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Model for end-stage liver disease score versus Child score in predicting the outcome of surgical procedures in patients with cirrhosis

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World Journal of Gastroenterology 2008年第11期14卷 1774-1780页

作者： Maarouf A Hoteit Amaar H Ghazale Andrew J Bain Eli s.rosenberg Kirk A Easley Frank A Anania Robin E Rutherford Division of Digestive Diseases Emory UniversityAtlanta GeorgiaUnited States Department of Internal Medicine Emory UniversityAtlantaGeorgiaUnited States Department of Biostatistics-Rollins school of Public Health Emory UniversityAtlanta GeorgiaUnited States

AIM： To determine factors affecting the outcome of patients with cirrhosis undergoing surgery and to compare the capacities of the Child-Turcotte-Pugh （CTP） and model for end-stage liver disease （MELD） score to predict that outcome. METHODs： We reviewed the charts of 195 patients with cirrhosis who underwent surgery at two teaching hospitals over a five-year period. The combined endpoint of death or hepatic decompensation was considered to be the primary endpoint. REsULTs： Patients who reached the endpoint had a higher MELD score, a higher CTP score and were more likely to have undergone an urgent procedure. Among patients undergoing elective surgical procedures, no statistically significant difference was noted in the mean MELD （12.8 ＋ 3.9 vs 12.6 ＋ 4.7, P = 0.9） or in the mean CTP （7.6 ± 1.2 vs 7.7 ± 1.7, P = 0.8） between patients who reached the endpoint and those who did not. Both mean scores were higher in the patients reaching the endpoint in the case of urgent procedures （MELD： 22.4 ± 8.7 vs 15.2 ± 6.4, P = 0.0007; CTP： 9.9 ± 1.8 vs 8.5 ± 1.8, P = 0.008）. The performances of the MELD and CTP scores in predicting the outcome of urgent surgery were only fair, without a significant difference between them （AUC = 0.755 ± 0.066 for MELD vs AUC = 0.696 ± 0.070 for CTP, P = 0.3）. CONCLUsION： The CTP and MELD scores performed equally, but only fairly in predicting the outcome of urgent surgical procedures. Larger studies are needed to better define the factors capable of predicting the outcome of elective surgical procedures in patients with ***, but only fairly in predicting the outcome of urgent surgical procedures. Larger studies are needed to better define the factors capable of predicting the outcome of elective surgical procedures in patients with cirrhosis.

关键词： Liver cirrhosis Prognosis severity of illness index surgical procedures Operative Postoperative complications

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Ecological correlates of sport and exercise participation among Thai adolescents:A hierarchical examination of a cross-sectional population survey

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Journal of sport and Health science 2023年第5期12卷 592-605页

作者： Areekul Amornsriwatanakul Leanne Lester Fiona C.Bull Michael rosenberg College of sports science and Technology Mahidol University999 Phutthamonthon Sai 4 SalayaPhutthamonthon DistrictNakhon Pathom 73170Thailand school of Human sciences(Exercise and sport science) The University of Western Australia35 Stirling HighwayNedlandsPerthWA 6009Australia Centre for Built Environment and Health School of Human SciencesThe University of Western Australia35 Stirling HighwayNedlandsPerthWA 6009Australia

Background:Understanding factors influencing adolescents’ sport/exercise participation(s/EP) is vital to developing effective interventions,but currently,evidence from less developed countries is *** purpose of this study was to examine correlates of s/EP across individual,interpersonal,and environmental levels in a nationally representative sample of Thai ***:Data from 4617 Thai adolescents aged 14-17 years old were obtained from recruited schools across *** on s/EP(outcome variable),and psychosocial,home,and community environment covariates were collected from individual adolescents using the Thailand Physical Activity Children survey,student *** environmental data were collected at the school level using a school Built Environment *** regressions taking into account school clustering effects were applied for data ***:At the individual level,age and body mass index were independently and strongly correlated with s/*** with high preference for physical activity(PA)(odd ratio(OR)=1.71,p st a moderate level of self-efficacy(OR=1.33,p=0.001) were more likely to have high s/*** the interpersonal level,adolescents whose parents joined their sports/exercise at least 1-2 times/week(OR=1.36,p=0.003) received>3 types of parental support(OR=1.43,p=0.005) and who received siblings’(OR=1.26,p=0.004) and friends’(OR=1.99,p support had a greater chance of high s/*** the environmental level,adolescents’ s/EP was greater when there were at least 3-4 pieces of home sport/exercise equipment(OR=2.77,p=0.003),grass areas at school(OR=1.56,p st 1-2 PA facilities in the community(OR=1.30,p=0.009).Conclusion:Multiple factors at different levels within an ecological framework influencing Thai adolescents’ s/EP were generally similar to those found in developed countries,despite some *** those interested in promoting and supporting Thai adole

关键词： National survey Noncommunicable diseases Physical activity Policy Thailand youthTagedEnd

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Merging bound states in the continuum in an open acoustic resonator

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem s.Pilipchuk sibo Huang Chen shen Almas F.sadreev Yong Li Andrey E.Miroshnichenko school of Physics and Electronic sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University school of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIs) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Covid-19 Vaccine Effectiveness in New York state

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四川生理科学杂志 2021年第10期43卷 1709-1709页

作者： Eli s.rosenberg From the New York state Department of Health Albany (E.S.R. V.D. D.E. U.E.B. J.K. R.H. D.H. M.W. E.L. M.B.C. D.G. H.A.Z.) and the University at Albany School of Public Health State University of New York Rensselaer (E.S.R. E.L.) - both in New York.

Background:Population-based data from the United states on the effectiveness of the three coronavirus disease 2019(Covid19)vaccines currently authorized by the Food and Drug Administration are *** declines in effectiveness are due to waning immunity,the B.1.617.2(delta)variant of the severe acute respiratory syndrome coronavirus 2(sARs-CoV-2),or other causes is ***:We used data for 8,690,825 adults in New York state to assess the effectiveness of the BNT162b2,mRNA-1273,and ***2.s vaccines against laboratory-confirmed Covid-19 and hospitalization with Covid-19(i.e.,Covid-19 diagnosed at or after admission).We compared cohorts defined according to vaccine product received,age,and month of full vaccination with age-specific unvaccinated cohorts by linking statewide testing,hospital,and vaccine registry *** assessed vaccine effectiveness against Covid-19 from May 1 through september 3,2021,and against hospitalization with Covid-19 from May 1 through August 31,2021.

关键词： vaccine immunity acute

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The impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CTP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NAssER MULLA YOUsEF KATIB AsIM M.ALMUGHAMsI DUAA s.ALKHAYAT MOHAMED MOsAAD sAMIR T.ALFOTIH RAWAN ALAOFI Department of Internal Medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King salman bin Abdulaziz Medical City Madinah42311Saudi Arabia Prince Mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in saudi *** study aimed to investigate the patterns of HCC and the effect of TNM staging,Alfa-fetoprotein(AFP),and Child-Turcotte Pugh(CTP)on patients’overall survival(Os).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in Os among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in Os(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the Os in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CTP score and Os(p-value=0.02).CTP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in Os among viral and non-viral HCC patients(p-value=0.008).Conclusions:The most common predictors for Os were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CTP score class C were all negatively associated with Os.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

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Awareness of non-alcoholic steatohepatitis and treatment guidelines:What are physicians telling us?

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World Journal of Hepatology 2021年第2期13卷 233-241页

作者： David Hermanus Wessels Zeil rosenberg Medical Office A.E.S.Chorley PR71NYLancashireUnited Kingdom Chief Medical Office Accelerated Enrollment SolutionsHorshamPA 19044United States

BACKGROUND There is an acute need to raise awareness of non-alcoholic fatty liver disease/nonalcoholic steatohepatitis(NAFLD/NAsH)among primary care physicians,endocrinologists and diabetologists to improve patient identification and address the current difficulties in NAsH clinical trial *** examined the extent of knowledge and practice regarding NAsH diagnosis and management guidelines.A randomized online convenience survey of 12869 physicians drawn from a national physician database of primary care physicians(PCPs),and gastroenterology and endocrinology specialists were queried via online *** results,based on a cohort of 185 respondents,showed gaps in knowledge and practice between these three groups of practitioners,with primary care providers having the lowest adherence to published guidelines for diagnosis of *** clear knowledge and patient identification at the point of presentation-which is often in primary care or with specialties other than hepatology–many patients with NAFLD and NAsH will remain undiagnosed and untreated,and clinical studies will continue to struggle with patient recruitment,hindering clinical development and optimal patient *** To determine knowledge base concerning NAsH diagnosis amongst gastroenterologists,endocrinologists and primary care physicians to improve referrals into clinical *** A randomized online convenience survey of 12869 physicians drawn from a national physician database of PCPs,and gastroenterology and endocrinology specialists was conducted yielding a sample of 185 *** The survey revealed that many physicians are either unaware of testing options other than biopsy,or do not use them in *** 46%of endocrinologists and 42%of primary care physicians indicated they would refer a patient for specialist workup if they suspected ***(25%)and inconvenience to patients(18%)are given as reasons for not referring those with suspected NAsH for *** stan

关键词： Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease Enrollment screening Diagnostics Guidelines

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Two Types of Liquid Phase separation Induced by soft Centrifugation in Aqueous Ethyl Acetate Using Ethanol as Cosolvent

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Research 2023年第3期6卷 451-460页

作者： Helmut Cölfen Rose rosenberg Dirk Haffke simon stemplinger Thomas Zemb Dominik Horinek Physical Chemistry Department of ChemistryUniversity of KonstanzUniversitätsstr.10D-78457 KonstanzGermany Institute for separation Chemistry ICsM U Montpellier/CEA/CNRs/ENsCM MarcouleFrance Institute of Physical and Theoretical Chemistry University of RegensburgD-93040 RegensburgGermany

Water/ethyl acetate/ethanol is widely used as a“green”extractant *** show that 2 different types of phase separation can be induced upon centrifugation in this ternary system using ethanol as a cosolvent of water and ethyl acetate:centrifuge-induced criticality and centrifuge-induced *** expected composition profiles of samples after centrifugation can be represented by bent lines in a ternary phase diagram when gravitational energy is added to the free energy of *** experimental equilibrium composition profiles behave qualitatively as expected and can be predicted using a phenomenological theory of *** concentration gradients are small except near the critical point,as expected for small ***,they are usable when accompanied by temperature *** findings open new possibilities of centrifugal separation,even if control is delicate during temperature *** schemes are accessible even at relatively low centrifugation speed for molecules that float and sediment with apparent molar masses several hundred times larger than the molecular mass.

关键词： separation ternary apparent

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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Colorectal carcinogenesis-update and perspectives

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World Journal of Gastroenterology 2014年第48期20卷 18151-18164页

作者： Hans Raskov Hans-Christian Pommergaard Jakob Burcharth Jacob rosenberg speciall?gecentret ved Diakonissestiftelsen 2000 Frederiksberg Denmark Department of surgery Herlev Hospital University of Copenhagen DK-2730 Herlev Denmark

Colorectal cancer(CRC)is a very common malignancy in the Western World and despite advances in surgery,chemotherapy and screening,it is still the second leading cause of cancer deaths in this part of the *** factors are found important in the development of CRC including colonocyte metbolism,high risk luminal environment,inflammation,as well as lifestyle factors such as diet,tobacco,and alchohol *** recent years focus has turned towards the genetics and molecular biology of CRC and several interesting and promising correlations and pathways have been *** major genetic pathways of CRC are the Chromosome Instability Pathway representing the pathway of sporadic CRC through the K-ras,APC,and P53 mutations,and the Microsatellite Instability Pathway representing the pathway of he re di t ar y non-polyposis c olon c anc e r t hrough mutations in mismatch repair *** identify early cancers,screening programs have been initiated,and the leading strategy has been the use of faecal occult blood testing followed by colonoscopy in positive *** the treatment of colorectal cancer,significant advances have been made in the recent *** molecular targets of CRC include at least two important cell surface receptors:the epidermal growth factorreceptor and the vascular endothelial growth factor *** genetic and molecular knowledge of CRC has widen the scientific and clinical perspectives of diagnosing and ***,despite significant advances in the understanding and treatment of CRC,results from targeted therapy are still not *** studies will determine the role for this new treatment modality.

关键词： Colorectal carcinogenesis Risk factors Microbiology Genetics Diet Microbiome Inflammation

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