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Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India

World Journal of Gastroenterology 2005年第45期11卷 7165-7168页

作者： Zahid Hussain syed s Ali syed A Husain Mohammad raish Deepika r sharma Premashis kar Pcr Hepatitis Laboratory Panacea Biotec Ltd Mohammad raish

AIM：（1） To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDs students who are at an increased risk of getting hepatitis B infection and come under high risk groups. （2） To assess the efficacy and safety of En/vac- HB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B accine developed and manufactured in India. METHODs： A prospective, comparative, and single blinded trial of rapid （0, 1, and 2 mo） hepatitis B immunization schedulewas reported. A total of three hundred and seven （212 females and 95 males） healthy volunteers divided into three age groups （18-29, 30-39, and 40-49） were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo. rEsULTs： Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 （96.5%） subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/ mL, while that in the age group of 30-39 years was 2 096.0 mlU/mL. In third age group of 40-49 years, anti- HBs titer was 1 592.0 mIU/mL. Hyper-responses （anti-HBs≥100 mIU/mL） were shown in 88.0% （271/307） of subjects. Eleven （3.5%） subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions （ADrs）. cONcLUsION： This vaccine （Enivac-HB） is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended

关键词： Enivac-HB Pichia pastoris Anti-HBsantibody Hepatitis B vaccine

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Acute liver failure due to natural killer-like T-cell leukemia/ lymphoma: A case report and review of the Literature

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World Journal of Gastroenterology 2006年第25期12卷 4089-4092页

作者： Evan s Dellon shannon r Morris Wozhan Tang cherie H Dunphy Mark W russo Department of Medicine University of North carolina school of Medicine Chapel HillNCUnited States Department of Pathology University of North carolina school of Medicine Chapel HillNCUnited States

Acute liver failure （ALF） is a medical emergency requiring immediate evaluation for liver transplantation. We describe an unusual case of a patient who presented with ascites, jaundice, and encephalopathy and was found to have ALF due to natural killer （Nk）-Iike T cell leukemia/lymphoma. The key immunophenotype was cD2＋, cD3＋, cD7＋, cD56＋. This diagnosis, which was based on findings in the peripheral blood and ascitic fluid, was confirmed with liver biopsy, and was a contraindication to liver transplantation. A review of the literature shows that hematologic malignancies are an uncommon cause of fulminant hepatic failure, and that Nk-like T-cell leukemia/lymphoma is a relatively recently recognized entity which is characteristically cD3＋ and cD56＋. This case demonstrates that liver biopsy is essential in diagnosing unusual causes of acute liver failure, and that infiltration of the liver with Nk-like T-cell lymphoma/leukemia can cause acute liver failure.

关键词： Liver failure Liver transplant Nutaral killer cell

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Fuzzy Based Ant colony Optimization scheduling in cloud computing

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computer systems science & Engineering 2022年第2期40卷 581-592页

作者： k.rajakumari M.Vinoth kumar Garima Verma s.Balu Dilip kumar sharma sudhakar sengan Department of computer science and Engineering School of EngineeringAvinashlingam Institute for Home Science and Higher Education for WomenCoimbatore641043Tamil NaduIndia Department of Information science and Engineering Dayananda Sagar Academy of Technology and ManagementBangalore560082India school of computing DIT UniversityDehradun248009UttarakhandIndia Department of computer science and Engineering Paavai Engineering CollegePachal637018Tamil NaduIndia Department of Mathematics Jaypee University of Engineering and TechnologyGuna473226M.P.India Department of computer science and Engineering PSN College of Engineering and TechnologyTirunelveli627152Tamil NaduIndia

cloud computing is an Information Technology deployment model established on *** scheduling states the set of rules for task allocations to an exact virtual machine in the cloud computing ***,task scheduling challenges such as optimal task scheduling performance solutions,are addressed in cloud ***,the cloud computing performance due to task scheduling is improved by proposing a Dynamic Weighted round-robin *** recommended DWrr algorithm improves the task scheduling performance by considering resource competencies,task priorities,and ***,a heuristic algorithm called Hybrid Particle swarm Parallel Ant colony Optimization is proposed to solve the task execution delay problem in DWrr based task *** the end,a fuzzy logic system is designed for HPsPAcO that expands task scheduling in the cloud environment.A fuzzy method is proposed for the inertia weight update of the PsO and pheromone trails update of the ***,the proposed Fuzzy Hybrid Particle swarm Parallel Ant colony Optimization on cloud computing achieves improved task scheduling by minimizing the execution and waiting time,system throughput,and maximizing resource utilization.

关键词： cloud computing scheduling ant colony optimization fuzzy logic

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Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis

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Asian Journal of Andrology 2020年第4期22卷 342-347页

作者： Joanne Wong Almas r Juma stephanie c Tran Jemma G Gasperoni sylvia V H Grommen Bert De Groef Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVictoria 3086Australia

Mice deficient in the transcription factor pleomorphic adenoma gene 1(PLAG1)exhibit reproductive issues that are characterized,in part,by decreased progressive sperm motility in the ***,the underlying cause of this impairment is *** epididymal transit is critical for sperm maturation and motility,the morphology of the epididymis of Plag1-deficient mice was investigated and the spatial expression patterns of PLAG1 protein and mrNA were *** X-gal staining and in situ hybridization,PLAG1 was shown to be widely expressed in both the epithelium and stroma in all regions of the mouse ***,the X-gal staining pattern was markedly different in the cauda,where it could be suggestive of PLAG1 secretion into the epididymal *** all ages investigated,the morphology of epididymides from Plag1 knockout(kO)mice was aberrant;the tubule failed to elongate and coil,particularly in the corpus and cauda,and the cauda was malformed,lacking its usual bulbous ***,the epididymides from Plag1 kO mice were significantly reduced in size relative to body *** 20%of Plag1-deficient mice,the left testicle and epididymis were *** impaired morphogenesis of the epididymal tubule is likely to be a major contributing factor to the fertility problems observed in male Plag1-deficient *** results also establish PLAG1 as an important regulator of male reproduction,not only through its involvement in testicular sperm production,but also via its role in the development and function of the epididymis.

关键词： development epididymis pleomorphic adenoma gene 1 tubule coiling Wolffian duct

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AcTIVATION MEcHANIsM OF AMOrPHOUs Ni_(63)Zr_(32)La_5 ALLOY HYDrOGENATION cATALYsT

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Acta Metallurgica sinica(English Letters) 1996年第4期9卷 291-297页

作者： Wang, X.k. shen, N.F. Lei, G.J. Gu, H.c.

The catalytic activity of amorphous Ni_63 Zr_32 La_5 ribbon for hydrogenation of ethyne to ethylene can be greatly enhanced when the alloy ribbon is pretreated with dilute acid solution,heated under negative atmosphere pressure and subjected to hydrogen reduction successively. The change of surface state of the ribbon during the activation has been analysed by AEs and XPs. The surface of as-received ribbon is covered with a thin film of La_2 O_3. After pretreatment. the surface concentrations of both Ni and Zr increase obviously, whereas the surface concentration of La decreases ***, on the surface of activated catalyst the Ni and NiO disperse finely on the matrix consisting of oxides of both Zr and La and a small amount of fluorides of Zr and La.

关键词： amorphous Ni_(63) Zr_(32) La_5 alloy catalyst activation mechanism

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Acquired Traits contribute More to Drought Tolerance in Wheat Than in rice

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Plant Phenomics 2020年第1期2卷 172-187页

作者： Preethi Vijayaraghavareddy ramu s.Vemanna Xinyou Yin Paul c.struik Udayakumar Makarla sheshshayee sreeman Department of crop Physiology University of Agricultural SciencesBengaluruIndia centre for crop systems Analysis Department of Plant SciencesWageningen University&ResearchPO Box 4306700 AK WageningenNetherlands regional centre for Biotechnology FaridabadHaryanaIndia

Drought tolerance is governed by constitutive and acquired *** them has relevance for sustaining crop productivity under *** levels of stress induce specific mechanisms that protect metabolism when stress becomes ***,we report a comparative assessment of“acquired drought tolerance(ADT)”traits in two rice cultivars,Ir64(drought susceptible)and Apo(tolerant),and a drought-tolerant wheat cultivar,*** seedlings were exposed to progressive concentrations of methyl viologen(MV),a stress inducer,before transferring to a severe concentration.“Induced”seedlings showed higher tolerance and recovery growth than seedlings exposed directly to severe stress.A novel phenomic platform with an automated irrigation system was used for precisely imposing soil moisture stress to capture ADT traits during the vegetative *** progression of drought was achieved through a software-controlled automated irrigation *** facility allowed the maintenance of the same level of soil moisture irrespective of differences in transpiration,and hence,this platform provided the most appropriate method to assess ADT *** biomass decreased more in Ir64 than in *** wheat cultivar showed lower levels of damage and higher recovery growth even compared to *** of rOs-scavenging enzymes and drought-responsive genes was significantly higher in Apo than in Ir64,but differences were only marginal between Apo and *** wheat cultivar showed significantly higher stomatal conductance,carbon gain,and biomass than the rice cultivars,under *** differences in ADT traits between cultivars as well as between species can be utilised for improving drought tolerance in crop plants.

关键词： cultivar Wheat drought

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Early results of circularity and centration of capsulotomy prepared by three different methods

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 76-82页

作者： Jagadesh c.reddy soumya Devta kiran kumar Vupparaboina Mohammad Hasnat Ali Pravin k.Vaddavalli cataract and refractive services Cornea InstituteL V Prasad Eye Institute(LVPEI)Hyderabad 500034India senior scientific Officer Srujana Centre for InnovationL V Prasad Eye Institute(LVPEI)Hyderabad 500034India Biostatistician Clinical Epidemiology and BiostatisticsL V Prasad Eye Institute(LVPEI)Hyderabad 500034India

AIM:To compare the difference of capsulotomy produced by precision pulse capsulotomy(PPc),manual(M-ccc),and femtosecond laser assisted capsulotomy(FLAc)in relation to intraocular lens(IOL)centration,circularity and its effect on visual ***:Prospective,non-randomized comparative study conducted at LV Prasad Eye Institute,Hyderabad,*** eyes of 52 patients were grouped into 3(FLAc,PPc and M-ccc)based on capsulotomy techniques *** consecutive eyes with uneventful phacoemulsification and with no comorbidities affecting the capsulotomy or visual outcome were included in each *** main outcome measure was IOL centration in relation to capsulotomy and *** outcome measures were post-operative visual acuity,manifest refraction and aberration profile between ***:At 5 wk the visual,refractive outcomes and endothelial cell density were comparable between the 3 *** median circularity index of FLAc was statistically significantly different to M-ccc or PPc(1-10)groups(Pc(11-20)was comparable to *** of IOL center in relation to capsulotomy was seen only between the PPc(1-10)group and FLAc group(P=0.02).The IOL was well centered in relation to the pupil in all the groups(P=0.46).The quality of vision parameters like the higher order aberrations,spherical aberration,coma,trefoil,modular transfer function,and strehl ratio were comparable between the ***:Our study shows that despite differences in the morphology of capsulotomy produced by PPc,M-ccc,FLAc a well-centered IOL can be *** measured capsular morphology parameters do not affect visual outcomes.

关键词： phacoemulsification capsulotomy intraocular lens centration precision pulse capsulotomy femtosecond laser assisted capsulotomy

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IMPrOVEMENT OF cArBIDE MOrPHOLOGY ANDMEcHANIcAL PrOPErTIEs OF cr12MoV sTEELs

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Acta Metallurgica sinica(English Letters) 2000年第5期13卷 1053-1058页

作者： cui, X.H. Jiang, Q.c. Wang, s.Q. He, Z.M. sch. of Mat. sci. and Eng. Jilin Univ. of Technol. Changchun 130025 China

compared with conventional cast cr12MoV steel and forged cr12MoV steels, carbide morphology and properties of modified cast cr12MoV steels were investigated by performing hardness test, impact test, fracture toughness test, fatigue crack propagation test, metallographic examination and quantitatively metallographic analysis. The results indicate that the carbide morphology in modified cast steel is characterized by uniformly-distributed granular carbide, which is different from that of conventional cast steel, but similar to that of forged steel. the impact toughness of modified cast steel is distinctly increased to 12.75 J/cm2 from 6.8 J/cm2 in the conventional cast steel with networked carbide, because of carbide granulation. Furthermore, The fracture toughness and fatigue-crack-propagation threshold of modified cast steel are not only higher than that of the conventional cast steel, but also higher than that of the forged steels.

关键词： Alloys carbides Mechanical properties Morphology

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Drawing insights from pion parton distributions

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chinese Physics c 2020年第3期44卷 12-17页

作者： Minghui Ding khépani raya Daniele Binosi Lei chang c.D.roberts s.M.schmidt school of Physics Nankai UniversityTianjin 300071China European centre for Theoretical studies in Nuclear Physics and related Areas(EcT^*)and Fondazione Bruno kessler Villa Tambosi Strada delle Tabarelle 286I-38123 Villazzano(TN)Italy school of Physics Nanjing UniversityNanjingJiangsu 210093China Institute for Nonperturbative Physics Nanjing UniversityNanjingJiangsu 210093China Institute for Advanced simulation Forschungszentrum Jülich and JARAD-52425 JülichGermany

A symmetry-preserving continuum approach to the two valence-body bound-state problem is used to calculate the valence, glue and sea distributions within the pion; unifying them with, inter alia, electromagnetic pion elastic and transition form factors. The analysis reveals the following momentum fractions at the scale ζ2:= 2GeV :〈xvalence〉 = 0.48（3）, 〈xglue〉 = 0.41（2）, 〈xsea〉 = 0.11（2）;and despite hardening induced by the emergent phenomenon of dynamical chiral symmetry breaking, the valence-quark distribution function, qπ（x）, exhibits the x ≈ 1 behaviour predicted by quantum chromodynamics（QcD）. After evolution to o ζ = 5.2 GeV, the prediction for qπ（x） matches that obtained using lattice-regularised QcD. This confluence should both stimulate improved analyses of existing data and aid in planning efforts to obtain new data on the pion distribution functions.

关键词： pion parton distribution bound state Dyson-schwinger equations

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PHAsE TrANsFOrMATION AND cHArAcTErIsTIcs IN FrEckLE ArEAs FOr INcONEL 625 sUPErALLOY

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Acta Metallurgica sinica(English Letters) 2005年第1期18卷 47-54页

作者： J.X.Dong M.c.Zhang Y.P.Zeng X.s.Xie UniversityofscienceandTechnologyBeijing Beijing100083China

The freckle formation and their phase characterizatics in freckle areas were investigated by means of microstructure analysis approaches and a thermodynamic equilibrium phase calculation method in an Inconel 625 allay. These results show that in freckle areas a large number of M6c, Mc, Laves and δ phases precipitate in grain boundaries even within grain due to the enrichment and segregation of Mo and Nb during solidification, which results in almost of these freckle areas covered by these complex precipitated phases and induces small grains in freckle areas. Equilibrium phase and liquid segregation calculation can give a reasonable interpretation of the freckle feature for this alloy.

关键词： freckle superalloy Inconel 625 thermodynamic calculation

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