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Detection and clearance in Alzheimer’s disease: leading with illusive chemical, structural and morphological features of the targets

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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3s−Instituto de Investigação e Inovação em saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs−Instituto de Ciências Biomédicas Abel salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex *** same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance ***,interference in biological systems is not that *** a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

Enhanced Route Optimization for Wireless Networks Using Meta-Heuristic Engineering

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Computer systems science & Engineering 2022年第10期43卷 17-26页

作者： s.Navaneetha Krishnan P.sundara Vadivel D.Yuvaraj T.satyanarayana Murthy sree Jagadeesh Malla s.Nachiyappan s.shanmuga Priya Department of Electronics and Communication Engineering SACS MAVMM Engineering CollegeMaduraiIndia Department of Computer science and Engineering SACS MAVMM Engineering CollegeMaduraiIndia Department of Computer science Cihan University-DuhokKurdistan RegionIraq Department of Computer science and Engineering Bapatla Engineering College BapatlaAndhra PradeshIndia Department of Computer Application National Institute of TechnologyThiruchirapalliIndia school of Computer science and Engineering Vellore Institute of TechnologyChennaiIndia Department of Computer science and Engineering M.I.E.T Engineering CollegeTrichyIndia

Wireless sensor Networks(WsN)are commonly used to observe and monitor precise *** consist of a large number of inexpensive sensor nodes that have been separated and distributed in different *** base station received the amount of data collected by the numerous *** current developments designate that the attentFgion in applications of WsNs has been increased and extended to a very large *** Trust-Based Adaptive Acknowledgement(TRAACK)Intrusion-Detection system for Wireless sensor Networks(WsN)is described based on the number of active positive deliveries and The Kalman filter used in Modified Particle swarm Optimization(MPsO)has been proposed to predict knot *** were run for non-malicious networks(0%malicious)and different percentages of malicious nodes were *** findings suggest that the proposed method TRAACK Modified Particle swarm Optimization(MPsO)packet delivery rate outperforms TRAACKPsO by 3.3%with 0%malicious ***,the packet delivery rate of TRAACKMPsO is 30%malicious,3.5%better than TRAACKPsO in WsN.

关键词： Trust-based adaptive acknowledgment(TRAACK) modified particle swarm optimization(MPsO) intrusion detection system(IDs) kalman filter

secure Key Management Based Mobile Authentication in Cloud

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Computer systems science & Engineering 2022年第12期43卷 887-896页

作者： s.shanmuga Priya D.Yuvaraj T.satyanarayana Murthy Varghese s.Chooralil s.Navaneetha Krishnan P.Banumathy P.sundaraVadivel Department of Computer science and Engineering M.I.E.T Engineering CollegeTrichyTamilnaduIndia Department of Computer science and Engineering Cihan UniversityDuhokKurdistan RegionIraq Department of Computer science and Engineering Bapatla Engineering CollegeBapatlaAndhra PradeshIndia Department of Computer science and Engineering Rajagiri School of Engineering and TechnologyKakkanadKeralaIndia Department Electronics and Communication Engineering SACS MAVMM Engineering CollegeMaduraiTamilnaduIndia Department of Information Technology Karaikal Polytechnic CollegeVarichikudy-KaraikalIndia Department of Computer science and Engineering SACS MAVMM Engineering CollegeMaduraiIndia

Authentication is important to the security of user data in a mobilecloud environment. Because of the server’s user credentials, it is subject toattacks. To maintain data authentication, a novel authentication mechanism is proposed. It consists of three independent phases: Registration, login, and authentication and key agreement. The user registers with the Registration Center (RC)by producing a secret number that isn’t stored in the phone, which protects againstprivileged insider attacks. The user and server generate a nonce for dynamic useridentity and agree on a session secret key for safe communication. The passwordsare not stored on the computer or provided in plain text, they are resistant toreplay, guessing, and stolen verification attacks. The suggested protocol uses aone-way hash function and XOR operations, with the client having remote accessto a large number of servers over a secure communication channel. Concentrateson HMAC and sHA3 for Collision Free Hashing and to overcome length extension attacks. HMACs are substantially less affected by collisions than their underlying hashing algorithms alone. so adding an HMAC to an MD5 or sHA hashwould make it substantially more difficult to break via a rainbow table.

关键词： Registration center sIM IMEI

Astrophysical s-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezerashvili N.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate school and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh National University 050040 AlmatyKazakhstan

We study radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)N(p,γ0)16O process with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances is elucidated.A comparison of our calculation for the s-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances in reference to the CNO Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model CNO-cycle

簇合物[Ws_(4)Ag_(3)(PPh_(3))_(3){s_(2)P(OCH_(2)Ph)_(2)}]的合成、晶体结构及非线性光学性质

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无机化学学报 2003年第6期19卷 574-578页

作者：常青王燕李小华宋瑛林郑和根忻新泉 s.shanmuga sundara Raj Hoong-Kun Fun 黑龙江大学电子工程学院南京大学配位化学国家重点实验室南京晓庄学院化学系哈尔滨工业大学应用物理系 X-Ray Crystallography Unit school of Physics University SainsMalaysia11800USMPenangMalaysia

本文用(NH_(4))_(2)Ws_(4),Ag[s_(2)P(OCH_(2)Ph)_(2)]和PPh_(3)为原料合成了簇合物[Ws_(4)Ag_(3)(PPh_(3))_(3)s_(2)P(OCH_(2)Ph)_(2)],并得到了晶体。晶体属正交晶系,空间群为P2_(1)2_(1)2_(1),晶胞参数a=1.32370(4)nm,b=1.34427(4)nm,c=3.83246(11)nm。X-射线单晶结构测定结果表明它具有巢状分子结构,配体(PhCH_(2)O)_(2)Ps^(-)_(2)(简称dtp)的两个s原子中的一个硫原子仅与一个金属原子配位,另一个硫原子则同时与两个金属原子配位。簇合物的非线性光学性质用脉宽8ns激光在532nm波长进行了研究。该化合物表现为一定的光学吸收和强的自聚焦效应,其三阶非线性吸收系数α_(2)=1.50×10^(-10)m·W^(-1),折射系数n_(2)=2.45×10^(-11)esu。

关键词：银(I)配合物晶体结构簇合物非线性光学性质

耐化学腐蚀和疏水性的食品包装用含snO_(2)生物纳米复合材料

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Transactions of Nonferrous Metals society of China 2023年第7期33卷 2136-2154页

作者： Joseph Raj XAVIER CDHANALAKsHMI shanmuga sundari CHANDRARAJ sPVINODHINI Department of Chemistry Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai-602105Tamil NaduIndia Department of Chemistry Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai-600062Tamil NaduIndia

研究了聚(天冬酰胺-共苯丙氨酸)(P(Asn-co-Phe)/snO_(2))对环氧树脂(EP)涂层防护性能的影响。电化学阻抗谱分析表明,与纯环氧树脂涂层相比,马口铁表面EP-P(Asn-co-Phe)/snO_(2)纳米复合材料涂层具有更好的防护作用。EP-P(Asn-co-Phe)/sn... 详细信息

研究了聚(天冬酰胺-共苯丙氨酸)(P(Asn-co-Phe)/snO_(2))对环氧树脂(EP)涂层防护性能的影响。电化学阻抗谱分析表明,与纯环氧树脂涂层相比,马口铁表面EP-P(Asn-co-Phe)/snO_(2)纳米复合材料涂层具有更好的防护作用。EP-P(Asn-co-Phe)/snO_(2)纳米复合材料涂层的电阻(Rcoat)为3854.70 kΩ·cm^(2),比环氧树脂涂层的大38倍。扫描电化学显微镜分析表明,EP-P(Asn-co-Phe)/snO_(2)的电流分布更小。通过XRD和sEM/EDX对降解产物进行分析,证实了功能化snO_(2)颗粒对环氧树脂涂层防护能力的影响。EP-P(Asn-co-Phe)/snO_(2)纳米复合材料涂层的水接触角为133°,证实了其疏水性。此外,与纯环氧树脂涂层相比,EP-P(Asn-co-Phe)/snO_(2)纳米材料复合涂层具有更高的力学性能和抗菌活性。综上,由于在环氧树脂基体中添加了P(Asn-co-Phe)/snO_(2)纳米颗粒,EP-P(Asn-co-Phe)/snO_(2)纳米复合材料提供了出色的屏障和力学性能,从而阻碍了材料的降解,有助于延长涂层钢的寿命。

关键词：马口铁环氧树脂 snO_(2) 纳米材料复合涂层共聚物热稳定性硬度

The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s disease

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Neural Regeneration Research 2024年第5期19卷 1150-1155页

作者： shuanglong Yi Linfang Wang Margaret s.Ho shiping Zhang school of Life science and Technology ShanghaiTech UniversityShanghaiChina College of Life sciences University of Chinese Academy of SciencesBeijingChina

Parkinson’s disease is a progressive neurodegenerative disease characterized by motor deficits,dopaminergic neuron loss,and brain accumulation ofα-synuclein aggregates called Lewy *** in protein degradation pathways,such as autophagy,has been demonstrated in neurons as a critical mechanism for eliminating protein aggregates in Parkinson’s ***,it is less well understood how protein aggregates are eliminated in glia,the other cell type in the *** the present study,we show that autophagy-related gene 9(Atg9),the only transmembrane protein in the autophagy machinery,is highly expressed in Drosophila glia from adult *** from immunostaining and live cell imaging analysis reveal that a portion of Atg9 localizes to the trans-Golgi network,autophagosomes,and lysosomes in ***9 is persistently in contact with these *** glial atg9 reduces the number of omegasomes and autophagosomes,and impairs autophagic substrate *** suggests that glial Atg9 participates in the early steps of autophagy,and hence the control of autophagic ***,loss of glial atg9 induces parkinsonian symptoms in Drosophila including progressive loss of dopaminergic neurons,locomotion deficits,and glial *** findings identify a functional role of Atg9 in glial autophagy and establish a potential link between glial autophagy and Parkinson’s *** results may provide new insights on the underlying mechanism of Parkinson’s disease.

关键词： Atg9 autophagy glia Parkinson’s disease

The Ca^(2+)-sensing receptor and the pocketome:comparing nature's complexity with human intervention in receptor modulation

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signal Transduction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda s.F.Matthees Carsten Hoffmann Institut fur Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany Friedrich-schiller-Universitat Jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper published in Nature,the relatively understudied Ca^(2+)-sensing,receptor(CasR)within the Gprotein-coupled receptor(GPCR)family C,gained attention due to pioneering research led by Georgios skiniotis ... 详细信息

关键词： stanford gained skin

sleep-based neuronal oscillations as a physiological biomarker for Alzheimer's disease:is night time the right time?

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Neural Regeneration Research 2024年第7期19卷 1417-1418页

作者： Jonathan Witton Erica s.Brady Michael T.Craig Department of Clinical and Biomedical sciences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Gladstone Institute for Neurological Disease San FranciscoCAUSA school of Psychology and Neuroscience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dementia is a devastating syndrome characterized by memory problems,confusion,and behavior changes that prevent people from performing everyday *** is the leading cause of dependency and disability amongst older people,resulting in a global economic cost of ~$1.3 *** 58 million people are currently afflicted by dementia worldwide,with Alzheimer s disease(AD) causing most(60-70%) of these cases.

关键词： Alzheimer everyday performing