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窄间隙焊工艺在厚壁压力容器制造中的应用

化工与通用机械 1980年第6期 54-62页

作者： s.sawada K.HORI 陈登丰北京市通用机械工业公司

十年前美国巴德尔研究所(Battelle Me-morial Institute)研究出窄间隙熔化极气体保护焊工艺。当时研究这种新型工艺的目的是企图通过减小坡口截面积的办法,达到缩短焊接时间和降低成本。其另一目的是,通过低输入热的焊接规范来改善焊缝... 详细信息

十年前美国巴德尔研究所(Battelle Me-morial Institute)研究出窄间隙熔化极气体保护焊工艺。当时研究这种新型工艺的目的是企图通过减小坡口截面积的办法,达到缩短焊接时间和降低成本。其另一目的是,通过低输入热的焊接规范来改善焊缝机械性能,同时采用这种工艺,也可能实现全位置焊接。自从引入窄间隙焊的概念后,作为一种厚板焊接的理想手段,很多国家都致力于窄间隙焊的研究。并且发展了多种应用窄间隙焊的方法。可是,由于焊接缺陷的问题没有解决,大多数施焊方法仍处于实验室阶段。日本拔柏葛—日立(Babcock-Hitachi)公司发展了几种专门技术,并把这些专门技术和传统的焊接工艺结合在一起,形成一种新型的独一无二的窄间隙焊方法。此法于1976年以来,已成功地用于实际生产,迄今所生产的焊缝总长已达100公里(以单层焊道长度计算)。

关键词：窄间隙焊埋弧焊电渣焊焊丝焊炬焊缝金属电弧焊熔焊焊棒焊接材料熔化极气体保护焊气保焊

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3，4，5-三氟化苯基液晶的物理特性

液晶通讯 1993年第3期1卷 1-7页

作者： s.sawada H.Yamamooi Y.Kubo F.Terashima Y.Goto ChissoPetrochemicalCo. 5-1GoiLchiharaChibaJapan

本文制备了3，4，5-三氟比末端基液晶。这种液晶具有电阻率高，△ε值大，△η值低，弹性常数小以及相对低的粘滞系数等特性。种新的液晶材料在有源矩阵显示中可实现高对比度和低驱动电压。

关键词：高对比度有源矩阵液晶材料驱动电压端基显示物理特性苯基粘滞系数弹性常数

3,4,5-三氟化苯基液晶的物理特性(英文)

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液晶与显示 1993年第3期 1-7页

作者： s.sawada,H.Yamamooi,Y.Kubo,F.Terashima,Y.Goto Japan Ckisgo Petrockemical Co. 5-1 Goi Ichikara China Japan Ckisgo Petrockemical Co. 5-1 Goi Ichikara China Ckisgo Petrockemical Co. Japan Ckisgo Petrockemical Co. 5-1 Goi Ichikara China Japan 5-1 Goi Ichikara China Japan Ckisgo Petrockemical Co. 5-1 Goi Ichikara China

本文制备了3,4,5-三氟比末端基液晶。这种液晶具有电阻率高,△ε值大,△n值低,弹性常数小以及相对低的粘滞系数等特性。种新的液晶材料在有源矩阵显示中可实现高对比度和低驱动电压。

关键词：通讯新闻晶体液晶

心脏CT测量心肌三维最大应变力鉴别心肌梗死

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国际医学放射学杂志 2017年第3期 368-369页

作者： Y.Tanabe T.Kido A.Kurata s.sawada H.suekuni T.Kido 张杨 Department of Radiology Ehime University Graduate School of Medicine

摘要目的评价心脏CT三维最大应变力(MP-strain)检测心肌梗死(MI)的可行性。方法回顾性分析43例进行过心脏CT及MRI检查病人的临床资料。利用体素追踪运动相干算法,采用16段模型测量CT心肌最大应变力峰值。根据晚期钆增强透壁程度(LGE)及... 详细信息

摘要目的评价心脏CT三维最大应变力(MP-strain)检测心肌梗死(MI)的可行性。方法回顾性分析43例进行过心脏CT及MRI检查病人的临床资料。利用体素追踪运动相干算法,采用16段模型测量CT心肌最大应变力峰值。根据晚期钆增强透壁程度(LGE)及与梗死心肌距离,将心肌节段分为4组(梗死段、边缘段、相邻段和远程段);梗死段/边缘段分别被定义为MI/LGE阳性。运用受试者操作特征(ROC)曲线对比分析CT测量MP-strain与MRI测量收缩期室壁增厚

关键词：心肌梗死最大应变心脏 CT

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating