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<i>Lactobacillus</i>GG supplementation on Anti-<i>Helicobacter pylori</i>Therapy-Related side Effects and Eradication Rates: A Meta-Analysis

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Open Journal of Internal Medicine 2015年第4期5卷 96-105页

作者： shristi shakya Guoqiang Zhang Huajian Hu Zhongyue Li Department of Gastroenterology Children’s Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Chongqing China

Background: Concerns still exist with respect to unsatisfactory eradication rates and/or therapy-associated side effects for the use of standard triple therapy in the treatment of Helicobacter pylori infection, which prompts considerable interest in new therapy. We systematically reviewed the literature to investigate whether Lactobacillus GG as supplementation to standard triple therapy could improve H. pylori eradication rates and/or reduce therapy-associated side effects. Methods: PubMed, EMBAsE, the Cochrane Central Register of Controlled Trials (CENTRAL) were systematically searched from their inception to August 4, 2015 for randomized controlled trials (RCTs). The language was restricted to English only. Results: Four RCTs involving a total of 305 participants (including 83 children) were included. Lactobacillus GG given along with triple therapy significantly reduced the risk of overall H. pylori therapy-related adverse effects (three RCTs, n = 221, RR 0.59, 95% CI 0.45 - 0.78), particularly of diarrhea (four RCTs, n = 285, RR 0.23, 95% CI 0.11 - 0.47), bloating (four RCTs, n = 289, RR 0.61, 95% CI 0.41 - 0.90), and taste disturbance (four RCTs, n = 288, RR 0.38, 95% CI 0.23 - 0.62). There were no significant differences between groups in the risk of other adverse effects. No beneficial effects of Lactobacillus GG were observed for H. pylori eradication rates (four RCTs, n = 284, RR 0.99, 95% CI 0.88 - 1.13). Conclusion: Current evidence indicates that Lactobacillus GG administered along with standard triple therapy is a feasible way to reduce therapy-related side effects, particularly diarrhea, bloating, and taste disturbance. However, Lactobacillus GG shows no effects on eradication rates.

关键词： Lactobacillus GG Helicobacter pylori side Effects Eradication Rate Meta-Analysis

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Impact of Right Ventricular Dysfunction in Morbidity and Mortality in Patients with Inferior Wall Myocardial Infarction Presenting to a Tertiary Care Center of Nepal

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World Journal of Cardiovascular Diseases 2023年第11期13卷 780-794页

作者： Abhishesh shakya Ratnamani Gajurel Chandramani Poudel Anish Baniya Ravi sahi Department of Cardiology Manmohan Cardiothoracic Vascular and Transplant Centre (MCVTC) Institute of Medicine TUTH Kathmandu Nepal Department of Cardiology Shahid Gangalal National Heart Centre Bansbari Nepal

Introduction: In comparison to anterior wall myocardial infarction, inferior wall myocardial infarction is generally regarded as a low risk event. The aim of this study was to evaluate the prognostic impact of right ventricular (RV) myocardial involvement in patients with inferior wall myocardial infarction (IWMI). Methods: This is an observational study of 82 consecutive IWMI patients admitted and treated in Manmohan Cardiothoracic, Vascular and Transplant Center (MCVTC) from May 15 2018 to June 15 2019. The clinical characteristics, risk factors profile, electrocardiographic, echocardiographic, including RV function and angiographic characteristics, complications and in-hospital deaths were analyzed. Results: The mean age of patients presenting with IMWI was 64.8 ± 13.8 years with predominance of male (67%). Right ventricular myocardial infarction was present in 34.1% of patient with RV dysfunction in 25.6% patients. Mean Tricuspid Annular Plane systolic Excursion (TAPsE), RV tricuspid annulus (s') and RV Fractional area change (FAC) in patients with RV dysfunction vs patients without RV dysfunction were 12.2 ± 3.3 mm vs 22.5 ± 3.5 mm (p s vs. 12.79 ± 2.16 cm/s respectively (p Conclusion: In inferior wall myocardial infarction, RV involvement with RV dysfunction is an independent risk factor for in-hospital mortality along with advanced age, complete atrioventricular block, higher Killip class, delayed hospital presentation, left ventricular ejection fraction ssel disease.

关键词： Anterior Wall Myocardial Infarction Inferior Wall Myocardial Infarction Right Ventricular Infarction Prognosis

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天疱疮患者206例皮损分泌物病原学及药敏结果分析

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中国皮肤性病学杂志 2012年第11期26卷 990-992,998页

作者：郭生红王琳李明辉 sanjaya shakya 杨延华张然康梅李薇四川大学华西医院皮肤性病科四川成都610041 新疆维吾尔自治区人民医院皮肤科新疆乌鲁木齐830001 成都武警医院康复科四川成都610041 四川大学华西医院医学检验部微生物室四川成都610041

目的分析天疱疮患者糜烂面皮损的病原菌组成及药敏情况,为临床早期合理选用抗生素提供依据。方法对本科2004年1月-2011年12月收治的206例天疱疮患者皮损分泌物细菌培养和药敏结果进行回顾性分析。结果分离出细菌200株中,金黄色葡萄球菌... 详细信息

目的分析天疱疮患者糜烂面皮损的病原菌组成及药敏情况,为临床早期合理选用抗生素提供依据。方法对本科2004年1月-2011年12月收治的206例天疱疮患者皮损分泌物细菌培养和药敏结果进行回顾性分析。结果分离出细菌200株中,金黄色葡萄球菌107株,耐甲氧西林金黄色葡萄球菌11株;50%以上金黄色葡萄球菌对青霉素、红霉素、克林霉素耐药,100%对万古霉素敏感,80%以上对利福平、复方新诺明敏感;29例多部位取材共检出病原菌53株。结论天疱疮糜烂面细菌主要由金黄色葡萄球菌构成,多数对青霉素、红霉素及克林霉素耐药,对万古霉素、利福平和复方新诺明敏感;病程长且多次就诊者易感染耐甲氧西林金黄色葡萄球菌;抗生素早期使用可参考皮损主要累及部位及该部位常见定植菌种类选择。

关键词：天疱疮病原学耐药性金黄色葡萄球菌

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s37-66 二烷基氯代磷酸酯的合成新方法

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中国医药工业杂志 2006年第10期37卷 654-654页

作者： shakya PD 王冠（摘）

1，3-二氯-5，5-二甲基乙内酰脲和二烷基氯代亚磷酸酯在四氯化碳或乙腈中，室温反应10～15min，生成相应的二烷基氯代磷酸酯。反应条件温和，时间短，环境友好，成本低。12例（1例是二苯基氯代磷酸酯，反应30min）收率94％～99％。

关键词：氯代磷酸酯二烷基二甲基乙内酰脲合成室温反应四氯化碳亚磷酸酯反应条件

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