成软骨细胞瘤、动脉瘤样骨囊肿、骨髓炎、骨样骨瘤、单房性骨囊肿;40岁以上病人髌骨病变常见有骨内痛风、

关键词：髌骨髌骨肿瘤骨肿瘤

经组织学证实的卵巢囊性腺纤维瘤的MRI形态学特征及强化模式评估

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国际医学放射学杂志 2013年第2期 182-182页

作者： Y.Z. Tang s. Liyanage P. Narayanan A. sahdev A. sohaib N. singh 李宁 Imaging Department Barts and the London NHS Trust London UK

目的评估经组织学证实的卵巢囊性腺纤维瘤(CAF)的MRI形态学及强化特征。方法回顾性分析47例经组织学证实的CAF(良性42例、交界性5例)。其中1例良性CAF合并同侧卵巢腺癌。记录其在MRI上的形态、信号及增强特征。结果 CAF的平均长径为80mm... 详细信息

目的评估经组织学证实的卵巢囊性腺纤维瘤(CAF)的MRI形态学及强化特征。方法回顾性分析47例经组织学证实的CAF(良性42例、交界性5例)。其中1例良性CAF合并同侧卵巢腺癌。记录其在MRI上的形态、信号及增强特征。结果 CAF的平均长径为80mm。45%的病例存在对侧卵巢的异常。85%的CAF可见实性成分,其中75%表现为T2WI上的低信号。74%的CAF可见分隔,其中1例为完全囊性的。大多数的实性成分及分隔的强化程度低于子宫肌层。对9例病人实性组织的对比剂流入率(WIR)进行评估,平均值为3.21/s。结论这是对经组织学证实的CAF进行MRI特征描述的数量最多的一次研究,包含了分隔、囊性成分及实性组织的典型的复杂附件病变。大多数实性成分表现为T2低信号和轻度强化。几乎一半的病例存在对侧卵巢的异常。要点①囊性腺纤维瘤是复杂的附件病变,包含分隔、囊性及实性成分。②囊性腺纤维瘤的一些MRI特征与卵巢恶性肿瘤相重叠。③几乎50%的囊性腺纤维瘤病人存在对侧卵巢的异常。④多数对侧卵巢病变为良性,但本研究发现4例交界性肿瘤。

关键词：囊性腺纤维瘤 MRI 附件肿瘤动态增强成像卵巢上皮性肿瘤

放射学专家与住院医师应用乳腺肿块计算机辅助分类的结果及观察者间差异

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国际医学放射学杂志 2011年第2期 167-167页

作者： s.singh J.Maxwell J.A.Baker J.L.Nicholas J.Y.Lo 秦乃姗 Ravin Advanced Imaging Laboratories Duke University Medical Center

目的评价专业乳腺影像医师和放射住院医师在描述乳腺肿块时存在的观察者间差异并确定病灶描述上的每一种差异如何影响计算机辅助诊断(CAD)计算机分类系

关键词：住院医师影像医师乳腺病灶乳腺肿块差异

发达国家纵向整合临床实习模式的发展及其对我国医学教育的启示

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中华医学教育杂志 2020年第9期40卷 748-752页

作者：李鸿鹤 David A Hirsh Tara A singh Yamini saravanan Rachel Hathaway Bianca shagrin Elizabeth Gaufberg Arundhati Ghosh 刘君李扬龄闻德亮中国医科大学国际医学教育研究院沈阳110122 哈佛大学医学院剑桥健康联盟马萨诸塞州剑桥市02139 中国医科大学沈阳110122

临床实习是医学生将理论知识转化为临床能力和深入临床环境学习的重要途径。纵向整合临床实习模式目前是一种创新性的临床教学方法和理念,它将连续性作为教学原则,很好地解决了原有临床实习中缺乏医疗连续性、课程连续性和教学指导连续... 详细信息

临床实习是医学生将理论知识转化为临床能力和深入临床环境学习的重要途径。纵向整合临床实习模式目前是一种创新性的临床教学方法和理念,它将连续性作为教学原则,很好地解决了原有临床实习中缺乏医疗连续性、课程连续性和教学指导连续性的问题,越来越多的医学院应用此种模式进行临床教学改革。本文对该实习模式的核心内涵、意义和哈佛剑桥模式及其发展与衍变进行阐述,并结合中国医学教育的实际需求进行分析,认为纵向整合临床实习模式可以提高我国临床医生培养质量,促进基层医疗人才队伍建设,增强住院医师规范化培训效果,有助于我国医学教育改革发展。

关键词：临床医学教育教育连续性纵向整合临床实习模式中国启示

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乙型脑炎病毒减毒株(2-8株)在蚊子传代细胞株内持续性感染的研究

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中国医学科学院学报 1981年第4期 231-236页

作者：陈伯权,Buckley s M 中国医学科学院病毒学研究所耶鲁大学医学院流行病和公共卫生研究所北京美国新港

乙脑2-8株感染singh’s Aedes albopictus Igarashi Clone C6/36细胞可持续产生高效价的病毒(TCD50log108.0～8.5/毫升)。在持续感染阶段,细胞可不断释放病毒,如收获病毒后换新鲜维持液,8小时内效价达TCD50log108;如每24小时收获病毒并... 详细信息

乙脑2-8株感染singh’s Aedes albopictus Igarashi Clone C6/36细胞可持续产生高效价的病毒(TCD50log108.0～8.5/毫升)。在持续感染阶段,细胞可不断释放病毒,如收获病毒后换新鲜维持液,8小时内效价达TCD50log108;如每24小时收获病毒并换液一次,始终可获高效价病毒。初次感染130～144天后,产生病毒的细胞占总细胞数7.6～14％。持续感染100天所获乙脑减毒株,其免疫力比原每株稍好,而毒力相若。

关键词：乙脑病毒持续感染细胞乙型脑炎病毒日本脑炎病毒虫媒病毒病毒效价传代细胞株减毒株持续性感染蚊子

腹部CT:迭代统计重建法与滤波反投影重建技术的比较

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国际医学放射学杂志 2011年第1期34卷 71-页

作者： s.singh M.K.Kalra J.Hsieh P.E.Licato s.Do H.H.Pien 于晓坤 Department of Radiology Massachusetts General Hospital

目的比较在不同X线管电流时间(50～200mAs)条件下通过迭代重建法(AsIR)与滤波反投影重建技术(FBP)获得腹部CT影像质量及病变显示能力。

关键词：投影重建噪声显示能力噪音 FBP 腹部病变 CT

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Notes for genera:Ascomycota

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Fungal Diversity 2017年第5期86卷 1-594页

作者： Nalin N.Wijayawardene Kevin D.Hyde Kunhiraman C.Rajeshkumar David L.Hawksworth Hugo Madrid Paul M.Kirk Uwe Braun Rajshree V.singh Pedro W.Crous Martin Kukwa Robert Lücking Cletus P.Kurtzman Andrey Yurkov Danny Haelewaters Andre´Aptroot H.Thorsten Lumbsch Einar Timdal Damien Ertz Javier Etayo Alan J.L.Phillips Johannes Z.Groenewald Moslem Papizadeh Laura selbmann Monika C.Dayarathne Gothamie Weerakoon E.B.Gareth Jones satinee suetrong Qing Tian Rafael F.Castanda-Ruiz Ali H.Bahkali Ka-Lai Pang Kazuaki Tanaka Dong Qin Dai Jariya sakayaroj Martina Hujslová Lorenzo Lombard Belle D.shenoy Ave suija sajeewa s.N.Maharachchikumbura Kasun M.Thambugala Dhanushka N.Wanasinghe Bharati O.sharma subhash Gaikwad Gargee Pandit Laura Zucconi silvano Onofri Eleonora Egidi Huzefa A.Raja Rampai Kodsueb Marcela E.s.Caceres sergio Perez-Ortega Patrícia O.Fiuza Josiane santana Monteiro Larissa N.Vasilyeva Roger G.shivas Maria Prieto Mats Wedin Ibai Olariaga Adebola Azeez Lateef Yamini Agrawal seyed Abolhassan shahzadeh fazeli Mohammad Ali Amoozegar Guo Zhu Zhao Walter P.Pfliegler Gunjan sharma Magdalena Oset Mohamed A.Abdel-Wahab susumu Takamatsu Konstanze Bensch Nimali Indeewari de silva AndréDe Kesel Anuruddha Karunarathna saranyaphat Boonmee Donald H.Pfister Yong-Zhong Lu Zong-Long Luo Nattawut Boonyuen Dinushani A.Daranagama Indunil C.senanayake subashini C.Jayasiri Milan C.samarakoon Xiang-Yu Zeng Mingkwan Doilom Luis Quijada sillma Rampadarath Gabriela Heredia Asha J.Dissanayake Ruvishika s.Jayawardana Rekhani H.Perera Li Zhou Tang Chayanard Phukhamsakda Margarita Hernańdez-Restrepo Xiaoya Ma saowaluck Tibpromma Luis F.P.Gusmao Darshani Weerahewa samantha C.Karunarathna Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Royal Botanic Gardens KewRichmondSurrey TW93DSUK Department of Life sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Jilin Agricultural University Changchun 130118JilinPeople’s Republic of China Centro de Geno´mica y Bioinforma´tica Facultad de CienciasUniversidad Mayor de ChileCamino La Pira´mide 5750HuechurabaSantiagoChile Martin-Luther-Universita¨t Institut fu¨r BiologieBereich Geobotanik und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of Gdan´skWita Stwosza 5980-308 Gdan´skPoland Botanic Garden and Botanical Museum Königin-Luise-Str.6-814195 BerlinGermany Mycotoxin Prevention and Applied Microbiology Research Unit National Center for Agricultural Utilization ResearchAgricultural Research ServiceU.S.Department of AgriculturePeoriaIL 61604USA Leibniz Institute DsMZ-German Collection of Microorganisms and Cell Cultures Inhoffenstraße 7B38124 BrunswickGermany farlow Reference Library and Herbarium of Cryptogamic Botany Harvard University22 Divinity AvenueCambridgeMA 02138USA Department of Organismic and Evolutionary Biology Harvard University22 Divinity AvenueCambridgeMA 02138USA ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands science&Education The Field Museum1400

Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to *** genera have been found to be polyphyletic,and their generic concepts have subsequently been *** names have thus been introduced for species which are phylogenetically distinct from the type species of particular *** ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic *** order to facilitate access to all important changes,it was desirable to compile these in a single *** present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are *** and summaries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the Fungi’in 2008 are *** notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since *** work is intended to provide the foundation for updating the ascomycete component of the"Without prejudice list of generic names of Fungi"published in 2013,which will be developed into a list of protected generic *** will be subjected to the XIXth International Botanical Congress in shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature Committee for Fungi(NCF).The previously invalidly published generic names Barriopsis,Collophora(as Collophorina),Cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),Lithophila,Palmomyces(as Palmaria)and saxomyces are validated,as are two previously invalid family names,Bartaliniaceae and *** species of Lalaria,which were invalidly published are trans

关键词： Article 59 Classification One name Pleomorphic fungi Taxonomy