检索结果-南通市图书馆

国外农学（蚕业） 1991年第4期 59-61页

作者： A.Arakawa s.shimizu 陈劲伟

我们开发了胶乳凝集试验检测家蚕感染IFV,CPV,DNV和NPV的方法(shimizu 等,1983;shimizu Arakawa,1986;Arakawa,1989)。

关键词：家蚕测定蛋白胶乳粒子凝集

在线全文

学校读者我要写书评

暂无评论

青藏高原那曲地区冰雹天气系统中的大气电场

高原气象 2000年第3期19卷 339-347页

作者：周筠珺陈成品刘黎平楚荣忠冯锦明张彤宋新民 M.Kajikawa H.Fujii Y.Aoi T.Koike s.shimizu K.Ueno 中国科学院寒区旱区环境与工程研究所甘肃省兰州市730000 Akikta University Nagaoka University of Technology Nagaoka Earth Observation Research Center National Space Development Agency of JapanTokyo The University of shiga Prefecture Shiga

利用 1 998年 4～ 9月间进行的GAME TIBET青藏高原云和降水的多普勒雷达及大气平均电场加强期观测实验资料 ,对青藏高原那曲地区的冰雹天气系统中的大气电场作了定量观测和研究。结果表明 :在降雹过程中大气电场强度基本上均为负值 ,其... 详细信息

利用 1 998年 4～ 9月间进行的GAME TIBET青藏高原云和降水的多普勒雷达及大气平均电场加强期观测实验资料 ,对青藏高原那曲地区的冰雹天气系统中的大气电场作了定量观测和研究。结果表明 :在降雹过程中大气电场强度基本上均为负值 ,其峰值也均强于- 2 2kVm- 1;在降雹过程中随着降雹时间的临近 ,大气电场强度不断增强 ,但降雹开始时大气电场强度并未达到其峰值 ,峰值出现的时刻比开始降雹的时刻略有滞后 ;在各降雹日中 ,较强的大气电场强度基本上对应着各冰雹谱分布段较多的冰雹数目 ,而这种较好的相关在各谱分布段上都表现出来 ;随着降雹时间的临近 ,每 5min闪电频数不断增强。在开始降雹时每 5min闪电频数平均达到 43,峰值的出现时刻略滞后于开始降雹的时刻 ,这一滞后时间一般平均在 3min左右 ;在降雹过程中 ,单位面积中的冰雹数目与对应时段内总闪电数有着较好的对数关系 ,相关系数R为 0 .9540。在降雹过程的时间序列上 ,冰雹云成熟期过后 ,总闪电次数与冰雹降雹率成反相关。

关键词：青藏高原那曲地区冰雹天气大气电场

GAME-TIBET青藏高原云和降水综合观测概况及初步结果

在线全文

学校读者我要写书评

暂无评论

高原气象 1999年第3期18卷 441-450页

作者：刘黎平楚荣忠宋新民周筠君冯锦明陈成品张彤 s.shimizu K.Ueno T.Koike H.Fujii H.Yamada Y.Aoi T.Ueno J.Horikomi M.Kajikawa Rshirooka J.Teshima 中国科学院兰州高原大气物理研究所甘肃省兰州市730000 EarthObservationResearchCenter NationalSpaceDevelopmentAgencyofJapan TheUniversityofshigaPrefecture ShigaJapan NagaokaUniversityofTechnology DepartmentofEarthandPlanetaryscience HokkaidoUniversity AkiktaUniversity Japan HokkaidoNationalAgriculturalExperimentstation KyushuUniversity

对中日合作青藏高原能量水分循环试验（ＧＡＭＥ ＴＩＢＥＴ）项目中云和降水的多普勒雷达观测使用的气象观测仪器和获取的资料等情况进行了扼要的总结，并给出了那曲地区降水的日变化、不同雨量计测量降水的对比分析、风速... 详细信息

对中日合作青藏高原能量水分循环试验（ＧＡＭＥ ＴＩＢＥＴ）项目中云和降水的多普勒雷达观测使用的气象观测仪器和获取的资料等情况进行了扼要的总结，并给出了那曲地区降水的日变化、不同雨量计测量降水的对比分析、风速对测量降水影响、多普勒雷达资料的个例分析及云的数值模拟等初步结果。

关键词：云降水多普勒雷达综合观测青藏高原

Revisiting cerebral endothelial cells in Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

A systematic review of progenitor survival and maturation in Parkinsonian models

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Discrete Circular Distributions with Applications to shared Orthologs of Paired Circular Genomes

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & sciences 2020年第6期123卷 1131-1149页

作者： Tomoaki Imoto Grace s.shieh Kunio shimizu school of Management and Information University of ShizuokaShizuokaJapan Institute of statistical science Academia SinicaTaipeiTaiwan school of statistical Thinking The Institute of Statistical MathematicsTokyoJapan

For structural comparisons of paired prokaryotic genomes,an important topic in synthetic and evolutionary biology,the locations of shared orthologous genes(henceforth orthologs)are observed as binned *** and other data,e.g.,wind directions recorded at monitoring sites and intensive care unit arrival times on the 24-hour clock,are counted in binned circular arcs,thus modeling them by discrete circular distributions(DCDs)is *** propose a novel method to construct a DCD from a base continuous circular distribution(CCD).The probability mass function is defined to take the normalized values of the probability density function at some pre-fixed equidistant points on the *** families of constructed DCDs which have normalizing constants in closed form are *** studies show that DCDs outperform the corresponding CCDs in modeling grouped(discrete)circular data,and minimum chi-square estimation outperforms maximum likelihood estimation for *** apply the constructed DCDs,invariant wrapped Poisson and wrapped discrete skew Laplace to compare the structures of paired bacterial ***,discrete four-parameter wrapped Cauchy(nonnegative trigonometric sums)distribution models multi-modal shared orthologs in Clostridium(sulfolobus)better than the others considered,in terms of AIC and Freedman’s goodness-of-fit *** result that different DCDs fit the shared orthologs is consistent with the fact they belong to two ***,these prokaryotes have a common favored site around 70°on the unit circle;this finding is important for building synthetic prokaryotic genomes in synthetic *** DCDs can also be applied to other binned circular data.

关键词： Bacterial genomes circular distribution goodness-of-fit test modeling synthetic and evolutionary biology.

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Understanding activity of butyrate at a cellular level

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber