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Papillary Muscle Function Does Not Predict Mitral regurgitation in Patients with Normal Left Ventricular systolic Function: A Transesophageal Echocardiographic study

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International Journal of Clinical Medicine 2011年第2期2卷 178-183页

作者： Ernest C. Madu Dainia s. Baugh Edwin Tulloch-reid Chiranjivi Potu Department of Medicine Division of Cardiovascular Medicine Heart Institute of the Caribbean Centre of Excellence for Cardiovascular Diseases and sports Physiology University of Technology

Objective: To evaluate LV papillary muscles (PM) function using transesophageal echocardiography (TEE), and to determine the relationship between PM function and mitral regurgitation in patients with normal left ventricular sys-tolic function. Design: TEE examinations were prospectively performed. End diastolic and end systolic PM lengths were obtained from the transgastric long axis views and fractional systolic shortening (Fs) was calculated. LV ejection fraction was determined using modified simpson rule and mitral regurgitation was determined using regurgitant jet area by color flow. setting: Tertiary Center. Patients: 85 consecutive adult patients (51 with mitral regurgitation and 34 without) with normal LV chamber dimensions and LV systolic function, meeting enrollment criteria. results: The % Fs in patients with mitral regurgitation was 21.7 ± 3.6% for anterior PM (APM) and 18.7 ± 4.6% for posterior PM (PPM). In those without mitral regurgitation, the values were as follows;22.6 ± 5.4% (APM) and 19.5 ± 3.8% (PPM). In a subgroup of patients with severe mitral regurgitation (n = 23), the values for PM Fs were 20.3 ± 6.8 (APM) and 18.4 ± 6.9 % (PPM). There was no statistically significant difference in PM fractional shortening between the groups. Anterior papillary muscle length was longer in those patients with mitral regurgitation compared to those without [(End-diastolic length (cm): 3.38 ± 0.61 v 2.88 ± 0.47(p: 0.008) and end-systolic length of 2.46 ± 0.51 v 2.17 ± 0.33 (p: 0.04)]. These differences are more pronounced in those with severe mitral regurgitation (p: 0.002 and 0.004 for EDL and EsL respectively. Conclusion: In patients with normal LVEF, PM contraction is similar in those with and without Mr. In patients with Mr however, anterior PM length (ED & Es) is significantly increased. Our data suggests that in patients with normal LVEF, PM dysfunction appears to play no significant role in the causation of Mr. Anterior papillary muscle length however, a

关键词： Mitral regurgitation TEE Papillary Muscle LV Function

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Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine

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Genes & Diseases 2017年第2期4卷 43-63页

作者： Cody s.Lee Elliot s.Bishop ruyi Zhang Xinyi Yu Evan M.Farina shujuan Yan Chen Zhao Zongyue Zeng Yi shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf russell r.reid Tong-Chuan He The University of Chicago Pritzker school of Medicine ChicagoIL 60637USA Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical UniversityChongqing 400016China Department of Laboratory Medicine and Clinical Diagnostics The Affiliated Yantai HospitalBinzhou Medical UniversityYantai 264100China Department of Immunology and Microbiology Beijing University of Chinese MedicineBeijing 100029China

With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted *** numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human *** is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene *** has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two *** all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue *** applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial *** fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral *** review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative *** challenges and future directions regarding the use of adenoviral vectors are also *** is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine.

关键词： Adenovirus Adenoviral vector Cell therapy Gene transfer Gene therapy Oncolytic virus regenerative medicine Vaccine development

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同步抽运飞秒光参量振荡器中的载波-包络相位控制及其应用

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科学通报 2008年第1期53卷 14-22页

作者：孙敬华 B.J.s.Gale D.T.reid Ultrafast Optics Group School of Engineering and Physical SciencesHeriot-Watt UniversityEdinburgh EH14 4ASUK 中国科学院物理研究所光物理开放实验室北京100080

同步抽运飞秒光参量振荡器(OPO)以及抽运源所构成的飞秒脉冲系统具有内在同步、多波长脉冲输出以及各脉冲的载波-包络相位(CEP)的内在关联等特性,在超宽频率梳以及脉冲的相干合成方面具有先天的优势.本文阐述了一系列该研究方向的最新成... 详细信息

同步抽运飞秒光参量振荡器(OPO)以及抽运源所构成的飞秒脉冲系统具有内在同步、多波长脉冲输出以及各脉冲的载波-包络相位(CEP)的内在关联等特性,在超宽频率梳以及脉冲的相干合成方面具有先天的优势.本文阐述了一系列该研究方向的最新成果,诸如探讨了OPO内载波-包络相位与能量守恒的关系,并通过实验进行了检验;利用自参考法控制了作为抽运源的飞秒钛宝石激光器CEP,并通过压电陶瓷(PZT)锁定了其脉冲重复频率;利用OPO产生的非相位匹配可见光,并以抽运光的超连续作为参考,通过OPO端镜上的快速PZT控制了OPO产生的所有脉冲的CEP,从而获得400nm～2.4μm超宽频率梳,控制精度高于1.2kHz带宽;并利用波长相近相位锁定的抽运光以及信号光倍频实现了不同脉冲的相位相干,为产生极窄的合成光脉冲打下了基础.

关键词：光参量振荡器载波-包络相位相干合成频率梳

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The Anti-Diabetic Potential of Thermally Treated Garlic, Turmeric, and Ginger in Pre-Diabetic Male Wistar rat Model

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Food and Nutrition sciences 2018年第4期9卷 420-431页

作者： Fredreana Hester M. Verghese s. Willis A. Baldwin M. reid L. shackelford r. sunkara L. Walker Food and Animal sciences Alabama A & M University Normal AL USA

spices (turmeric (T), ginger (GI), and garlic (GA) (TGG)) have been used for centuries for food preservation, flavors, and medicinal properties. research suggests that TGG contain potent antioxidants that may prevent and/or delay chronic diseases such as cancer, diabetes, and heart diseases. Heat treatment of spices may potentially increase antioxidative activity by modifying the inherent chemical structure of potent antioxidative compounds in spices. The purpose of this study was to determine the anti-diabetic potential of thermally treated TGG on Wistar male rats. Two-week-old male Wistar rats were randomly assigned to 8 groups (N = 24, n = 3) including control AIN-93G Diet (C) and high fat (HFD) and high sugar (Hs) (glucose 10%) diet and treatment HFD/Hs diets containing T, GA, GI (1% and 2%) singly for 11 weeks. Weekly feed intake, body weight, and blood glucose levels were recorded. rats were sacrificed at 13 wks. by CO2 asphyxiation. Liver, pancreas, adipose (thigh), cecum, femur, urine, and serum samples were collected for quantitative determination of detoxification and antioxidative enzyme analysis, bone mineralization, and cholesterol using standard protocol. Of spice-incorporated diets, rats fed turmeric (1%) exhibited the lowest reduction in blood glucose levels at 90 mg/dL compared to the control 58 mg/dL. Additionally rats fed TGG at both concentrations resulted in an induction of antioxidant (GsH) and antioxidant enzyme (GPx) activity with significantly (p ≤ 0.05) higher levels compared to the control. serum total cholesterol levels were lower in spice-incorporated diets compared to control HFD/Hs fed rats. Therefore, the use of thermal application on spices presents promise in potentiating the antioxidant effects and thereby their potential health promoting properties.

关键词： Type 2 Diabetes Bioactive Compounds Wistar rats spices

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Overexpression of an ABA biosynthesis gene using a stress-inducible promoter enhances drought resistance in petunia

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Horticulture research 2015年第1期2卷 255-263页

作者： Alejandro C Estrada-Melo Chao Ma Michael s reid Cai-Zhong Jiang Department of Plant sciences University of California DavisDavisCAUSA United states Department of Agriculture Crops Pathology and Genetic Research UnitAgricultural Research ServiceDavisCAUSA

The response of plants to drought stress includes reduced transpiration as stomates close in response to increased abscisic acid(ABA)*** overexpression of 9-cis-epoxycarotenoid dioxygenase(NCED),a key enzyme in ABA biosynthesis,increases drought resistance,but causes negative pleiotropic effects on plant growth and *** overexpressed the tomato NCED(LeNCED1)in petunia plants under the control of a stress-inducible promoter,*** water stress,the transgenic plants had increased transcripts of NCED mrNA,elevated leaf ABA concentrations,increased concentrations of proline,and a significant increase in drought *** transgenic plants also displayed the expected decreases in stomatal conductance,transpiration,and *** 14 days without water,the control plants were dead,but the transgenic plants,though wilted,recovered fully when ***-watered transgenic plants grew like non-transformed control plants and there was no effect of the transgene on seed dormancy.

关键词： inducible pet drought

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Predicting the distribution of the Asian tapir in Peninsular Malaysia using maximum entropy modeling

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Integrative Zoology 2012年第4期7卷 400-406页

作者： Gopalasamy reuben CLEMENTs D.Mark rAYAN sheema Abdul AZIZ Kae KAWANIsHI Carl TrAEHOLT David MAGINTAN Muhammad Fadlli Abdul YAZI reid TINGLEY Center for Tropical Environmental and sustainability science and school of Marine and Tropical Biology James Cook UniversityCairnsAustralia Center for Malaysian Indigenous studies University of MalayaKuala LumpurMalaysia WWF Malaysia Petaling JayaMalaysia Durrell Institute of Conservation and Ecology University of KentCanterburyUK Malaysian Conservation Alliance for Tigers(MYCAT)secretariat's Office Petaling JayaMalaysia Copenhagen Zoo CopenhagenDenmark Department of Wldife and National Parks Peninsular Malaysia Kuala LumpurMalaysia school of Biological sciences University of SydneySydneyAustralia

In 2008,the IUCN threat status of the Asian tapir(Tapirus indicus)was reclasified from‘vulnerable'to‘en-dangered'.The latest distribution map from the IUCN red List suggests that the tapirs'native range is becom-ing increasingly fragmented in Peninsular Malaysia,but distribution data collected by local researchers sug-gest a more extensive geographical ***,we compile a database of 1261 tapir occurrence records within Peninsular Malaysia,and demonstrate that this species,indeed,has a much broader geographical range than the IUCN range map ***,extreme spatial and temporal bias in these records limits their utility for conservation ***,we used maximum entropy(MaxEnt)modeling to elucidate the potential ex-tent of the Asian tapir's occurrence in Peninsular Malaysia while accounting for bias in existing distribution *** MaxEnt model predicted that the Asian tapir has a wider geographic range than our fine-scale data and the IUCN range map both *** 37%of Peninsular Malaysia contains potentially suit-able tapir *** results justify a revision to the Asian tapir's extent of occurrence in the IUCN red ***,our modeling demonstrated that selectively logged forests encompass 45%of potentially suitable tapir habitats,underscoring the importance of these habitats for the conservation of this species in Peninsular Malaysia.

关键词： ecological niche IUCN Malayan tapir mammal MaxEnt species distribution model

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Liver cell therapies:cellular sources and grafting strategies

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Frontiers of Medicine 2023年第3期17卷 432-457页

作者： Wencheng Zhang Yangyang Cui Yuan Du Yong Yang Ting Fang Fengfeng Lu Weixia Kong Canjun Xiao Jun shi Lola M.reid Zhiying He Institute for regenerative Medicine Ji’an HospitalShanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200123China shanghai Engineering research Center of stem Cells Translational Medicine Shanghai 200335China shanghai Institute of stem Cell research and Clinical Translation Shanghai 200120China Postgraduate Training Base of shanghai East Hospital Jinzhou Medical UniversityJinzhou 121001China The First Affiliated Hospital of Nanchang University Nanchang 330006China Graduate school of Frontier Biosciences Osaka UniversitySuitaOsaka565-0871Japan Department of General surgery Ji’an HospitalShanghai East HospitalSchool of MedicineTongji UniversityJi’an 343006China Department of Cell Biology and Physiology and Program in Molecular Biology and Biotechnology/UNC school of Medicine Chapel HillNC 27599USA

The liver has a complex cellular composition and a remarkable regenerative *** primary cell types in the liver are two parenchymal cell populations,hepatocytes and cholangiocytes,that perform most of the functions of the liver and that are helped through interactions with non-parenchymal cell types comprising stellate cells,endothelia and various hemopoietic cell *** regulation of the cells in the liver is mediated by an insoluble complex of proteins and carbohydrates,the extracellular matrix,working synergistically with soluble paracrine and systemic *** recent years,with the rapid development of genetic sequencing technologies,research on the liver’s cellular composition and its regulatory mechanisms during various conditions has been extensively *** breakthroughs in strategies for cell transplantation are enabling a future in which there can be a rescue of patients with end-stage liver diseases,offering potential solutions to the chronic shortage of livers and alternatives to liver *** review will focus on the cellular mechanisms of liver homeostasis and how to select ideal sources of cells to be transplanted to achieve liver regeneration and *** advances are summarized for promoting the treatment of end-stage liver diseases by forms of cell transplantation that now include grafting strategies.

关键词： liver regeneration hepatocytes cholangiocytes stem cells organoids regulatory mechanisms transplantation/grafting strategies

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sATB2:A versatile transcriptional regulator of craniofacial and skeleton development,neurogenesis and tumorigenesis,and its applications in regenerative medicine

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Genes & Diseases 2022年第1期9卷 95-107,I0005页

作者： Xia Huang Qiuman Chen Wenping Luo Mikhail Pakvasa Yuxin Zhang Liwen Zheng shuang Li Zhuohui Yang Huan Zeng Fang Liang Fugui Zhang Daniel A.Hu Kevin H.Qin Eric J.Wang David s.Qin russell r.reid Tong-Chuan He Aravind Athiviraham Mostafa El Dafrawy Hongmei Zhang stomatological Hospital of Chongqing Medical University Chongqing 401147PR China Chongqing Key Laboratory of Oral Diseases and Biomedical sciences Chongqing 401147PR China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA The Pritzker school of Medicine The University of Chicago Medical CenterChicagoIL 60637USA Department of surgery The University of Chicago Medical CenterChicagoIL 60637USA Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing 401147PR China

sATB2(special AT-rich sequence-binding protein 2)is a member of the special AT-rich binding protein *** a transcription regulator,sATB2 mainly integrates higher-order chromatin ***2 expression appears to be tissue-and stage-specific,and is governed by several cellular signaling molecules and *** in branchial arches and osteoblast-lineage cells,sATB2 plays a significant role in craniofacial pattern and skeleton *** addition to regulating osteogenic differentiation,sATB2 also displays versatile functions in neural development and cancer *** an osteoinductive factor,sATB2 holds great promise in improving bone regeneration toward bone defect *** this review,we have summarized our current understanding of the physiological and pathological functions of sATB2 in craniofacial and skeleton development,neurogenesis,tumorigenesis and regenerative medicine.

关键词： Bone regeneration Development Neurogenesis sATB2 Tumorigenesis

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The effect of introduction of misoprostol for induction of labour on pregnancy in gravidas with pre-eclampsia

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Open Journal of Obstetrics and Gynecology 2011年第2期1卷 64-69页

作者： Horace Fletcher Marvin reid Nadine Johnson 不详

Misoprostol has revolutionized labour induction since the early 1990’s, because it is inexpensive and very effective. Eclampsia is common unless the pregnancy can be terminated by induction or by caesarean section. This study was done to determine the impact of Misoprostol used for induction of labour, on the outcome in patients with pre-eclampsia (PE) at the University of the West Indies Kingston Jamaica. This was a retrospective analysis of pre-eclamptic women who were managed before and after the introduction of misoprostol into routine usage for induction of labour. We compared 793 women (controls) in the pre misoprostol era (1986-1991) with 709 in the misoprostol era (1993-1998). Outcome variables were the frequency of mild and severe PE, eclampsia, misoprostol and syntocinon inductions, foetal complications and use of caesarean section (Cs). Analysis of frequency of eclampsia, neonatal admissions and Cs, during the misoprostol years, was also done to eliminate other confounding variables because of the influence of each era. Logistic regression was used to determine the impact of all variables. In comparison to controls, patients induced in the misoprostol years had a greater incidence of severe PE (p ssions (p = 0.007), foetal distress (p r Cs rate (p r oxytocin inductions (p r, sub group analysis of the misoprostol years alone, showed a reduction in the incidence of Cs, eclampsia, and neonatal admissions in women who were induced with misoprostol (p stic regression revealed a lower odds of Cs delivery (Or 0.867, 95% confidence interval .02, .37) using misoprostol. These findings suggest that in patients with PE, induction of labor with Misoprostol had a beneficial effect on pregnancy outcome with a decreased incidence of Cs, eclampsia and neonatal admissions, but it has not had a significant impact on the main problems in these patients between the two eras as other factors may

关键词： Misoprostol Eclampsia Labour Induction

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CXCr4-Expressing Glial Precursor Cells Demonstrate Enhanced Migratory Tropism for Glioma

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Journal of Cancer Therapy 2012年第6期3卷 1086-1091页

作者： Moneeb Ehtesham reid C. Thompson Department of Neurological surgery Vanderbilt University Medical Center Nashville USA.

Malignant glioma remains one of the most intractable of human cancers principally due to the highly infiltrative nature of these neoplasms. The use of neural precursor cells (NPC) has received considerable attention based on their ability to selectively migrate towards disseminated areas of tumor in vivo and their described ability to deliver tumor-directed therapies specifically to infiltrating tumor cells. Fundamental to optimizing the use of these cells for potential clinical translation is the development of an understanding regarding the biologic cues that govern their ability to migrate towards infiltrative glioma foci. To this end, in this paper we detail that NPC selected for double-expression of the glial-precursor marker A2B5 and the cell-surface chemokine receptor, CXCr4, demonstrate enhanced in vitro gliomadirected tropism. These findings demonstrate the relevance of these markers for the phenotypic segregation of an optimally tumor-tropic NPC sub-population as a means of enhancing NPC-based therapeutic strategies for the treatment of glioma.

关键词： Glioma CXCr4 Neural Precursor Cells Brain Tumor(s)

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