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sintered Fe-0.8%c-1.0%si-0.4%cu P/M steel Preform Behaviour During cold Upsetting

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Journal of Iron and steel research International 2008年第5期15卷 81-87页

作者： A rajeshkannan k s Pandey s shanmugam r Narayanasamy Thiagarajar college of Engineering ThiruparankundramMadurai 625015Tamil NaduIndia Maulana Azad National Institute of Technology Bhopal 462007Madhya PradeshIndia Department of Mechanical Engineering National Institute of TechnologyTiruchirappalli 620015Tamil NaduIndia Department of Production Engineering National Institute of TechnologyTiruchirappalli 620015Tamil NaduIndia

cold upsetting experiments were carried out on sintered Fe 0.8%c1.0%si-0. 4%cu steel preforms in order to evaluate their deformation characteristics. Powder preforms of 86 % of theoretical density, with two different ratios of height to diameter, were prepared using a suitable die set assembly on a 1.0 MN capacity hydraulic testing machine. sintering was carried out in an electric muffle furnace for 1.5 h at 1 150 ℃. Each sintered compact was subjected to incremental loading of 0.04 MN under dry friction condition till a crack appeared at the free surfaces. The experimental results were critically analysed, the stress as a function of strain and densification was obtained, then the work hardening behaviour was analyzed. It has been found that in the process of enhancing densification, strength and strain hardening is also induced during upsetting, but the work hardening behaviour is not homogenously enhanced against strain and densification.

关键词： cold upsetting stress height strain densification work hardening behaviour

Bianchi Type-I string cosmological Model with Bulk Viscosity and Time-Dependent Λ term

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chinese Physics Letters 2011年第9期28卷 31-33页

作者： r.k.Tiwari s.sharma Department of Mathematics Govt.Model Science CollegeRewa(MP)India Department of Mathematics Rayat Polytechnic CollegeSBS Nagar(Punjab)India

Einstein field equations with the cosmological constant is considered in the presence of bulk viscosity in a Bianchi type-I *** of the field equations are obtained by assuming the following conditions:the bulk viscosity is proportional to the expansion scalarξ∝θ;the expansion scalar is proportional to shear scalarθ∝σ;andΛis proportional to the Hubble parameterΛ∝*** corresponding interpretations of the cosmological solutions are also discussed.

关键词： viscosity Bianchi cosmo

spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural regeneration research 2025年第3期20卷 725-739页

作者： Benjamin r.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam center for cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg school of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALs2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions sPAsT spastin

stability of triple diffusive convection in a viscoelastic fluid-saturated porous layer

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Applied Mathematics and Mechanics(English Edition) 2018年第10期39卷 1385-1410页

作者： k.r.rAGHUNATHA I.s.sHIVAkUMArA Department of Mathematics Bangalore University

The triple diffusive convection in an Oldroyd-B fluid-saturated porous layer is investigated by performing linear and weakly nonlinear stability analyses. The condition for the onset of stationary and oscillatory is derived analytically. contrary to the observed phenomenon in Newtonian fluids, the presence of viscoelasticity of the fluid is to degenerate the quasiperiodic bifurcation from the steady quiescent state. Under certain conditions, it is found that disconnected closed convex oscillatory neutral curves occur, indicating the requirement of three critical values of the thermal Darcy-rayleigh number to identify the linear instability criteria instead of the usual single value, which is a novel result enunciated from the present study for an Oldroyd-B fluid saturating a porous medium. The similarities and differences of linear instability characteristics of Oldroyd-B, Maxwell, and Newtonian fluids are also highlighted. The stability of oscillatory finite amplitude convection is discussed by deriving a cubic Landau equation,and the convective heat and mass transfer are analyzed for different values of physical parameters.

关键词： Oldroyd-B fluid bifurcation instability perturbation method nonlinear stability heat and mass transfer

saddle Point criteria in Nonsmooth semi-Infinite Minimax Fractional Programming Problems

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Journal of systems science & complexity 2018年第2期31卷 446-462页

作者： MIsHrA s k sINGH Yadvendra VErMA r U Department of Mathematics Banaras Hindu University Varanasi-221005 India. Department of Mathematics Texas State University USA

This paper considers a nonsmooth semi-infinite minimax fractional programming problem（sIMFP） involving locally Lipschitz invex functions. The authors establish necessary optimality conditions for sIMFP. The authors establish the relationship between an optimal solution of sIMFP and saddle point of scalar Lagrange function for sIMFP. Further, the authors study saddle point criteria of a vector Lagrange function defined for sIMFP.

关键词： Generalized convexity Lagrange function nonsmooth programming problems saddlepoint semi-infinite minimax fractional programming problems.

Photoelectrocatrocatalytic hydrolysis of starch by using sprayed ZnO thin films

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Journal of semiconductors 2013年第5期34卷 13-15页

作者： r.T.sapkal s.s.shinde k.Y.rajpure c.H.Bhosale Electrochemical Materials Laboratory Department of PhysicsShivaji UniversityKolhapur-416004India

： Thin films of zinc oxide have been deposited onto glass/FTO substrates at optimized 400 ℃ by using a chemical spray pyrolysis technique. Deposited films are characterized for their structural, morphological optical and photocatalytic activity by using XrD, an sEM, a UV-vis spectrophotometer, and a PEc single-cell reactor. Films are polycrystalline and have a hexagonal （wurtzite） crystal structure with c-axis （002） orientation growth perpendicular to the substrate surface. The observed direct band gap is about 3.22 eV for typical films prepared at 400 ℃. The photocatalytic activity of starch with a ZnO photocatalyst has been studied by using a novel photoelectrocatalytic process.

关键词： photoelectrocatalysis hydrolysis starch DNsA

NEcAB family of neuronal calcium-binding proteins in health and disease

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Neural regeneration research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.E.schafer sudena Wang Michael J.schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NEcAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized c-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NEcAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NEcAB2 interacts with predominantly striatal G-protein-coupled receptors, while NEcAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NEcAB proteins exhibit distinct subcellular localizations: NEcAB1 is found in the nucleus and cytosol, NEcAB2 resides in endosomes and the plasma membrane, and NEcAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NEcAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NEcAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Improving maintenance efficiency and safety through a human-centric approach

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Advances in Manufacturing 2021年第1期9卷 104-114页

作者： c.Y.siew s.k.Ong A.Y.c.Nee Graduate school for Integrative sciences and Engineering National University of Singapore28 Medical DriveSingapore 117456Singapore Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1Singapore 117576Singapore

This paper presents an adaptive human-machine interface(HMI)that can provide appropriate sets of digital maintenanceinformation and guidance to an operator during *** takes into consideration the expertise level of the operator and the maintenance context and *** proposed human-centric methodology considers the heart rate,intention,and expertise level of the operator,which can be captured using sensors during maintenance.A set of rules is formulated based on the sensor data to infer the state of the operator during a maintenance *** on the operator state,the adaptive HMI can augment the operator's senses using a scheme that combines visual,audio,and haptic guidance cues during maintenance to enhance the operator's ability to perceive information and perform maintenance *** schemes of visual,audio,and haptic cues are developed based on a comparison of the best practices obtained from experienced operators.

关键词： Augmented reality(Ar) Ergonomics Product development Maintenance

Friction stir based welding and processing technologies-processes,parameters,microstructures and applications:A review

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Journal of Materials science & Technology 2018年第1期34卷 1-38页

作者： G.k.Padhy c.s.Wu s.Gao MOE key Lab for Liquid-solid structure Evolution and Materials Processing Institute of Materials Joining Shandong University

Friction stir welding [FsW） has achieved remarkable success in the joining and processing of aluminium alloys and other softer structural alloys. conventional FsW, however, has not been entirely successful in the joining, processing and manufacturing of different desired materials essential to meet the sophis- ticated green globe requirements. Through the efforts of improving the process and transferring the existing friction stir knowledge base to other advanced applications, several friction stir based daughter technologies have emerged over the timeline, A few among these technologies are well developed while others are under the process of emergence. Beginning with a broad classification of the scattered fric- tions stir based technologies into two categories, welding and processing, it appears now time to know, compile and review these to enable their rapid access for reference and academia. In this review article, the friction stir based technologies classified under the categol^J of welding are those applied for join- ing of materials while the remnant are labeled as friction stir processing （FsP） technologies. This review article presents an overview of four general aspects of both the developed and the developing friction stir based technologies, their associated process parameters, metallurgical features of their products and their feasibility and application to various materials. The lesser known and emerging technologies have been emphasized.

关键词： Friction stir welding Friction stir processing Friction stir scribe Friction stir riveting Friction stir channeling Friction stir forming Friction stir surfacing Friction stir additive manufacturing Friction stir cladding